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Discovering

Collagen

The most complete reference booklet about collagen!

NEW! Genacol ® Instant More details inside PAGES 10 - 11
NEW!
Genacol ®
Instant
More details inside
PAGES 10 - 11

Collagen

can help:

Joint pain, Fibromyalgia, Wrinkles and more

Think collagen, think Genacol ® !

INDEX

Collagen, the glue of life!

2

How the body rebuilds itself

3

Why is collagen necessary for youth and health?

4

Cartilage Collagen and sleep

5

Diseases due to collagen deficiency

6, 7

Collagen and skin

8

Genacol ® ! A new discovery

9

NNEEWW!! Genacol ® Instant - Instant relief!

10

Genacol ® - Clinical Trials

12, 13, 14

Dr. Price’s Study Dr. Sal Martingano’s comments

13

History of Genacol ®

15

Testimonials

11, 16, 17, 18, 19, 20, 21

Frequently asked questions about Genacol ®

22, 23, 24

Bibliography

25

Dear Readers,
Dear Readers,
Dear Readers, This reference booklet was produced in order to answer your questions about collagen. You
Dear Readers, This reference booklet was produced in order to answer your questions about collagen. You

This reference booklet was produced in order to answer your questions about collagen. You will find a lot of information on collagen and its properties. Included as well, are clear and simple explanations about problems related to collagen deficiency. You’ll understand why Genacol ® can bring you the help that you are looking for.

Genacol ® is the result of more than 20 years of research. Thanks to a unique and exclusive process called AminoLock ® Sequence Technology discovered by the DirectLab Inc. Research and Development Division, Genacol ® is the only 100% pure collagen product that has this concentration of amino acids.

This booklet contains important information about collagen and will clearly explain both the difference and superiority of Genacol ® as compared to other collagen products.

Enjoy your reading!

A. Prud’Homme, n.d. Vice-President International Sales

1

2

Collagen, the glue of life!

Collagen is present in all multi-cellular

organisms. It is the fibrous structural protein that makes up the white fibers (collagen fibers) of skin, tendons, bones, cartilage, and all other connective tissues. It also provides structure throughout the gelatinous substances of the body, such as in the vitreous humor of the eye. In other words, collagen is

natural protein that makes up most of the

body’s structural support and is the primary

a

substance of connective tissue. It is this fibrous connective tissue that holds our body together.

Collagen gives to different organs and tissues their strength and elasticity. Collagen makes up 25% of the dry protein weight in the human body. About 75% of our skin is made of it, and overall, some 30% of our entire body is collagen. Collagen is part of the natural makeup of our tendons, ligaments, joints, muscles, hair, skin, and vital organs. When the body’s essential supply of collagen is reduced, the body is affected. Weakness, fatigue, aches, pain, and an overall lack of energy are frequent symptoms of the problem – symptoms that only increase as we get older.

addition to its many structural properties,

collagen serves as a major catalyst for the growth and repair of nearly all of the body’s tissues. Many different aging and collagen disorders are related to a deficiency of this vital protein.

In

are related to a deficiency of this vital protein. In Normal collagen fibers Arthritic collagen fibers

Normal collagen fibers

Arthritic collagen fibers

Collagen molecule

to a deficiency of this vital protein. In Normal collagen fibers Arthritic collagen fibers Collagen molecule
to a deficiency of this vital protein. In Normal collagen fibers Arthritic collagen fibers Collagen molecule
to a deficiency of this vital protein. In Normal collagen fibers Arthritic collagen fibers Collagen molecule

How the body rebuilds itself

Whether the body can efficiently rebuild and repair itself is dependent upon its ability to convert one body resource into another. This process of protein synthesis is a metabolic process requiring collagen as a catalyst. As collagen diminishes in the body, both the resource and the catalyst are reduced.

Producers of health food supplements have consistently recognized the need for collagen supplements. The body manufactures its own collagen every single day, but since production diminishes with age, the available supply of collagen quickly becomes less than enough. Deterioration of various body parts gradually follows. The first signs are wrinkles and the beginning of unexplained joint pain. This is only part of the effects. As health begins within the body, the secret to a young and healthy appearance is to act on the cause of the deterioration before it takes hold.

act on the cause of the deterioration before it takes hold. Many factors can harm and
act on the cause of the deterioration before it takes hold. Many factors can harm and
Many factors can harm and reduce our body’s collagen production. Smoking, drinking alcohol on a
Many factors can harm and reduce
our body’s collagen production.
Smoking, drinking alcohol on a regular
basis, coffee, intensive stress and
excessive physical training are some
of the factors responsible. Also,
infections, pollution and bad climatic
conditions as well as medication and
drugs weaken our organism.
Those of us who wish to look and
feel younger should be interested in
collagen synthesis. Therefore, any
food supplement that can enhance
the rebuilding or healing process of
our body is something that we should
strongly consider.

The tendons of our body act like rubber bands. These fibers are made up in large part of collagen. To maintain elasticity and flexibility, our tendons require a large amount of collagen, especially after an injury or because of the natural aging process.

our tendons require a large amount of collagen, especially after an injury or because of the

3

Why is collagen necessary for youth and health?

Why is collagen necessary for youth and health? Collagen is naturally produced by the body. It

Collagen is naturally produced by the body. It is vital to the body’s functioning because it is the tie that binds! The body’s use of collagen cannot be overstated. It makes up the body’s joints, muscles, hair, skin, tendons, and ligaments. It provides structure to our body and forms the molecular cables that strengthen the tendons. Collagen makes up the vast resilient sheets that support our skin and internal organs. Bones and teeth are formed when the body adds minerals to collagen.

COLLAGEN AND AGING The body’s production of collagen slows with aging. Things we have always done, like running or jumping, suddenly seem more painful. Injuries that have never proven serious before begin to hurt us. Joint pain becomes more problematic. With continued aging, our connective and muscle tissues break down due to an increase in collagen deficiency and damage. As a result, we experience a weakening of our skeletal structure. We start to feel the pain of aging. So, what should we do to nourish our joints?

pain of aging. So, what should we do to nourish our joints? Collagen, looking for the

Collagen, looking for the fountain of youth

Collagen fibers are woven together like pieces of fabric to form a network in which
Collagen fibers are woven together
like pieces of fabric to form a network
in which new cells grow and reproduce.
Any time the body needs to build
new cells, such as in the healing or
growing process, collagen plays a
central role. Collagen is the substance
that protects and supports the softer
tissue of the body, and it is what
connects them to our skeleton. In
other words, collagen is both the
material and the glue that holds our
body together.
Outside the body, the slowing of the
skin’s production of collagen becomes
increasingly more pronounced. The
skin starts to wrinkle. It loses its
youthful glow. The appearance of
healthful radiance vanishes. Soon
we develop ridges and furrows, red
marks and brown spots. Our skin
loses elasticity and moisture.
vanishes. Soon we develop ridges and furrows, red marks and brown spots. Our skin loses elasticity

Cartilage

Collagen and sleep

Cartilage Collagen and sleep Cartilage is a rather firm rubber material that covers the extremities of

Cartilage is a rather firm rubber material that covers the extremities of bones in normal joints. The primary function of cartilage is to reduce joint friction and, since cartilage can change shape when compressed, serve as a shock absorber for the bones.

