You are on page 1of 22

Curriculum Vitae

Massimo Caputo (MD, FRCS, MCh)


(1) PERSONAL INFORMATION
Date of Birth 02.05.1968
Nationality Italian
Languages
English: Fluent
Italian: Fluent
Address
(Home)
10 Canynge Square
Clifton
Bristol
BS8 3LA

Spanish: Fair
(Work)
Bristol Royal Hospital for Children
Upper Maudlin Street
Bristol
BS2 8BJ

Web Site: http://www.bristol.ac.uk/bhi/people/massimo-caputo/overview.html


(2) PRESENT APPOINTMENT
April 2012 Professor of Congenital Cardiac Surgery,
Bristol Heart Institute/Bristol Royal Hospital for Children NHS Foundation Trust; School of
Clinical Sciences, University of Bristol.
From May 2014 I have been invited to set up the Congenital Heart Surgery Program at the
RUSH University Medical Center in Chicago, where I have been appointed Director of
Congenital Heart Surgery.
This is a full-time clinical academic appointment with a 50:50 clinical: research split. My
clinical interests include neonatal surgery, complex aortic surgery in young adults, minimally
invasive pulmonary valve surgery, mitral and tricuspid valve repair. I perform over 200
complex major cardiac procedures per year. My 30 day mortality rates have been constantly
below 1%
(3) PREVIOUS APPOINTMENTS
2008-2012
2004-2008
2003-2004
2000-2003
1998-2000
1995- 1997
1992-1998

Reader/Consultant in Cardiothoracic Surgery, Bristol Heart Institute/Bristol Royal


Hospital for Children NHS Foundation Trust, University of Bristol.
Senior Lecturer/Consultant in Cardiothoracic Surgery, Cardiac, Anaesthetic and
Radiological Sciences, Bristol Royal Infirmary, University of Bristol.
Attending Surgeon in Paediatric Surgery, Thorax Centre, University of Leiden, The
Netherland.
Senior Registrar/Lecturer, Cardiac, Anaesthetic and Radiological Sciences, Bristol Royal
Infirmary, University of Bristol.
Staff Surgeon (Senior Registrar Level), Dept. of Cardiac Surgery, University Hospital San
Raffaele, Milan.
Clinical Research Fellow, Bristol Heart Institute, University of Bristol.
Specialist Trainee in Cardiac Surgery, Dept. of Cardiac Surgery, University Federico II,
Naples.

(4) ACADEMIC QUALIFICATIONS


Jan 2006
May 2003
May 2000

Honorary Fellow of the Royal Collage of Surgeons of England (FRCS)


GMC Specialist Registration in Cardio-Thoracic Surgery
Master of Surgery (MCh)
University of Bristol, UK
Thesis on: The Effects of Different Techniques of Myocardial Protection on the Myocardial
Concentrations of Amino Acids in the Ischaemic-Reperfused Heart of Patients Undergoing
Coronary Artery Surgery
March 1998 Specialization in Cardiac Surgery (Final Exam)
University of Naples, Italy, March 1998

M Caputo/Page 2 of 22

July 1992

June 1992

Thesis on: Intermittent Antegrade Warm Blood Cardioplegia in Patients Undergoing


Coronary Artery Surgery: a Prospective Randomized Study on the Use of Magnesium.
Medical Doctorate (MD)
University of Naples, Italy, July 1992
Thesis on: The Use of the Internal Mammary Arteries in Myocardial Revascularization.
Degree in Medicine and Surgery
University-Hospital Federico II, Medical School, Naples, Italy (1986-1992).

(5) AWARDS, HONOURS & DISTINCTIONS


2015
2014
2014
2011
2012
2011
2011
2008
2006
2005
2004
2004
2004
19991998
1998
1992
1991
1990
1989

Sir Jules Thorn Award for Biochemical Research (1.5M).


Professor of Surgery, Rush University Medical Centre, Chicago, US.
Chief of Pediatric and Congenital Heart Surgery, Rush University Medical Centre,
Chicago, US.
Theme Leader for Congenital Heart Surgery, NIHR Biochemical Research Unit for
Cardiovascular Research in Bristol (7M)
John Parker Medal, Annual Meeting of the Society for Cardiothoracic Surgery Great
Britain and Ireland, Manchester.
John Parker Medal, Annual Meeting of the Society for Cardiothoracic Surgery Great
Britain and Ireland, London.
Honorary Member, Syrian British Medical Society.
Chief Surgeon for the charity Al-Dir Charity Hospital to establish the congenital cardiac
surgical program at the Homs University, Syria.
Honorary Surgeon for the charity Cardiostart to perform adult and paediatric cardiac
surgery in Arequipe, Peru.
Member of the BRI Team winner of the Hospital Doctor Award 2005 (for Surgery) for the
work on beating heart coronary surgery.
Visiting Professor Paediatric Cardiac Unit, University of West Indies, Trinidad and Tobago.
Garfield Weston Senior Lecturer Fellowship (2004-2009)
Travelling Fellowship to work at the Paediatric Cardiac Surgical Unit, University of Leiden,
The Netherlands.
Visiting Teacher at the annual International Heart School J.W.Kirklin, Bergamo, Italy.
Travelling Fellowship to work at the Dept. of Cardio-Thoracic Surgery for a month,
University of Groningen, The Netherlands.
Distinction (60/60 cum laude), Specialist in Cardiac Surgery, University of Naples, Italy.
MD, Distinction (110/110 cum laude), Final Examination, University of Naples, Italy.
Winner of ERASMUS/ECTS European Community Grant, University of Manchester, UK.
Winner of ERASMUS/ECTS European Community Grant, University of Bristol, UK.
Winner of ERASMUS European Community Grant, Universite Catolique de Louven,
Belgium.

(6) TEACHING AND TRAINING


I am recognised expert in several fields of cardiac surgery and I have given invited lectures on these topics
at national and international meeting, educational seminars and postgraduate courses. This includes being a
faculty member on the Bristol Training Course in Cardiac Surgery, the Human Disease Course, the
Paediatric Ground Round Program and the Bristol Paediatric Simulation Programme. In 2000 I was
appointed to a Visiting Teacher position at the International Heart School J W Kirklin in Bergamo, Italy.
This is now recognised as the European School for Cardio-Thoracic Training. I am routinely involved in the
preparation of monthly audits meetings for the Cardiothoracic Services at the Bristol Royal Hospital for
Children and the Bristol heart Institute, and the junior doctors training for the Fellowship Examination. I am
also the supervisor for Research Registrars with projects for Higher Degree thesis.
I have developed a monitoring system for assessing performance new surgical techniques, which greatly
facilitate the auditing and constant monitoring of the results. This work has been widely published and has

M Caputo/Page 3 of 22

become fundamental in monitoring the training process of our specialist registers as well as the consultants
in learning new surgical techniques.
Since January 2000, I have been involved as the chief surgeon, in the development of the Paediatric Cardiac
Unit at the University of West Indies in Trinidad and Tobago, teaching local doctors and nurses, and since
March 2006 I am an honorary surgeon for the International Compassionate Medical Assistance
CardioStart, participating in a clinical and educational mission in Peru.
Since September 2009 I have started a video assisted anatomical course on the most common congenital
abnormalities with videos recorded by myself of the most important surgical procedures performed at the
Bristol Royal Hospital for Children. The lectures are run together with a cardiologist (for the pre-operative
investigations) and have been greatly successful. The web site with all these interactive lectures is being
developed: http://www.bristol.ac.uk/bhi/people/massimo-caputo/overview.html.
Since 2010 I have also been appointed as surgical adviser for congenital heart surgery at the Bristol Medical
Simulation Centre.
I act as external reviewer to several UK and European Universities for undergraduate and post-graduate
degrees and Unit Assessment.
Since 2013 I am the teaching leader for the congenital heart disease theme for the MSc in Translational
Cardiovascular Medicine at the University of Bristol.
Since April 2014 I have been nominated academic mentor for the CardioThoracic and Vascular Residency
Program at the Rush University Medical Center.
Undergraduate teaching
Medical students have been allocated to my firm on a routine basis with teaching/practicals delivered
during out-patient clinics, ward rounds, and theatre sessions.

Surgical Management of Heart Disease. University of Bristol. Human Disease Course for Dental
Students.

Routinely hosted and supervised medical students from abroad. Each student spent approximately 8
weeks working in the Bristol Heart Institute.

Supervisor for Research Elective from several UK and international Universities.

