IARC Classification

Agents Classified by the IARC Monographs, Volumes 1111
CAS No
Agent
026148-68-5
000083-32-9
025732-74-5
000075-07-0
000075-07-0
A-alpha-C (2-Amino-9H-pyrido[2,3-b]indole)
Acenaphthene
Acepyrene (3,4-dihydrocyclopenta[cd]pyrene)
Acetaldehyde
Acetaldehyde associated with consumption of alcoholic
beverages
Acetamide
Acetaminophen (see Paracetamol)
Acheson process, occupational exposure associated with
Aciclovir
Acid mists, strong inorganic
Acridine orange
Acriflavinium chloride
Acrolein
Acrylamide
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
Acrylic acid
Acrylic fibres
Acrylonitrile
Acrylonitrile-butadiene-styrene copolymers
Actinomycin D
Adriamycin
AF-2 [2-(2-Furyl)-3-(5-nitro-2-furyl)acrylamide]
Aflatoxins
000060-35-5
000103-90-2
059277-89-3
000494-38-2
008018-07-3
000107-02-8
000079-06-1
000079-10-7
000107-13-1
000050-76-0
023214-92-8
003688-53-7
001402-68-2
Group
006795-23-9 Aflatoxin M1
002757-90-6 Agaritine
Alcoholic beverages
000116-06-3 Aldicarb
000309-00-2 Aldrin
Aloe vera, whole leaf extract
000107-05-1 Allyl chloride
000057-06-7 Allyl isothiocyanate
002835-39-4 Allyl isovalerate
Alpha particles (see Radionuclides)
Aluminium production
Year
2B
3
3
2B
1
40, Sup 7
92
92
36, Sup 7, 71
100E
1987
2010
2010
1999
2012
2B
7, Sup 7, 71
1999
1
3
1
3
3
3
2A
111
76
54, 100F
16, Sup 7
13, Sup 7
63, Sup 7
60, Sup 7
3
3
2B
3
3
2A
19, Sup 7, 71
19, Sup 7
71
19, Sup 7
10, Sup 7
10, Sup 7
1999
1987
1999
1987
1987
1987
2B
1
31, Sup 7
56, 82, 100F,
Sup 7
56
31, Sup 7
44, 96, 100E
53
5, Sup 7
108
36, Sup 7, 71
73, Sup 7
36, Sup 7, 71
1987
2012
2B
3
1
3
3
2B
3
3
3
1
Volume
34, Sup 7,
92, 100F
In prep
2000
2012
1987
1987
1995
1994
1993
1987
2012
1991
1987
in prep
1999
1999
1999
2012

CAS No
Agent
000915-67-3
004657-93-6
000117-79-3
000060-09-3
000097-56-3
000150-13-0
000092-67-1
Amaranth
5-Aminoacenaphthene
2-Aminoanthraquinone
para-Aminoazobenzene
ortho-Aminoazotoluene
para-Aminobenzoic acid
4-Aminobiphenyl
3
3
3
2B
2B
3
1
000081-49-2
000082-28-0
000712-68-5
000099-57-0
000121-88-0
000119-34-6
000121-66-4
002432-99-7
000061-82-5
1-Amino-2,4-dibromoanthraquinone
1-Amino-2-methylanthraquinone
2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole
2-Amino-4-nitrophenol
2-Amino-5-nitrothiazole
11-Aminoundecanoic acid
Amitrole
(NB: Overall evaluation downgraded to Group 3 with
Ampicillin
Amsacrine
Androgenic (anabolic) steroids
Anaesthetics, volatile
Angelicin plus ultraviolet A radiation
Aniline
ortho-Anisidine
para-Anisidine
Anthanthrene
Anthracene
Anthranilic acid
Anthraquinone
Antimony trioxide
Antimony trisulfide
Apholate
para-Aramid fibrils
Aramite
Areca nut
000069-53-4
051264-14-3
000523-50-2
000062-53-3
000090-04-0
000104-94-9
000191-26-4
000120-12-7
000118-92-3
000084-65-1
001309-64-4
001345-04-6
000052-46-0
024938-64-5
000140-57-8
Group
Volume
Year
2B
3
2B
3
3
3
3
3
3
8, Sup 7
16, Sup 7
27, Sup 7
8, Sup 7
8, Sup 7
16, Sup 7
1, Sup 7, 99,
100F
101
27, Sup 7
7, Sup 7
57
57
16, Sup 7
31, Sup 7
39, Sup 7
79, Sup 7
1987
1987
1987
1987
1987
1987
2012
2013
1987
1987
1993
1993
1987
1987
1987
2001
3
2B
2A
3
3
3
2B
3
3
3
3
2B
2B
3
3
3
2B
1
50
76
Sup 7
11, Sup 7
40, Sup 7
27, Sup 7
Sup 7, 73
27, Sup 7
92, Sup 7
92, Sup 7
16, Sup 7
101
47
47
9, Sup 7
68
5, Sup 7
85, 100E
1990
2000
1987
1987
1987
1987
1999
1987
2010
2010
1987
2013
1989
1989
1987
1997
1987
2012

CAS No
Agent
Group
000313-67-7 Aristolochic acid

(NB: Overall evaluation upgraded to Group 1 based on
mechanistic and other relevant data)
000313-67-7 Aristolochic acid, plants containing
007440-38-2 Arsenic and inorganic arsenic compounds
064436-13-1 Arsenobetaine and other organic arsenic compounds that
are not metabolized in humans
Art glass, glass containers and pressed ware
(manufacture of)
001332-21-4 Asbestos (all forms, including actinolite, amosite,
013768-00-8 anthophyllite, chrysotile, crocidolite, tremolite)
(NB: Mineral substances (e.g. talc or vermiculite) that
012172-73-5
contain asbestos should also be regarded as
017068-78-9 carcinogenic to humans.)
012001-29-5
012001-28-4
014567-73-8
001912-24-9 Atrazine
012174-11-7 Attapulgite (see Palygorskite)
000492-80-8 Auramine
Auramine production
000151-56-4 Aziridine
(NB: Overall evaluation upgraded to Group 2B with
001072-52-2 2-(1-Aziridinyl)ethanol
000800-24-8 Aziridyl benzoquinone
000103-33-3 Azobenzene
000202-94-8 11H-Benz[bc]aceanthrylene
000202-33-5 Benz[j]aceanthrylene
supporting mechanistic and other relevant data)
Year
82, 100A
2012
1
1
82, 100A
23, Sup 7,
100C
100C
2012
2012
58
1993
14, Sup 7,
100C
2012
53, 73
1999
1, Sup 7, 99,
100F
Sup 7, 99,
100F
13, Sup 7
50
2012
3
2A
2B
1
012192-57-3 Aurothioglucose
000320-67-2 Azacitidine
000115-02-6 Azaserine
000446-86-6 Azathioprine
Volume
3
2A
2B
1
2012
2012
1987
1990
1987
2012
2B
10, Sup 7
26, Sup 7,
100A
9, Sup 7, 71
3
3
3
3
2B
9, Sup 7
9, Sup 7
8, Sup 7
92
92
1987
1987
1987
2010
2010
1999

CAS No
Agent
Group
000211-91-6 Benz[l]aceanthrylene
000225-11-6 Benz[a]acridine
3
3
000225-51-4 Benz[c]acridine
000056-55-3 Benz[a]anthracene
000071-43-2 Benzene
000214-17-5
000196-78-1
000203-33-8
000205-99-2
000203-12-3
000205-82-3
000207-08-9
000238-84-6
000243-17-4
000205-12-9
000271-89-6
000239-35-0
000191-24-2
000195-19-7
000119-61-9
000050-32-8
000192-97-2
000105-11-3
000094-36-0
000140-11-4
001694-09-3
007440-41-7
2010
2013
3
3
3
2B
3
2B
2B
3
3
3
2B
3
3
2B
92
92
92, Sup 7
92
92, Sup 7
92
92
92, Sup 7
92, Sup 7
92, Sup 7
63
103
92, Sup 7
92, Sup 7
2010
2010
2010
2010
2010
2010
2010
2010
2010
2010
1995
2013
2010
2010
2B
1
101
Sup 7, 92,
100F
2013
2012
3
3
3
3
2B
1
92, Sup 7
29, Sup 7, 71
36, Sup 7, 71
40, Sup 7, 71
16, Sup 7
Sup 7, 58,
100C
2010
1999
1999
1999
1987
2012
Benzidine, dyes metabolized to

Benzo[b]chrysene
Benzo[g]chrysene
Benzo[a]fluoranthene
Benzo[b]fluoranthene
Benzo[ghi]fluoranthene
Benzo[j]fluoranthene
Benzo[k]fluoranthene
Benzo[a]fluorene
Benzo[b]fluorene
Benzo[c]fluorene
Benzofuran
Benzo[b]naphtho[2,1-d]thiophene
Benzo[ghi]perylene
Benzo[c]phenanthrene
Benzophenone
Benzo[a]pyrene
Benzo[e]pyrene
para-Benzoquinone dioxime
Benzoyl peroxide
Benzyl acetate
Benzyl violet 4B
Beryllium and beryllium compounds
Beta particles (see Radionuclides)
Year
92
32, Sup 7,
103
32, Sup 7,
103
92, Sup 7
29, Sup 7.
100F
29, Sup 7,
99, 100F
99, 100F
2B
1
000092-87-5 Benzidine
Volume
2013
2010
2012
2012
2012

CAS No
002168-68-5
003296-90-0
000111-44-4
000494-03-1
Agent
Group
Betel quid with tobacco
Betel quid without tobacco
Biomass fuel (primarily wood), indoor emissions from

household combustion of
Bis(1-aziridinyl)morpholinophosphine sulfide
2,2-Bis(bromomethyl)propane-1,3-diol
Bis(2-chloroethyl)ether
N,N-Bis(2-chloroethyl)-2-naphthylamine (see
Chlornaphazine)
Bischloroethyl nitrosourea (BCNU)
1,2-Bis(chloromethoxy)ethane
1,4-Bis(chloromethoxymethyl)benzene
Bis(chloromethyl)ether; chloromethyl methyl ether
(technical-grade)
000154-93-8
013483-18-6
056894-91-8
000542-88-1
000107-30-2
000108-60-1 Bis(2-chloro-1-methylethyl)ether
002386-90-5 Bis(2,3-epoxycyclopentyl)ether
000117-81-7 Bis(2-ethylhexyl) phthalate (see Di(2-ethylhexyl)
phthalate)
001675-54-3 Bisphenol A diglycidyl ether (Araldite)
Bisulfites
008052-42-4 Bitumens, extracts of steam-refined and air-refined;
steam-refined, cracking-residue and air-refined
bitumens
(see Bitumens, occupational exposures)
Bitumens, occupational exposure to hard bitumens and
their emissions during mastic asphalt work
064742-93-4 Bitumens, occupational exposure to oxidized bitumens
and their emissions during roofing
008052-42-4 Bitumens, occupational exposure to straight-run bitumens
064741-56-6 and their emissions during road paving
BK polyomavirus (BKV)
011056-06-7 Bleomycins
000129-17-9 Blue VRS
Boot and shoe manufacture and repair (see Leather dust,
Benzene)
Bracken fern
003844-45-9 Brilliant Blue FCF, disodium salt
Volume
Year
2A
Sup 7, 85,
100E
Sup 7, 85,
100E
95
2012
2010
3
2B
3
9, Sup 7
77
9, Sup 7, 71
1987
2000
1999
2A
3
3
1
26, Sup 7
15; Sup 7, 71
15; Sup 7, 71
4, Sup 7,
100F
1987
1999
1999
2012
3
3
41, Sup 7, 71
47, 71
1999
1999
3
3
47, 71
54
35, Sup 7
1999
1992
1987
2B
103
2013
2A
103
2013
2B
103
2013
2B
2B
104
26, Sup 7
2013
1987
16, Sup 7
25, Sup 7
1987
1987
2B
3
40, Sup 7
16, Sup 7
1987
1987
2012