The vast majority of collagen’s catalytic work is best conducted by the body at night during sleep. Sleep is not an interruption of activity but simply another form of activity. It is indispen- sable for healing.

form of activity. It is indispen- sable for healing. Research has proved that a large part

Research has proved that a large part of the essential metabolic work in the repair of the body takes place when we sleep. Sleep is divided into several phases. Our body regenerates during phase 2 and 3; however, it regenerates the most during the first phase called the Alpha phase. In other words, during the Alpha phase our body uses its full regenerative capacity. During the Alpha phase, our system looks for available amino acids and nutrients in order to trans- form them into essential elements for our body. The sleep cycle repeats itself several times over many hours.

Collagen is a key component of cartilage (67%), providing it with its strength. When the
Collagen is a key component of
cartilage (67%), providing it with its
strength. When the body’s collagen
production is reduced, cartilage
production is affected and so are all
the body’s systems that contain
cartilage. Cartilage can change
shape because it is composed of
over 70% of water, which can be
redistributed with compression or
movement. Since cartilage does not
contain nerves, in the beginning, you
never feel pain when these changes
occur. As we age, this shock absorbing
quality is reduced due to collagen
deficiency which is why activities like
running and jumping feel less com-
fortable as we get older.
The ability to convert collagen into
bio-digestible elements takes place
while we sleep. So, in order to develop
muscles, tendons, ligaments and to
rebuild and repair organs and skin,
the body must go through a process
of protein synthesis that happens
specifically during the Alpha phase.
One thing is for sure, sleep is really
important and essential for good health!
specifically during the Alpha phase. One thing is for sure, sleep is really important and essential

Diseases due to collagen deficiency

Diseases due to collagen deficiency, long associated with aging, are not only found in the elderly. They form an entire group of diseases that involve abnormalities of the immune system. The blood plasma of patients with disease due to collagen deficiency show significant levels of auto-antibodies. This antigen-antibody reaction leads to inflammation of many of the body’s vital tissues. Here is a brief description of some of these diseases and a list of some auto-immune diseases:

Arthritis

Arthritis is a general term describing inflammation of the joints. The most known form of arthritis is osteoarthritis, which is also called degenerative joint disease. Osteoarthritis is associated with a breakdown of cartilage in joints and most commonly occurs in the hips, knees, shoulders and spine. It can dramatically affect the fingers and toes.

All arthritis sufferers share common symptoms of severe pain and loss of movement in both range and motion, all of which cause premature aging and lead to a diminished quality of life. Research has demonstrated that when people suffer from arthritis, a selective destruction of collagen in the joint cartilage has occurred. White blood cells attack the joint cartilage, which in turn activates the immune system to develop antibodies. These antibodies turn around and attack what they perceive to now be the enemy, i.e. ‘’collagen’’. Consequently, the immune system’s response is to attack all the cartilage that is degenerating in the body. So, even if there may only be a problem in one wrist or knee, both wrists hurt, both knees hurt, our back, our hips, and both shoulders feel the pain. In the end, the result is the same: age-related pain increases along with a pronounced loss in quality of life.

increases along with a pronounced loss in quality of life. Rheumatic disease is a frequently-used term,

Rheumatic disease is a frequently-used term, since rheumatoid arthritis, the most common of all diseases, displays many characteristics of this group. The cost of traditional arthritis treatment

has skyrocketed from $65 billion in 1992 to nearly $480 billion in 2002. Most of the cost went to disability payments and lost time at work. The effects of arthritis result in 20,000 deaths as well as 2 million hospitalizations each and every year.

as well as 2 million hospitalizations each and every year. Furthermore, there is an additional horrific

Furthermore, there is an additional horrific cost of treating the side effects of arthritis medications, including corticosteroid drugs and immune sup- pressive drugs. Without a doubt, collagen-related diseases represent a terrible burden on society.

With 60 million Americans suffering from arthritis, we can say that there is an arthritis
With 60 million Americans suffering from arthritis,
we can say that there is an arthritis epidemic. John
Klippel, Medical Director of the Arthritis Foundation,
flatly stated: this should be a wake up call. We’ve
always thought the problem was greater than
expected. Studies and testimonies have demonstrat-
ed that a hydrolysate of collagen such as Genacol ®
is one of the most effective solutions.
Fibromyalgia and collagen
The acceptance of fibromyalgia as a disease and
its definitive diagnosis has been hampered by a
lack of knowledge concerning the underlying
physiopathology of this disease and the lack
of specific biochemical markers applicable to
its diagnosis.
Research has shown that fibromyalgia patients
(diagnosis made by the American College of
Rheumatology) had a lower amount of intramuscular
collagen and lower levels of collagen metabolites
(urine and serum). This may lower the threshold for
muscle micro-injury and contribute to the remodeling
of the extra-cellular matrix and collagen deposit
around the nerve fibers, as well as contribute to the
lower pain threshold at the tender points.

The average complaint level of pain in people who have had medically diagnosed fibromyalgia for 2-15 years and are taking a "collagen hydrolysate" decreased significantly in an overall group average, and, in some individuals, quite dramatically. In our opinion, patients with fibromyalgia may improve symptomatically their chronic pain by taking "collagen hydrolysate" such as Genacol ® .

Bursitis, tendonitis and tendinosis

Bursitis is caused by arthritis inflammation or by infection. The joint areas most commonly affected are the shoulders, elbows, wrists, hips, back, and ankles, etc.

Individuals with bursitis have pain, tenderness and stiffness near the affected area. Local muscle weakness frequently develops as a result of avoiding painful joint movements, such as those caused by climbing stairs.

Tendinotis, an inflammation of the tendons, has frequently been considered the cause of tendon pain and the associated loss of strength and movement. More recently, researchers have discovered that most people diagnosed with this disease have no sign of tendon inflammation. Consequently, medical science has come to see tendonitis more properly classified as tendinosis. Nowadays, the terms are interchangeable.