Pastoral Care: personal tutor to 1st, 2nd, 3rd year medical Students (1- 2 per year).
Postgraduate teaching
I have responsibility for supervising postgraduate students aiming to post-graduate higher degrees including
designing the study, getting ethical approval and R&D registration, sourcing funding, and selecting the
student. I also advise students during the conduct of the trial, data collection, writing-up of publications, and
final thesis. Most of my post-graduate students have now reached consultant level in UK and abroad.
As a Clinical Academic I train junior doctors allocated to my firm. Since my appointment I have contributed
to the training/teaching of either a Specialist Registrar, or a Clinical Fellow allocated to my firm on a sixmonths rotation basis. I am co-organiser of the weekly Paediatric Teaching Programme for junior doctors.
I am the Principal Lecturer in charge of the Congenital Heart Disease section of the MSC in Translational
Cardiovascular Medicine, University of Bristol http://www.youtube.com/watch?v=2WwLoUdG5wQ
I am the director of the congenital heart surgical resident program at the Rush Medical College, Chicago,
US.
Current postgraduate fellows
Saif Jaimy: 2015 (BHF pump priming PhD, joint supervision)
Pouya Sadeghi Pour: 2015 (BHF pump priming PhD, joint supervision)
Dominga Iacobazzi: 2013 (SPARK Foundation, Post-Doc, joint supervisor)
Megan Swim: 2013 (University of Bristol PhD Scholarship, principal supervisor)
Henry Jia: 2014 (Enid Linder Foundation, Post-Doc, principal supervisor)
Guido Piles: 2012 (NIHR Clinical lecturer, joint supervision)
Past postgraduate students
Henry Jia: awarded PhD 2014 (Enid Linder Foundation, joint supervisor)
A Mukthari: awarded MD 2104 (BUPA Foundation grant, principal supervisor)

M Caputo/Page 4 of 22

Palash Barman: 2008 (BHF, PhD, joint supervisor)


M Cherif: awarded PhD 2010 (joint supervisor)
Kirk Santo: awarded MD 2009 (principal supervisor)
Rafiq Anis: awarded MD 2008 (principal supervisor)
A. Lotto: awarded MCh in 2006 (joint supervisor).
P Modi: awarded an MD in 2003 (joint supervisor).
Other teaching responsibilities
Teacher for the Residency Program in Cardiothoracic Surgery, RUSH University Medical Center,
Chicago, IL.
Teacher at the Cardiology Education Programme 2004, 2005, University of Bristol.
Teacher of the annual Adult Congenital Heart Disease study day (since 2004), University of Bristol.
(7) RESEARCH
Major Achievements
Since my appointment to a Reader position in 2008, I have achieved a total of 10 successful grants for a
total approximately of 3 million. In October 2008 the Bristol Heart Institute has also been granted 7
million for the NIHR Biomedical Research Unit (BRU) for Cardiovascular Disease, with my congenital
projects successfully chosen for funding. A 7 million award has been recently achieved at the University of
Bristol and the University Hospitals Bristol NHS Foundation Trust to fund the renewal of the BRU for
Cardiovascular Disease with congenital heart disease chosen as a major research area under my direct
leadership (approximately 1 million for research in the congenital field). In 2014 I have been awarded the
prestigious Sir Jules Thorn Award for Biochemical Research in stem cell tissue engineering in congenital
heart surgery (1.5M). At the same time I have published several original articles, review articles, book
chapters and presented videos my innovative surgical techniques at the most prestigious international
meeting and specialised websites.
I have established an international reputation in two major areas of translation research:
i)
Improving clinical outcomes in myocardial revascularization surgery.
ii)
Improving cardiopulmonary bypass (CPB) and cardioprotective strategies for myocardial
preservation in congenital heart surgery
Adult cardiac surgery
I have led the first controlled randomised trial on the use of epidural anaesthesia (BHF support) during off
pump coronary artery bypass surgery, demonstrating a significant decrease in hospital morbidity, intensive
care and hospital stay, and had a significant impact in changing clinical practice around the world. At the
same time I have evaluated the impact of pre-operative use of ACE inhibitors on hospital outcomes in
patients undergoing heart surgery. This study, presented at the American College of Cardiology 2008
received significant media coverage and a TV interview with the Editor of JACC. The study findings were
widely published in the scientific internet press and it has been included in the 2011 ACCF/AHA Guideline
for CABG Surgery (www.medlive.cn/uploadfile/2011/1110/20111110104731867.pdfguidelines). Finally,
my work on the effects of pre-operative renal dysfunction on clinical outcomes in patients undergoing
cardiac surgery, has led to the development of new tools for risk stratification. This study had a significant
international resonance and we were invited to present our findings at the American Heart Association 2010.
Congenital Heart Surgery
I have conducted two major control randomised trials, supported by the BHF and NHIR BRU Bristol,
comparing normothermic vs hypothermic (THERMIC) and hypoxic vs normoxic (OXIC) CPB in paediatric
patients. Furthermore I have started a very new and exciting work on the relationship between chronic
hypoxia and gene expression, and the molecular mechanisms underlying the effects of re-oxygenation injury
on organ dysfunction in cyanotic heart patients undergoing surgical repair (BHF Fellowship). The OXIC
trial has had a significant international resonance and we were invited to present our findings at the
American Heart Association in 2011 and American Association of Thoracic Surgery in 2012 and 2014.
Furthermore the THERMIC Trial has provided the first evidence in a randomised controlled trial that in
infants and children requiring correction of congenital heart disease, normothermic CPB was associated with

M Caputo/Page 5 of 22

reduced oxidative stress, myocardial reperfusion and renal injury, compared with hypothermic CPB,
opening an international debate of whether cooling children undergoing cardiac surgery is really necessary
and potentially detrimental. This trial was presented at the American Association of Thoracic Surgery in
2011 and won the John Parker Medal at the Annual Meeting of the Society for Cardiothoracic Surgery Great
Britain and Ireland.
Overall these last 4 years of my research in adult and congenital heart surgery have been a complete success.
They have provided vital data regarding CPB and myocardial protection strategies in a very vulnerable and
high risk group of patients. They have demonstrated the real possibility of conducting randomised studies in
children despite all the difficulties in enrolling this group of patients and the related lack of such studies
internationally. They have also given the Bristol Heart Institute and the Bristol Royal Hospital for Children
an international reputation in the field of paediatric cardiac surgery launching the base for vital international
collaboration. Finally and more importantly the results of all these studies have changed our clinical practice
and have greatly contributed to the outstanding clinical outcomes (30 day mortality of 1% form the CCAD
data with no mortality for the benchmark operations) that the Bristol Royal Hospital for Children has
achieved in the last 10 years, putting this Unit one of the top three in the country along with Birminghams
and Great Ormond Street.
Furthermore, I have recently secured funding ( 300,000) for a new excited project in collaboration with
professor Anthony Hollander, on stem cell and tissue engineered valves, aiming at testing the in vitro
creation of tissue engineered valves and conduits based on decellularized matrix reseeded with autologous
cord blood and tissue stem cells. Tissue-engineered valves, conduits and vascular patches made of living
tissue could function like a native structure with the potential to grow and remodel, avoiding dangerous reoperations, and improving survival and quality of life in children undergoing heart surgery. This project has
generated a significant interest in the public (Alumni support) and industry (RED) for raising funding and
has been an important part of our recent application Cell Therapy Technology & Innovation Centre (TIC)
coordinated by RED. For this project I have been awarded the prestigeous Sir Jules Thorn Award for
Biochemical Research (1.5M) as Principal Investigator.
My research activity and its translation into the clinical arena has played a vital part in our recent application
for the Safe and Sustainable process aiming at reducing the number of congenital cardiac centres in UK
from 11 to 6/7. Bristol Royal Hospital for Children was selected in all the possible options and will therefore
became the central hub in the South West for congenital cardiac surgery, performing more than 600-700
cases per year. This will give us an incredible opportunity to carry on and expand all our clinical trials and
translational research under the support of the BHF and NIHR BRU Bristol.
PEER REVIEWED PUBLICATIONS
Academic Journal Papers (personal contrubution %)
1. Sok Leng Kang, Andrew Tometzki, Massimo Caputo, Gareth Morgan, Andrew Parry, Robin
Martin. Long term follow up of perventricular device closure of muscular ventricular septal defects
in children. Catheter Cardiovasc Interv. 2015 Jan 9. doi: 10.1002/ccd.25821. [Epub ahead of print].
2. Dominga Iacobazzi, Indira Caraeva, Myriam Cherif, Gianni D Angelini, Massimo Caputo,
Mohamed T Ghorbel. Protein phosphatase 1 beta is modulated by chronic hypoxia and involved in
the angiogenic endothelial cell migration. Cell Physiol Biochem J 2015 (in press)
3. (30%) Miceli A, Romeo F, Glauber M, de Siena PM, Caputo M, Angelini GD. Preoperative anemia
increases mortality and postoperative morbidity after cardiac surgery. J Cardiothorac Surg. 2014 Aug
5;9:137.
4. (50%) Skerritt C, Chen Q, Parry AJ, Wolf A, Pawadi A, Caputo M. The arterial switch operation:
rebirth of a service ten years after the Bristol Inquire. Journal of Heart Surgery and Treatment 2014,
Volume 1, N 01 SS0002.

