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Spring 2006

TR 1112:15 CN 1.102

BIOL/CHEM 3361

Biochemistry I
Instructor/TA Robert Marsh Vincet Cirillo Nataliya GurichVrasic Eduardo Jaramillo Shruthi Naik Jenny Perng
Huseyin Tac

Room No. Telephone No. FO 3.310 972-UTD-2511 FN 3.116 972-UTD-4157 FO 3.206

E-Mail rmarsh@utdallas.edu cirillo@utdallas.edu nxg010400@utdallas.edu elj021000@utdallas.edu

Office Hours TR 1:00-2:00 PM TR 1:00-2:00 PM

214-208-8915 504-274-9463

ssn022000@utdallas.edu jxp038000@utdallas.edu huseyin.tac@student.utdallas.edu

Workshop ( BIOL 3161) is required for both BIOL and CHEM students. Workshops will meet starting Tues. Jan. 11 Text: Biochemistry, 3 rd edition, by Garrett and Grisham (ISBN 0-534-49033-6)
Jemiolo & Theg's 3 rd edition Student Manual to accompany Biochemistry by Garrett and Grisham (ISBN 0534-49035-2) will be used in the Workshops, BIO 3161.

Click on the following for copies of assigned Problem Sets:

Problem Set 1 rev. 1/9/06 , Problem Set 2, Problem Set 3, Problem Set 4
Check out the Garrett and Grisham Website for help with Difficult Concepts, e.g., Acid/Base Theory:
Jan 11 through March 1 (Dr. Marsh) Two exams × 20% each = 40% of grade March 3 through end of semester (Dr. Cirillo) Two exams × 20% each = 40% of grade

http://www.brookscole.com/chemistry_d/templates/student_resources/0030223180_garrettgrisham/HardToGrasp/HardToGras

Workshop Problem Sets = 20% of grade. There will be 4 problem sets; each will count toward your grade. The grade scale will be: A+ 88-100, A 84-87, A- 80-83 B+ 76-79, B 72-75, B- 68-71 C+ 64-67, C 60-63, C- 56-59 D+ 52-55, D 48-51, D- 44-47

F ≤ 43 Decimal points will be rounded up on final class averages. You will receive the same letter grade in both BIOL/CHEM 3361 and BIOL 3161

Do not miss the exams as make-up exams will only be given in the case of a documented emergency
Academic Dishonesty Policy: Students are required to abide by UT-Dallas policies concerning academic integrity (for details, see http://www.utdallas.edu/student/slife/scholastic.html). Failure to comply with these terms will be subject to appropriate disciplinary action Students with Disabilities: If you have a disability that requires accommodation, you must notify the instructor and file a request through Disability Services (SU 1.610, x2098) on or before the first day of class. By doing so, you can be assured of full cooperation in making appropriate arrangements.

Class schedule: (Click on the highlighted topics for a set of lecture figures and notes.)
Date Tues. Jan. 10 Thurs. Jan. 12 Tues. Jan. 17 Thurs. Jan. 19 Tues. Jan. 24 Wed. Jan. 25 Thurs. Jan. 26 Tues. Jan.31 Thurs. Feb. 2 Tues. Feb. 7 Thurs. Feb. 9 Tues. Feb. 14 Thurs. Feb. 16 Tues. Feb. 21 Thurs. Feb. 23 Tues. Feb. 28 Thurs. March 2 Tues. March 7 Thurs. March 9 Tues. March 14 Thurs. March 16 Thurs. March 16 Tues. March 21 Topic Introduction; Weak interactions Water and Acid/base properties Thermodynamics of Biological Systems Review of thermodynamic principles cont. Structures and properties of amino acids Last day to drop course without a W Protein primary structure Review List for Exam #1, Example exam questions EXAM #1 on Chap. 1-5 Bring a scantron form, no. F-1712 for the exam Protein purification & characterization Protein secondary, tertiary, and quaternary structure Protein structure cont. Enzyme kinetics Inhibition kinetics ; Bisubstrate kinetics Irreversible inhibition ;Chaperones; Protein denaturants Catch-up and review for exam Review List for Exam #2, Example exam questions EXAM #2 Chap. 5 appendix, Chap. 6, 13 & Sec. 31.1 Bring a scantron form, no. F-1712 for the exam Mechanisms of enzyme action Spring Break Spring Break Enzyme active sites; catalytic mechanisms Enzyme regulation; Hemoglobin Last day to drop course with a WP/WF Carbohydrates; Metabolism - Part I Assignment Chap. 1 Chap. 2 Handout as an alternate to Chap. 3 Chap. 4 Chap. 5 Problem Set #1 due

Appendix to Chap. 5 Chap. 6 Chap. 6 Chap. 13.1 - 13.3 Chap. 13.4 - 13.7 Sec. 31.1 on pp 10231027 Problem Set #2 due

Chap. 14.1-14.6

Chap 14.7 Chap. 15, 15 appendix Chap. 7.1-7.3,17.117.3

Thurs. March 23

Glycolysis - First Phase

Chap. 18.118.3 Problem Set #3 due

Tues. March 28 Thurs. March 30 Tues. April 4 Thurs. April 6 Tues. April 11 Thurs. April 13 Tues. April 18 Thurs. April 20 Tues. April 25

EXAM #3 on Chap. 7.1-7.3, 14, 15, 15 Appendix, 17.1-17.3, 18.1-18.3 - Bring a scantron form, no. F1712 for the exam Glycolysis - Second Phase TCA cycle - Part I TCA cycle - Part II Respiration; Oxidative phosphorylation Gluconeogenesis; Glycogen metabolism Pentose pathway Review for exam EXAM #4 on Chap. 18.4-18.7, 19, 20, 22 - FINAL Bring a scantron form, no. F-1712 for the exam

Chap. 18.4-18.7 Chap. 19.1-19.5 Chap. 19.6-19.10 Chap. 20 Chap. 22.1-22.5 Chap. 22.6 Problem Set #4 due