Anti-Aging Skin Therapy

CLINICAL
BULLETIN
DIMINISHING SKIN VITALITY: A COMBINATION OF EFFECTS
Numerous factors contribute to changes in the appearance of skin:
• The natural 28-day cycle during which skin cells are born, grow, and die may
be altered by environmental damage, lifestyle, and aging. This allows dead cells
to build up on the skin’s surface, causing dullness and sallowness and affecting
skin’s ability to hold moisture.
• Skin may become depleted of critical nutrients, such as vitamin C, leading to
loss of firmness.
• Excess sun exposure may cause irregular formation of pigment, leading to
brown patches or freckles.
• The skin’s natural process of repairing sun damage may lead to
invisible solar scars, which appear as fine lines or deeper wrinkles.
Because changes in the skin are related to numerous factors, no single treatment
can completely improve all the visible effects of stress and environmental aging.

RESTORATION OF SKIN VITALITY:

THE BENEFITS OF COMBINATION THERAPY
By understanding how skin changes and ages, dermatological science has brought
us new ways to improve skin’s appearance. We now have advanced cosmetic
treatments that work effectively on the top layers of skin where the effects of age
and the sun are most visible.
Importantly, many leading skin Nourishing effects
researchers have demonstrated Effects of AHA of Vitamin C
that comprehensive improvement Stratum Comeum
of skin’s appearance requires a
combination of treatments for
optimal results. Such a compre-
Other layers
hensive system would offer a of the
number of treatment ingredients Epidermis
and related benefits:
Basal Cell Layer
• Effective concentration of lactic
acid (10% or more) at the
appropriate pH levels to help
 relieve skin of rough surface texture and help lessen appearance of lines
and wrinkles.
• Naturalanti-irritants to improve comfort during lactic acid treatment and calm
the minor inflammation often related to environmental damage
• Powerful humectants to keep skin cells drenched in moisture, critical to health
and vitality
• VitaminC to help restore skin firmness and support the skin’s natural
defense mechanisms
• DNA enzymes to improve skin suppleness
• Sunscreens that provide the UVA and UVB protection necessary to prevent
further environmental damage and pigmentation changes.

CLINICAL STUDIES PROVE THAT ONE TREATMENT SYSTEM

RAPIDLY RETURNS SKIN TO A MORE YOUTHFUL STATE
An eight-week study was conducted to assess improvement in skin appearance
from using Nu Skin 180° Anti-Aging Skin Therapy. The study was performed by
an independent testing laboratory with the following method:
118 participants between the ages of 25 and 65 with visible signs of photo
damage were enrolled in the study. Each participant was instructed to
follow a specific regimen which consisted of use of 180° Face Wash (vitamin
C-depositing cleanser) followed by 180° Skin Mist (soothing/calming toner),
180° Cell Renewal Fluid (lactic acid 9.8%, salicylic acid 0.2%), and 180° UV
Block Hydrator SPF 18 each morning and 180° Face Wash, 180° Skin Mist,
and 180° Night Complex each evening. Participants returned to the study
center for clinical assessment at one-, four-, and eight-week time points.

RESULTS
Nearly 100% of participants in the study experienced improvement in the
appearance of their skin. Improvement was noted as early as the first seven-day
time point. The most dramatic rate of improvement in appearance was noted
at weeks one and four, with continuing improvement through week eight.
 PERCENT OF STUDY PARTICIPANTS EXPERIENCING IMPROVEMENT
Measurement Week 1 Week 4 Week 8
Reduction in appearance of fine lines 88 72 91
Improvement in elasticity 87 83 94
Improvement in texture 75 78 97
Improvement in pigmentation 62 50 85
Improvement in clarity 71 69 97
Overall 77 70 93

PERCENT IMPROVEMENT EXPERIENCED BY STUDY PARTICIPANTS

Reduction in Appearance of Fine Lines Elasticity Increase

50 60
40 50
40
30
30
20
20
10 10

0 0
Week 1 Week 4 Week 8 Week 1 Week 4 Week 8

Texture Improvement Pigmentation Improvement

80 35
70 30
60
25
50
40 20
30 15
20 10
10 5
0 0
Week 1 Week 4 Week 8 Week 1 Week 4 Week 8

Clarity Improvement
50

40

30

20

10

0
Week 1 Week 4 Week 8
CONCLUSION
For individuals with mild to more advanced signs of environmental aging,
regular use of the Nu Skin 180° Anti-Aging Skin Therapy System for four to
eight weeks results in restoration of the appearance and feel of smoother,
clearer, and younger skin.

