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PhD thesis' “CONTRIBUTIONS TO THE ROLE OF DIET AND EXERCISE IN COMBAT non-alcoholic hepatic

steatosis "investigated the relationship between non-alcoholic fatty liver disease, physical therapy and
diet, through the changes that are installed during the evolution of liver steatosis, under ultrasound .
Non-alcoholic fatty liver disease, including hepatic steatosis (HS) and non-alcoholic steatohepatitis
(NASH) is a major health problem in modern society, and its prevalence is increasing.
The research took place in the period 2006-2011, the Faculty of Medicine and Pharmacy "Gr Popa "Iasi
under the guidance of Prof. Dr. Neamţu Corneliu. Lucrarea lead scientist has considered a total of 1804
patients aged between 18 and 89 years, male or female type, select both urban and rural. Of 1804
patients were monitored certain biochemical and anthropometric parameters in order to evaluate and
study the formation of representative batch. We aimed to exclude patients with metabolic syndrome
and fatty liver, due to other causes: alcohol consumption, viral etiology, these criteria helps to reduce
the number of study participants. Finally, were selected 120 patients with clinical manifestations,
laboratory and ultrasound for non-alcoholic fatty liver disease who met the following criteria: value of
serum triglycerides> 100 mg / dl; serum cholesterol value> 200 mg / dl; index BMI> 25.
Batch distribution of the 120 patients allowed uniform composition three groups: group A, B and C.
Subjects were divided randomly into 3 groups of 40 subjects each. I found this method is the best,
because every second of the three groups could be considered as witnesses for the third, giving me so
posililitatea to prove the most effective method in the evolution of non-alcoholic fatty liver. A lot
Subjects underwent physical therapy program combined with a nutrition counseling program, group B
subjects have only a program of nutritional counseling and group C subjects have only a kinetic program.
Results have shown that diet and exercise alone or together are effective methods of lowering BMI and
abdominal circumference, including in patients with non-alcoholic fatty liver disease. The study showed
that there is no universal optimal therapy applicable to all patients, an individualized approach is the
best strategy. Diet associated physical therapy resulted in the most spectacular individual results, but
also had a dropout rate almost double compared to the groups that followed only diet or physical
therapy. Following the evolution of non-alcoholic fatty liver was done at 6 months, 24 months and 48
months, aiming at and the benefits that remain in the absence of continuing diet and / or physical
therapy. It was found that although most of the patients had returned from four years earlier lifestyle
study, ultrasound liver changes have improved, they remain below the level of the entry in the study.
There was a decrease in the degree of hepatic steatosis, especially in subjects whose value has
significantly decreased serum triglycerides.
In conclusion, the correlations presented and the impact of treatment on patients bring new evidence of
reciprocal influence between fatty liver, cholesterol, triglyceridemia and BMI, and improve steatosis in
kinesiology + diet and the possible role of liver ultrasound in monitoring the evolution of the disease.
Dr.Plesea -Condratovici Alina