Tendinosis/Tendonitis is caused by a breakdown of the collagen-composed tendon. Collagen contributes to the rope-like structure of a tendon and to its strength. When collagen breaks down, small tears appear in the tendon, weakening it and causing pain. It is especially wearing on those who perform repetitious tasks in their jobs, sports or daily activities.

Bursitis, tendonitis/tendinosis can be successfully treated by letting the painful areas rest, applying ice or taking a collagen supplement like Genacol ® . This gives the body time to repair and repro- duce the damaged cartilage, provided that the body is still producing the necessary amount of collagen.

A few more exam- ples of diseases relating to collagen deficiency

Here is a list of diseases which DirectLab Inc has fre- quently received eloquent testimonies where a sig- nificant decline of the symptoms and pain were noticed after taking Genacol ® : All arthritic types, osteoarthritis, fibromyalgia, bursitis, tendonitis or tendinosis, acute rheumatic fever, lupus erythematosus, dermatomyositis, infectious scleroderma, arthritis, polymyositis, ankylosing spondylitis, etc. Here are more details about two of these diseases:

etc. Here are more details about two of these diseases: -Systemic lupus erythematosus (SLE) is the
-Systemic lupus erythematosus (SLE) is the most common and serious type of lupus. With SLE,
-Systemic lupus erythematosus (SLE) is the
most common and serious type of lupus. With
SLE, the immune system that normally protects
the body from germs, viruses, and bacteria
begins to malfunction. It generates antibodies
that attack healthy tissue in different parts of the
body. These tissues become inflamed as a
result. Inflammation can occur in the skin, muscles,
joints, heart, lungs, kidneys, blood vessels and
the nervous system.
-The word scleroderma means 'hard skin.'
Scleroderma is a condition where the skin gets
thick and hard. Hydrolysate of collagen has
been given to people suffering from this disease
with good results. More research is needed to
prove that collagen can really help.

Some collagen diseases have no satisfactory treatment, but most can be treated medically. For example, rheumatoid arthritis is commonly treated with aspirin-like compounds, corticosteroids and immunosuppressive agents, used separately or in combination. Some collagen diseases, like rheumatic fever, are treated with antibiotics, but unfortunately, in traditional medicine no treatment gives complete satisfaction at the moment.

with antibiotics, but unfortunately, in traditional medicine no treatment gives complete satisfaction at the moment. 7

8

Collagen and skin

At about twenty-five years of age, the body’s collagen production decreases in the skin. This process accelerates between the ages of forty and fifty. Many studies have shown that our normal collagen production can diminish at a rate of 1% per year after the age of forty which means that, by the age of fifty-five, the body has lost approximately 15% of its capacity to produce collagen. By the age of seventy, the loss of collagen production can diminish by 30%.

A few facts:

- Collagen makes up the majority of the derma.

A few facts: - Collagen makes up the majority of the derma. - Collagen is not

- Collagen is not found in food. It is made by the fibroblasts of the body.

- Collagen is the structure, the molecule that holds our body together.

- Collagen is the most abundant protein in the body. - Our body is composed
- Collagen is the most abundant protein in
the body.
- Our body is composed primarily of connective
tissues and collagen makes up 85 % of all
connective tissues.
- Collagen is the protein that supports our skin.
Due to its composition, collagen is the most
complex protein of the connective tissues of the
human body.

When the production of collagen slows down, the skin retains less water, gets thinner and begins to wrinkle.

The lack of collagen in the skin becomes apparent with thinner skin. Little by little, capillary tissues of the skin become thicker, which reduces the capacity of the skin to retain nutrients and water. The skin then presents a bigger risk of developing wrinkles, stretch marks and infections. Its color and pigmentation change, and brown spots appear. Since the skin is less healthy, its capacity to serve as barrier to bacteria and viruses is reduced. A supplement of collagen can largely help to regenerate skin tissues and so helps to slow down the aging process, particularly if it is ingested, since the effect will occur throughout the whole body.

to slow down the aging process, particularly if it is ingested, since the effect will occur

Genacol ® ! A new discovery

Genacol ® ! A new discovery Genacol ® is a hydrolysate of collagen, generated by an
Genacol ® ! A new discovery Genacol ® is a hydrolysate of collagen, generated by an

Genacol ® is a hydrolysate of collagen, generated by an enzymatic process and re-modulation of amino/peptides. This exclusive process is called AminoLock ® Sequence Technology.

DirectLab Inc. produces a very high quality collagen product, in 400 mg capsules, without any preservative or fillers. No other collagen product on the market possesses the same concentration of amino acids as found in Genacol ® .

amino/peptides. Genacol ® is manu- factured under the highest biotech- nological standards and conforms to government requirements.

A collagen matrix is a safe, formulated substance that stimulates the pro- duction of many different kinds of collagen in the body. The collagen matrix, formulated from pure collagen, produces incredible results in the human body when used on a regular basis. Genacol ® is a protein complex that uses specific AminoLock ® Sequence Technology. No other product on the market contains this concentration. In order to obtain this concentration of amino acids, it would be necessary to have up to 10 times more collagen.

The unique manufacturing process called AminoLock ® Sequence Tech- nology is an exclusive approach developed
The unique manufacturing process
called AminoLock ® Sequence Tech-
nology is an exclusive approach
developed by the Research and
Development Division of DirectLab
Inc. and consists of enhancing collagen
AminoLock ® Sequence Technology
exclusive to Genacol ®

PRINCIPAL TYPES OF COLLAGEN

Genacol ® is a collagen matrix that can help stimulate the production of the principal types of collagen which make up 99% of all collagen found in the body. They are present in the body in the following way:

Type I

Type II

Type III - Liver, lungs and arteries; Type IV - Kidneys and many other internal organs; Type V - Cells surfaces, hair and placenta.

- Bones, tendons, ligaments and skin; - Cartilage and structure of the eyes;

Genacol ® is the only product that has this special amino acid combination.

® is the only product that has this special amino acid combination. Example of a typical
® is the only product that has this special amino acid combination. Example of a typical
® is the only product that has this special amino acid combination. Example of a typical

Genacol ® Instant - Instant relief!

Genacol ® Instant - Instant relief! This high quality product is a topical gel with added

This high quality product is a topical gel with added Genacol ® microbeads designed to relieve local muscular, rheumatic and arthritic pains. These microbeads are essential and in large part, responsible for the excellent results of the product. Here is why:

for the excellent results of the product. Here is why: After more than two years of

After more than two years of development, DirectLab inc. is proud to present their new product, Genacol ® Instant.