NU SKIN 180° ANTI-AGING SKIN THERAPY

Indication
Nu Skin 180° Anti-Aging Skin Therapy is an intense cosmetic treatment system
that helps restore a more youthful appearance to skin that exhibits rough surface
texture, changes in color and tone, loss of firmness, and fine lines and wrinkles
associated with stress and environmental aging.

DIRECTIONS FOR USE

Morning:
1. Moisten face and neck with lukewarm water. Place a small amount of
Face Wash on the palm of your hand and work into a lather. Massage into
skin, gently but thoroughly. Rinse face with warm water and pat dry. Avoid
eye area.
2. Spray Skin Mist onto dry, cleansed skin.
3. Dispense a small amount of Cell Renewal Fluid onto your fingertips and
gently smooth onto face and neck, avoiding the eye area. (Each vial should
last approximately 7 to 10 days.)
4. Apply UV Block Hydrator SPF 18 to face in an upward-outward motion.

Evening:
1. Moisten face and neck with lukewarm water. Place a small amount of
Face Wash on the palm of your hand and work into a lather. Massage into
skin, gently but thoroughly. Rinse face with warm water and pat dry. Avoid
eye area.
2. Spray Skin Mist onto dry, cleansed skin.
3. Smooth Night Complex over forehead, cheeks, nose, chin, and neck.
WARNINGS OR PRECAUTIONS
• Always use Skin Mist before applying Cell Renewal Fluid.
• Alpha Hydroxy Acids may make skin more sensitive to the sun; therefore, during
the day always use UV Block Hydrator SPF 18 after applying Cell Renewal Fluid.
• Keep out of eyes and do not apply products on eyelids. If product gets into
eyes, rinse thoroughly with water.
• Ifa considerable amount of irritation is experienced, discontinue use and
consult a physician if necessary.
• For external use only.
• Keep out of reach of children.

Ingredients Benefits
Lactic Acid (alpha hydroxy acid) Exfoliation, reduction of fine lines and wrinkles

Cucumber Extract Soothes, calms, and cools skin

DNA Enzymes Helps diminish signs of sun damage

Ginkgo Biloba Extract Improves skin’s radiance, calms inflamed skin

Ginseng Extract Revitalizes and enhances skin’s appearance

Grape Seed Extract An effective antioxidant, soothes skin

Licorice Root Extract Provides calming benefits to the skin

Micronized Zinc Oxide Blocks UVA and UVB rays

Milk Enzyme Stimulates recovery from harsh environment

Mushroom Extract Diminishes appearance of pores; firms and tones skin

HMW Complex Helps reduce irritating effects, prevents redness

Vitamin C (ascorbic acid) Reduces appearance of lines and wrinkles

Vitamin C Esters Provides antioxidant benefits to the skin

REFERENCES
1. Thueson DO, Chan EK, Oechsli LM, Hahn GS. The Roles of pH and
Concentration in Lactic Acid-induced Stimulation of Epidermal Turnover.
Dermatol Surg 1998;24:641-45.
2. Barone P. How to Deliver Good Glycolic Acid Therapy. Dermatology Times
1997:59.
3. Yu RJ, Van Scott EJ. Bioavailability of Alpha-hydroxy Acids in Topical
Formulations. Cosmetic Dermatology 1996;9(6):54-62.
4. Ditre CM, Griffin TD, Murphy GF, Sueki H, Telegan B, Johnson WC, Yu RJ,
VanScott EJ. Effects of a-Hydroxy Acids on Photoaged Skin: A Pilot Clinical,
Histologic, and Ultrastructural Study. J Am Acad Dermatol 1996;34(2):187-95.
5. Colven RM, Pinnell SR. Topical Vitamin C in Aging. Clin Dermatol
1996;14(2):227-34
6. Ponec M, Weerheim A, Kempenaar J, Julder A, Gooris GS, Bouwstra J,
Mommaas AM. The Formation of Competent Barrier Lipids in Reconstructed
Human Epidermis Requires the Presence of Vitamin C. J Invest Dermatol
1997;109(3):348-55.
7. Alster TS, West TB. Effect of Topical Vitamin C on Postoperative Carbon
Dioxide Laser Resurfacing Erythema. Dermatol Surg 1998;24(3):331-4.
8. Stewart MS, Cameron GS, Pence BC. Antioxidant Nutrients Protect Against
UVB-Induced Oxidative Damage to DNA of Mouse Keratinocytes in Culture.
J Invest Dermatol 1996;106(5):1086-9.

For any questions regarding the clinical bulletin or the use of Nu Skin 180°,
please call 1-887-INFO180 or send an e-mail to info180@nuskin.com.
75 West Center
Provo UT 84601
www.nuskinusa.com

01 100586
90012732