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LBM 3

Step 1.


Menggaung: permukaan dinding yg tidak datar dan terlihat cekung
Eksudat: the fluid flow to interstitial cause of inflammation process.
Granulasi: fibrosa tissue that means process healing injury

Step 2.
1. What kinds of disease by ulcer in genital?
2. Why the psysical examination get multiple ulcer, irregular margin, dinding menggaung, and get
the pain?
3. How the process of papul and pustule to be ulcer?
4. What the relation between PSK and the disease?
5. How to diagnose the disease?
6. Definition of ulcer?
7. How is the pathogenesis from the disease (herpes simpleks genital, ulkus mole, shifillis)?
8. Why the injury can be multiple?
9. Mechanism of eksudat to be (+) and also the ulcer can be granulation?
10. Can this disease not happened not only on epitel genital? Why?
11. UKK of abnormality?
12. Prognose and complication?
13. Treatment?
Step 3.
1. What kinds of disease by ulcer in genital?
 Ulcer mole : cause by streptococcus ducrey or haemophilus ducrey
 Shipillis : treponema pallidum
 Herpes genital : herpes simplex virus
Ulcer divided by pain (ulcer mole & herpes simplex) and not pain (shipillis)
Ulcer cause of trauma, piodermi, and varicella
2. Why on the psysical examination get multiple ulcer, irregular margin, dinding menggaung, and
get the pain?
Bactery Inoculant the skin (epithelia)  PMN, macrophage  mengeluarkan toxin (hemolisin)
 toxin lisis, merusak jaringan fibro elastin  ulcer
3. How the process of papul and pustule to be ulcer?
Epitel keratin tjd penonjolan krn hiperkeratinasi  papul tergaruk, gesekan (trauma) 
sebagian kulit akan hilang  ulcer
Papul & pustule = ukk primer
Ulcer = ukk sekunder
4. What the relation between PSK and the disease?

The disease is Sexual transmitted disease  the man or woman has the bacteria which cause of the disease 5. mikroskop medan gelap & tes serologi) dan herpes simplex virus (kultur)  Ada genital ulcer dan limfadenopati  Ada eksudat  Kultur ulcus mole Px sediaan apus : didapatkan kuman basil berkelompok. enzimnya fibroleptin menghancurkan fibroelastin  jar. Sampai dermis atau bahkan sampai subdermis/subkutis. membentuk rantai Px gram : take the spesiment from the ulcer  look at the microscope  tampilan H. kuning ke abuabuan  (+) Biopsy : 3 zones  zone a : jar. erosi +. How to diagnose the disease?  Patient have one or more painful ulcer  Menyingkirkan penyakit kemungkinan sifilis (px. dx dgn px mikroskop electron 6. zone c: sel plasma & limfosit Ketiga dari px diatas mengacu pada penyakit ulkus mole Gambar UKK?? Shipillis : tdk nyeri. px mikroskop gelap Herpes :ada riwayat vesikel berkelompok. kapiler. oral mucus. Can this disease not happened not only on epitel genital? Why? Predileksi di laki2 : preputium dan frenulum. shifillis)? Shipillis : backterinya t. ada indurasi. Granulasi Ulkus mole : ada di atas Herpes simplex : kontak lewat mukosa. Why the injury can be multiple? The structur is different  polisakarida mengikat antivodi  mengenali epitope  imun kebal 9. ducrey Kultur : menggunakan media gonokokal agar. 7. . zone b : sel plasma. dada. pallidum toxin nya HDCDT. neutrophil. Definition of ulcer? A site of damage to the skin or mucose membrane that is characterized by the formation of pus. Nekrotik. How is the pathogenesis from the disease (herpes simpleks genital. media coklat agar  gambaran koloni. ada ulkus tetap suerfisial. lipat paha. death of tissue and is frecuently accompined by inflammatory reaction. fibrin. secret  inokulasi ke mukosa  port the entry  infeksi  ke nervus perifer  ascenden  ganglia basalis autonomic  laten 8. ulkus mole. rekurrens.

kanamycin. pancyclovir Shipillis : cephalosporin Step 4. Bukan termasuk penyakit sistemik.sel target nya di mukosa dan kulit lecet  bakteri masuk  lebih sering di mukosa drpd di keratin. eritromisin Herpes simplex : ancyclovir. Prognose and complication? Prognosis baik jika treatment dilakukan dgn tepat 11. inokulasi langsung 10. chloramphenicol. Treatment? Ulcus mole : sulfonamide. STI Drips Sores Painfull painless Herpes genital    Vesikel Non vascular Px = kultur Ulkus mole syphillis      Pustule Vascular Px = cultur Limphogranuloma. Papul nonvasculardar kfield . tetrasiklin. streptomisin.