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Keywords:
Fibrinogen
Hemorrhage
Massive transfusion protocol
Maternal morbidity
Maternal mortality
Postpartum hemorrhage
Tranexamic acid
Transfusion
a b s t r a c t
Transfusion therapy in postpartum hemorrhage (PPH) traditionally has been modeled after precedents set in
the Vietnam and Korean wars. However, data from recent military combat casualties suggest a different
transfusion strategy. Transfusion of packed red blood cells, fresh frozen plasma, and platelets in a ratio of
1:1:1 improves dilutional coagulopathy and survival. Women who present with low brinogen at the time
of diagnosis of PPH have poorer outcomes and might benet from early brinogen replacement. The
antibrinolytic agent, tranexamic acid, decreases bleeding and progression to severe PPH, but its role in
PPH management is evolving. Observational data suggest that the use of recombinant factor VIIa should be
limited to bleeding that has not responded to an optimal transfusion strategy. Point-of-care testing using
thromboelastography is helpful in guiding the selection of blood products to be transfused. Additionally, massive transfusion protocols can decrease the overall number of products transfused and improve outcomes.
2012 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
1. Introduction
Transfusion is the mainstay of management for postpartum hemorrhage (PPH). However, today's transfusion therapy in PPH is not
based on data from randomized clinical trials but rather on observational data derived from the Vietnam and Korean wars [1,2]. Although
treatment trials for PPH are in progress [3,4], recent studies of military combat casualties in the Iraq and Afghanistan wars encourage us to
reconsider transfusion strategies for the management of PPH.
2. Ratios of products transfused
The relative amounts of the various blood products selected for
transfusion affect the overall survival of patients with massive hemorrhage [57]. Traditionally, volume resuscitation begins with infusions
of crystalloid and colloid followed by transfusion of red blood cells
(RBC). This approach works well to correct hypovolemia; however,
it signicantly worsens existing dilutional coagulopathy and enhances
brinolysis [8,9]. Data from over 8000 patients analyzed in the
German Trauma Registry revealed that up to 34% of patients were
coagulopathic at the time of evaluation in the Emergency Department.
The extent of coagulopathy was proportional to the amount of prior
crystalloid infusion: 40% with 2000 mL and 70% with 4000 mL of intravenous uids administered [9].
Addressing dilutional coagulopathy earlier in the course of hemorrhage by increasing the ratio of fresh frozen plasma (FFP) units to RBC
Corresponding author at: Department of Obstetrics and Gynecology, Feinberg School
of Medicine, Chicago, IL 60611, USA. Tel.: +1 312 432 9880.
E-mail address: lgk395@northwestern.edu (L. Keith).
0020-7292/$ see front matter 2012 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
doi:10.1016/j.ijgo.2012.07.001