M Caputo/Page 6 of 22

5. (30%) Cherif M, Caputo M, Nakaoka Y, Angelini GD, Ghorbel M. Gab1 is modulated by chronic
hypoxia in children with cyanotic congenital heart defect and its overexpression reduces apoptosis in
rat neonatal cardiomyocytes. Biomed Research International 2015 (in press).
6. (30%) Jenkins EL, Caputo M, Angelini GD, Ghorbel M. Chronic hypoxia downregulates ZO-2
expression in children with cyanotic congenital heart defect. Biomed Research International 2014.
7. (30%) Ghorbel M, Patel N, Sheikh M, Angelini GD, Caputo M, Murphy G. Changes in renal
medulla gene expression in a pre-clinical model of post cardiopulmonary bypass acute kidney injury.
BioMed Central Genomics 2014 Oct 21;15:916.
8. (30%) Dorobantu DM, Sharabiani MT, Hayes A, Martin R, Angelini GD, Parry AJ, Caputo M,
Stoica S. Predictors for survival and reintervention in simple and complex subaortic stenosis: results
from a prospective, procedure-based national database. J Thorac Cardiovasc Surg. 2014 Jul 30. pii:
S0022-5223(14)00984-2. doi: 10.1016/j.jtcvs.2014.06.091. [Epub ahead of print].
9. (30%) Zebele C, Chivasso P, Bruno D, Sedmakov C, Angelini G, Caputo M, Parry A, Stoica S. The
Ross operation in children and young adult from the UK National Database. Presented at the
EACTS/ESTS Joint Annual Meeting. Vienna, 2013. World Journal For Pediatric And Congenital
Heart Surgery 2014 Jun 23;5(3):406-412.
10. (20%) Basude S, Trinder J, Caputo M, Curtis S. Pregnancy outcome and follow-up cardiac outcome
in women with aortic valve replacement. Obstretic Medicine 2014; 7:29-33.
11. (70%) Caputo M, Mohktari A, Miceli M, Ghorbel M, Suleiman MS. Controlling Reoxygenation
During Cardiopulmonary Bypass Reduces Inflammatory and Stress Response in Patients with Single
Ventricular Physiology Undergoing Heart Surgery. J Thorac Cardiovasc Surg. 2014 Jun 6. pii:
S0022-5223(14)00723-5. doi: 10.1016/j.jtcvs.2014.06.001. [Epub ahead of print].
12. (30%) Chen Q, Caputo M, Stoica S, Nicholson E, Stuart G, Wolf A, Parry AJ. Continuous Selective
Cerebral Perfusion for Repair of Interrupted Aortic Arch is Applicable to Even Low Birth Weight
Neonates. J Cardio-Toracic Surg 2014 (in press)
13. (30%) Chen Q, Kia M, Caputo M, Stoica S, Tulloh R, Parry A. Does the persistence of pulsatile
antegrade pulmonary blood flow following the bidirectional Glenn procedure affect long term
outcomesi? Eur J CardioThorac Surg 2014 Apr 30 [Epub ahead of print].
14. (50%) Fino C, Iacovoni, Caputo M, et al. Restrictive Mitral Valve Annuloplasty versus Mitral
Valve Replacement for Functional Ischemic Mitral Regurgitation: An Exercise Echocardiographic
Study.
J
Thorac
Cardiovasc
Surg
2013;
4
(doi:pii:
S0022-5223(13)01134-3.
10.1016/j.jtcvs.2013.05.053. [Epub ahead of print].
15. (50%) Rajakaruna C, Rogers C, Pike K, Alwair H, Cohen A, Tomkins S, Angelini GD, Caputo M.
Superior haemodynamic stability during off-pump coronary surgery with thoracic epidural
anaesthesia: results from a prospective randomized controlled trial. Interactive CardioVascular and
Thoracic Surgery 2013; 16:602-7
16. (50%) Ghorbel MT, Mokhtari A, Sheikh M, Angelini GD, Caputo M. Controlled Reoxygenation
Cardiopulmonary Bypass is Associated with Reduced Transcriptomic Changes in Cyanotic
Tetralogy of Fallot Patients Undergoing Surgery. Physiol Genomics. 2012 Nov 15;44(22):1098-106.
17. (50%) Chen Q, Turner M, Caputo M, Stoica S, Marianeschi S, Parry A. Pulmonary Valve
Implantation using Self-expanding Tissue Valve without Cardiopulmonary Bypass Reduces
Operation Time and Blood Product Usage. J Thorac Cardiovasc Surg 2012 Jun 17. [Epub ahead of
print]
18. (50%) Miceli A, Duggan SM, Aresu G, de Siena PM, Romeo F, Glauber M, Caputo M, Angelini
GD. Combined clopidogrel and aspirin treatment up to surgery increases the risk of postoperative
myocardial infarction, blood loss and reoperation for bleeding in patients undergoing coronary artery
bypass grafting. Eur J Cardiothorac Surg 2013 Apr;43(4):722-8.
19. (70%) de Siena P, Chen Q, Parry AJ, Caputo M. Reverse Subclavian Flap and Aorto-Pulmonary
Window Technique for Repair of Interrupted Aortic Arch and Truncus Arteriosus. Interact
Cardiovasc Thorac Surg. 2011;13(3):354-5.
20. (50%) Kenny D, Polson JW, Martin RP, Caputo M, Wilson DG, Cockcroft JR, Paton JF, Wolf AR.
Relationship of aortic pulse wave velocity and baroreceptor reflex sensitivity to blood pressure
control in patients with repaired coarctation of the aorta. Am Heart J. 2011; 162(2):398-404.

M Caputo/Page 7 of 22

21. (90%) Caputo M, Patel N, Angelini GD, de Siena P, Stoica S, Parry AJ, Rogers CA. The Effects of
Normothermic and Hypothermic Cardiopulmonary Bypass on Renal Injury in Paediatric Open-Heart
Surgery: a Prospective Randomised Study. J Thorac Cardiovasc Surg. 2011;142(5):1114-1121.
22. (50%) Murzi M, Caputo M, Aresu G, Duggan S, Angelini GD. Training residents in off pump
coronary artery bypass surgery: a 14 year experience. J Thorac Cardiovasc Surg 2012;143(6):124753.
23. (50%) Murzi M, Caputo M, Aresu G, Duggan S, Miceli A, Glauber M, Angelini GD. On-pump and
off-pump coronary artery bypass grafting in patients with left main stem disease: A propensity score
analysis. J Thorac Cardiovasc Surg. 2012;143(6):1382-8.
24. (70%) Caputo M, Santo KC, Angelini GD, Fino C, Agostini M, Grossi C, Suleiman MS, Reeves
BC. Warm blood cardioplegia supplemented with low or high dose magnesium for patients
undergoing CABG: a randomised controlled trial. Eur J Cardiothorac Surg 2011;40(3):722-9.
25. (90%) Caputo M, Alwair H, Rogers CA, Pike K, Cohen A, Monk C, Tomkins S, Ryder I,
Moscariello C, Lucchetti V, Angelini GD. Thoracic epidural anesthesia improves early outcomes in
patients undergoing off-pump coronary artery bypass surgery: a prospective, randomized, controlled
trial. Anesthesiology 2011; 114:380-390.
26. (70%) Miceli A, Bruno VD, Capoun R, Romeo F, Angelini GD, Caputo M. Occult Renal
Dysfunction: A Mortality and Morbidity Risk Factor in Coronary Artery Bypass Grafting Surgery. J
Thorac Cardiovasc Surg 2011; 141(3):771-6.
27. (70%) Miceli A, Bruno VD, Capoun R, Duggan S, Romeo F, Angelini GD, Caputo M. Mild Renal
Dysfunction in Patients Undergoing Cardiac Surgery: a New Risk Factor for EuroSCORE. Heart.
2011;97(5):362-5.
28. (50%) Miceli A, Duggan SM, Capoun R, Romeo F, Caputo M, Angelini GD. A clinical score to
predict the need for intraaortic balloon pump in patients undergoing coronary artery bypass grafting.
Ann Thorac Surg 2010; 90:522-6.
29. (30%) Kenny D, Polson JW, Martin RP, Wilson DG, Caputo M, Cockcroft JR, Paton JF, Wolf AR.
Surgical approach for aortic coarctation influences arterial compliance and blood pressure. Ann
Thorac Surg 2010; 90:600-4.
30. (30%)Capoun R, Thomas M, Caputo M, Asimakopoulos G. Surgical treatment of tricuspid valve
endocarditis: a single centre experience. Perfusion 2010; 25:169-73.
31. (50%) Ghorbel M, Cherif M, Mokhtari A, Bruno D, Caputo M, Angelini GD. Off-pump coronary
artery bypass surgery is associated with fewer gene expression changes in the human myocardium in
comparison to on-pump surgery. Physiological Genomics 2010; 42:67-75.
32. (50%) Chen Q, Langton-Hewer S, Marriage S, Hayes A, Caputo M, Pawade A, Parry AJ. Influence
of tracheobronchomalacia on outcome of surgery in children with congenital heart disease and its
management. Ann Thorac Surg 2009; 88:1970-4.
33. (70%) Miceli A, Capoun R, Fino C, Narayan P, Bryan A, Angelini GD, Caputo M. The effect of
Angiotensin-converting enzyme therapy on early outcome in patients undergoing coronary artery
bypass grafting surgery. J Am Coll Cardiol 2009; 54:1778-84.
34. (50%) Narayan P, Yeatman M, Caputo M, Capoun R, Ciulli F, Jeremy JY, Angelini GD. Saphenous
vein harvest with the Mayo extraluminal dissector: is endothelial function preserved? J Thorac
Cardiovasc Surg 2009;138(2):508-10.
35. (70%) Miceli A, Fino C, Fiorani B, Yeatman M, Angelini GD, Caputo M. The effects of
preoperative statin treatment on the incidence of atrial fibrillation in patients undergoing CABG
surgery. In print in Ann Thorac Surg 2009, 87:1853-8.
36. (30%) Imura H, Caputo M, Lim K, Oki M, Suleiman MS, Shimizu K, Angelini GD. Pulmonary
abnormalities after cardiopulmonary bypass: beneficial effects of low frequency mechanical
ventilation during bypass. J Thorac Cardiovasc Surg 2009, 137:1530-7.
37. (90%) Caputo M, Mokhtari A, Gorhbel M, Rogers CA, Wolf A, Chen Q, Angelini GD, Parry AJ.
The Effects of Normoxic Cardiopulmonary Bypass on Myocardial Injury, Oxidative Stress, and
Inflammatory Response in Paediatric Open-Heart Surgery: a Prospective Randomised Study. J
Thorac Cardiovasc Surg 2009; 138:206-14.