CAS No
Agent
005589-96-8
083463-62-1
000075-27-4
000074-96-4
000075-25-2
000055-98-1
Bromochloroacetic acid
Bromochloroacetonitrile
Bromodichloromethane
Bromoethane
Bromoform
Busulfan
Group
2B
3
2B
3
3
1
000106-99-0 1,3-Butadiene
000055-98-1
000111-76-2
057018-52-7
000141-32-2
025013-16-5
000128-37-0
000085-68-7
003068-88-0
000096-48-0
007440-43-9
000331-39-5
000058-08-2
000056-25-7
000105-60-2
002425-06-1
000133-06-2
000063-25-2
000086-74-8
020073-24-9 3-Carbethoxypsoralen
001333-86-4 Carbon black
Carbon electrode manufacture
308068-56-6 Carbon nanotubes, multi-walled MWCNT-7
308068-56-6 Carbon nanotubes, multi-walled, other than MWCNT-7
308068-56-6 Carbon nanotubes, single-walled
000056-23-5 Carbon tetrachloride
003567-69-9 Carmoisine
Year
101
52, 71
52, 71
52, 71
52, 71
4, Sup 7,
100A
Sup 7, 54,
71, 97, 100F
2013
1999
1999
1999
1999
2012
3
3
3
2B
3
3
2B
3
1
2B
3
3
3
4
2A
88
88
39, Sup 7, 71
40, Sup 7
40, Sup 7
Sup 7, 73
11, Sup 7, 71
11, Sup 7, 71
58, 100C
56
51
92
10, Sup 7
39, Sup 7, 71
53
2006
2006
1999
1987
1987
1999
1999
1999
2012
1993
1991
2010
1987
1999
1991
3
3
2B
30, Sup 7
12, Sup 7
32, Sup 7,
71, 103
40, Sup 7
Sup 7, 65, 93
92
111
111
111
20, Sup 7, 71
8, Sup 7
1987
1987
2013
1,4-Butanediol dimethanesulfonate (see Busulfan)

2-Butoxyethanol
1-tert-Butoxypropan-2-ol
n-Butyl acrylate
Butylated hydroxyanisole (BHA)
Butylated hydroxytoluene (BHT)
Butyl benzyl phthalate
beta-Butyrolactone
gamma-Butyrolactone
Cadmium and cadmium compounds
Caffeic acid
Caffeine
Calcium carbide production
Cantharidin
Caprolactam
Captafol
Captan
Carbaryl
Carbazole
Volume
3
2B
2A
2B
3
3
2B
3
2012
1987
2010
2010
In prep
In prep
In prep
1999
1987

CAS No
053973-98-1
009000-07-1
000120-80-9
000075-87-6
000302-17-0
000305-03-3
Agent
Group
Carpentry and joinery

Carrageenan, degraded (Poligeenan)
Carrageenan, native
Catechol
Chimney sweeping (see Soot)
Chloral
Chloral hydrate
Chlorambucil
2B
2B
3
2B
000107-14-2
000106-47-8
000510-15-6
000124-48-1
077439-76-0
000075-45-6
000075-00-3
013010-47-4
Chloroacetonitrile
para-Chloroaniline
Chlorobenzilate
Chlorodibromomethane
3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone
Chlorodifluoromethane
Chloroethane
1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU)
013909-09-6 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea
(Methyl-CCNU) (see Semustine)
000593-70-4 Chlorofluoromethane
000067-66-3 Chloroform
Year
1987
1987
1987
1999
2010
2014
2014
2012
3
2A
25, Sup 7
31, Sup 7
31, Sup 7
15, Sup 7, 71
92
63, 84, 106
63, 84, 106
26, Sup 7,
100A
84
Sup 7, 50
2B
2B
3
2B
3
2B
Sup 7, 53, 79
20, Sup 7
30, Sup 7
48
52
48
2001
1987
1987
1990
1991
1990
2A
29, Sup 7, 71
1999
2012
3
2B
3
3
2B
3
3
2A
4, Sup 7,
100A
52, 71
57
30, Sup 7
52, 71
84
41, Sup 7, 71
52, 71
26, Sup 7
1999
1993
1987
1999
2004
1999
1999
1987
3
2B
41, Sup 7, 71
Sup 7, 73
1999
1999
2A
2A
1
010599-90-3 Chloramine
000056-75-7 Chloramphenicol
000057-74-9 Chlordane
000143-50-0 Chlordecone (Kepone)
006164-98-3 Chlordimeform
000115-28-6 Chlorendic acid
Chlorinated drinking-water
Chlorinated paraffins of average carbon chain length C12
and average degree of chlorination approximately 60%
000098-87-3 alpha-Chlorinated toluenes (benzal chloride,
000098-07-7 benzotrichloride, benzyl chloride) and benzoyl chloride
(combined exposures)
000100-44-7
000098-88-4
000494-03-1 Chlornaphazine
Volume
2004
1990

CAS No
Agent
Group
000107-30-2 Chloromethyl methyl ether (see Bis(chloromethyl)ether;

chloromethyl methyl ether)
000513-37-1 1-Chloro-2-methylpropene
000563-47-3 3-Chloro-2-methylpropene
000088-73-3 Chloronitrobenzenes
000121-73-3
000100-00-5
Chlorophenols (see Polychlorophenols)
Chlorophenoxy herbicides
005131-60-2 4-Chloro-meta-phenylenediamine
000095-83-0 4-Chloro-ortho-phenylenediamine
000126-99-8 Chloroprene
000101-21-3 Chloropropham
000054-05-7 Chloroquine
001897-45-6 Chlorothalonil
000095-69-2 4-Chloro-ortho-toluidine
000095-79-4 5-Chloro-ortho-toluidine
000075-88-7 2-Chloro-1,1,1-trifluoroethane
054749-90-5 Chlorozotocin
000057-88-5 Cholesterol
007440-47-3 Chromium, metallic
016065-83-1 Chromium (III) compounds
018540-29-9 Chromium (VI) compounds
000218-01-9
000532-82-1
006373-74-6
000523-44-4
006459-94-5
000569-61-9
001937-37-7
002602-46-2
002429-74-5
016071-86-6
001936-15-8
002425-85-6
059865-13-3
Chrysene
Chrysoidine
CI Acid Orange 3
CI Acid Orange 20
CI Acid Red 114
CI Basic Red 9
CI Direct Black 38 (see Benzidine, dyes metabolized to)
CI Direct Blue 6 (see Benzidine, dyes metabolized to)
CI Direct Blue 15
CI Direct Brown 95 (see Benzidine, dyes metabolized to)
CI Orange G
CI Pigment Red 3
Ciclosporin (see Cyclosporine)
Volume
Year
2B
3
3
63
63
65
1995
1995
1996
2B
3
2B
2B
3
3
2B
2A
3
3
2A
41, Sup 7
27, Sup 7
27, Sup 7
Sup 7, 71
12, Sup 7
13, Sup 7
Sup 7, 73
77, 99
77, 99
41, Sup 7, 71
50
1987
1987
1987
1999
1987
1987
1999
2010
2010
1999
1990
1987
1990
1990
2012
2B
3
3
3
2B
2B
31, Sup 7
Sup 7, 49
49
Sup 7, 49,
100C
92
8, Sup 7
57
8, Sup 7
57
57, 99
2010
1987
1993
1987
1993
2010
2B
57
1993
8, Sup 7
57
1987
1993
3
3
3
1
3
3

CAS No
Agent
Group
051481-61-9 Cimetidine
000087-29-6 Cinnamyl anthranilate
015663-27-1 Cisplatin
000518-75-2 Citrinin
006358-53-8 Citrus Red No. 2
000637-07-0 Clofibrate
000050-41-9 Clomiphene citrate
Clonorchis sinensis (infection with)
Coal, indoor emissions from household combustion of
Coal dust
Coal gasification
008007-45-2 Coal tars (see Coal-tar distillation)
008007-45-2 Coal-tar distillation
065996-93-2 Coal-tar pitch
010380-28-6
000191-07-1
000091-64-5
008001-58-9
000102-50-1
000120-71-8
004170-30-3
Continuous glass filament (see Glass filament)

Copper 8-hydroxyquinoline
Coronene
Coumarin
Creosotes
meta-Cresidine
para-Cresidine
Crotonaldehyde
Year
3
3
2A
50
Sup 7, 77
26, Sup 7
1990
2000
1987
3
2B
3
3
1
1
3
1
1987
1987
1996
1987
2012
2012
1997
2012
2B
40, Sup 7
8, Sup 7
Sup 7, 66
21, Sup 7
61, 100B
95, 100E
68
Sup 7, 92,
100F
35, Sup 7
92, 100F
35, Sup 7,
100F
52
2A
86
2006
2B
2B
2B
2B
86
86
101
51
2006
2006
2013
1991
Sup 7, 92,
100F
2012
15, Sup 7
32, Sup 7, 92
Sup 7, 77
Sup 7, 92
27, Sup 7
27, Sup 7
63
1987
1987
2000
2010
1987
1987
1995
1
1
007440-48-4 Cobalt and cobalt compounds

(NB: Evaluated as a group)
007440-48-4 Cobalt metal with tungsten carbide
012070-12-1
007440-48-4 Cobalt metal without tungsten carbide
010026-24-1 Cobalt sulfate and other soluble cobalt(II) salts
068603-42-9 Coconut oil diethanolamine condensate
Coffee (urinary bladder)
(NB: There is some evidence of an inverse relationship
between coffee drinking and cancer of the large bowel;
coffee drinking could not be classified as to its
carcinogenicity to other organs)
Coke production
Volume
3
3
3
2A
3
2B
3
1987
2012
2012
1991

