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The Pharmaceutical Magazine

Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur
(March 2008)

Omeprazole:
An Overview
Rakesh SINGH
Institute of Pharmacy
Pt. Ravishankar Shukla University
Raipur-492010

Chemical structure

Pharmacology: Omeprazole is a compound that
inhibits gastric acid secretion and is indicated in
the treatment of gastroesophageal reflux disease
(GERD), the healing of erosive esophagitis, and
H. pylori eradication to reduce the risk of
duodenal ulcer recurrence. Omeprazole belongs

5-methoxy-2-[(4-methoxy-3,5-dimethyl-pyridin-2yl)methylsulfinyl]-3H-benzoimidazole

to a new class of antisecretory compounds, the
substituted benzimidazoles, that do not exhibit
anticholinergic or H2 histamine antagonistic

Molecular Weight: 345.417 g/mol

properties, but that suppress gastric acid

Melting Point: 156 °C

secretion by specific inhibition of the H+/K+

H2O Solubility: 82.3 mg/L

ATPase enzyme system at the secretory surface

State: Solid
Log P / Hydrophobicity: 1.166
Drug Category: Anti-ulcer Agents, Proton-pump
Inhibitor.
Indication: For the treatment of gastroesophageal reflux disease.

of the gastric parietal cell. Because this enzyme
system is regarded as the acid (proton) pump
within the gastric mucosa, omeprazole has been
characterized as a gastric acid-pump inhibitor, in
that it blocks the final step of acid production.
This effect is dose-related and leads to inhibition

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By acting specifically on the proton pump. omeprazole blocks the final step in acid production. headache. Half Life: 0. Asian edition. urticaria. 12601 twin brook parkway. vomiting. and dry mouth. dellusion.. abdominal pain.T. 3.5-1 hour CIMS “current index of medical specialities” Julyoctober 2005. nausea. inc. S.The Pharmaceutical Magazine Institute of Pharmacy. MD 20852. 2. Raipur (Dec 2007) of both basal and stimulated acid secretion Marketed products: irrespective of the stimulus. diaphoresis. confusion. USP/NF. INDIA Dosage Forms: Oral tablets Contraindications: hypersensitivity Adverse reaction: anemia. The official compendia of standards. Toxicity: REFERANCES Symptoms of overdose include blurred vision. Walter Lund. Twelfth edition. London the Biotransformation: Hepatic. thus reducing gastric acidity. flushing. tachycardia. 2003. 2 . diarrhea. Ravishankar Shukla University. reversible confusion. nausea. United state pharmacopoeial convention. constipation. The pharmaceutical codex “principal and practices Protein Binding: 95% of pharmaceutics” Editor. Absorption: Absorption is rapid. 1994. hallucination. absolute bioavailability (compared to intravenous Dosage form Capsule Capsule Capsule Capsule Capsule Capsule Capsule Capsule Capsule Capsule Tablet Tablet Tablet Tablet Company name Sanofi aventies Avalanche Biochem PCI CFL NIPIL Moraceae pharma kramer Cipla Bio E Ordain Triton Systopic triton administration) is about 30-40% at doses of 2040 mg. U. pharmaceutical press. Pt. drowsiness.I. depression etc. 1. Rockville.no Drug Mechanism of Action: Omeprazole is a proton 1 2 3 4 5 6 7 8 9 10 11 12 13 14 Acichek Avizol Biocid Capocid Coszol Cozep Ezol Lokit Lomac Loress Omag Procid Tacko-M Zaprocid pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+ATPase in the gastric parietal cell.