M Caputo/Page 8 of 22

38. (50%) Kenny D, Morgan G, Bajwa A, Farrow C, Parry A, Caputo M, Tometzki A, Martin R.
Evolution of transcatheter closure of perimembranous ventricular septal defects in a single centre.
Catheter Cardiovasc Interv. 2009;73:568-75.
39. (70%) Caputo M, Alwair H, Rogers CA, Ginty M, Monk C, Thomkins S, Mokhtari A, Angelini GD.
Myocardial, inflammatory and stress responses in OPCAB surgery with thoracic epidural anesthesia.
Ann Thorac Surg 2009;87(4):1119-26.
40. (70%) Narayan P, Reeves BC, Rizvi SA, Ismail H, Bryan AJ, Angelini GD, Nightingale A, Caputo
M. Haemodynamic evaluation and mid term outcomes after aortic valve replacement with size 19
Perimount prosthetic valves. Ann Thorac Surg 2008;86:1799-803.
41. (90%) Caputo M, Anis RR, Rogers C, Ahmad N, Karsch KR, Rizvi SA, Angelini GD, Oberhoff M.
Coronary collaterals circulation: effects on outcomes after coronary artery surgery. Ann Thorac Surg
2008;85:71-9.
42. (30%) Narayan P, Rogers CA, Caputo M, Angelini GD, Bryan AJ. Influence of Concomitant
CABG on Early and Midterm Outcome of Surgery of the Ascending Aorta/Arch. Heart
2007;93(2):232-7.
43. (30%) Reeves B, Ascione R, Caputo M, Angelini GD. Morbidity and mortality following acute
conversion from off-pump to on-pump coronary surgery. Eur J Cardiothorac Surg 2006;29:941-7.
44. (30%) Narayan P, Rogers C, Caputo M, Angelini GD, Bryan AJ. Ascending aorta or arch surgery:
is previous cardiac surgery a risk factor? Asian Cardiovasc Thorac Ann 2006;14:14-9.
45. (70%) Modi P, Suleiman MS, Reeves B, Pawade A, Parry AJ, Angelini GD, Caputo M. Changes in
myocardial free amino acids during paediatric cardiac surgery: a randomised controlled trial of three
cardioplegic techniques. Eur J Cardiothorac Surg 2006;30:41-8.
46. (70%) Modi P, Suleiman MS, Reeves B, Pawade A, Parry AJ, Angelini GD, Caputo M. Free amino
acids in hearts of pediatric patients with congenital heart disease: the effects of cyanosis, age and
pathology. Ann Thorac Surg 2006;81:943-9.
47. (90%) Caputo M, Reeves B, Rajakaruna C, Alwair H, Santo K, Angelini GD. Incomplete
revascularisation during Opcab surgery is associated with reduced mid-term event free survival. Ann
Thorac Surg 2005; 80:2141-7.
48. (30%) Narayan P, Caputo M, Jones J, Al-Tai S, Angelini GD, Wilde P.Postoperative chest
radiographic changes after on- and off-pump coronary surgery. Clin Radiol 2005;60:693-9.
49. (30%) Murphy GJ, Rogers C, Halwair H, Lansdowne WB, Channon I, Choen AM, Caputo M,
Angelini GD. Safety, efficacy and costs of intraoperative cell salvage and autotransfusion following
OPCAB surgery: a randomised trial. J Thorac Cardiovasc Surg 2005, 130:20-8.
50. (90%) Caputo M, Bays S, Rogers C, Pawade A, Parry A, Suleiman M-S, Angelini GD. The Effects
of Normothermic and Hypothermic Cardiopulmonary Bypass on Myocardial Injury, Oxidative
Stress, and Inflammatory Response in Paediatric Open-Heart Surgery: a Prospective Randomised
Study. Ann Thorac Surg 2005;80:982-8.
51. (90%) Caputo M, Reeves B, Rogers C, Ascione R, Angelini GD. Use of control charts for
monitoring the performance of residents during training in off-pump coronary surgery. J Thorac
Cardiovasc Surg 2004;128:907-15.
52. (50%) Rogers C, Reeves B, Caputo M, Garesh JS, Bonser RS, Angelini GD. Control charts methods
for monitoring cardiac surgical and their interpretation. J Thorac Cardiovasc Surg 2004;128:811-9.
53. (70%) Modi P, Suleiman M-S, Pawade A, Parry AJ, Angelini GD, Caputo M. Basal metabolic state
of hearts of patients with congenital heart disease: the effect of cyanosis, age and volume-loading.
Ann Thorac Surg 2004;78:1710-6.
54. (50%) Narayan P, Caputo M, Alwair H, Mahesh B, Angelini GD, Bryan AJ. Early and mid-term
outcome of surgery of the ascending aorta/aortic arch: is there a relationship with caseload? Eur J
Cardiothorac Surg 2004; 25:676-82.
55. (70%) Modi P, Reeves B, Pawade A, Parry A, Suleiman M-S, Angelini GD, Caputo M. Myocardial
metabolic changes during pediatric open heart surgery: a randomised controlled study of three
cardioplegic techniques. J Thorac Cardiovasc Surg 2004;128:67-75.

M Caputo/Page 9 of 22

56. (70%) Imura H, Duncan HP, Corfield AP, Myerscough N, Caputo M. Increased airway mucins after
cardiopulmonary bypass associated with postoperative respiratory complications in children. J
Thorac Cardiovasc Surg 2004;127:963-9.
57. (50%) Lotto AA, Ascione R, Caputo M, Bryan AJ, Angelini GD, Suleiman MS. Myocardial
protection with intermittent cold blood during aortic valve operation: antegrade versus retrograde
delivery. Ann Thorac Surg 2003;76:1227-33.
58. (90%) Caputo M, B Reeves, G Marchetto, B Mahesh, K Lim, G Angelini. Radial versus right
internal thoracic artery as second arterial conduit for coronary surgery: early and mid-term outcomes.
J Thorac Cardiovasc Surg 2003; 126:39-47.
59. (50%) Modi P, Imura H, Pawade A, Parry A, Suleiman M-S, Angelini GD, Caputo M. Pathologyrelated troponin I release and clinical outcome after pediatric open heart surgery. J Card Surg
2003;18:295-300.
60. (50%) Imura H, Modi P, Pawade A, Parry A, Suleiman M-S, Angelini GD, Caputo M. Cardiac
troponin I in neonates undergoing the arterial switch operation. Ann Thorac Surg 2002;74:19982002.
61. (50%) Modi P, Caputo M, Imura H, Pawade A, Parry A, Suleiman M-S, Angelini GD.
Cardiopulmonary bypass-induced myocardial reoxygenation injury in cyanotic paediatric patients. J
Thorac Cardiovasc Surg 2002;124:1035-6.
62. (70%) Caputo M, M Yeatman, P Narayan, G Marchetto, R Ascione, S Barrow, G D Angelini.
Effects of off pump coronary surgery with right ventricular assist device on organ functions and
inflammatory response: a randomised controlled trial. Ann Thorac Surg 2002;74:2088-95.
63. (90%) Caputo M, Bryan AJ, Capoun R, Mahesh B, Ciulli F, Hutter J, Angelini GD. The Evolution
of Training in Off-pump Coronary Surgery in a Single Institution. Ann Thorac Surg 2002;74:S14037.
64. (90%) Caputo M, Modi P, Imura H, Pawade A, Parry AJ, Suleiman MS, Angelini GD. Cold blood
versus cold crystalloid cardioplegia for repair of ventricular septal defects in pediatric heart surgery:
a randomized controlled trial. Ann Thorac Surg 2002;74:530-4; discussion 535.
65. (50%) Yeatman M, Caputo M, Narayan P, Ghosh AK, Ascione R, Ryder I, Angelini GD.
Intracoronary shunts reduce transient intraoperative myocardial dysfunction during off-pump
coronary operations. Ann Thorac Surg 2002;73:1411-7.
66. (30%) Ascione R, Caputo M, Gomes WJ, Lotto AA, Bryan AJ, Angelini GD, Suleiman MS.
Myocardial injury in hypertrophic hearts of patients undergoing aortic valve surgery using cold or
warm blood cardioplegia. Eur J Cardiothorac Surg 2002;21:440-6.
67. (70%) Yeatman M, Caputo M, Narayan P, Lotto AA, Ascione R, Angelini GD. Magnesium
supplemented warm blood cardioplegia for coronary artery surgery: a randomised clinical study.
Ann Thorac Surg 2002;73:112-8.
68. (70%) Caputo M, Chamberlain MH, Ozalp F, Underwood MJ, Ciulli F, Angelini GD. Off-pump
coronary operations can be safely taught to cardiothoracic trainees. Ann Thorac Surg 2001;71:12159.
69. (50%) Lim K, Caputo M, Ascione R, West C, Angelini GD, Bryan AJ. A prospective randomised
comparison of CarboMedics and St Jude Medical mechanical heart valve prosthesis: an interim
report. J Thorac Cardiovasc Surg 2002;123:21-32.
70. (70%) Imura H, Caputo M, Parry A, Pawade A, Angelini GD, Suleiman MS. Age-dependent and
hypoxia-related differences in myocardial protection during pediatric open heart surgery. Circulation
2001;103:1551-6.
71. (50%) Yeatman M, Caputo M, Ascione R, Ciulli F, Angelini GD Off-pump coronary artery bypass
surgery for critical left main stem disease: safety, efficacy and outcome. Eur J Cardiothorac Surg
2001;19:239-44.
72. (50%) Ascione R, Caputo M, Calori G, Lloyd CT, Underwood MJ, Angelini GD.Predictors of atrial
fibrillation after conventional and beating heart coronary surgery: A prospective, randomized study.
Circulation 2000;102:1530-5.