CAS No
Agent
Group
008002-05-9
000098-82-8
014901-08-7
000139-05-9
012663-46-6
000108-94-1
000202-98-2
027208-37-3
Crude oil
Cumene
Cycasin
Cyclamates (sodium cyclamate)
Cyclochlorotine
Cyclohexanone
4H-Cyclopenta[def]chrysene
Cyclopenta[cd]pyrene
007099-43-6 5,6-Cyclopenteno-1,2-benzanthracene
000050-18-0 Cyclophosphamide
006055-19-2
059865-13-3 Cyclosporine
079217-60-0
004342-03-4 Dacarbazine
005160-02-1 D & C Red No. 9
000117-10-2 Dantron (Chrysazin; 1,8-Dihydroxyanthraquinone)
000080-08-0 Dapsone
020830-81-3 Daunomycin
000050-29-3 DDT (4,4'-Dichlorodiphenyltrichloroethane)
001163-19-5 Decabromodiphenyl oxide
052918-63-5 Deltamethrin
000083-63-6 Diacetylaminoazotoluene
000613-35-4 N,N'-Diacetylbenzidine
002303-16-4 Diallate
000615-05-4 2,4-Diaminoanisole
000101-80-4 4,4'-Diaminodiphenyl ether
000099-56-9 1,2-Diamino-4-nitrobenzene
005307-14-2 1,4-Diamino-2-nitrobenzene
000095-80-7 2,4-Diaminotoluene
000095-70-5 2,5-Diaminotoluene
000439-14-5 Diazepam
000334-88-3 Diazomethane
000226-36-8 Dibenz[a,h]acridine
000224-42-0 Dibenz[a,j]acridine
10
Volume
Year
3
2B
2B
3
3
3
3
2A
45
101
10, Sup 7
Sup 7, 73
10, Sup 7
47, 71
92
Sup 7, 92
1989
2013
1987
1999
1987
1999
2010
2010
3
1
92
26, Sup 7,
100A
2010
2012
50, 100A
2012
2B
3
2B
3
2B
2B
3
3
3
2B
3
2B
2B
3
3
2B
3
3
3
2B
26, Sup 7
Sup 7, 57
50
24, Sup 7
10, Sup 7
Sup 7, 53
48, 71
53
8, Sup 7
16, Sup 7
30, Sup 7
Sup 7, 79
29, Sup 7
16, Sup 7
Sup 7, 57
16, Sup 7
16, Sup 7
Sup 7, 66
7, Sup 7
32, Sup 7,
103
32, Sup 7,
103
1987
1993
1990
1987
1987
1991
1999
1991
1987
1987
1987
2001
1987
1987
1993
1987
1987
1996
1987
2013
2A
2013

CAS No
Agent
Group
000224-53-3 Dibenz[c,h]acridine
000215-58-7 Dibenz[a,c]anthracene
000053-70-3 Dibenz[a,h]anthracene
000224-41-9 Dibenz[a,j]anthracene
000194-59-2 7H-Dibenzo[c,g]carbazole
000262-12-4
005385-75-1
000207-83-0
000192-47-2
000192-65-4
000189-64-0
000189-55-9
000191-30-0
3
3
3
3
3
2B
2B
2A
000192-51-8
000132-65-0
000631-64-1
003252-43-5
000096-12-8
000096-13-9
000079-43-6
003018-12-0
007572-29-4
000541-73-1
000095-50-1
000106-46-7
000091-94-1
000110-57-6
028434-86-8
000107-06-2
000075-09-2
Dibenzo-para-dioxin
Dibenzo[a,e]fluoranthene
13H-Dibenzo[a,g]fluorene
Dibenzo[h,rst]pentaphene
Dibenzo[a,e]pyrene
Dibenzo[a,h]pyrene
Dibenzo[a,i]pyrene
Dibenzo[a,l]pyrene
Dibenzo[e,l]pyrene
Dibenzothiophene
Dibromoacetic acid
Dibromoacetonitrile
1,2-Dibromo-3-chloropropane
2,3-Dibromopropan-1-ol
Dichloroacetic acid
Dichloroacetonitrile
Dichloroacetylene
meta-Dichlorobenzene
ortho-Dichlorobenzene
para-Dichlorobenzene
3,3'-Dichlorobenzidine
trans-1,4-Dichlorobutene
3,3'-Dichloro-4,4'-diaminodiphenyl ether
1,2-Dichloroethane
Dichloromethane (Methylene chloride)
000609-20-1 2,6-Dichloro-para-phenylenediamine
Year
2B
103
2013
3
2A
Sup 7, 92
Sup 7, 92
2010
2010
3
2B
Sup 7, 92
32, Sup 7,
103
69
Sup 7, 92
92
Sup 7, 92
Sup 7, 92
Sup 7, 92
92
Sup 7, 92
2010
2013
3
3
2B
2B
2B
2B
2B
3
3
3
3
2B
2B
3
2B
2B
2A
3
11
Volume
92
103
101
52, 71, 101
20, Sup 7, 71
77
63, 84, 106
52, 71
39, Sup 7, 71
73
Sup 7, 73
Sup 7, 73
29, Sup 7
15, Sup 7, 71
16, Sup 7
20, Sup 7, 71
Sup 7, 71,
110
39, Sup 7
1997
2010
2010
2010
2010
2010
2010
2010
2010
2013
2013
2013
1999
2000
2014
1999
1999
1999
1999
1999
1987
1999
1987
1999
in prep
1987

CAS No
Agent
Group
000078-87-5 1,2-Dichloropropane
000096-23-1
000542-75-6
000062-73-7
000115-32-2
069655-05-6
000060-57-1
001464-53-5
1,3-Dichloro-2-propanol
1,3-Dichloropropene (technical-grade)
Dichlorvos
Dicofol
Didanosine
Dieldrin
1,2:3,4-Diepoxybutane (see Monographs on 1,3Butadiene)
Diesel engine exhaust (see Engine exhaust, diesel)
Diesel fuels, distillate (light)
Diesel fuel, marine
000111-42-2 Diethanolamine
000103-23-1 Di(2-ethylhexyl) adipate
000117-81-7 Di(2-ethylhexyl)phthalate
2B
2B
2B
3
3
3
001615-80-1 1,2-Diethylhydrazine
000056-53-1 Diethylstilbestrol
2B
1
000064-67-5 Diethyl sulfate

000105-55-5 N,N'-Diethylthiourea
000101-90-6 Diglycidyl resorcinol ether
020830-75-5 Digoxin
000641-48-5 Dihydroaceanthrylene
000094-58-6 Dihydrosafrole
000794-93-4 Dihydroxymethylfuratrizine (see also Panfuran S)
002973-10-6 Diisopropyl sulfate
000828-00-2 Dimethoxane
000119-90-4 3,3'-Dimethoxybenzidine (ortho-Dianisidine)
000091-93-0 3,3'-Dimethoxybenzidine-4,4'-diisocyanate
000060-11-7 para-Dimethylaminoazobenzene
000140-56-7 para-Dimethylaminoazobenzenediazo sodium sulfonate
025962-77-0 trans-2-[(Dimethylamino)methylimino]-5-[2-(5-nitro-2furyl)-vinyl]-1,3,4-oxadiazole
022975-76-4 4,4'-Dimethylangelicin plus ultraviolet A radiation
12
Volume
Year
41, Sup 7,
71, 110
101
41, Sup 7, 71
Sup 7, 53
30, Sup 7
76
5, Sup 7
11, Sup 7
in prep
2013
1999
1991
1987
2000
1987
1987
3
2B
45
45
1989
1989
2B
3
2B
2013
2000
2013
2A
77, 101
Sup 7, 77
Sup 7, 77,
101
4, Sup 7, 71
21, Sup 7,
100A
54, 71
3
2B
2B
3
2B
3
2B
3
2B
3
2B
3
2B
79
36, Sup 7, 71
108
92
10, Sup 7
24, Sup 7
54, 71
15, Sup 7
4, Sup 7
39, Sup 7
8, Sup 7
8, Sup 7
7, Sup 7
2001
1999
in prep
2010
1987
1987
1999
1987
1987
1987
1987
1987
1987
Sup 7
1999
2012
1999
1987

CAS No
Agent
004063-41-6
000087-62-7
000121-69-7
000075-60-5
000119-93-7
000079-44-7
4,5'-Dimethylangelicin plus ultraviolet A radiation

2,6-Dimethylaniline (2,6-Xylidine)
N,N-Dimethylaniline
Dimethylarsinic acid
3,3'-Dimethylbenzidine (ortho-Tolidine)
Dimethylcarbamoyl chloride
Dimethylformamide
1,1-Dimethylhydrazine
1,2-Dimethylhydrazine
Dimethyl hydrogen phosphite
1,4-Dimethylphenanthrene
Dimethyl sulfate
3,7-Dinitrofluoranthene
3,9-Dinitrofluoranthene
1,3-Dinitropyrene
1,6-Dinitropyrene
1,8-Dinitropyrene
000068-12-2
000057-14-7
000540-73-8
000868-85-9
022349-59-3
000077-78-1
105735-71-5
022506-53-2
075321-20-9
042397-64-8
042397-65-9
Group
000101-25-7
000121-14-2
000606-20-2
000618-85-9
000123-91-1
000492-17-1
002475-45-8
002832-40-8
000097-77-8
001143-38-0
040762-15-0
000562-10-7
082413-20-5
Dinitrosopentamethylenetetramine
2,4-Dinitrotoluene
2,6-Dinitrotoluene
3,5-Dinitrotoluene
1,4-Dioxane
2,4'-Diphenyldiamine
Disperse Blue 1
Disperse Yellow 3
Disulfiram
Dithranol
Doxefazepam
Doxylamine succinate
Droloxifene
Dry cleaning (occupational exposures in)
000150-69-6 Dulcin
13
Volume
Year
3
2B
3
2B
2B
2A
Sup 7
57
57
100C
1, Sup 7
12, Sup 7, 71
1987
1993
1993
2012
1987
1999
3
2B
2A
47, 71
4, Sup 7, 71
4, Sup 7, 71
1999
1999
1999
3
3
2A
48, 71
Sup 7, 92
4, Sup 7, 71
1999
2010
1999
2B
2B
2B
2B
2B
46, 65, 105

46, 65, 105
46, 105
46, 105
Sup 7, 46,
105
11, Sup 7
65
65
65
11, Sup 7, 71
16, Sup 7
48
48
12, Sup 7
13; Sup 7
66
79
66
63
12, Sup 7
2013
2013
2013
2013
2013
3
2B
2B
3
2B
3
2B
3
3
3
3
3
3
2B
3
1987
1996
1996
1996
1999
1987
1990
1990
1987
1987
1996
2001
1996
1995
1987