Due to the bio activity of collagen, our laboratory concentrated on developing a new technology
Due to the bio activity of collagen, our
laboratory concentrated on developing a
new technology able to adequately isolate
Genacol ® in order to maximize its bio activity
when applied. We reached our goal by
inserting Genacol ® into the microbeads.
By gently rubbing the painful area with
Genacol ® Instant, the microbeads
release the collagen, immediately activating
and rapidly relieving muscular, rheumatic
and arthritic pains.
Furthermore, when the mild wintergreen smell
quickly fades away, Genacol ® Instant
relieves not only your pain but leaves your
skin feeling soft and smooth.
The soothing effect of Genacol ® Instant
will allow you to pursue your daily activities,
enjoyably and pain free.
Genacol ® and Genacol ® Instant are
both available in all pharmacies and health
food stores.
Genacol ® and Genacol ® Instant are both available in all pharmacies and health food stores.
Genacol ® and Genacol ® Instant are both available in all pharmacies and health food stores.

INSTANT RELIEF!

Testimony

Testimony About a month ago, I injured myself when I fell off my leg exerciser, which

About a month ago, I injured myself when I fell off my leg exerciser, which is located near my washing machine.

Being a heavy person, I tired to avoid falling off by shifting all my weight to my left wrist. This had a devastating effect on my entire side and neck. I then felt intense burning and a numbing sensation for several minutes all the way down to my feet. After the numbness stopped, the pain and inflammation remained intense. Furthermore, I hurt my leg because when I fell, my thigh hit the exerciser which caused a huge bump on my leg. I then went to my doctor who examined me and prescribed anti-inflammatory drugs and painkillers. After using these products for several days without any conclusive results, a friend of mine talked to me about this new product called Genacol ® Instant. On top of being a natural product, it is supposedly very effective. So I decided to try the product. After using the product for a few days and by applying it 4 times a day, the inflammation disappeared and the pain also diminished by 85% which allowed me to go on normally with my daily activities. As for the bump on my leg, it quickly disappeared and instead of becoming all shades of colour, the bump went from blue to the normal skin colour. With each application I felt a light freshness and afterwards the pain would disappear instantly.

I

realized how much it was helping me! Thanks to Genacol ® Instant I can sleep comfortably and without any pain. Otherwise, my neck would hurt all night and would prevent me from getting a good night’s sleep.

had to go a few days without the product and that quickly made me

Genacol ® Instant is truly responsible for my rapid healing and I recommend

it to everyone.

Thanks a million!!
Thanks a million!!
healing and I recommend it to everyone. Thanks a million!! Mrs. Éliane Bossé, Montréal, QC Genacol

Mrs. Éliane Bossé, Montréal, QC

Thanks a million!! Mrs. Éliane Bossé, Montréal, QC Genacol ® Instant microbeads relieve muscular,

Genacol ® Instant microbeads relieve muscular, rheumatic and arthritic pain.

Genacol ® - Clinical Trials

Genacol ® - Clinical Trials Dr. Stephen Ho, M.D. Genacol ® is the best of all
Genacol ® - Clinical Trials Dr. Stephen Ho, M.D. Genacol ® is the best of all

Dr. Stephen Ho, M.D.

Genacol ® is the best of all products because it is a collagen matrix.

COLLAGEN PRODUCTS ARE NOT ALL THE SAME.

Not all collagen products are the same. Of the very few collagen products, most have a very low absorption rate, something in the neighbourhood of 20%.

the groups. The Genacol ® group obtained the best results, followed by the liquid collagen, the collagen supplement, the placebo, and then the control group. The study was independent, and Dr. Ho was not paid by any commercial entity for conducting it. Table 1 summarizes the results. (See reference on page 13)

Genacol ® is the best of these products, because it is, first of all, a
Genacol ® is the best of these products,
because it is, first of all, a collagen
matrix. It stimulates production of the
various types of collagen rather than
just one of the fourteen kinds.
Genacol ® is produced from pure
collagen through a complex formulation
process carried out in Canada as a
result of a partnership between
DirectLab Inc. and a biotechnological
laboratory. The end product is Genacol ® ,
which has been demonstrated to
have a very high bio-availability.
The Genacol ® group recorded a
considerable reduction of aches
and pains. This group also recorded
feeling much younger and stronger.
The liquid collagen group, using a
Type II collagen in liquid form,
demonstrated favourable improve-
ments, but nearly 30% less than
the Genacol ® group. Genacol ® is the
best of all products because it is a
collagen matrix.

In a very significant three-month study aimed at comparing Genacol ® with a liquid collagen as well as an over-the-counter collagen supplement, Dr. Stephen Ho, a well known trauma physician, evaluated the results using five groups of test subjects. Each group consisted of 30 subjects, all similar in size, weight, health condition, age, and gender. The first group was given Genacol ® over a 90-day period; the second group took liquid collagen; the third group received a common collagen supplement; the fourth group was given a placebo composed of neutral ingredients; and the fifth group (the control group) was given nothing at all.

Group III, which was administered an over-the-counter collagen supplement, showed only nominal improvement. It obtained the same results as the placebo group. The placebo group, Group IV received only a non-bioactive capsule. There were minor improve- ments recorded, most of which can be attributed to psychological factors, given that they expected results. This group was unaware that it was not being given any collagen. The Control group, Group V was given neither Type II collagen nor a placebo. In composition, age, gender, and state of health, the members were similar to Groups I through IV. Histories were taken at the beginning of the study and at the end. No changes were observed.

of the study and at the end. No changes were observed. A physical history was taken

A physical history was taken before and after the 90-day study to compare

Dr. Ho’s conclusion was that the Genacol ® brand collagen matrix in its pure, dry-state form was far superior to that of the liquid or the over-the-counter collagen supplement. He also concluded that Genacol ® , taken on a regular

basis, resulted in a more youthful appearance and feeling. Pain was significantly reduced. He also stated that the group taking Genacol ® reported a more restful and longer sleep period, as well as more energy during waking hours.

sleep period, as well as more energy during waking hours.   Table 1 Comparison Study of
 

Table 1 Comparison Study of collagen matrix and Type II collagen Summary

 
 

Group I

Group II

Group III

Groupe IV

Group V

Genacol ®

Liquid

Collagen

Placebo

Control

Collagen

Supplement

Group

Reduction in

         

aches and

Considerable

Favourable

Some

Some

None

pains

Noticeable

         

change in

Considerable

Favourable

Very little

None

None

skin

Noticeable

         

feelings of

Considerable

Favourable

Very little

Small

None

renewed

energy

Dr. Price’s Study

Dr. Patrick Price, a Houston health professional, conducted another major independent study on Genacol ® , which used three groups of patients that were essentially identical in makeup. Dr. Price found that Genacol ® produced highly-observable improvement in energy, arthritic and injury pain relief, as well as skin texture. A placebo group had only minor improvements, and the control group, like the one in Dr. Ho’s study, remained the same.