M Caputo/Page 10 of 22

73. (50%) Birdi I, Caputo M, Underwood M, Bryan AJ, Angelini GD. The effects of cardiopulmonary
bypass temperature on inflammatory response following cardiopulmonary bypass. Eur J
Cardiothorac Surg 1999;16:540-5.
74. (50%) Suleiman MS, Lucchetti V, Caputo M, Angelini GD. Short periods of regional ischaemia and
reperfusion provoke release of troponin I from the human hearts. Clin Chim Acta 1999;284:25-30.
75. (30%) Birdi I, Caputo M, Underwood M, Angelini GD, Bryan AJ. Influence of normothermic
systemic perfusion temperature on cold myocardial protection during coronary artery bypass surgery.
Cardiovasc Surg 1999;7:369-74.
76. (30%) Ascione R, Lloyd CT, Gomes WJ, Caputo M, Bryan AJ, Angelini GD. Beating versus
arrested heart revascularization: evaluation of myocardial function in a prospective randomized
study. Eur J Cardiothorac Surg 1999;15:685-90.
77. (30%) Lucchetti V, Capasso F, Caputo M, Grimaldi G, Capece M, Brando G, Caprio S, Angelini
GD. Intracoronary shunt prevents left ventricular function impairment during beating heart coronary
revascularization. Eur J Cardiothorac Surg 1999;15:255-9.
78. (70%) Suleiman MS, Caputo M, Ascione R, Bryan AJ, Lucchetti V, Gomes WJ, Angelini GD.
Metabolic differences between hearts of patients with aortic valve disease and hearts of patients with
ischaemic disease. J Mol Cell Cardiol 1998;30:2519-23.
79. (90%) Caputo M, Bryan AJ, Calafiore AM, Suleiman MS, Angelini GD. Intermittent antegrade
hyperkalaemic warm blood cardioplegia supplemented with magnesium prevents myocardial
substrate derangement in patients undergoing coronary artery bypass surgery. Eur J Cardiothorac
Surg 1998;14:596-601.
80. (50%) Lucchetti V, Caputo M, Suleiman MS, Capece M, Brando G, Angelini GD. Beating heart
coronary revascularization without metabolic myocardial damage. Eur J Cardiothorac Surg
1998;14:443-4.
81. (90%) Caputo M, Dihmis WC, Bryan AJ, Suleiman MS, Angelini GD. Warm blood hyperkalaemic
reperfusion ('hot shot') prevents myocardial substrate derangement in patients undergoing coronary
artery bypass surgery. Eur J Cardiothorac Surg 1998;13:559-64.
82. (50%) Birdi I, Caputo M, Hutter JA, Bryan AJ, Angelini GD. Troponin I release during minimally
invasive coronary artery surgery. J Thorac Cardiovasc Surg 1997;114:509-10.
83. (90%) Caputo M, Dihmis W, Birdi I, Reeves B, Suleiman MS, Angelini GD, Bryan AJ.Cardiac
troponin T and troponin I release during coronary artery surgery using cold crystalloid and cold
blood cardioplegia. Eur J Cardiothorac Surg 1997;12:254-60.
84. (50%) Suleiman MS, Moffatt AC, Dihmis WC, Caputo M, Hutter JA, Angelini GD, Bryan AJ.
Effect of ischaemia and reperfusion on the intracellular concentration of taurine and glutamine in the
hearts of patients undergoing coronary artery surgery. Biochim Biophys Acta 1997 13;1324:223-31.
85. (50%) Suleiman MS, Dihmis WC, Caputo M, Angelini GD, Bryan AJ. Changes in myocardial
concentration of glutamate and aspartate during coronary artery surgery. Am J Physiol
1997;272:H1063-9.
86. (30%) Di Tommaso L, Caputo M, Ascione R, Janelli G, De Amicis V, Spampinato N Carotid
endarterectomy and myocardial revascularization. A single stage procedure. Minerva Cardioangiol.
1995;43:469-74.
87. (30%) Stassano P, Rispo G, Losi M, Caputo M, Spampinato N. Annular abscesses and GRF glue. J
Card Surg. 1994;9:357-60.
Chapters in Edited Books
1. (50%) Ghorbel M, Angelini GD, and Caputo M. Gene expression profiling - a new approach in the
study of congenital heart disease. Front Lines Of Thoracic Surgery 2012 (ISBN 978-953-307-915-8).
2. Caputo M. The TOF child (second edition): Cardiac Problems. 2011.
3. Caputo M. Myocardial protection strategies in paediatric cardiac surgery. Oxford Handbook of
Congenital Heart Disease 2011.
4. (90%) Caputo M, Narayan P, Angelini GD. Revascularization of the ischaemic myocardium:
conventional surgery with aortic cross-clamping. Multimedia Manual of Cardiothoracic
Surgery2005. http://mmcts.ctsnetjournals.org/cgi/content/full/2006/0315/mmcts.2004.000828.

M Caputo/Page 11 of 22

5. (50%) Suleiman M-S, Imura H, Caputo M, Angelini GD, Modi P, Ascione R, Lotto AA, Parry A,
Pawade A. Metabolic differences between pediatric and adult hearts: implications for reperfusion
injury and cardiac surgery. Book Chapter in Cardiac Development, ed. by B. Ostadal, M. Nagano
& N.S. Dhalla, Kluwer Academic Publishers, Boston, 2002.
Official Reports
1. Caputo M. Member of the panel for the Research and Evaluation of the University of Milan. March
2013.
2. Caputo M. Safe and Sustainable Application: Research in paediatric cardiac surgery.
http://workspaces/Teams/SafeandSustainablePaediatricCardiacSurgery 3. Parry AJ, Caputo M. Protocol for Paediatric Cardiology.
http://connect/Divisions/WomensandChildrens/Documents/wd 32 protocol hbk 2008.doc - 1MB 4. Parry AJ, Caputo M. Paediatric Cardiac Unit Annual Report 2009-10. Bristol Congenital Heart Centre
The University Hospitals Bristol NHS Foundation Trust.
http://connect/Divisions/WomensandChildrens/clinicalservices/paedcardiology/Documents/Paediatric
Cardiac Unit Annual Report SML.pdf.
5. Parry AJ, Caputo M. Hypoplastic Left Heart Protocol. Bristol Congenital Heart Centre The University
Hospitals Bristol NHS Foundation Trust.
http://connect/Divisions/WomensandChildrens/childrensclinicalservices/PaediatricTheatresSite/Paedia
tricCardiacTheatre/Pages/dmslinks.aspx
Reviews & Editorials
1.

(50%) Jia H, Caputo M, Ghorbel M. Stem cell in vascular graft tissue engineering for congenital heart
surgery. Interv Cardiol 2013; 5(6):647-62.

2.

(70%) de Siena P, Ghorbel M, Chen Q, Yim D, Caputo M. Common arterial trunk: review of surgical
strategies and future research. Expert Rev Cardiovasc Ther. 2011;9(12):1527-38.
3. (30%) Murphy GJ, Rogers C, Caputo M, Angelini GD. Acquiring proficiency in off pump coronary
surgery: traversing the learning curve, reproducibility and quality control. Review article. Ann Thorac
Surg 2005;80:1965-70.
4. (70%) Mahesh B, Angelini GD, Caputo M, Jin XY, Bryan AJ. Prosthetic valve endocarditis. Review
article. Ann Thorac Surg 2005;80:1151-8.
5. (30%) Angelini GD, Caputo M, Ascione R. OPCAB Surgery - Can you teach new tricks to old and
young
dogs?
Editorial.
The
Beating
Heart
Surgery
Centre.
http://www.ctsnet.org/innovation/beatingheart/. October 2003.
6. (30%) Murphy GJ, Ascione R, Caputo M, Angelini GD. Operative Factors that Contribute to PostOperative Atrial Fibrillation: Insights from a Prospective Randomized Trial. Review article. Card
Electrophysiol Rev. 2003;7:136-9.
7. (50%) Ascione R, Caputo M, Angelini GD. Off pump coronary artery bypass grafting: not a flash in
the pan. Review article. Ann Thorac Surg 2003;75:306-16.
8. (90%) Caputo M, Schreuder J, Fino C, Baan J, Alfieri O. Assessment of myocardial performance with
ventricular pressure-volume relations: clinical applications in cardiac surgery. Review article. Ital Heart
J 2000;1:269-74.
9. (50%) Lotto AA, Caputo M, Ascione R, Lloyd CT, Lucchetti V, Angelini GD. Evaluation of
myocardial metabolism and function during beating heart coronary surgery. Review article. Eur J
Cardiothorac Surg 1999;16 Suppl 1:S112-6.
10. (90%) Caputo M, Ascione R, Angelini GD, Suleiman M-S, Bryan AJ. The end of the cold era: from
intermittent cold to intermittent warm blood cardioplegia. Review article. Eur J Cardio-Thoracic Surg
1998, 14: 467-475.
11. (90%) Caputo M, Wilde P, Angelini GD. Management of postinfarction ventricular septal defect. Br J
Hosp Med 1996;54:562-6.
Surgical Videos on the CTSnet.org

