You are on page 1of 1

CONTRACEPTIVES DRUGS

FEMALE HORMONAL CONTRACEPTIVE
ORAL CONTRACEPTIVE
CONTRACEPTION WITH
POSTCOITAL
LONG ACTING
CONTRACEPTION
PROGESTINS
A. COMBINED PILLS
 MedroxyIt is a method for
 Progestin + estrogen
progesterone
contraception which will
 Mechanism ?
Given IM
prevent pregnancy if
Inhibit ovulation by
50mg/month
administered within 72
inhibition of
@ 150mg/3hrs after unprotected
secretion of
4months
intercourse
hypothalamic GnRF
Effective
Inhibit implantation
No significant
 Ethinylestradiol +
by changed
danger
norgestrel
endometrial
Menstrual
 tablets within
condition
irregularities
72hrs followed
Inhibit fertilization by
are common
by 2 doses 12
increase cervical
Infertility may
hrs later
mucous secretion
persists for
 Adverse effect ?
many months
 Estrogen alone
GIT disturbances
after stopping
 Ethinylestradiol
Oedema, Mastalgia
treatment
 Twice daily for
Headache
5days
Breakthrough
 Progestin implants
bleeding
Subdermal
 Progestin only
Increase weight and
capsule
 Norgesterol
pigmentation
containing
 Twice daily for
thromboembolism
levonorgestrel
a day
B. MINI PILL
Long term
 progestin only
contraceptive
 Mifepristone
 less effective compare to
Protection for
 Once
combined pill
approximately
 alone
 acts by the same
5yrs
mechanism except that
suppression of ovulation
is only 50% (via –ve FB of
LH)
CONTRAINDICATIONS
PREPARATIONS
 Estrogen dependent
 Estrogen : ethinyl
neoplasm
estradiol / mestranol
 Thromboembolic disease
 Progestins :
 Myocardial infarction
norethindrone /
 Abnormal uterine bleeding
norgestrel / ethynodiol
 Pregnancy
ADMINISTRATION
 Hepatic dysfunction
th
Start on the 5 day of
 Hyperlipidemia
menstrual cycle and
 Diabetes
continued daily for 21
 Hypertension
days
 Migraine
 Depression and epilepsy

MALE HORMONAL

 Mechanism :
 Both FSH and hight
conc of intra-testicular
testerone (+ LH) are
essential for
spermatogenesis in
adult testis
 Decrease GnTH 
decrease effect of FSH
on sperm production
 decrease
intratesticular
testosterone 
reversible inhibition of
spermatogenesis
 Agents used
1. testosterone alone
- FB inhibition
hypothalamus and
pituitary  inhibition of
GnTH release
- produce azospermia –
oligospermia
- does not have 100%
contraceptive efficacy
- produce side effects of
high dose of testosterone
2.testosterone combined
with progestin
- less testosterone dose 
less side effect
Increase degree of
spermatogenic suppression
 P4 act directly on leydig
cells  decrease synthesis
of testosterone & decrease
expression of LH receptors
 decrease intratesticular
testosterone concentration
3. GnRH antagonist +
testosterone
- prevents hypogonadism