Dr. Sal Martingano’s comments

There are many types of collagen that make up most of the body’s skin, tendons, bones, cartilage, and other connective tissue. Although naturally produced by the body, collagen production declines after the age of 25. Degenerative collagen diseases associated with aging affect the entire body. Collagen diseases include arthritis, fibromyalgia, bursitis, tendonitis, and other related conditions. Wrinkling, liver spots and joint pain are symptoms of degenerating collagen. Recently, new collagen products that help with collagen diseases have appeared on the market. These tend to be Type II collagen, collagen matrix, and collagen-derived products such as glucosamine-chondroitin. Of the three, the collagen matrix has been found to be the most effective. The recommended form of collagen matrix is Genacol ® . This product is far more bioactive than other products that have been clinically tested.

Genacol ® - Clinical Trials (continued)

Genacol ® - Clinical Trials (continued) Although more clinical research is required in order to determine

Although more clinical research is required in order to determine the effectiveness of the various food supplements, numerous studies have already revealed the beneficial effects of certain nutrients on joint health. Collagen hydrolysate proves to be up to now, one of the most promising food supplements. Collagen is the most abundant protein in the system. It structures tendons, cartilaginous tissues, bones and connective tissues. The composition of collagen hydrolysate of animal origin is similar to the collagen found in human cartilage.

Why does collagen hy-

drolysate

the treatment of osteo-

arthritis?

contribute

Research leads to believe that collagen hydrolysate can stimulate the synthesis of collagen, which plays an important role in

maintaining healthy joints. During the convention, Steffen Oesser Ph. D, who is part of the General and Thoracic Surgery Department at the University of Kiel in Germany, presented a resume of study results on collagen hydrolysate. In order to determine if collagen hydrolysate can effectively reach the joint tissues and modify them, researchers of the University of Kiel studied the absorption rate and the accumulation level of collagen hydrolysate by controlling its absorption in the human organism. According to the results of that study, the rapid absorption of the collagen hydrolysate in the gastrointestinal tract doubled the quantity of nutrients accumulated in the

tract doubled the quantity of nutrients accumulated in the cartilaginous tissue of the treated patients in

cartilaginous tissue of the treated patients in comparison with the patients from the control group. These results lead to believe that the collagen hydrolysate reaches the tissues and can cumulate in the long term.

The next step of the trial consisted in determining if collagen hydrolysate could have a positive

influence on the joint tissue after its accumulation. That positive influence had to translate in
influence on the joint tissue after its accumulation.
That positive influence had to translate in
two effects: inhibition of the deterioration of
the supporting joint tissue
to
Collagen hydrolysate
has proved to be
up to now, one of
the most promising
food supplements.
and/or stimulation of new
cartilaginous cells, aiming to
compensate for the naturally
damaged tissues. Thanks to
a benchmark cellular culture,
researchers were able to
demonstrate that the pre-
sence of collagen hydrolysate
stimulated collagen produc-
tion. However, natural colla-
gen would not exert that
stimulating effect.
Furthermore, researchers stimulated the supporting
joint tissue in order to assure their reproduction
in the presence of collagen hydrolysate, dimini-
shing the degenerative impairing of the joint
tissue. “These results are of certain importance.
They allow us to understand that collagen
hydrolysate reaches not only the aimed joint
tissue but its presence can also positively trans-
form the joint”, added the Dr Oesser.
Reference: PR Newswire on behalf of GELITA
Health Initiative
www.gelita-health-initiative.com/en

AminoLock ® Sequence Technology exclusive by Genacol ®

History of Genacol ®

In the mid 90’s, a research and development company located north of Montreal, Quebec, discovered collagen’s properties

as a dietary supplement. These researchers

developed various formulas in collaboration with laboratories with very high technological standards of manufacturing. These formulas were quickly appreciated by the natural health community.

were quickly appreciated by the natural health community. M. Guy Michaud President of DirectLab Inc. Over
were quickly appreciated by the natural health community. M. Guy Michaud President of DirectLab Inc. Over

M. Guy Michaud

President of DirectLab Inc.

Over several years, this product was distributed successfully in various ways. Under Mr. Guy Michaud’s
Over several years, this product was
distributed successfully in various ways.
Under Mr. Guy Michaud’s presidency, in
October 2000, a new laboratory, DirectLab
Inc. was created and Genacol ® made
its market debut. DirectLab Inc. is now

biotechnological laboratory that uses

a unique process called AminoLock ® Sequence Technology. This concept is now one of the best available.

a

uses a unique process called AminoLock ® Sequence Technology . This concept is now one of

Testimonials

DirectLab has collected numerous testimonies sent regularly by satisfied Genacol ® users

A year and a half ago, during a wrestling match, I seriously injured my left
A year and a half ago, during a wrestling match, I seriously
injured my left shoulder: tears in the ligaments and tendons
of the shoulder. I really thought that it was the end of
my career. Doctors prescribed anti-inflammatory drugs
but they didn’t work. The pain persisted. One day, one of
my students suggested I try Genacol ® but I was sceptical.
Since I was continuing to train and as my injury was still
hurting a lot, I finally decided to take Genacol ® .
At the end of the first month, I already had very good
results. Before beginning Genacol ® , my shoulder worked only at 25%.
After two months of Genacol ® , my shoulder has improved to 80%!!! I
learned that Genacol ® helps to rebuild tissues, I know now that it’s true
because I am living proof!! I had excellent results with Genacol ® and I
confirm that it is a wonderful product! I want to suggest to all athletes
who have joint, tendon or muscular pain to use Genacol ® . I use my body to
wrestle and Genacol ® helps my body to wrestle!!!!
Congratulations and thanks to Genacol ® !
Jacques Rougeau,
Professional wrestler

I’m pleased to tell you that my wife Marjorie definitely feels that the Genacol ® program is good for her. She was recently advised to undergo knee replacement surgery, having almost no cartilage left. We have no Medicare plan and, as you know, the cost of knee replacements is pretty high. We saw your ad in a national magazine and decided to contact you. Marjorie has been taking Genacol ® for over a month. She used to complain constantly about feeling tired and lacking energy. Now, she feels that Genacol ® is doing the trick: she walks better and uses her crutch less and less. Let’s see what happens later on, but it’s already a major improvement. She will continue taking Genacol ® and will have another X-ray done in six months. For now, surgery is no longer an alter- native, but Genacol ® is. Thanks again and I will keep you posted on the evolution of her condition on a regular basis.