M Caputo/Page 12 of 22

The CTSnet.org is the most important and popular cardiothoracic surgical network, with the widest surgical
community worldwhile
1. Caputo M, Stoica S, Wolf A, Skerritt C, Lansdowne W, Parry A. Selective Cerebro-Myocardial
Perfusion in Hypoplastic Aortic Arch Repair. http://www.ctsnet.org/article/selective-cerebromyocardial-perfusion-hypoplastic-aortic-arch-repair
2. Caputo M, Chivasso P, Skerritt C, Ofoe V. Unusual Presentation of Large Aortic Arch Aneurysms
Associated with Aortic Coarctation in a 15-Year-Old Girl.
3. Massimo
Caputo
Discusses
His
Experience
as
a
CTSNet
Contributor.
http://www.ctsnet.org/article/massimo-caputo-discusses-his-experience-ctsnet-contributor
4. Caputo M, Chen Q, Parry AJ, Wolf A, Kenny D. Two Strategies for Hybrid Pulmonary Valve
Replacement. CTSnet Congenital Video. http://ctsnet.org/article/two-surgical-strategies-correctionanomalous-origin-right-coronary-artery-young-adults
5. Ragini P, Stoica S, Hamilton M, Skerritt C, Caputo M. Two Surgical Strategies for Correction of
Anomalous Origin of the Right Coronary Artery in Young Adults. CTSnet Congenital Video.
6. Caputo M, Parry AJ, Stoica S, Da Silva JP. The surgical strategy of the Cone Repair for Ebstein
Anomaly. CTSnet Congenital Video. http://www.ctsnet.org/article/cone-reconstruction-tricuspid-valverepair-ebstein-anomaly
7. de Siena P, Caputo M. Reverse subclavian flap and aorto-pulmonary window technique for repair of
interrupted aortic arch and truncus arteriosus. CTSnet Paediatric Video Presentation.
http://www.ctsnet.org/sections/videosection/videos/vg2012_caputoM-reverseSubclavian
Other Publications (media, internet)
1. Caputo M. Selective Cerebro-Myocardial Perfusion in Hypoplastic Aortic Arch Repair. AATS 2013
Video Presentation.
2. Tometzki A, Caputo M. Ebsteins Anomaly, Medical advisors (Bristol Royal Hospital for Children).
www.ebsteins.org
3. Massimo Caputo - research profile on BiomedExperts. Our study found that patients on ACE
inhibitors 24 to 48 hours before coronary artery bypass graft surgery have worse early outcomes, says
Dr. Massimo Caputo at the Bristol Royal hospital for Children
www.cardiosmart.org/News/Default.aspx?id=3155
4. Massimo Caputo - research profile on BiomedExperts:Coronary Artery Bypass, Heart Arrest, Induced,
Troponin I, Treatment Outcome, Myocardial Reperfusion Injury, Myocardium.
www.biomedexperts.com/Profile.bme/191212/Massimo_Caputo
5. Bristol University | Cellular and Molecular Medicine | Adult stem cells
This new project is in collaboration with Massimo Caputo in the University's Bristol Heart Institute
and is being funded by The James Tudor Foundation.
www.bristol.ac.uk/cellmolmed/stem-cells/adult/
6. Miceli A, Caputo M. Medical News: ACE-Inhibitor May Contribute to Poor CABG
www.medpagetoday.com/Surgery/.../1550713 Aug 2009.
7. Miceli A, Caputo M. A recent Science Advisory from the American Heart Association (AHA)
recommended ... Dr Antonio Miceli (University of Bristol, UK) and colleagues
www.e-medicum.com/.../busquedaTematica.php?inicio=520...
8. Miceli A, Caputo M. 2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery ...
www.medlive.cn/uploadfile/2011/1110/20111110104731867.pdf
9. Miceli A, Caputo M. ACE Inhibitors May Negatively Impact CABG Outcomes - Study finds ...
www.modernmedicine.com/modernmedicine/Nursing/.../637808
10. Caputo M. Health Imaging News Portals | | JACC: ACE inhibitors may ...
www.healthimaging.com/index.php?option=com...0
Case Reports, Letters & Other Publications
1. Roldan S, Pieles G, Caputo M, Morgan G, Stoica S, Parry A. Tricuspid atresia with truncus arteriosus:
successful surgical treatment. Ann Thorac Surg. 2014 Aug;98(2):721-3.

M Caputo/Page 13 of 22

2.

3.
4.
5.

6.
7.

8.
9.
10.
11.
12.
13.

14.
15.
16.

17.

18.
19.

Connolly GM, Armstrong C, Caputo M, Morgan GJ. Staged interventional and surgical management
for complex low birthweight tetralogy of Fallot: another imperfect but legitimate strategy. BMJ Case
Rep. 2013 Sep 30;2013. pii: bcr2013201085. doi: 10.1136/bcr-2013-201085.
Caputo M, Rogers C. Response to letter: Normothermia or hypothermia during pediatric cardiac
surgery. No answer as yet. J Thorac Cardiovasc Surg 2012; 143:758-9.
Coates LJ, McNally J, Caputo M, Cusick E. Survival in a 2-year-old boy with hemorrhage secondary
to an aortoesophageal fistula. J Pediatr Surg. 2011;46(12):2394-6.
Miceli A, Angelini GD, Caputo M . Risk of assessing mortality risk in elective cardiac operations: age,
creatinine, ejection fraction, and the law of parsimony. Circulation 2010; Mar 2;121(8):e226; author
reply e227-e228.
Narayan P, Rahaman N, Molnar TF, and Caputo M. Chylothorax Following Cardiac Surgery Caused
by Unusual Lymphatic Anatomy. Asian Cardiovasc Thorac Ann 2007;15:e58-e59.
Chen Q, Modi P, Caputo M, Pawade A. Truncus arteriosus with interrupted aortic arch: successful
repair using modified cardiopulmonary bypass and surgical techniques. Ann Thorac Surg.
2006;82:1884-6.
Mahesh B, Caputo M, Angelini GD, Bryan AJ. Treatment of an aortic fungal false aneurysm by
composite stentless porcine/pericardial conduit: a case report. Cardiovasc Surg. 2003;11:93-5.
Caputo M, Reeves B, Angelini GD. Radial versus right internal thoracic artery for myocardial
revascularization . J Thorac Cardiovasc Surg 2004;127:891-2.
Caputo M, Carcagni A, Presbitero P, Gallotti R. Partial anomalous left pulmonary venous return. J
Cardiovasc Surg. 2003;44:61-3.
Narayan P, Caputo M, Roidl M, Casula R. The use of off pump surgery for management of penetrating
coronary artery injury. Eur J Cardiothorac Surg. 2002;21:361-2.
Caputo M, Ascione R, Calori G, Lloyd CT, Underwood MJ, Angelini GD. Response to: Is
cardiopulmonary bypass really the cause of postoperative atrial fibrillation? Circulation 2002; 104:36e.
Ascione R, Caputo M, Calori G, Lloyd CT, Underwood MJ, Marchetto G, Angelini GD. Response to:
Interatrial block and the incidence of postoperative atrial fibrillation: the effects of off pump coronary
surgery. Circulation 2002; 103:130e.
Fiorani B, Caputo M, Dell'Antonio G, Alfieri O. Cardiac papillary fibroelastoma: report of two cases.
G Ital Cardiol. 1999;29:1027-9.
Caputo M, Nicolini F, Franciosi G, Gallotti R. Coronary artery spasm after coronary artery bypass
grafting. Eur J Cardiothorac Surg 1999;15:545-8.
Birdi I, Caputo M, Underwood MJ, Angelini GD, Bryan AJ. Normothermic systemic perfusion does
not compromise cold myocardial protection during coronary artery surgery. Heart 1996; supplement 1,
Vol 75, No 5.
Suleiman MS, Dihmis WC, Caputo M, Angelini GD, Hutter JA, Bryan AJ. Changes in the intracellular
concentration of myocardial glutamine in patients undergoing coronary artery bypass surgery using
crystalloid and blood cardioplegia. Biochem Soc Trans. 1996;24:487S.
Izzat MB, Caputo M, Angelini GD. Evaluation of the hemodynamic performance of stentless porcine
aortic valves. Ann Thorac Surg. 1995;60:1461.
Suleiman M-S, Dihmis WC, Caputo M, Angelini GD, Hutter JA, Bryan AJ. Changes in the
intracellular concentration of myocardial taurine during cardiac arrest and on reperfusion in patients
undergoing coronary artery bypass surgery using crystalloid and blood cardioplegia. J Physiol (4.3)
1996;491:160-161.

