Glutathione. What is glutathione, how is glutathione made and how to safely increase glutathione levels answered on the Web Site. Glutathione used to treat toxicity, acne, cancer, HIV, allergies, Alzheimer's disease, cystic fibrosis, diabetes, hepatitis, liver dysfunction and more.

What is Glutathione Glutathione is a small molecule made up of three amino acids, which exists in almost every cell of the body. However, Glutathione, must be generated within the cell from its precursors before it can work effectively in the body. The presence of glutathione is required to maintain the normal function of the immune system. It is known to play a critical role in the multiplication of lymphocytes (the cells that mediate specific immunity) which occurs in the development of an effective immune response. Furthermore, the cells of the immune system produce many oxiradicals as a result of their normal functioning, resulting in a need for higher concentrations of antioxidants than most cells. Glutathione plays a crucial role in fulfilling this requirement. How to Make Glutathione Naturally Within the Body There are several ways a body can manufacture glutathione. It is true it takes 3 amino acids for the body to manufacture glutathione but our bodies can take food, turn the foods into the substance to manufacture the 3 needed amino acids needed to manufacture glutathione. This is also the natural method for a body to create glutathione. As an example, asparagus and watermelon will make glutathione. With all of the breaking news regarding glutathione as an antioxidant as well as part of the reason for the development of autism, many supplements are suddenly jumping on the glutathione bandwagon. Glutathione is not new to this Web Site. We have been using glutathione for years to assist individuals to taper off psychotropic medications. One thing that has been overlooked by many still is the role of glutathione within the liver as well as the role of glutathione transporting a toxin to the liver. The whey proteins mentioned on this site do not activate glutathione within the liver or create the glutathione enzyme necessary to transport the toxin to the liver. The non-essential amino acid homocysteine is produced in the body with the metabolism of the amino acid methionine. Homocysteine is usually broken down into the amino acid cysteine. Cysteine is one of the amino acids needed by the cells to make intracellular glutathione. If your body does not convert homocysteine to cysteine the intracellular glutathione conversion will not take place. The rapid conversion of homocysteine is critical. If conversion takes place too slow, homocysteine will accumulate in the body and damage cell membranes, damage blood vessels, increase the risk of cardiovascular disease, and atherosclerosis.

Rapid conversion of homocysteine requires an individual to have adequate amount of vitamin B6, B12, and folate. Over 50% of the population in the world has a genetic defect in the pathway needed to metabolize B6, B12, and folate. Metabolism of homocysteine (sulphur-containing amino acid) is accomplished in the remethylation cycle where vitamin B12 and folic acid are essential coenzymes and degraded to methionine or through transsulfuration, which use as cofactors folate, vitamin B6 and vitamin B12 and is degraded to cystathionine. The physician can check for hyperhomocysteine (higher than normal amount of homocysteine) with a blood test. Many medication side effects, physiological symptomology and other body and mental symptoms can be eliminated with treatment with vitamins B6, B12 and folate. Age is a factor of B6, B12 and folate metabolism despite an individuals DNA. With age, the enzyme needed to metabolize B6, B12 and folate will be depleted and the need to supplement through nutrition increases proportionally. The only way for an individual to receive adequate amount of B6, B12, and folate is with nutrition. The supplemental capsule or tablet form will not metabolize. High levels of homocysteine will be toxic on cells that line the arteries which will make the blood prone to clotting and promote bad cholesterol (LDL) which will be deposited as plaque in blood vessels. Cysteine helps to detoxify toxins and protect the body from radiation damage. Cysteine as well as selenium work hand in hand with vitamin E. Cysteine also needs selenium to be effective. Cysteine will bind with soluble iron, chelates heavy metals, and breaks down mucus in the respiratory tract, beneficial for bronchitis, emphysema, and tuberculosis. Of note: Cysteine as a stand-alone supplement should be avoided due to toxicity. Glutathione - Recap Cysteine is the pre-cursor to glutathione, the body’s natural antioxidant. Glutathione regulates the antioxidant redox state, and allows the body to recycle its store of antioxidants including: vitamin A, C, E and Co-enzyme Q10. Free cysteine in unstable and is readily oxidized producing compounds that could have harmful effects. Glutathione cannot be absorbed by cells and so must be re-synthesized intracellularly. Glutathione is the antioxidant that is prevalent in every cell in the human body. Glutathione is primarily synthesized in the liver where it is abundantly present. 80-90% of the blood that leaves the stomach and intestines passes through the liver. The blood carries important nutrients to the liver where they are metabolized into substances vital to life. In the same way, exogenous toxic substances reach the liver where they are either activated or transformed into less toxic derivatives. Glutathione plays a crucial role in the liver’s biotransformation system. The liver biotransformation system comprises important functions:

1. Filtering alcohol and other toxic substances from the blood. 2. Processing drugs and medications absorbed through the digestive system, enabling the
body to use them effectively and ultimately dispose of them. The liver uses glutathione to process; alcohol, caffeine, medications, nicotine as an example, to process such substances and remove them from the blood. Cysteine is the limiting factor in glutathione synthesis, ensuring an adequate supply of glutathione helps cleanse the blood of toxins and substances. The role of glutathione and its inter-workings with alcohol and the metabolism has received the attention of scientist for years. With alcohol metabolism using the P 450 enzymes, much of the alcohol studies can be transformed into applicable knowledge with antidepressants and other medications that use the same system. Ethanol and Glutathione Reduced glutathione plays a critical role in the cellular detoxification processes including the metabolism of peroxides, the conjugation with electrophils and the scavenging of the free radicals. The relevance of glutathione in ethanol metabolism consists mainly in compensating for alcohol-related oxidative stress. Oxidative stress is a disturbance in the pro-oxidant/antioxidant balance (increased pro-oxidant levels), which may be achieved by either an enhancement of oxidative reactions leading to the increased formation of reactive oxygen species (ROS) or by a decrease of the antioxidant defense. Whether you are working with alcohol or most medications, both will activate the microsomal Cytochrome P450-dependant enzyme system, especially the subclass CYP2E1, that plays an important role in the liver detoxification. With antidepressants it will usually be with the subclass CYP2D6 or the CYP2C9 pathways. Glutathione (GSH) will be depleted within the cells and liver and also in other organs in the body due to the absorption of toxins by glutathione. The Creation of Glutathione Knowing the theory of glutathione is useful but without the correct application of the data it is pointless. Increasing glutathione intracellularly can be done in only a few ways. Using a whey protein designed in such as way to present to the cells the required amino acids in the exact sequence or by nutrients and or foods. The natural way for our body to produce intracellular glutathione is with all natural nutrients. This is also how I recommend an individual increase intracellular glutathione. Why? If you use a whey protein designed to produce glutathione, you will have an increase but the process is being accomplished in an unnatural manner. Imagine you have a car that will not start because the battery is low in power. You can give the car a jumpstart and drive down the road but the chances are you will need to keep getting a jumpstart every time you wish to drive.

The above example is what is happening when you bypass the natural structure of the body. If you were to fill the battery with water and put it on a slow charge until it was at full power you should not have to rely on a jumpstart again. This example is what should take place within the body regarding the creation of glutathione. Putting the correct nutrients in the body and allowing the body to use the nutrients to eventually manufacture glutathione not only gets those body parts working again but also promotes longterm health. Your body can manufacture glutathione with the correct nutrients. Glutathione as a Detoxicant Supplemental detoxicants become necessary as our environment becomes increasingly polluted. Our food and water sources are contaminated with chemicals. One of our main defenses against pollutants is glutathione, which is present in the liver in high concentrations. Glutathione acts as a detoxifying agent by combining with undesirable substances and ridding the body of them through urine and bile. It is important to note that unless the Colon, Liver and Blood are also detoxified, the benefits of Glutathione as a detoxicant may be minimized. To Get a Little More Technical About Glutathione "Glutathione is a ubiquitous tripeptide molecule, consisting of three amino acids joined together. These are cysteine, glutamic acid and glycine - three of the twenty two amino acids which comprise the building blocks of all known proteins. In general, the amino-end of one amino acid combines with the acid-end of another to form a peptide bond with the elimination of water. Chains of amino acids are called proteins. The sequence of amino acids and the arrangement in space of each peptide bond defines some specific structural features of all proteins and olegopeptides (few amino acids in sequence) that relate to their function." Glutathione (Psychoneurobiology) "Free radicals and oxyradicals have been recognized by psychoneurobiologist as playing an important role in the development and progression of many of these disorders. The brain is particularly susceptible to free radical attack because it generates more oxidative-by-products per gram of tissue than any other organ. The brain's main antioxidant is glutathione- it's importance cannot be overstated." "Oxidative stress and glutathione are important factors in such various disorders as brain injury, neurodegenerative disease, schizophrenia, Down syndrome and other pathologies." Disorders of the brain and nervous system that are linked to oxidative stress Brain Injury Brain injury Trauma Stroke Ischemia Toxicity of lead, mercury, etc. Neurodegenerative disease Parkinson's disease Alzheimer's dementia Multiple sclerosis (MS) Lou Gehrig's disease (ALS) Lipofuscinosis (Batten's disease) Others Schizophrenia Down syndrome Tardive dyskinesia Sleep deprivation Huntington's chorea

"Many neurological and psychiatric disease processes are characterized by high levels of oxidative stress and free radical formation, as well as abnormalities in glutathione metabolism and antioxidant defenses." Source Dr. Gutman M.D. Glutathione GSH Dr. Perlmutter: "Eighty to ninety percent improve dramatically. It's felt that the mechanism that allows it to work is in increasing the sensitivity to certain receptors to dopamine. Glutathione doesn't raise dopamine levels, but it allows the dopamine in the brain to be more effective. That's not a new idea in medicine. Diabetic drugs work not by increasing insulin, but by increasing the receptors to insulin. Glutathione not only increases sensitivity to dopamine, but also to serotonin, which may explain why many of our depressed PD patients have a remarkable improvement." Increasing glutathione in the body has been proven to be essential in the treatment of disease. Antidepressants and other medications deplete the body and brain of glutathione. Functions of Glutathione Enhancing the Immune System - Your bodies immune activity, involving unimpeded multiplication of lymphocytes and antibody production, requires maintenance of normal levels of glutathione inside the lymphocytes. Antioxidant and Free Radical Scavenger - Glutathione plays a central protective role against the damaging effects of bacteria, viruses, pollutants and free radicals. Regulator of Other Antioxidants - Without glutathione, other important antioxidants such as vitamins C and E cannot do their job adequately to protect your body against disease. A Detoxifying Agent - Another major function of glutathione is in the detoxification of foreign chemical compounds such as carcinogens and harmful metabolites.

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