Kind regards, Grant Cooper, Port Elizabeth, South Africa

After a great career in the National Hockey League, I was suffering from multiple injuries.
After a great career in the National Hockey League,
I was suffering from multiple injuries. Two years ago,
I heard about Genacol ® . I was really sceptical about
the effectiveness of all these natural products. In
spite of this fact, I started to take it. I felt the
difference right away. Since I had a knee injury which
required surgery, Genacol ® helped me to go on with all
my activities without too much pain. Recently, I
finally had my surgery and I have to say that Genacol ® allowed me to recover
in the most encouraging way! So, I am now a spokesman for Genacol ® and I talk
about it to a lot of people. It’s still a pleasure to hear about those people who
come back and thank me for advising them about this great product! Also, my
spouse is no longer suffering from a painful arm tendonitis.
I am truly encouraging everybody who’s suffering from arthritis or joint pain
to use this great Canadian product, Genacol ® .
Thanks Genacol ® !!!
Yvan Cournoyer, #12
Montreal Canadian Ambassador

I originally purchased Genacol ® because I have very thin hair and wanted it

to thicken, which is what happened. It’s great. But something else also happened: now, when I get up in the morning and walk down the stairs, my knees are a lot more flexible and don’t creak any more. It’s a lovely surprise!

Rene Arnold

Being on the Pro-Celebrity Golf Circuit and always a fitness enthusiast, I felt

I had done irreversible damage to my knees. When I was first approached

about Pure-Col*, I was sceptical, but willing to give anything a try. I tried the product for 6 months. When I stopped taking it, the pain returned. Now, I would not do without Pure-Col*! This is a revolutionary product, and, as a bonus I look and feel younger.

John Miles, musician and artist, UK

Dear Sir/Madam,

My wife is 75 years old, and I am 79 years old. Both of us were suffering from arthritis pain. Only one week after taking your miracle "Collagen Exclusive Matrix" supplement, at the dosage recommended on your bottle, our quality of life has improved tremendously.

I highly recommend your product to anyone whom can use it for its intended

purpose. Your product caught my eye, on your display unit, conspicuously placed at the front counter of our local Pharmacy. At first I thought it was kind of expensive, but then after trying your product, I concluded that it was money well spent. It most certainly performed as advertised.

May I take this opportunity to congratulate your Company for introducing such an excellent product?

Regards,

V. Pucci

I am a retired 62 year old. For the past two years I’ve suffered from

tendonitis in my left knee, which restricted my physical activities. Cycling, walking and training became, for someone very active, completely impossible.

I tried chiropractors, many cortisone injections, and even the services of an orthotherapeutic practitioner. Despite all these treatments, my pain continued and even became worse. I was considering knee surgery when

a friend suggested I try Genacol ® . I had nothing to lose. I started at 5 capsules a night for the first week, and then reduced to 4 capsules for the following weeks. To my great satisfaction, I was able to see an improvement

in 12 days. I am now on my second bottle. I take 3 capsules at night before

bedtime and I let Genacol ® do its work. My knee no longer hurts, I’ve started gardening and cycling again, which in itself is a great improvement,

and I’ve lost 5 pounds. I feel so much better!

Thank you Genacol ® . Thank you also to my friend for recommending this wonderful, completely natural product.

Hélène Benoît, Gatineau

I have been afflicted by fibromyalgia for more than eleven years. This

diagnosis was confirmed by an experienced rheumatologist. For a long time, the pain restricted my quality of life. Without any strength in my legs, I had to resign myself to using a wheelchair. I started to take Genacol ® , 6 capsules each day, and 3 weeks after, results are there! My sleep is better, my pain which I lived with 24 hours a day, diminished a lot! I am now able to take a little walk and I feel really happy!

Thank you Genacol ® !! Benoit Cyr, Québec

happy! Thank you Genacol ® !! Benoit Cyr, Québec Being a high-level athlete for many years,

Being a high-level athlete for many years,

I often have to deal with injuries. For

several months, I had to endure awful

sciatic pain. Given my allergy to anti- inflammatory drugs, I didn’t know what

to do anymore. One day, someone told me

about Genacol ® , a product that could surely help me. A few months before the World Championship, I had nothing to lose, so I decided to try this natural product. To my big surprise, the pain lessened and I rediscovered the flexibility that I had lost. I kept on taking Genacol ® and the pain completely disappeared. I came back from the World Championship injury-free and with two medals! With Genacol ® , I am a sure winner!

with two medals! With Genacol ® , I am a sure winner! Marie-Hélène Leboeuf, 24-year old,

Marie-Hélène Leboeuf, 24-year old, World Champion W.K.A. 2003-2005 Karate

I had been suffering from acute tendonitis (tennis elbow) for over a year. Anti-

inflammatory drugs had bad side effects for me. Cortisone injections were painful

and not very helpful in the long run. I was taking ibuprofen every single day to help ease the intense pain. I started taking Genacol ® on January 26, 2007. For 2 weeks

I took 6 capsules a day, following the recommendation of a friend who had taken

this supplement. I then reduced the dosage to 3 capsules a day. Here we are, February 22, 2007, and I am no longer in need of any type of pain reliever, indeed,

I haven’t been taking anything for the pain for about 2 weeks. I am convinced that

Genacol ® is the reason why. I have added no other supplement to my diet except Genacol ® . I plan on continuing to take this wonderful collagen supplement, and will

let you know how I am doing with long term use of Genacol ® . Thanks Genacol ® , for giving me back the use of my arm! Christine Lockett, Blainville, Québec

I had problems with the mobility of one arm and one leg as well as problems

with my back, my cartilage and my tendons. Following a problem in my spinal column, I had surgery that was, thank God, successful. After the surgery I was prescribed anti-inflammatory drugs, which I had no interest in taking. My son had me try Genacol ® and seeing the beneficial results that he had with this product, I decided to follow the treatment for 6 months. After this period, I have had an improvement of 90% in the mobility of my leg and my shoulder problems have also disappeared. Conscientious of the well being of people, I counselled a few doctors on my experience. They have followed the treatment and are now prescribing it to their patients. Thank you Genacol ®

Mr. Raymond Touret, businessman Fort-de-France, Martinique

I have been diabetic for more than 25 years, and must give myself many insulin

injections a day. When you are diabetic, it is strongly recommended to exercise. However, I could not exercise because I had very painful knees. Taking Genacol ®

has changed my life! Working as a construction contractor, walking on site to supervise the work had become very difficult. But with Genacol ® the aches and pains in my knees have disappeared and I no longer have difficulty walking or climbing stairs. The fact that I can now exercise, on the advice of my doctor, I have been able to reduce my insulin injections by 40 %. When you are diabetic, doctors tell you to keep away from natural products so you don’t dare try some- thing natural. Now I am convinced that, thanks to Genacol ® , I have a new life!