Forthcoming Publications
1.
2.

Successful expansion and grafting on a biodegradable matrix of human myocardium pericytes from
neonates and infants undergoing congenital heart surgery. JAHA (under evaluation)
Caputo M, Saif J, Rajakaruna C, Brooks M, Angelini GD, Emanueli C. MicroRNAs in vascular tissue
engineering and angiogenesis. Adv Drug Delivery Review

M Caputo/Page 14 of 22

3.

Duggirala A, Delogu F, Angelini TG, Smith T, Caputo M, Rajakaruna C, Emanueli C. Non coding
RNAs in aortic aneurysmal disease. Vasc Pharmacology
4. Fudulu D, Caputo M, Parry AJ, Angelini GD, Stoica S. Surgical outcomes following repair of
anomalous origin of the coronary artery from the pulmonary artery: results from a national audit. To be
presented at the SCTS/ACTA Annual Meeting: Manchester 25th -27th March 2015.
5. (30%) C. Fino, A. Iacovoni, P. Ferrero, E. DElia, M. Merlo, A. Miceli, M. Senni, L. Galletti,
M.Caputo, J. Magne. Determinants of long term functional capacity in patients undergoing mitral valve
annuloplasty or mitral valve replacement for ischaemic mitral regurgitation. J Thorac Cardiovasc Surg
2014.
6. Caputo M, Saif J, Rajakaruna C, Brook M, Angelini GD, Emanueli C. MicroRNAs in vascular tissue
engineering and angiogenesis. Advance Drug Delivery Review 2014.
7. Mohamed T Ghorbel, Dominga Iacobazzi, Megan Swim, Nandita Singh, Gianni Angelini, Massimo
Caputo. Tissue engineering vascular grafts for congenital heart corrective surgery using autologous
thymus-derived stem cells. Stem Cell and Development (in preparation)
8. Megan Swim, Dominga Iacobazzi, Massimo Caputo, Mohamed T Ghorbel. Characterization of tissueengineered matrices used in congenital heart surgery: a scanning electron microscopy study.
BioMaterials (in preparation)
9. Jia H, Ghorbel M, Iacobazzi D, Madeddu P, Hollander A, Caputo, M. Umbilical cord blood derived
stem cells exhibit great potential in producing a full range of functional vascular cells for vascular tissue
regeneration used in congenital heart surgery. Circ Research (in preparation)
10. Dominga Iacobazzi, Megan Swim, Huidong Jia, Massimo Caputo, Mohamed T Ghorbel. Comparative
decellularization protocols of porcine pulmonary artery and pericardium for Stem Cells-based Tissue
Engineering. BioMaterials (in preparation)
11. Anne-Lorraine Bouquiaux, Adrian Upex, Guillaume Chanoit, Kristina Britchford, Anita Thomas,
Mohamed Ghorbel, Pamela J Murison & Massimo Caputo. Development of a recovery piglet model
for left pulmonary artery grafting. J of Veterinary Science (in preparation).

Research Grants
A total of 21 successful grants and a Senior Lecturer Fellowship for a total approximately of 4M.
In October 2008 he was the lead paediatric principal investigator for the successful award of the first Bristol
NIHR Biomedical Research Unit (BRU) in cardiovascular diseases (Total funding 7.1M) and for the most
recent renewal 2012-2017 (Total funding 7M). Of this funding approximately 1.5M have been awarded
to congenital heart surgery with Dr Caputo as theme leader and principal investigator. In 2014 he was
awarded the prestigious Sir Jules Thorn Award for Biochemical Research (1.5M).
1.

2.

3.

4.
5.

6.

Emanueli C, Caputo M. Optimising protocols for induced pluripotent stem cells to be used for tissue
engineering solutions in congenital heart disease patients requiring cardiac surgery. British Heart
Foundation PhD project. 50,000
OCollaghan C, Elliot M, Caputo M. Can naturally occurring stress hormones and prescribed
catecholamines increase the risk of serious infections following paediatric cardiac surgery? British
Heart Foundation (project grant submitted). 210,000
Caputo M, Madeddu P, Emanueli C, Hollander A, Angelini GD. Stem cell therapy for treatment of
congenital heart disease: mending the youngest heart. Sir Jules Thorn Award for Biochemical Research.
1,500,000
Madeddu P, Angelini GD, Ascione R, Caputo M, Emanueli C. System biology of pericytes and
adventitial stem cells. MRC (program grant submitted). 1,550,000
Caputo M, Chanoit G, Sulleiman MS, Tulloh R. The cardio-protective efficacy of cardioplegic
solutions supplemented with Sildenafil in neonatal pig model of CPB and cardioplegic arrest. British
Heart Foundation (project grant submitted). 209,000
Emanueli C, Caputo M, Angelini GD, Rajakaruna C. A tissue engineered approach for local
microRNA therapy for thoracic aortic aneurysm: a large animal model. BHF pump priming grant
(2014-2016). 20,000.

M Caputo/Page 15 of 22

Tulloh R, George S, Suleiman M.S, Caputo M. Right VENtricle function in CHildren RVENCH
study. A comparative study of the dysfunctional right ventricle in different congenital heart diseases.
SPARKS. For Childrens Health. 145,000.
8. Caputo M, Ghorbel M, Hollander A. The use of the thymus for stem cell differentiation in congenital
heart surgery. University of Bristol PhD Scholarship (2013-2016). 80,000.
9. Caputo M. Translation of the in vitro stem cell diffrentiantion for tissue engeenired conduits into a
large animal model. Enid Linden Foundation (2013-2016). 150,000.
10. Caputo M, Ghorbel M, Hollander H. Implantation of pulmonary valve conduit seeded with autologous
stem cell: an animal model. The Ellis Foundation (2011-2014), 220,000.
11. Caputo M. Protecting the heart and the patient in paediatric cardiac surgery. Garfield Weston
Foundation (2013-2015). 130,000.
12. Caputo M, Hollander H. Identifying the optimal stem cell populations for tissue regeneration. Enid
Linden Foundation (2010-2013). 90,000
13. Kenny D, Martin R, Tsai-Goodman B, Caputo M. An MRI evaluation of aortic coarctation repair with
either end-to-end or sub-clavian flap anastomosis. David Telling Trust (2010-2011). 20,000.
14. Caputo M, Ghorbel M, Rogers C. Normoxic versus hyperoxic cardiopulmonary bypass in cyanotic
children undergoing open heart surgery: a prospective, randomised controlled trial. Garefield Weston
Foundation (2007-2009). 130,000.
15. Caputo M, Angelini GD, Reeves B, Deaves T. Neurological Evaluation and Intelligence Testing in
Cyanotic Children Undergoing Open Heart Surgery Using Normoxic or Hyperoxic Cardiopulmonary
Bypass. BUPA Foundation (2006-2008). 88,040.
16. Caputo M, Ghorbel M. Intermediate Fellowship: The identification of the molecular processes
underlying re-oxygenation injury in children undergoing repair of cyanotic congenital heart disease.
British Heart Foundation (2005-2008). 120,230.
17. Caputo M, Angelini GD. The evaluation of Perimount biological valve performance with dobutamine
stress echocardiography: a clinical study. Edwards Laboratoty (2005-2006). 10,000.
18. Suleiman MS, Halestrap AP, Caputo M. The role of the mitochondrial permeability transition in
immature hearts during ischaemia and reperfusion injury. British Heart Foundation (2004-2006).
133,870.
19. Caputo M. Five year Senior Lecturer Fellowship for research in paediatric heart surgery. Garefield
Weston Foundation (2004-2009). 250,000.
20. Caputo M. Improving CPB and myocardial protection strategies in congenital heart surgery. Garefield
Weston Foundation (2005-2009). 100,000.
21. Caputo M, Wolf A, Monk C, Angelini GD. The effects of epidural anaesthesia on inflammatory and
stress responses, and clinical outcomes in patients undergoing off pump coronary surgery: a prospective
randomised trial. British Heart Foundation (2003-2006). 110,529.
22. Caputo M, Angelini GD, Suleiman MS. Normoxic vs hyperoxic cardio-pulmonary bypass in children
undergoing repair of Tetralogy of Fallot. BUPA Foundation (2004-2006). 64,352.
23. Caputo M, Reeves B, Suleiman MS, Angelini GD. Low or high magnesium concentration in
Intermittent warm blood cardioplegia in patients undergoing coronary artery surgery: a prospective
randomised study. British Heart Foundation (2002-2005). 104,189.
24. Parry AJ, Caputo M, Wolf A, Angelini GD. Cerebral Injury Associated with Cardiopulmonary Bypass
in Infants: the Impact of Cyanosis. British Heart Foundation (2002-2003). 22,073.
25. Caputo M, Heyderman R, Parry AJ, Suleiman MS, Angelini GD. A prospective randomised study of
the effects of normothermic & hypothermic cardiopulmonary bypass in children undergoing open heart
surgery. British Heart Foundation (2001-2003). 121,535.
26. Suleiman MS, Ascione R, Caputo M, Angelini GD. The effect of hot shot blood cardioplegia on
clinical outcome, myocardial metabolism & reperfusion injury during aortic valve surgery. British Heart
Foundation (2001-2003). 64,794.
27. Caputo M, Angelini GD. Assessment of myocardial performance during beating heart coronary surgery
in patients with impaired left ventricular function: haemodynamic and metabolic changes with or
without the use of IABP. Datascope (2001-2002). $50,000.
7.

