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Biochemistry II (Bio 3362) Spring Semester 2006 Tuesday & Thursday, 9:30 -10:45 Room CN 1.

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Text: “Biochemistry ” by R.H. Garrett and C.M. Grisham, 3 rd edition (2005) There are two instructors in the course, Drs. S. Gavva and R. Draper. There are four midterm exams on dates listed in the schedule below. The final grade will be the average of the four midterms. Make-up exams will be allowed only in exceptional cases, and only if evidence documenting the reason is supplied. Make-up exams may have a verbal component. Dates Jan. 10 Jan. 12 Jan. 17 Jan. 19 Jan. 24 Jan. 26 Jan. 31 Feb. 2 Feb. 7 Feb. 9 Feb. 14 Feb. 16 Feb. 21 Feb. 23 Feb. 28 March 2 March 7,9 March 14 March 16 March 21 March 23 March 28 March 30 April 4 April 6 April 11 April 13 April 18 April 20 Class 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 Instructor S. Gavva S. Gavva S. Gavva S. Gavva S. Gavva S. Gavva S. Gavva S. S. S. S. S. Gavva Gavva Gavva Gavva Gavva Lecture 1 2 3 4 5 6 7 Reading G&G Ch. 21 G&G Ch. 21 G&G Ch. 25 G&G Ch. 25 G&G Ch. 25 G&G Ch. 25 G&G Ch. 25 Topics Photosynthesis and photophosphorylation CO 2 fixation The nitrogen cycle, nitrogen acquisition, ammonia assimilation, and glutamine synthetase Amino acid synthesis I: transaminases, the glutamate family and the urea cycle Amino acid synthesis II: the aspartate and pyruvate families Amino acid synthesis III: the 3-P-glycerate and aromatic amino acids, sulfur metabolism, histidine Amino acid synthesis IV: Aspects of amino acid degradation Midterm Exam I Purine synthesis to IMP Purine synthesis (continued), salvage and degradation Pyrimidines and deoxyribonucleotide synthesis Nucleotides and nucleic acids Structures of nucleic acids Lipid structures figures Midterm Exam 2 Membrane structure: lipids and proteins figures SPRING BREAK Membrane structure: lipids and proteins figures Membrane transport figures Membrane transport figures Fatty acid catabolism figures Fatty acid catabolism figures Biosynthesis of fatty acids and lipids: sterols and sterol metabolism figures Midterm Exam 3 Biosynthesis of fatty acids and lipids: sterols and sterol metabolism figures Biosynthesis of fatty acids and lipids: sterols and sterol metabolism Integration of metabolism figures Review Midterm Exam 4

8 9 10 11 12 13 14 15 16 17 18 19 20

G&G Ch. 26 G&G Ch. 26 G&G Ch. 26 G&G Ch. 10 G&G Ch. 11 G&G Ch. 8 G&G Ch. 9 G&G Ch. 9 G&G Ch. 9 G&G Ch. 9 G&G Ch. 23 G&G Ch. 23 G&G Ch. 24

S. Gavva R. Draper S. Gavva R. Draper R. Draper R. Draper R. Draper R. Draper R. Draper R. Draper R. Draper R. Draper R. Draper R. Draper R. Draper R. Draper

21 22 23 24 25

G&G Ch. 24 G&G Ch. 24 G&G Ch. 27

Syllabus Addendum
Objectives:
This course is the second of a two-course sequence that provides students with a working knowledge of the

macromolecules and fundamental metabolic pathways of prokaryotes and eukaryotes, with emphasis on human systems. Biochemistry II is devoted to mastering 1) photosynthesis; 2) the metabolism of amino acids, and nucleic acids; 3) the structure, function and metabolism of lipids with emphasis on biological membranes and how lipid metabolism is integrated with carbohydrate metabolic pathways. Relevance to human physiology, medicine, and understanding diseases are used to stimulate students to begin the integration of biochemistry with other disciplines. The goal is to provide students with the fundamental biochemical knowledge and insight needed for them to constructively use biochemistry, both as a means of understanding biological processes in general and for creative problem solving.

Student Conduct
Each student in this course is expected to exercise independent scholarly thought, expression and aptitude. This addendum to the course syllabus is provided to assist you in developing and maintaining academic integrity while seeking scholastic success. General Comments: l All academic exercises ( including assignments, essays, laboratory experiments and reports, examinations, etc.) require individual, independent work. Any exception(s) will be clearly identified. l Be sure your name or identifying number is on your paper. l Complete and turn in academic exercises on time and in the required format ( hardcopy, electronic, etc. ). l Retain confirmation of document delivery if submitted electronically. l Retain all research notes and drafts until the project or assignment has been graded. l Obtain written authorization from your instructor prior to submitting a portion of academic work previously submitted for any academic exercise. ( This includes an individual or group project submitted for another course or at another
school.)

Essays and Significant Papers: Be prepared To present periodic drafts of work in process To correctly and completely reference all sources of information using the citation format prescribed To turn your completed assignment in timely and in the prescribed manner (electronic, hardcopy, etc. ) Examinations: Be prepared To leave all personal belonging at the front of the room or other designated location (this includes cell phones, turned off of course, and beverage containers) To present your UTD Comet Card To remove your cap or hat To remove the batteries from any electronic device (e.g. calculator) To exchange blue books or bring them early as required To change seating To sign out when exiting the testing room To be escorted for lavatory use All episodes of suspected scholastic dishonesty will be reported according to University policy. Students who violate University rules on scholastic dishonesty are subject to disciplinary penalties, including the possibility of failure in the course and/or dismissal from the University. Since such dishonesty harms the individual, all students and the University, policies on scholastic dishonesty will be strictly enforced. Penalties that may be assessed for scholastic dishonesty may be reviewed in Subchapter D. Penalties at http://www.utdallas.edu/student/slife/chapter49.html.