CAS No
000072-20-8
015086-94-9
000106-89-8
000106-88-7
000141-37-7
024560-98-3
066733-21-9
Agent
Group
Dyes metabolized to benzidine (see Benzidine, dyes

metabolized to)
Electric fields, extremely low-frequency
Electric fields, static
Endrin
Engine exhaust, diesel
Engine exhaust, gasoline
Eosin
Epichlorohydrin
1,2-Epoxybutane
3,4-Epoxy-6-methylcyclohexylmethyl-3,4-epoxy-6methylcyclo-hexanecarboxylate
cis-9,10-Epoxystearic acid
Epstein-Barr virus
Erionite
029975-16-4 Estazolam
Estrogen therapy, postmenopausal
Estrogen-progestogen menopausal therapy (combined)
Estrogen-progestogen oral contraceptives (combined)
(NB: There is also convincing evidence in humans that
these agents confer a protective effect against cancer in
the endometrium and ovary)
000064-17-5 Ethanol in alcoholic beverages
000536-33-4 Ethionamide
000140-88-5 Ethyl acrylate
000100-41-4 Ethylbenzene
000051-79-6 Ethyl carbamate (Urethane)
000074-85-1 Ethylene
000106-93-4 Ethylene dibromide
000075-21-8 Ethylene oxide
000420-12-2 Ethylene sulfide
14
Volume
Year
3
3
3
1
2B
3
2A
80
80
5, Sup 7
46, 105
46, 105
15, Sup 7
11, Sup 7, 71
2002
2002
1987
2013
2013
1987
1999
2B
47, 71
1999
11, Sup 7, 71
1999
3
1
1
1999
2012
2012
3
1
1
1
11, Sup 7, 71
70, 100B
42, Sup 7,
100C
66
72, 100A
72, 91, 100A
72, 91, 100A
1
3
2B
2B
2A
3
2A
96, 100E
13, Sup 7
39, Sup 7, 71
77
7, Sup 7, 96
Sup 7, 60
15, Sup 7, 71
2012
1987
1999
2000
2010
1994
1999
Sup 7, 60,
97, 100F
2012
11, Sup 7
1987
1996
2012
2012
2012

CAS No
Agent
Group
000096-45-7 Ethylenethiourea
000103-11-7 2-Ethylhexyl acrylate
000062-50-0 Ethyl methanesulfonate
000759-73-9 N-Ethyl-N-nitrosourea
005456-28-0 Ethyl selenac
020941-65-5 Ethyl tellurac
033419-42-0 Etoposide
033419-42-0 Etoposide in combination with cisplatin and bleomycin
015663-27-1
011056-06-7
000097-53-0 Eugenol
000314-13-6 Evans blue
002353-45-9 Fast Green FCF
051630-58-1 Fenvalerate
014484-64-1 Ferbam
001309-37-1 Ferric oxide
Firefighter (occupational exposure as a)
Fission products, including strontium-90
Flat-glass and specialty glass (manufacture of)
002164-17-2 Fluometuron
000206-44-0 Fluoranthene
000086-73-7 Fluorene
Fluorescent lighting
016984-48-8 Fluorides (inorganic, used in drinking-water)
Fluoro-edenite fibrous amphibole
000051-21-8 5-Fluorouracil
Foreign bodies (see Surgical implants and other foreign
bodies)
000050-00-0 Formaldehyde
003570-75-0 2-(2-Formylhydrazino)-4-(5-nitro-2-furyl)thiazole
Frying, emissions from high-temperature
Fuel oils, distillate (light)
Fuel oils, residual (heavy)
15
Volume
Year
Sup 7, 79
2001
3
2B
2A
60
7, Sup 7
17, Sup 7
1994
1987
1987
3
3
1
12, Sup 7
12, Sup 7
76, 100A
1987
1987
2012
76, 100A
2012
3
3
3
3
3
3
2B
1
3
3
3
3
3
3
1
3
36, Sup 7
8, Sup 7
16, Sup 7
53
12, Sup 7
1, Sup 7
98
100D
58
30, Sup 7
Sup 7, 92
Sup 7, 92
55
27, Sup 7
111
26, Sup 7
1987
1987
1987
1991
1987
1987
2010
2012
1993
1987
2010
2010
1992
1987
In prep
1987
Sup 7, 62,
88, 100F
7, Sup 7
95
45
45
2012
2B
2A
3
2B
1987
2010
1989
1989

CAS No
Agent
116355-83-0
000110-00-9
000067-45-8
000098-01-1
Fumonisin B1
Furan
Furazolidone
Furfural
Furniture and cabinet making (see Wood dust)
Furosemide (Frusemide)
Fusarium graminearum, F. culmorum, and F.
crookwellense, toxins derived from (zearalenone,
deoxynivalenol, nivalenol, and fusarenone X)
Fusarium moniliforme, toxins derived from (fumonisin B1,
fumonisin B2, and fusarin C)
Fusarium sporotrichioides, toxins derived from (T-2 toxin)
Gallium arsenide (see Arsenic and inorganic arsenic
compounds)
Gamma-Radiation (see X- and Gamma-Radiation)
Gasoline
Gasoline engine exhaust (see Engine exhaust, gasoline)
Gemfibrozil
Ginkgo biloba extract
Glass filament, continuous
Glu-P-1 (2-Amino-6-methyldipyrido[1,2-a:3',2'd]imidazole)
Glu-P-2 (2-Aminodipyrido[1,2-a:3',2'-d]imidazole)
Glycidaldehyde
Glycidol
Glycidyl oleate
Glycidyl stearate
Goldenseal root powder
Griseofulvin
Guinea Green B
Gyromitrin
Haematite
Haematite mining (underground)
Hair colouring products (personal use of)
Hairdresser or barber (occupational exposure as a)
3
2A
000054-31-9
116355-83-0
001303-00-0
025812-30-0
090045-36-6
067730-11-4
067730-10-3
000765-34-4
000556-52-5
005431-33-4
007460-84-6
000126-07-8
004680-78-8
016568-02-8
001317-60-8
Group
16
2B
2B
3
3
Volume
Year
82
63
31, Sup 7
63
25, Sup 7
50
Sup 7, 56
2002
1995
1987
1995
1987
1990
1993
56
1993
56
86, 100C
1993
2012
2B
45
1989
3
2B
3
2B
66
108
43, 81
40, Sup 7
2B
2B
2A
40, Sup 7
11, Sup 7, 71
77
3
3
2B
2B
3
3
3
1
11, Sup 7
11, Sup 7
108
Sup 7, 79
16, Sup 7
31, Sup 7
1, Sup 7
1, Sup 7,
100D
57, 99
57, 99
3
3
2B
3
1996
in prep
2002
1987
1987
1999
2000
1987
1987
in prep
2001
1987
1987
1987
2012
2010
2010

CAS No
Agent
002784-94-3
033229-34-4
002871-01-4
059820-43-8
HC Blue No. 1
HC Blue No. 2
HC Red No. 3
HC Yellow No. 4
Helicobacter pylori (infection with)
Hepatitis B virus (chronic infection with)
Hepatitis C virus (chronic infection with)
Hepatitis D virus
Heptachlor
Hexachlorobenzene
Hexachlorobutadiene
Hexachlorocyclohexanes
Hexachloroethane
Hexachlorophene
2,4-Hexadienal
Hexamethylphosphoramide
High-temperature frying (see Frying)
Hot mate (see Mate, hot)
Household combustion of biomass fuel (see Biomass
fuel, indoor emissions from household combustion of)
Household combustion of coal (see Coal, indoor
emissions from household combustion)
Human herpesvirus type 4 (see Epstein-Barr virus)
Human herpesvirus type 8 (see Kaposi sarcoma
herpesvirus)
Human immunodeficiency virus type 1 (infection with)
Human immunodeficiency virus type 2 (infection with)
Human papillomavirus genus beta (except types 5 and 8)
and genus gamma
Human papillomavirus types 5 and 8 (in patients with
epidermodysplasia verruciformis)
Human papillomavirus types 6 and 11
Human papillomavirus types 16, 18, 31, 33, 35, 39, 45,
51, 52, 56, 58, 59
(NB: The HPV types that have been classified as
carcinogenic to humans can differ by an order of
magnitude in risk for cervical cancer)
Human papillomavirus types 26, 53, 66, 67, 70, 73, 82
Human papillomavirus types 30, 34, 69, 85, 97
(NB: Classified by phylogenetic analogy to the HPV
genus alpha types classified in Group 1)
000076-44-8
000118-74-1
000087-68-3
000067-72-1
000070-30-4
000142-83-6
000680-31-9
Group
17
Volume
Year
2B
3
3
3
1
1
1
3
2B
2B
3
2B
2B
3
2B
2B
57
57
57
57
61, 100B
59, 100B
59, 100B
59
Sup 7, 53, 79
Sup 7, 79
73
20, Sup 7
73
20, Sup 7
101
15, Sup 7, 71
1993
1993
1993
1993
2012
2012
2012
1994
2001
2001
1999
1987
1999
1987
2013
1999
1
2B
3
67, 100B
67
90, 100B
2012
1996
2012
2B
100B
2012
90, 100B
64, 90, 100B
2012
2012
100B
100B
2012
2012
3
1
2B
2B

CAS No
023255-93-8
000086-54-4
000302-01-2
007647-01-0
000058-93-5
007722-84-1
000123-31-9
000129-43-1
001689-82-3
000148-24-3
026782-43-4
000127-07-1
000193-39-5
022398-80-7
010043-66-0
076180-96-6
Agent
Group
Human papillomavirus type 68

Human T-cell lymphotropic virus type I
Human T-cell lymphotropic virus type II
Hycanthone mesylate
Hydralazine
Hydrazine
Hydrochloric acid
Hydrochlorothiazide
Hydrogen peroxide
Hydroquinone
1-Hydroxyanthraquinone
4-Hydroxyazobenzene
8-Hydroxyquinoline
Hydroxysenkirkine
Hydroxyurea
Hypochlorite salts
Indeno[1,2,3-cd]pyrene
Indium phosphide
(NB: Overall evaluation upgraded to Group 2A)
Insulation glass wool
Involuntary smoking (see Tobacco smoke, second-hand)
Iodine-131 (see Radioiodines)
Ionizing radiation (all types)
IQ (2-Amino-3-methylimidazo[4,5-f]quinoline)
Iron and steel founding (occupational exposure during)
009004-66-4
009004-51-7
001338-16-5
015503-86-3
000054-85-3
003778-73-2
000078-79-5
000067-63-0
Iron-dextran complex
Iron-dextrin complex
Iron sorbitol-citric acid complex
Isatidine
Isonicotinic acid hydrazide (Isoniazid)
Isophosphamide
Isoprene
Isopropyl alcohol
Isopropyl alcohol manufacture using strong acids
Isopropyl oils
000120-58-1 Isosafrole
18
2A
1
3
3
3
2B
3
2B
3
3
2B
3
3
3
3
3
2B
2A
3
1
2A
1
2B
3
3
3
3
3
2B
3
1
3
3
Volume
Year
100B
67, 100B
67
13, Sup 7
24, Sup 7
4, Sup 7, 71
54
50, 108
36, Sup 7, 71
15, Sup 7, 71
82
8, Sup 7
13, Sup 7
10, Sup 7
76
52
Sup 7, 92
86
2012
2012
1996
1987
1987
1999
1992
in prep
1999
1999
2002
1987
1987
1987
2000
1991
2010
2006
43, 81
2002
100D
Sup 7, 56
2012
1993
34, Sup 7,
100F
2, Sup 7
2, Sup 7
2, Sup 7
10, Sup 7
4, Sup 7
26, Sup 7
60, 71
15, Sup 7, 71
Sup 7, 100F
15, Sup 7, 71
10, Sup 7
2012
1987
1987
1987
1987
1987
1987
1999
1999
2012
1999
1987

