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Key words :
Efficacy of Chlorhexidine, Chlorhexidine
mouth care, Ventilator Associated
Pneumonia
Correspondence at :
Dr. Suresh K. Sharma
Professor, College of Nursing,
Dayanand Medical College & Hospital,
Ludhiana, Punjab
Introduction
The pathogenesis of ventilatorassociated pneumonia (VAP) involves
aspiration of bacteria from the oropharynx
into the lung, and subsequent failure of host
defenses to clear the bacteria resulting in
development of lung infection 1. In
mechanically ventilated, intensive care unit
patients, the major potential respiratory
bacterial pathogens (PRPs) include
Staphylococcus aureus, Pseudomonas
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Objectives
To assess the efficacy of chlorhexidine
mouth care in prevention of VAP.
Patient population: This Randomized
control trial was approved by the Institutional
Ethical Committee. Subjects for this study
were recruited from patients admitted to the
Medical, Surgical and Neuro-surgery Intensive
Care Units of Dayanand Medical College &
Hospital (DMCH), Ludhiana, who were
mechanically ventilated. DMCH is a 1200bedded tertiary care providing hospital and
is an affiliated teaching facility for the Baba
Farid Univeristy of Health Sciences, Faridkot,
Punjab. The average length of stay in this unit
in the year before the start of the study was
approximately nineteen days. Over the past
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171
0.12% CHX was applied using a rinsesaturated oral foam applicator twice
daily (morning 7 AM and evening 7 PM).
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173
N 260
Exp. group
(n=130) f (%)
Control group
(n=130)f (%)
12 (09.2)
24 (18.5)
37 (28.5)
57 (43.8)
09 (06.9)
27 (20.8)
43 (33.1)
51 (39.2)
2 =0.387NS
Gender
Male
Female
97 (74.6)
33 (25.4)
94 (72.3)
36 (27.7)
2 =1.456NS
d.f. = 1
Habitat
Rural
Urban
56 (43.1)
74 (56.9)
52 (40.0)
78 (60.0)
2=0.934NS
Medical diagnosis
Medical
Surgical
51 (39.2)
79 (60.8)
49 (37.7)
81 (62.3)
2 =0.456NS
d.f.=1
Admitted from
Community
Hospital ward
Nursing Home
Other ICU
22 (16.9)
26 (20.0)
63 (48.5)
19 (14.6)
19 (14.6)
27 (20.8)
66 (50.8)
18 (13.8)
2 =1.012NS
d.f. = 3
2-test
d.f. = 3
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N = 260
Exp. group
(n=130) f (%)
Control group
(n=130)f (%)
2-test
Present
07 (05.7)
46 (35.4)
36.045*
Absent
123 (94.9)
84 (64.6)
d.f.= 1
2 - test
01 (14.3)
02 (28.6)
04 (57.1)
0.174NS
8 (17.4)
10 (21.7)
28 (60.9)
d.f.= 1
175
2.
176
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177
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