Yvon Deschesnes, Mirabel, Qc. Contractor thanks to new and healthy life!

For several years I have been suffering from arthritis pain, sore back, muscle cramping, pain in my fingers, knees, bones, joints, etc. I am 56 years old, work as an office technician and an activity coordinator for

senior citizens. I have many social activities. I did research on Internet to try to find something that would help ease my many aches and pains.

I do not believe in taking products like Vioxx or other medication of that

nature. I found Genacol ® , I tried it, and I can tell you that after only 4 days I started to feel the benefits in my joints. I tell my friends that Genacol ® is truly miraculous. I certify that Genacol ® is a real miracle! I told my doctor about and also told him that my aches and pains have diminished by 80 % after only 3 weeks of using Genacol ® . I continue to take Genacol ® because I can now exercise and continue to do my work without any pain.

Yours Truly, Jacqueline Vézina, Rivière-au-Renard, QC

February 8, 2006

I wanted to let you know that this is a fantastic product. I purchased

this product for my mother who is 71 years old. She really suffers from fibromyalgia and arthritis and severe leg cramps every night. She has

been on your product now for about 3 weeks and she thinks it is a miracle

in a bottle. She has not experienced one single leg cramp and her movement

is fantastic! She feels wonderful and I am so happy for her because I have seen her suffer for years. I personally have been on this product for about the same amount of time and I have noticed skin changes and great bowel movements.

Thank you for a wonderful product! I have told lots of people about this great thing! Tammy

Quelle merveille!

I have been taking Genacol ® for 50 days now - my knee is so much better

(I injured it 2 years ago). The pain is almost gone and my range of motion is so much improved. You can count on me for a testimonial – eh oui, même en français. Vraiment, je suis épatée.

Merci,

Sabine Davies

Hello,

I

just wanted to let people know that I have started using Genacol ® and

in

only one week I have noticed the difference in my skin and pain in my

bones. I have Lupus and also have skin cancer and since I have been taking this product I noticed my bone pain is not as bad as usual and my skin is

starting to smooth in only one week. I cannot imagine what I will feel like

in a few months! I am getting this product for my mother and my sisters

as this is amazing I will not stop using this, just give it a try!! You will not be unhappy I can tell you.

Shelley Craig

Toronto, ON

Frequently Asked Questions about Genacol ®

What is the difference between collagen and glucosamine?

Collagen makes up 67% of cartilage as opposed to only 1% of glucosamine. Glucosamine is an amino sugar whereas collagen is a molecule containing amino acids. Glucosamine is only found in large quantities in the liquid of the synovial membrane. Collagen is also found in the synovial membrane but in larger quantities since it is the most abundant structural protein in the body. Glucosamine acts more like a lubricant in the joints while collagen contributes to the global regeneration of the joint at all levels: tendons, ligaments, cartilage, muscles, membranes and the synovial liquid.

What is the ideal dosage?

If you drink about 1.5 liters of water per day (please note that this quantity is the one recom- mended for good health and not only for taking Genacol ® ), you can begin with 3 capsules per day at bedtime. If you are not used to drinking this minimum quantity of water, start with 1 capsule per day during the first week, increase the quantity of

per day during the first week, increase the quantity of water you drink and then you
water you drink and then you may go on to the recommended dosage. After a
water you drink and then you may go on to the
recommended dosage. After a few weeks of
treatment and in order to optimize the results, you
can double the dose to 6 capsules per day, i.e.,
3 at bedtime and 3 before breakfast. Caution: for
people taking medication, it would be preferable to
leave a 2 hour period between Genacol ® and any
medication.
How long must I take Genacol ® ?
We suggest taking 3 capsules per day for the first
3 to 6 weeks and then progressively move to the
dosage that best suits you. In cases of degene-
rative diseases, in order to maintain the beneficial
effects and avoid recurring problems of pain and
discomfort, it is suggested taking Genacol ® on a
permanent basis. Please note: According to an
internal survey, the majority of people had results
after only one bottle.
What other situations could Genacol ® be used for?
Besides arthritis, osteoarthritis and fibromyalgia,
Genacol ® can be used in cases of tendonitis, bursitis,
hernia, carpal tunnel syndrome and all other
auto-immune diseases as well as for aesthetic
purposes such as toning the skin and muscles.
Generally speaking, Genacol ® can be used in
cases of joint and muscular pain, as well as to help
hydrate and tone the skin.

What’s the difference between Genacol ® and other products such as those containing Type II collagen?

Genacol ® is a matrix created by a procedure called AminoLock ® Sequence Technology developed by DirectLab Inc. This matrix is produced from a complex containing many types of collagen, thus making it a far more complete product than the ones using only Type II collagen. See reference on page 9.

Why is it suggested taking Genacol ® at bedtime?

It is suggested taking Genacol ® at bedtime, because during the Alpha phase which takes place during the first 90 minutes of sleep, the body searches for the nutrients necessary to repair itself. The essential nutrients contained in Genacol ® (amino acids) will be used by the body at this precise time in an optimal manner. Therefore, it’s better to take it at bedtime. Even though it’s better to take Genacol ® at night, certain circumstances may make it impossible to take it at that time. It would then be preferable to take it in the morning, 30 minutes before breakfast. See reference on page 5.

that time. It would then be preferable to take it in the morning, 30 minutes before

Who should take Genacol ® ?

Given that the body produces less collagen with aging, every adult can benefit from Genacol ® .

Can I take Genacol ® if I am diabetic?

Contrary to glucosamine, Genacol ® should not affect the glucose level in your blood. Proteins do not affect blood sugar levels. Since Genacol ® is a protein; you can safely use this product without any fear with the approval of your health care professional. Therefore people with diabetes can benefit fully from Genacol ® .

Can I take Genacol ® if I have a fragile stomach?

Yes, there are no side effects from taking Genacol ® for people having a fragile stomach. In order to facilitate digestion, you can remove the collagen powder from the capsule and take it with some water.

Is Genacol ® absorbed by the body?

Yes, absolutely. The protein is micronised or reduced to a fine powder which permits a more effective absorption.

Are there certain health conditions for which it is not recommended to take Genacol ® ?

Collagen products are generally recognized as safe. However, if you are pregnant or breastfeeding, there is not enough current information in regards to the safe use of collagen. According to Health Canada, the manufacturers of natural products are not permitted to express an opinion on the subject. We therefore recommend that you get a medical opinion.

Can I take Genacol ® with medicine or supplements?