CAS No
Agent
Group
006870-67-3 Jacobine
JC polyomavirus (JCV)
Jet fuel
000520-18-3 Kaempferol
Kaposi sarcoma herpesvirus
009000-38-8 Kava extract
000501-30-4 Kojic acid
000303-34-4 Lasiocarpine
000105-74-8 Lauroyl peroxide
007439-92-1 Lead
Lead compounds, inorganic
Lead compounds, organic
(NB: Organic lead compounds are metabolized at least
in part, to ionic lead both in humans and animals. To the
extent that ionic lead, generated from organic lead, is
present in the body, it will be expected to exert the
toxicities associated with inorganic lead.)
Leather dust
Leather goods manufacture
Leather tanning and processing
005141-20-8 Light Green SF
005989-27-5 d-Limonene
Lumber and sawmill industries (including logging)
021884-44-6 Luteoskyrin
Madder root (Rubia tinctorum)
000632-99-5 Magenta
Magenta production
000121-75-5
000123-33-1
000542-78-9
012427-38-2
000551-74-6
3
2B
3
3
1
2B
3
2B
3
2B
2A
3
19
Year
10, Sup 7
104
45
31, Sup 7
70, 100B
108
79
10, Sup 7
36, Sup 7, 71
23, Sup 7
Sup 7, 87
23, Sup 7, 87
1987
2013
1989
1987
2012
in prep
2001
1987
1999
1987
2006
2006
1
3
3
3
3
100C
25, Sup 7
25, Sup 7
16, Sup 7
56, 73
2012
1987
1987
1987
1999
3
3
3
2B
25, Sup 7
10, Sup 7
82
Sup 7, 57,
99, 100F
Sup 7, 57,
99, 100F
80
80
104
1987
1987
2002
2012
30, Sup 7
4, Sup 7
36, Sup 7, 71
12, Sup 7
9, Sup 7
1987
1987
1999
1987
1987
Magnetic fields, extremely low-frequency

Magnetic fields, static
Malaria (caused by infection with Plasmodium falciparum
in holoendemic areas)
Malathion
Maleic hydrazide
Malonaldehyde
Maneb
Mannomustine dihydrochloride
Volume
2B
3
2A
3
3
3
3
3
2012
2002
2002
2013

CAS No
Agent
068006-83-7
013045-94-8
000071-58-9
077094-11-2
077500-04-0
000108-78-1
Mate
Mate, hot
MeA-alpha-C (2-Amino-3-methyl-9H-pyrido[2,3-b]indole)
Medphalan
Medroxyprogesterone acetate
MeIQ (2-Amino-3,4-dimethylimidazo[4,5-f]quinoline)
MeIQx (2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline)
Melamine
Melphalan
000148-82-3
Group
000050-44-2 6-Mercaptopurine
007439-97-6 Mercury and inorganic mercury compounds
Merkel cell polyomavirus (MCV)
000531-76-0 Merphalan
Metabisulfites
000060-56-0 Methimazole
000059-05-2 Methotrexate
000072-43-5 Methoxychlor
000298-81-7 Methoxsalen (8-methoxypsoralen) plus ultraviolet A
radiation
000484-20-8 5-Methoxypsoralen
000096-33-3 Methyl acrylate
073459-03-7 5-Methylangelicin plus ultraviolet A radiation
000124-58-3 Methylarsonic acid
000075-55-8 2-Methylaziridine (Propyleneimine)
000592-62-1 Methylazoxymethanol acetate
000074-83-9 Methyl bromide
001634-04-4 Methyl tert-butyl ether
000598-55-0 Methyl carbamate
000074-87-3 Methyl chloride
003351-28-8 1-Methylchrysene
20
Volume
Year
3
2A
2B
3
2B
2B
2B
3
51
51
40, Sup 7
9, Sup 7
21, Sup 7
Sup 7, 56
Sup 7, 56
Sup 7, 73
1991
1991
1987
1987
1987
1993
1993
1999
2012
1987
1993
2013
1987
1992
2001
1987
1987
2012
2A
9, Sup 7,
100A
26, Sup 7
58
104
9, Sup 7
54
79
26, Sup 7
20, Sup 7
24, Sup 7,
100A
40, Sup 7
3
3
2B
2B
2B
3
3
3
3
3
3
3
3
2B
39, Sup 7, 71
Sup 7
100C
9, Sup 7, 71
10, Sup 7
41, Sup 7, 71
73
12, Sup 7
41, Sup 7, 71
Sup 7, 92
Sup 7, 92
Sup 7, 92
Sup 7, 92
Sup 7, 92
1999
1987
2012
1999
1987
1999
1999
1987
1999
2010
2010
2010
2010
2010
3
3
2A
2B
3
3
3
3
1
1987

CAS No
Agent
Group
000099-80-9 N-Methyl-N,4-dinitrosoaniline
000101-14-4 4,4'-Methylenebis(2-chloroaniline) (MOCA)
000838-88-0 4,4'-Methylene bis(2-methylaniline)
007220-79-3 Methylene blue
000101-77-9 4,4'-Methylenedianiline
000101-68-8 4,4'-Methylenediphenyl diisocyanate
000093-15-2 Methyleugenol
033543-31-6 2-Methylfluoranthene
001706-01-0 3-Methylfluoranthene
000078-98-8 Methylglyoxal
000693-98-1 2-Methylimidazole
000822-36-6 4-Methylimidazole
000074-88-4 Methyl iodide
000108-10-1 Methyl isobutyl ketone
Methylmercury compounds
000080-62-6 Methyl methacrylate
000066-27-3 Methyl methanesulfonate
000129-15-7 2-Methyl-1-nitroanthraquinone (uncertain purity)
000070-25-7 N-Methyl-N-nitro-N-nitrosoguanidine (MNNG)
000684-93-5 N-Methyl-N-nitrosourea
000615-53-2 N-Methyl-N-nitrosourethane
090456-67-0 N-Methylolacrylamide
000298-00-0 Methyl parathion
000832-69-9 1-Methylphenanthrene
085878-63-3 7-Methylpyrido[3,4-c]psoralen
000493-52-7 Methyl red
000144-34-3 Methyl selenac
000098-83-9 -Methylstyrene
000056-04-2 Methylthiouracil
000443-48-1 Metronidazole
21
3
3
1
Volume
Sup 7, 92
1, Sup 7
Sup 7, 57,
99, 100F
Year
2010
1987
2012
2B
3
2B
3
2B
3
3
3
2B
2B
3
2B
2B
4, Sup 7
108
39, Sup 7
19, Sup 7, 71
101
Sup 7, 92
Sup 7, 92
51
101
101
41, Sup 7, 71
101
58
1987
in prep
1987
1999
2013
2010
2010
1991
2013
2013
1999
2013
1993
3
2A
Sup 7, 60
7, Sup 7, 71
1994
1999
2B
2A
27, Sup 7
4, Sup 7
1987
1987
2A
17, Sup 7
1987
2B
3
3
3
3
3
3
2B
4, Sup 7
60
30, Sup 7
Sup 7, 92
40, Sup 7
8, Sup 7
12, Sup 7
101
1987
1994
1987
2010
1987
1987
1987
2013
2B
2B
Sup 7, 79
13, Sup 7
2001
1987

CAS No
Agent
Group
000101-61-1 Michlers base [4,4-methylenebis(N,N-dimethyl)benzenamine]

000090-94-8 Michlers ketone [4,4-Bis(dimethylamino)benzophenone]
101043-37-2 Microcystin-LR
Microcystis extracts
Mineral oils, highly-refined
Mineral oils, untreated or mildly treated
002385-85-5 Mirex
000050-07-7 Mitomycin C
065271-80-9 Mitoxantrone
Modacrylic fibres
000096-24-2 3-Monochloro-1,2-propanediol
000315-22-0 Monocrotaline
000124-58-3 Monomethylarsonic acid (see Methylarsonic acid)
000150-68-5 Monuron
MOPP and other combined chemotherapy including
alkylating agents
000110-91-8 Morpholine
003795-88-8 5-(Morpholinomethyl)-3-[(5-nitrofurfurylidene)amino]-2oxazolidinone
308068-56-6 Multi-walled carbon nanotubes MWCNT-7
308068-56-6 Multi-walled carbon nanotubes other than MWCNT-7
000083-66-9 Musk ambrette
000081-15-2 Musk xylene
000505-60-2 Mustard gas (see Sulfur mustard)
000055-98-1 Myleran (see Busulfan)
003771-19-5 Nafenopin
000091-20-3 Naphthalene
002243-62-1 1,5-Naphthalenediamine
003173-72-6 1,5-Naphthalene diisocyanate
111189-32-3 Naphtho[1,2-b]fluoranthene
000203-20-3 Naphtho[2,1-a]fluoranthene
000193-09-9 Naphtho[2,3-e]pyrene
000134-32-7 1-Naphthylamine
000091-59-8 2-Naphthylamine
000086-88-4 1-Naphthylthiourea (ANTU)
000139-94-6 Nithiazide
Year
2B
27, Sup 7, 99
2010
2B
2B
3
3
1
2010
2010
2010
1987
2012
2B
2B
2B
3
2B
2B
2B
3
1
99
94
94
33, Sup 7
33, Sup 7,
100F
20, Sup 7
10, Sup 7
76
19, Sup 7
101
10, Sup 7
100C
Sup 7, 53
Sup 7, 100A
1987
1987
2000
1987
2013
1987
2012
1991
2012
3
2B
47, 71
7, Sup 7
1999
1987
2B
3
3
3
111
111
65
65
2B
2B
3
3
3
3
3
3
1
24, Sup 7
82
27, Sup 7
19, Sup 7, 71
92
92
92
4, Sup 7
4, Sup 7, 99,
100F
30, Sup 7
31, Sup 7
3
3
22
Volume
In prep
In prep
1996
1996
1987
2002
1987
1999
2010
2010
2010
1987
2012
1987
1987

CAS No
Agent
Group
Neutron radiation
(NB: Overall evaluation upgraded to Group 1 with
007440-02-0 Nickel, metallic and alloys
Nickel compounds
Volume
Year
75, 100D
2012
2B
1
1990
2012
2B
2A
Sup 7, 49
Sup 7, 49,
100C
11
13, Sup 7
94
1976
1987
2010
2B
48, 73
1999
000602-87-9
000099-59-2
000091-23-6
000602-60-8
017117-34-9
000098-95-3
020268-51-3
063041-90-7
000092-93-3
007496-02-8
Nickel refining (see Nickel compounds)

