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Mechanisms of Amphetamine Neurotoxicity

Mechanisms of Amphetamine Neurotoxicity (Cont’d) MS Quinton & BK Yamamoto. 2006 .

withdrawals or abstinence • Displays sensitization & recurs quickly with re-use after abstinence Physical Deterioration – most common: skin ulcerations and “meth mouth” Causes: • Dry mouth – change in pH & bacteria • Thirst & hunger – high consumption of sugary carbonated drinks • ↑ motor activity  grind teeth • Lack of drive to keep up basic hygiene .Other Long-term Effects of Amphetamines Psychosis – paranoid state characterized by hallucinations and delusions and occasionally violent behavior • Slow onset – takes a while to begin (months to years of meth use • Can occur during use.