As far as we know, there is no medical interaction with the use of Genacol ® . Genacol ® is a safe amino acid complex and it is considered as a nutritional supplement. Yet, we recommend you get a medical opinion. As already mentioned, you should wait 2 hours before taking Genacol ® , in order to minimize the risk of interaction with each substance.

to minimize the risk of interaction with each substance. How many amino acids does Genacol ®

How many amino acids does Genacol ® contain?

Genacol ® contains all common amino acids in its matrix, except for Tryptophan. Tryptophan is not one of the amino acids found naturally in collagen. Every capsule contains 400 mg. of our pure collagen matrix without fillers, which makes Genacol ® one of the purest collagen supplements on the market.

What does “AminoLock ® Sequence Technology” mean?

We use a unique manufacturing process called AminoLock ® Sequence Technology, which in turn generates an enzymatic process that recon- figures the profile of amino acids. This exclusive approach developed by our Research & Development Division meets the highest nutraceutical standards, creating a unique product promoting the five main types of collagen and using a specific sequence of amino acids. See reference on page 9.

What is the source of the amino acids found in Genacol ® ?

Genacol ® is composed of hydrolyzed collagen proteins which mean that they have been purified with a unique enzymatic process. DirectLab Inc., through its AminoLock ® Sequence Technology, only uses certain fragments of bovine protein from Germany (subcutaneous source, therefore there is no contact with the animal’s blood or organs) that have undergone strict and thorough analysis to guarantee that the product is totally safe. No types of mad cow disease (bovine spongiform ence- phalopathy) or any other illnesses have ever been detected from this source. The product is certified by the Government of Canada and by Health Canada among other agencies to meet the highest nutraceutical standards.

Please note:

These statements have not been evaluated by Health Canada. However, Genacol ® conforms to the requirements of Health Canada This booklet has been produced as a source of informa- tion about collagen. The booklet is not to be used as a diagnostic tool, nor to treat, heal, or prevent illness. Genacol ® should be considered as a basic nutritional supplement. However, it is recommended to seek advice from your health care professional.

to seek advice from your health care professional. Can I give Genacol ® to my pet?
to seek advice from your health care professional. Can I give Genacol ® to my pet?

Can I give Genacol ® to my pet?

The good news is that you can give Genacol ® to your pet. Calculate one capsule per 40 pounds daily. It is more effective to open the capsule and give the powder in it to your pet between meals (empty stomach). Place the powder on a dry and clean surface. Pets normally love it! There is no possibility to give an overdose of collagen to your pet as the body naturally eliminates any excess.

it! There is no possibility to give an overdose of collagen to your pet as the

BIBLIOGRAPHY:

Miller-Keane, Medical Dictionary, 2002. A. Berton, V. Rigot and al., “Involvement of Type II

Fibronectin in the efficient inhibition of gelatinases

A and B by long-chain unsaturated fatty acids”,

Journal of Biological Chemistry, June 2001. Alex Suth, DC, during a personal interview, April

2003.

Shelton, Gene, “Collagen and arthritis”, Health

Remedies Notebook, 2002.

National Cardiovascular Disease Statistics, Office

of the Surgeon General, Washington D.C 2003.

“Effects of oral administration of collagen on

rheumatoid arthritis”, a Harvard School of Medicine study published in the Journal of Science, Boston, Massachusetts, 2003. Cochran, Charles, “Lubricate your joints”, Canadian Journal of Health and Nutrition, March

2001.

Christopher M. and al., “The hierarchical role in

binding Timp-2 of the unique cationic clusters of hemopexin modules Iii and Iv”, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia,

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fibroblasts cultured in fibrin gels”, Experimental Cell Research, 223: 127-134.

O. Steinbrocker et al., Journal of American

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gens and enzymes of collagen biosynthesis”, Collagen Research Unit, Biocentre Oulu and

Department of Medical Biochemistry and Molecular Biology, University of Oulu, Finland, 2001. Collagen studies, Brown University, Department of Orthopedics, 1997.

Bjorn Steffensen Dagger and al., “The involvement

of Type II fibronectin modules of human gelatinase

A in cell surface localization and activation”,

abstract from the Faculty of Dentistry and the

Department of Biochemistry and Molecular Biology, University of British Columbia.

Ho Stephen, “A catalyst study of collagen interac-

tion”, Journal of Applied Research, Las Vegas, NA,

2003

Jeff Wilson and al. “Ca++ induced switch from helix

to sheet triggers collagen binding”, American

Crystallographic Association, annual meeting, July

21, 2001.

Leroux J.Y., a well-known Canadian immunologist specializing in collagen research, speaking during

a nationally broadcast television special, “The loss

of youth”, 2003.

Hunter G.K and al., “Modulation of crystal formation

by bone phosphoproteins: Role of glutamic Acid-

rich sequences in the nucleation of hydroxyapatite by bone sialoprotein”, Biochemistry Journal.

302:175-179.

N.A. Nandriopoulos and al., Arthritis Rheum. 19, 613 (1976); D.E. Trentham et al., NEJM, 299, 327 (1978); A.Tarkowski et al., Arthritis Rheumatism,

Li

S. and al., “Innate diversity of adult human

32, 1087 (1989)

Sprott H., Muller A., Heine H., “Collagen cross-links

arterial smooth muscle cells: cloning of distinct subtypes from the internal thoracic artery”, Circulation Research, 89:517-525. Michael W.Smith, “Understanding Arthritis”, Treatment and Detection, June 2002.

Olson GB., Savage S, Olson J., “The effects of collagen hydrolysate on symptoms of chronic fibromyalgia and tempomandibular joint pain, Cranio, 18(2): 135-41, 2000

Anu Muona: Type XV collagen. “Complete

in

fibromyalgia syndrome”, Z. Rheumatol. 57 Suppl

structures of the human Col15A1and mouse

2:

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Col15a1genes, location of type XV collagen protein

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Danneskiold-Samsoe B., Bliddal H., “Collagen and muscle pathology in fibromyalgia patients”, Rheumatology. 43: 27-31, 2004

Dr.

Sal Martingano, one of the nation’s acknow-

ledged collagen experts and researchers, speaking

www.emedicine.com

a taped national radio broadcast appearance, “Reasons for aging”, 2002

in

www.arthrite.ca

25

For more information: www.genacol.ca 1 (888) 240-3002 Any and all reproduction is strictly prohibited and

For more information:

www.genacol.ca 1 (888) 240-3002

Any and all reproduction is strictly prohibited and subject to copyright infringement laws.

Legal deposit: 3 rd trimester 2008, National Library of Canada and National Library of Quebec.