Niridazole
Nitrate or nitrite (ingested) under conditions that result in
endogenous nitrosation
Nitrilotriacetic acid and its salts
5-Nitroacenaphthene
5-Nitro-ortho-anisidine
2-Nitroanisole
9-Nitroanthracene
3-Nitrobenzanthrone
Nitrobenzene
7-Nitrobenz[a]anthracene
6-Nitrobenzo[a]pyrene
4-Nitrobiphenyl
6-Nitrochrysene
2B
3
2B
3
2B
2B
3
3
3
2A
1987
1987
1996
1987
2013
1996
1989
1989
1987
2013
001836-75-5
000892-21-7
000607-57-8
000059-87-0
000067-20-9
000555-84-0
000531-82-8
000051-75-2
000126-85-2
000075-52-5
000086-57-7
000581-89-5
020589-63-3
000079-46-9
005522-43-0
Nitrofen (technical-grade)
3-Nitrofluoranthene
2-Nitrofluorene
Nitrofural (Nitrofurazone)
Nitrofurantoin
1-[(5-Nitrofurfurylidene)amino]-2-imidazolidinone
N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide
Nitrogen mustard
Nitrogen mustard N-oxide
Nitromethane
1-Nitronaphthalene
2-Nitronaphthalene
3-Nitroperylene
2-Nitropropane
1-Nitropyrene
2B
3
2B
3
3
2B
2B
2A
2B
2B
3
3
3
2B
2A
16, Sup 7
27, Sup 7
65
33, Sup 7
105
65
46
Sup 7, 46
4, Sup 7
Sup 7, 46,
105
30, Sup 7
33, Sup 7
46, 105
50
50
7, Sup 7
7, Sup 7
9, Sup 7
9, Sup 7
77
46
46
46
29, Sup 7, 71
Sup 7, 46,
105
46
000061-57-4
000139-13-9
000789-07-1 2-Nitropyrene
23
1987
1987
2013
1990
1990
1987
1987
1987
1987
2000
1989
1989
1989
1999
2013
1989

CAS No
Agent
057835-92-4
037620-20-5
071267-22-6
000924-16-3
001116-54-7
000055-18-5
4-Nitropyrene
N'-Nitrosoanabasine (NAB)
N'-Nitrosoanatabine (NAT)
N-Nitrosodi-n-butylamine
N-Nitrosodiethanolamine
N-Nitrosodiethylamine
N-Nitrosodimethylamine
N-Nitrosodiphenylamine
para-Nitrosodiphenylamine
N-Nitrosodi-n-propylamine
N-Nitrosofolic acid
N-Nitrosoguvacine
N-Nitrosoguvacoline
N-Nitrosohydroxyproline
3-(N-Nitrosomethylamino)propionaldehyde
3-(N-Nitrosomethylamino)propionitrile
N-Nitrosomethylethylamine
N-Nitrosomethylvinylamine
N-Nitrosomorpholine
N'-Nitrosonornicotine (NNN) and 4-(NNitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK)
N-Nitrosopiperidine
N-Nitrosoproline
N-Nitrosopyrrolidine
N-Nitrososarcosine
2-Nitrotoluene
Nitrotoluenes
000062-75-9
000086-30-6
000156-10-5
000621-64-7
029291-35-8
055557-01-2
055557-02-3
030310-80-6
085502-23-4
060153-49-3
010595-95-6
004549-40-0
000059-89-2
016543-55-8
064091-91-4
000100-75-4
007519-36-0
000930-55-2
013256-22-9
000088-72-2
Group
000099-08-1
000099-99-0
000099-55-8 5-Nitro-ortho-toluidine
000804-36-4 Nitrovin
118399-22-7 Nodularins
24
Volume
Year
2B
3
3
2B
2B
2A
46, 105
37, Sup 7, 89
37, Sup 7, 89
17, Sup 7
17, Sup 7, 77
17, Sup 7
2013
2007
2007
1987
2000
1987
2A
17, Sup 7
1987
3
3
2B
3
3
3
3
3
2B
2B
2B
2B
1
27, Sup 7
27, Sup 7
17, Sup 7
17, Sup 7
Sup 7, 85
Sup 7, 85
17, Sup 7
Sup 7, 85
Sup 7, 85
17, Sup 7
17, Sup 7
17, Sup 7
Sup 7, 89,
100E
1987
1987
1987
1987
2004
2004
1987
2004
2004
1987
1987
1987
2012
2B
3
2B
2B
2A
17, Sup 7
17, Sup 7
17, Sup 7
17, Sup 7
101
1987
1987
1987
1987
2013
65
1996
3
3
3
48
31, Sup 7
94
1990
1987
2010

CAS No
025038-54-4
000303-47-9
022966-79-6
002646-17-5
000523-44-4
001936-15-8
000604-75-1
000129-20-4
012174-11-7
012174-11-7
000794-93-4
000103-90-2
010048-32-5
000056-38-2
000149-29-1
Agent
Group
Non-arsenical insecticides (occupational exposures in

spraying and application of)
Nylon 6
Ochratoxin A
Oestradiol mustard
Oestrogen (see Estrogen)
Oil Orange SS
Opisthorchis felineus (infection with)
Opisthorchis viverrini (infection with)
Oral contraceptives, combined estrogen-progestogen
(see Estrogen-progestogen oral contraceptives)
Orange I (see CI Acid Orange 20)
Orange G (see CI Orange G)
Outdoor air pollution
Outdoor air pollution, particulate matter in
Oxazepam
Oxyphenbutazone
Painter (occupational exposure as a)
Paint manufacture (occupational exposure in)
Palygorskite (Attapulgite) (long fibres, > 5 micrometres)
Palygorskite (Attapulgite)(short fibres, < 5 micrometres)
Panfuran S (containing dihydroxymethylfuratrizine)
Paracetamol (Acetaminophen)
Parasorbic acid
Parathion
Particulate matter in outdoor air pollution (see Outdoor air
pollution, particulate matter in)
Patulin
Paving and roofing with coal-tar pitch (see Coal-tar pitch)
000090-65-3 Penicillic acid

057465-28-8 3,4,5,3,4-Pentachlorobiphenyl (PCB-126)
(see Polychlorinated biphenyls, dioxin-like, with a TEF
according to WHO)
057117-31-4 2,3,4,7,8-Pentachlorodibenzofuran
000076-01-7 Pentachloroethane
000087-86-5 Pentachlorophenol (see Polychlorophenols)
037319-17-8 Pentosan polysulfate sodium
25
Volume
Year
2A
53
1991
3
2B
3
19, Sup 7
Sup 7, 56
9, Sup 7
1987
1993
1987
2B
3
1
8, Sup 7
61
61, 100B
1987
1994
2012
1
1
2B
3
1
3
2B
3
2B
3
3
3
109
109
Sup 7, 66
13, Sup 7
47, 98, 100F
47
68
68
24, Sup 7
50, 73
10, Sup 7
30, Sup 7
in prep
in prep
1996
1987
2012
1989
1997
1997
1987
1999
1987
1987
1987
2010
3
1
40, Sup 7
35, Sup 7,
92, 100F
10, Sup 7
100F
100F
2012
41, Sup 7, 71
53, 71
108
2B
1987
2012
1999
1999
in prep

CAS No
Agent
000335-67-1
052645-53-1
000198-55-0
060102-37-6
Perfluorooctanoic acid
Permethrin
Perylene
Petasitenine
Petroleum refining (occupational exposures in)
Petroleum solvents
Pickled vegetables (traditional in Asia)
Phenacetin
Phenacetin, analgesic mixtures containing
Phenanthrene
Phenazopyridine hydrochloride
Phenelzine sulfate
Phenicarbazide
Phenobarbital
Phenol
Phenolphthalein
Phenoxybenzamine hydrochloride
Phenylbutazone
meta-Phenylenediamine
para-Phenylenediamine
Phenyl glycidyl ether
N-Phenyl-2-naphthylamine
ortho-Phenylphenol
Phenytoin
PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine)
Phosphorus-32, as phosphate
Picene
Picloram
Pioglitazone
Piperonyl butoxide
Plutonium
Poligeenan (see Carrageenan, degraded)
Polyacrylic acid
000062-44-2
000085-01-8
000136-40-3
000156-51-4
000103-03-7
000050-06-6
000108-95-2
000077-09-8
000063-92-3
000050-33-9
000108-45-2
000106-50-3
000122-60-1
000135-88-6
000090-43-7
000057-41-0
105650-23-5
014596-37-3
000213-46-7
001918-02-1
111025-46-8
000051-03-6
007440-07-5
053973-98-1
009003-01-4
Group
26
Volume
Year
2B
3
3
3
2A
3
2B
1
110
53
Sup 7, 92
31, Sup 7
45
47
56
24, Sup 7,
100A
in prep
1991
2010
1987
1989
1989
1993
2012
1
3
2B
3
3
2B
3
2B
2B
3
3
3
2B
3
3
2B
2B
1
3
3
2A
3
1
Sup 7, 100A
Sup 7, 92
24, Sup 7
24, Sup 7
12, Sup 7
Sup 7, 79
47, 71
76
24, Sup 7
13, Sup 7
16, Sup 7
16, Sup 7
47, 71
16, Sup 7
73
Sup 7, 66
56
78, 100D
92
53
108
30, Sup 7
78, 100D
2012
2010
1987
1987
1987
2001
1999
2000
1987
1987
1987
1987
1999
1987
1999
1996
1993
2012
2010
1991
in prep
1987
2012
19, Sup 7
1987

CAS No
Agent
Group
059536-65-1 Polybrominated biphenyls

supporting evidence from other relevant data, namely
mechanistic similarity with polychlorinated biphenyls
classified in Group 1)
001336-36-3 Polychlorinated biphenyls
009010-98-4
009002-88-4
009016-87-9
009011-14-7
009003-07-0
009003-53-6
009002-84-0
009009-54-5
009003-20-7
009002-89-5
009002-86-2
009003-39-8
003564-09-8
003761-53-3
004548-53-2
023746-34-1
007758-01-2
002955-38-6
029069-24-7
000053-03-2
000125-33-7
Polychlorinated biphenyls, dioxin-like, with a Toxicity

Equivalency Factor (TEF) according to WHO (PCBs 77,
81, 105, 114, 118, 123, 126, 156, 157, 167, 169, 189)
strong supporting evidence from other relevant data)
Polychlorinated dibenzo-para-dioxins (other than 2,3,7,8tetrachlorodibenzo-para-dioxin)
Polychlorinated dibenzofurans
(see 2,3,4,7,8-Pentachlorodibenzofuran)
Polychlorophenols and their sodium salts (mixed
exposures)
Polychloroprene
Polyethylene
Polymethylene polyphenyl isocyanate
Polymethyl methacrylate
Polypropylene
Polystyrene
Polytetrafluoroethylene
Polyurethane foams
Polyvinyl acetate
Polyvinyl alcohol
Polyvinyl chloride
Polyvinyl pyrrolidone
Ponceau 3R
Ponceau MX
Ponceau SX
Potassium bis(2-hydroxyethyl)dithiocarbamate
Potassium bromate
Prazepam
Prednimustine
Prednisone
Primidone
Printing inks
Printing processes (occupational exposures in)
27
Volume
Year
2A
41, Sup 7,
107
in prep
in prep
18, Sup 7,
107
107
69
1997
69
1997
2B
53, 71
1999
3
3
3
3
3
3
3
3
3
3
3
3
2B
2B
3
3
2B
3
3
3
2B
3
2B
19, Sup 7
19, Sup 7
19, Sup 7
19, Sup 7
19, Sup 7
19, Sup 7
19, Sup 7
19, Sup 7
19, Sup 7
19, Sup 7
19, Sup 7
19, Sup 7, 71
8, Sup 7
8, Sup 7
8, Sup 7
12, Sup 7
Sup 7, 73
66
50
26, Sup 7
108
65
65
in prep
1987
1987
1987
1987
1987
1987
1987
1987
1987
1987
1987
1987
1987
1987
1987
1987
1999
1996
1990
1987
in prep
1996
1996

CAS No
Agent
Group
000366-70-1 Procarbazine hydrochloride

Proflavine salts
Progestins
Progestogen-only contraceptives
000051-02-5 Pronetalol hydrochloride
001120-71-4 1,3-Propane sultone
000122-42-9 Propham
000057-57-8 beta-Propiolactone
000627-12-3 n-Propyl carbamate
000115-07-1 Propylene
000075-56-9 Propylene oxide
000051-52-5 Propylthiouracil
087625-62-5 Ptaquiloside
000089-82-7 Pulegone
Pulp and paper manufacture
000129-00-0 Pyrene
000110-86-1 Pyridine
085878-62-2 Pyrido[3,4-c]psoralen
000058-14-0 Pyrimethamine
000117-39-5 Quercetin
000106-51-4 para-Quinone
000082-68-8 Quintozene (Pentachloronitrobenzene)
Radiofrequency electromagnetic fields1
Radioiodines, including iodine-131
Radionuclides, alpha-particle-emitting, internally
deposited
(NB: Specific radionuclides for which there is sufficient
evidence in humans are also listed individually as
Group 1 agents)
Radionuclides, beta-particle-emitting, internally deposited
(NB: Specific radionuclides for which there is sufficient
evidence in humans are also listed individually as
Group 1 agents)
013233-32-4 Radium-224 and its decay products
010043-92-2 Radon-222 and its decay products
28
Volume
Year
2A
26, Sup 7
1987
3
2B
2B
3
2A
24, Sup 7
Sup 7
72
13, Sup 7
4, Sup 7, 71,
110
1987
1987
1999
1987
in prep
3
2B
3
3
2B
2B
3
2B
3
3
3
3
3
3
3
3
2B
1
1
12, Sup 7
4, Sup 7, 71
12, Sup 7
Sup 7, 60
Sup 7, 60
Sup 7, 79
40, Sup 7
108
25, Sup 7
Sup 7, 92
77
40, Sup 7
13, Sup 7
Sup 7, 73
15, Sup 7, 71
5, Sup 7
102
78, 100D
78, 100D
1987
1999
1987
1994
1994
2001
1987
in prep
1987
2010
2000
1987
1987
1999
1999
1987
2013
2012
2012
78, 100D
2012
1
1
1
1
78, 100D
78, 100D
78, 100D
43, 78, 100D
2012
2012
2012
2012

CAS No
Agent
000050-55-5
000108-46-3
000480-54-6
000081-88-9
000989-38-8
023246-96-0
013292-46-1
026308-28-1
122320-73-4
Refractory ceramic fibres

Reserpine
Resorcinol
Retrorsine
Rhodamine B
Rhodamine 6G
Riddelliine
Rifampicin
Ripazepam
Rosiglitazone
Rubber manufacturing industry
Group
Volume
Year
2002
1987
1999
1987
1987
1987
2002
1987
1996
in prep
2012
3
3
3
3
43, 81
24, Sup 7
15, Sup 7, 71
10, Sup 7
16, Sup 7
16, Sup 7
10, Sup 7, 82
24, Sup 7
66
108
28, Sup 7,
100F
40, Sup 7
43, 81
2, Sup 7
Sup 7, 73
2B
1
3
1
2B
3
3
3
1
10, Sup 7
56, 100E
8, Sup 7
61, 100B
61
61
9, Sup 7
12, Sup 7
Sup 7, 100A
1987
2012
1987
2012
1994
1994
1987
1987
2012
10, Sup 7
31, Sup 7
Sup 7, 68
35, Sup 7,
100F
98
40, Sup 7
Sup 7, 68
Sup 7, 68,
100C
111
1987
1987
1997
2012
2B
3
3
3
3
3
2B
3
3
3
1
023537-16-8 Rugulosin
Rock (stone) wool
008047-67-4 Saccharated iron oxide
000081-07-2 Saccharin and its salts
000094-59-7 Safrole
Salted fish, Chinese-style
000085-83-6 Scarlet Red
Schistosoma haematobium (infection with)
Schistosoma japonicum (infection with)
Schistosoma mansoni (infection with)
007782-49-2 Selenium and selenium compounds
000563-41-7 Semicarbazide hydrochloride
013909-09-6 Semustine [1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1nitrosourea, Methyl-CCNU]
000480-81-9 Seneciphylline
002318-18-5 Senkirkine
015501-74-3 Sepiolite
068308-34-9 Shale oils
3
3
3
1
Shiftwork that involves circadian disruption

000138-59-0 Shikimic acid
007631-86-9 Silica, amorphous
014808-60-7 Silica dust, crystalline, in the form of quartz or cristobalite
2A
3
3
1
308076-74-6 Silicon carbide, fibrous
2B
29
1987
2002
1987
1999
2010
1987
1997
2012
In prep

CAS No
Agent
Group
409-21-2 Silicon carbide whiskers

000122-34-9 Simazine
308068-56-6 Single-walled carbon nanotubes
Slag wool
007758-19-2 Sodium chlorite
000148-18-5 Sodium diethyldithiocarbamate
000132-27-4 Sodium ortho-phenylphenate
Solar radiation
Soot (as found in occupational exposure of chimney
sweeps)
Special-purpose fibres such as E-glass and '475' glass
fibres
000052-01-7 Spironolactone
010048-13-2 Sterigmatocystin
018883-66-4 Streptozotocin
Stress (see Volume 100)
007664-93-9 Strong-inorganic-acid mists containing sulfuric acid (see
Acid mists)
010098-97-2 Strontium-90 (see Fission products)
000100-42-5 Styrene
009003-54-7 Styrene-acrylonitrile copolymers
009003-55-8 Styrene-butadiene copolymers
000096-09-3 Styrene-7,8-oxide
000108-30-5 Succinic anhydride
000842-07-9 Sudan I
003118-97-6 Sudan II
000085-86-9 Sudan III
006416-57-5 Sudan Brown RR
006368-72-5 Sudan Red 7B
000127-69-5 Sulfafurazole (Sulfisoxazole)
000095-06-7 Sulfallate
000057-68-1 Sulfamethazine
000723-46-6 Sulfamethoxazole
000599-79-1 Sulfasalazine
Sulfites
007446-09-5 Sulfur dioxide
30
Volume
Year
In prep
1999
In prep
2002
1991
1987
1999
2012
2012
2B
111
53, 73
111
43, 81
52
12, Sup 7
Sup 7, 73
55, 100D
35, Sup 7,
92, 100F
81
3
2B
2B
Sup 7, 79
10, Sup 7
17, Sup 7
2001
1987
1987
2B
3
3
2A
60, 82
19, Sup .7
19, Sup 7
Sup 7, 60
2002
1987
1987
1994
3
3
3
3
3
3
3
2B
3
15, Sup 7
8, Sup 7
8, Sup 7
8, Sup 7
8, Sup 7
8, Sup 7
24, Sup 7
30, Sup 7
79
1987
1987
1987
1987
1987
1987
1987
1987
2001
3
2B
3
3
Sup 7, 79
108
54
54
2001
in prep
1992
1992
2A
3
3
3
3
3
2B
1
1
2002

CAS No
Agent
Group
000505-60-2 Sulfur mustard
002783-94-0
022571-95-5
014807-96-6
014807-96-6
014807-96-6
010540-29-1
001401-55-4
000846-50-4
029767-20-2
008001-50-1
015721-02-5
001746-01-6
Sunlamps and sunbeds (see Ultraviolet-emitting tanning

devices)
Sunset Yellow FCF
Surgical implants and other foreign bodies:
- Polymeric implants prepared as thin smooth film (with
the exception of poly(glycolic acid))
- Metallic implants prepared as thin smooth films
- Implanted foreign bodies of metallic cobalt, metallic
nickel and an alloy powder containing 66-67% nickel,
13-16% chromium and 7% iron
Surgical implants and other foreign bodies:
- Organic polymeric materials (as a group)
- Orthopaedic implants of complex composition
- Cardiac pacemakers
- Silicone breast implants
- Implanted foreign bodies of metallic chromium or
titanium and of cobalt-based, chromium-based and
titanium-based alloys, stainless steel and depleted
uranium
- Dental materials
- Ceramic implants
SV40 polyomavirus
Symphytine
Talc containing asbestiform fibres (see Asbestos)
Talc not containing asbestos or asbestiform fibres
Talc-based body powder (perineal use of)
Tamoxifen
(NB: There is also conclusive evidence that tamoxifen
reduces the risk of contralateral breast cancer in breast
cancer patients)
Tannic acid and tannins
Tea
Temazepam
Teniposide
Terpene polychlorinates (Strobane)
2,2',5,5'-Tetrachlorobenzidine
2,3,7,8-Tetrachlorodibenzo-para-dioxin
000630-20-6 1,1,1,2-Tetrachloroethane
Year
9, Sup 7,
100F
2012
3
2B
8, Sup 7
74
1987
1999
74
1999
3
3
3
2B
1
104
31, Sup 7
42, Sup 7
42, Sup 7, 93
93
66, 100A
2013
1987
1987
2010
2010
2012
3
3
3
2A
10, Sup 7
51
66
76
1987
1991
1996
2000
3
3
1
5, Sup 7
27, Sup 7
Sup 7, 69,
100F
41, Sup 7,
71, 106
1987
1987
2012
2B
31
Volume
2014

CAS No
Agent
Group
000079-34-5 1,1,2,2-Tetrachloroethane
2B
000127-18-4 Tetrachloroethylene (Perchloroethylene)
2A
022248-79-9 Tetrachlorvinphos
000116-14-3 Tetrafluoroethylene
(NB: Overall evaluation upgraded to Group 2A)
Tetrakis(hydroxymethyl)phosphonium salts
000509-14-8 Tetranitromethane
Textile manufacturing industry (work in)
000083-67-0 Theobromine
000058-55-9 Theophylline
000062-55-5 Thioacetamide
000139-65-1 4,4'-Thiodianiline
000052-24-4 Thiotepa
3
2A
000141-90-2
000062-56-6
000137-26-8
007440-29-1
013463-67-7
2B
3
3
1
2B
1
Thiouracil
Thiourea
Thiram
Thorium-232 and its decay products
Titanium dioxide
Tobacco, smokeless
3
2B
2B
3
3
2B
2B
1
Tobacco smoke, second-hand

Tobacco smoking
000108-88-3 Toluene
026471-62-5 Toluene diisocyanates
000095-53-4 ortho-Toluidine
1
1
3
2B
1
089778-26-7 Toremifene
008001-35-2 Toxaphene (Polychlorinated camphenes)
Toxins derived from certain Fusarium species (see
Fusarium)
000299-75-2 Treosulfan
3
2B
000396-01-0
021259-20-1
000052-68-6
000817-09-4
000076-03-9
2B
3
3
2B
2B
Triamterene
T2-Trichothecene
Trichlorfon
Trichlormethine (Trimustine hydrochloride)
Trichloroacetic acid
32
Volume
20, Sup 7,
71, 106
Sup 7, 63,
106
30, Sup 7
19, Sup 7,
71, 110
48, 71
65
48
51
51
7, Sup 7
27, Sup 7
Sup 7, 50,
100A
Sup 7, 79
Sup 7, 79
Sup 7, 53
78, 100D
47, 93
Sup 7, 89,
100E
83, 100E
83, 100E
47, 71
39, Sup 7, 71
Sup 7, 77,
99, 100F
66
Sup 7, 79
26, Sup 7,
100A
108
31, Sup 7
30, Sup 7
Sup 7, 50
63, 84, 106
Year
2014
2014
1987
in prep
1999
1996
1990
1991
1991
1987
1987
2012
2001
2001
1991
2012
2010
2012
2012
2012
1999
1999
2012
1996
2001
2012
in prep
1987
1987
1990
2014

CAS No
Agent
000545-06-2
000071-55-6
000079-00-5
000079-01-6
Trichloroacetonitrile
1,1,1-Trichloroethane
1,1,2-Trichloroethane
Trichloroethylene
000096-18-4
000102-71-6
001954-28-5
001582-09-8
090370-29-9
000137-17-7
000088-05-1
003902-71-4
000118-96-7
000217-59-4
000068-76-8
000545-55-1
000051-18-3
000115-96-8
038571-73-2
000126-72-7
1,2,3-Trichloropropane
Triethanolamine
Triethylene glycol diglycidyl ether
Trifluralin
4,4',6-Trimethylangelicin plus ultraviolet A radiation
2,4,5-Trimethylaniline
2,4,6-Trimethylaniline
4,5',8-Trimethylpsoralen
2,4,6-Trinitrotoluene
Triphenylene
Tris(aziridinyl)-para-benzoquinone (Triaziquone)
Tris(1-aziridinyl)phosphine oxide
2,4,6-Tris(1-aziridinyl)-s-triazine
Tris(2-chloroethyl) phosphate
1,2,3-Tris(chloromethoxy)propane
Tris(2,3-dibromopropyl) phosphate
Tris(2-methyl-1-aziridinyl)phosphine oxide
Trp-P-1 (3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole)
Trp-P-2 (3-Amino-1-methyl-5H-pyrido[4,3-b]indole)
Trypan blue
Tungsten carbide with cobalt metal (see Cobalt metal
with tungsten carbide)
000057-39-6
062450-06-0
062450-07-1
000072-57-1
012070-12-1
007440-48-4
000066-75-1
001314-62-1
000128-66-5
000143-67-9
002068-78-2
000108-05-4
Group
3
3
3
1
Ultraviolet radiation (wavelengths 100-400 nm,

encompassing UVA, UVB, and UVC)
Ultraviolet-emitting tanning devices
Uracil mustard
Urethane (see Ethyl carbamate)
Vanadium pentoxide
Vat Yellow 4
Vinblastine sulfate
Vincristine sulfate
Vinyl acetate
33
Volume
Year
2A
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2A
52, 71
20, Sup 7, 71
52, 71
Sup 7, 63,
106
63
77
11, Sup 7, 71
53
Sup 7
27, Sup 7
27, Sup 7
40, Sup 7
65
Sup 7, 92
9, Sup 7
9, Sup 7
9, Sup 7
48, 71
15, Sup 7, 71
20, Sup 7, 71
1999
1999
1999
2014
1995
2000
1999
1991
1987
1987
1987
1987
1996
2010
1987
1987
1987
1999
1999
1999
3
2B
2B
2B
9, Sup 7
31, Sup 7
31, Sup 7
8, Sup 7
1987
1987
1987
1987
55, 100D
2012
1
2B
100D
9, Sup 7
2012
1987
2B
3
3
3
2B
86
48
26, Sup 7
26, Sup 7
Sup 7, 63
2006
1990
1987
1987
1995

CAS No
Agent
Group
000593-60-2 Vinyl bromide

(NB: (1) Overall evaluation upgraded to Group 2A
based on mechanistic and other relevant data;
(2) For practical purposes, vinyl bromide should be
considered to act similarly to the human carcinogen
vinyl chloride.)
000075-01-4 Vinyl chloride
2A
009003-22-9
000100-40-3
000106-87-6
000075-02-5
000075-35-4
009011-06-7
000075-38-7
000088-12-0
025013-15-4
012001-79-5
013983-17-0
001330-20-7
000095-68-1
000095-78-3
000085-84-7
000131-79-3
007481-89-2
000315-18-4
001318-02-1
030516-87-1
Vinyl chloride-vinyl acetate copolymers

4-Vinylcyclohexene
4-Vinylcyclohexene diepoxide
Vinyl fluoride
(NB: (1) Overall evaluation upgraded to Group 2A
based on mechanistic and other relevant data;
(2) For practical purposes, vinyl fluoride should be
considered to act similarly to the human carcinogen
vinyl chloride.)
Vinylidene chloride
Vinylidene chloride-vinyl chloride copolymers
Vinylidene fluoride
N-Vinyl-2-pyrrolidone
Vinyl toluene
Vitamin K substances
Welding fumes
(NB: Volume 100D concluded that there is sufficient
evidence for ocular melanoma in welders)
Wollastonite
Wood dust
Wood smoke (see Biomass fuel, indoor emissions from
household combustion)
X- and Gamma-Radiation
Xylenes
2,4-Xylidine
2,5-Xylidine
Yellow AB
Yellow OB
Zalcitabine
Zectran
Zeolites other than erionite (clinoptilolite,
phillipsite,mordenite, non-fibrous Japanese zeolite,
synthetic zeolites)
Zidovudine (AZT)
34
Volume
Year
39, Sup 7,
71, 97
2008
2012
3
2B
2B
2A
Sup 7, 97,
100F
19, Sup 7
Sup 7, 60
Sup 7, 60
Sup 7, 63, 97
1987
1994
1994
2008
3
3
3
3
3
3
2B
39, Sup 7, 71
19, Sup 7
39, Sup 7, 71
19, Sup 7, 71
60
76
49
1999
1987
1999
1999
1994
2000
1990
3
1
Sup 7, 68
62, 100C
1997
2012
1
3
3
3
3
3
2B
3
3
75, 100D
47, 71
16, Sup 7
16, Sup 7
8, Sup 7
8, Sup 7
76
12, Sup 7
68
2012
1999
1987
1987
1987
1987
2000
1987
1997
2B
76
2000

CAS No
Agent
Group
012122-67-7 Zineb
000137-30-4 Ziram
1
3
3
Includes radiofrequency electromagnetic fields from wireless phones
Last update: 17 October 2014
35
Volume
12, Sup 7
Sup 7, 53
Year
1987
1991

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Agents Classified by the IARC Monographs, Volumes 1111

Agents Classified by the IARC Monographs, Volumes 1111

Agents Classified by the IARC Monographs, Volumes 1111

000313-67-7 Aristolochic acid

Agents Classified by the IARC Monographs, Volumes 1111

Benzidine, dyes metabolized to

Agents Classified by the IARC Monographs, Volumes 1111

Betel quid with tobacco

Betel quid without tobacco

Biomass fuel (primarily wood), indoor emissions from

Agents Classified by the IARC Monographs, Volumes 1111

1,4-Butanediol dimethanesulfonate (see Busulfan)

Agents Classified by the IARC Monographs, Volumes 1111

Carpentry and joinery

Agents Classified by the IARC Monographs, Volumes 1111

000107-30-2 Chloromethyl methyl ether (see Bis(chloromethyl)ether;

Agents Classified by the IARC Monographs, Volumes 1111

Continuous glass filament (see Glass filament)

007440-48-4 Cobalt and cobalt compounds

Agents Classified by the IARC Monographs, Volumes 1111

Agents Classified by the IARC Monographs, Volumes 1111

Agents Classified by the IARC Monographs, Volumes 1111

000064-67-5 Diethyl sulfate

Agents Classified by the IARC Monographs, Volumes 1111

4,5'-Dimethylangelicin plus ultraviolet A radiation

46, 65, 105

Agents Classified by the IARC Monographs, Volumes 1111

Dyes metabolized to benzidine (see Benzidine, dyes

Agents Classified by the IARC Monographs, Volumes 1111

Agents Classified by the IARC Monographs, Volumes 1111

Agents Classified by the IARC Monographs, Volumes 1111

Agents Classified by the IARC Monographs, Volumes 1111

Human papillomavirus type 68

Agents Classified by the IARC Monographs, Volumes 1111

Magnetic fields, extremely low-frequency

Agents Classified by the IARC Monographs, Volumes 1111

Agents Classified by the IARC Monographs, Volumes 1111

Agents Classified by the IARC Monographs, Volumes 1111

000101-61-1 Michlers base [4,4-methylenebis(N,N-dimethyl)benzenamine]

Agents Classified by the IARC Monographs, Volumes 1111

Nickel refining (see Nickel compounds)

Agents Classified by the IARC Monographs, Volumes 1111

Agents Classified by the IARC Monographs, Volumes 1111

Non-arsenical insecticides (occupational exposures in

000090-65-3 Penicillic acid

Agents Classified by the IARC Monographs, Volumes 1111

Agents Classified by the IARC Monographs, Volumes 1111

059536-65-1 Polybrominated biphenyls

Polychlorinated biphenyls, dioxin-like, with a Toxicity

Agents Classified by the IARC Monographs, Volumes 1111

000366-70-1 Procarbazine hydrochloride

Agents Classified by the IARC Monographs, Volumes 1111

Refractory ceramic fibres

Shiftwork that involves circadian disruption

308076-74-6 Silicon carbide, fibrous

Agents Classified by the IARC Monographs, Volumes 1111

409-21-2 Silicon carbide whiskers

Agents Classified by the IARC Monographs, Volumes 1111

000505-60-2 Sulfur mustard

Sunlamps and sunbeds (see Ultraviolet-emitting tanning

Agents Classified by the IARC Monographs, Volumes 1111

000127-18-4 Tetrachloroethylene (Perchloroethylene)

Tobacco smoke, second-hand

Agents Classified by the IARC Monographs, Volumes 1111