M Caputo/Page 16 of 22

Indications of External Recognition


Chief Editor
Frontiers in Surgery (Cardiothoracic surgery) www.frontiersin.org
Editorial Board
CTSnet.org (International Outreach Committee Member) the most important and popular
cardiothoracic surgical network, with the widest surgical community worldwhile
Journal of Cardiac Surgery and Treatment
Cogent OA, the new Open Access imprint at Taylor & Francis / Informa, a new series of
innovative online Open Access journals that seek to extend the visibility of medical research and also
help to build new connections and collaborations within and between research fields.
(http://www.cogentoa.com)
International Scholarly Research Network (ISRN) Surgery, an open access journal that is designed
to provide a fast peer review process for manuscripts in the surgical field.
Medical Sciences (http://www.mdpi.com/journal/medsci, ISSN 2076-3271), a new peer-reviewed and
open access journal providing a platform for advances in research related to medical science.
Journal of Clinical Cardiology, an open access journal specialized in clinical and basic science
cardiology. (http://www.annexpublishers.com/journals/journal-of-clinical-cardiology/jhome.php)
BioMed Research International, Special Issue on Cardioprotection During Adult and Paediatric Open
Heart Surgery. Guest Editor.
Faculty Member: PICS, one of the most important and followed international conference on
interventional cardiology and cardiac surgery in congenital heart disease.
Faculty Member: SCTS, the annual cardiothoracic conference of the Society of CardioThoracic
Surgery of UK and Ireland.
Faculty Member: Fetal Cardiac Symposium, the annual fetal cardiological and interventional
symposium in Chicago.
Appointments to National or International Bodies
Associate Member by invitation of the Syrian British Medical Society (2009)
Chief Surgeon for the charity Al-Dir Charity Hospital to establish the congenital cardiac surgical
program at the Homs University, Syria (2008).
Visiting Professor Paediatric Cardiac Unit, University of West Indies, Trinidad and Tobago (2004).
Committee Member of the Department of Public Health and Innovation General Directorate for
Scientific and Biomedical Research and Research Institutes Supervision, Ministry of Health, Republic
of Italy; http://www.salute.gov.it/
External Examiner for the Academic Promotion Commettee of the Jordan University of Science and
Technology (JUST).
Invitations to Examine for Higher Degrees
External Examiner (European PhD) at the University of Rome, Italy 2011.
Invited Lectures
1. Surgical and cellular strategies in hypoplastic left heart syndrome. Joint Paediatric Meeting at the
Illinois Medical Centre. Cook County Hospital, Chicago, Jan 2015.
2. Tissue engineering for congenital heart disease. Bristol Cardiovascular Regenerative Conference.
Bristol, UK, February 2015.
3. New development in congenital heart surgery. Cardiology Grand Rounds. Rush University Medical
School, Octobet 2014.
4. Stem cell research in congenital heart disease. American Heart Association Midwest Affiliate.
Friends of the Heart Scientific Session. Chicago, November 2014.
5. The Oxic Trial. SICCH annual meeting, Rome, November 2014.
6. The use of stem cell tissue engineering in congenital heart surgery: mending the youngest hearts.
SICCH annual meeting, Rome, November 2014.

M Caputo/Page 17 of 22

7. Gene therapy and Stem Cell in Congenital Heart Disease Patients. 7th National Conference ACHA,
Chicago, September 2014.
8. The dilated aortic root in the ACHD patients: surgical strategies and timing. 7th National Conference
ACHA, Chicago, September 2014.
9. The use of stem cell tissue engineering in congenital heart surgery. Basic and Advances Fetal
Cardiac Symposium and Meeting. Chicago, June 2014.
10. PDA stenting: a surgical prospective. PICS Chicago, June 2014
11. Mending the youngest hearts. Joint Paediatric Meeting at the Illinois Medical Centre. Cook County
Hospital, Chicago, May 2014.
12. Surgical intervention and outcomes of PDA in preterm and term infants. Welsh Paediatric
Cardiovascular Network Meeting. Cardiff October 2013.
13. New research developments in congenital heart surgery. International Clinical Trials Day.
University of Bristol and University Hospital Bristol NHS Foundation Trust, May 2013.
14. The use of stem cell technology in congenital heart surgery. School of Clinical Sciences Research
Showcase. Southmead Hospital North Bristol Trust, May 2013.
15. Identifying the optimal stem cell populations for tissue regeneration in congenital heart surgery.
PICS Miami 2013.
16. Initial clinical experience with the Injectable Pulmonary Valves in a GUCH population. PICS Miami
2013.
17. Temperature management in congenital heart surgery. New Horizons in Cardiopulmonary Perfusion.
Bologna, Italy March 2012.
18. The development of warm blood cardioplegia in paediatric heart surgery. Congenital Heart Centre
Research BRU Meeting. Leicester, December 2011.
19. Right ventricular outflow tract obstruction in patient with previous sarcoma. The Royal Society of
Medicine Cardiothoracic Meeting, July 2011.
20. Public Lecture at the Bristol Alumni Week End: The use of Stem Cell for Creating Live Conduits in
Children with Congenital Heart Disease. Victoria Rooms. July 2011.
21. Annual Meeting of the American Heart Association, Baltimore 2010. Renal Function and Cardiac
Surgery.
22. What is new in congenital heart surgery? Joint meeting of the Society of Intensive Care of the West
of England and Society of Devon Intensive Therapist. September 2008, Exeter, UK.
23. British Congenital Cardiac Association Annual Meeting. Controlled reoxygenation during CPB in
cyanotic children undergoing cardiac surgery: a prospective, randomised trial, November 2007,
Leeds, UK.
24. British Congenital Cardiac Association Annual Meeting. Myocardial protection in paediatric
cardiac surgery, November 2006, Bath, UK.
25. New Trends in Cardiovascular Research, Naples, Italy, June 2006.
26. The Italian National Health Service Education Program. Recent development in aortic surgery.
Avellino, Italy, November 2005.
27. Annual Meeting of the Asian Society of CardioThoracic Surgery. Haemodynamic evaluation of the
Carbomedics mechanical valve prosthesis with dobutamine stress echocardiography. Chiang Mai,
Thailand, 2004.
28. Annual Heart Failure Rehabilitation Meeting. Surgical treatment of heart failure: early and midterm results. Yeovil, UK, 2003.
29. Paediatric cardiac surgery in the developing countries: the Trinidad experience. Bergamo, Italy
2003.
30. 51th Meeting of the ESCVS. Haemodynamic evaluation of small size Sorin mechanical prosthesis
in aortic position using dobutamine stress echocardiography. Helsinki 2002.
31. The International Conference on Off-pump Coronary Surgery, Hong Kong, 2002.
32. The International workshop on off-pump myocardial revascularization -live surgery. Off-pump
coronary surgery can be safely taught to cardio-thoracic trainees. Bristol, 2000.
33. The Seminars in Cardio-Vascular Research. Age-dependent and hypoxia-related differences in
myocardial protection during paediatric open heart surgery. Bristol, 2000.

M Caputo/Page 18 of 22

34. The Seminars in Cardiology and Cardiac Surgery. Off-pump coronary surgery. Milan, 1999.
35. The International workshop on off-pump myocardial revascularization -live surgery. The use of
intracoronary shunts during beating heart coronary surgery: the effects on myocardial function and
metabolism. Bristol, 1998.
36. The Seminars in Cardio-Vascular Research. The effects of different strategies of myocardial
protection on ischaemia-reperfusion injury in patients undergoing coronary artery bypass surgery.
Bristol, 1996.
37. The Workshop on Markers of Myocardial Cell Injury. Troponin T and Troponin I release during
coronary artery surgery using cold crystalloid and cold blood cardioplegia. Cardiff, 1996.
Conference papers (AATS, STS, EACTS, ACC, AHA, ESC).
My research has been presented in over 200 oral and poster presentations to regional, national and
international meetings. In particular, I have been routinely invited over the last 10 years to present my work
at the most prestigious American and European cardiothoracic and cardiology annual meetings.
1.

Caputo M. Stem cell tissue engineering for the treatment of congenital heart disease: mending the
youngest hearts. American Heart Association Midwest Affiliate. Friends of the Heart Scientific Session.
Chicago, November 2014.
2. Madeddu P, Caputo M. Stem cell in congenital heart disease. Presented at the Annual Meeting of the
American Heart Association, Chicago, November 2014.
3. Fino C, Ferrero P, Iacovoni A, Delia E, Merlo M, Galletti L, Caputo M, Senni M, Magne J.
Mechanical versus biological prosthesis for chronic ischemic mitral valve regurgitation: a long term
hemodynamic and functional capacity comparison. Presented at the Annual Meeting of the American
Heart Association, Chicago, November 2014.
4. Fino C, Cugola D, Ferrero P, Iacovoni A, Merlo M, Delia E, Galletti L, Caputo M, Mantovani L,
Magne J. Mechanical versus bioprosthetic mitral valve replacement: analysis of functional and
hemodynamic data. Presented at the Annual Meeting of the American Heart Association, Chicago,
November 2014.
5. Sharabiani MT, Dorobantu DM, Turner M, Tometzki A, Angelini GD, Caputo M, Parry AJ, Stoica SS.
Aortic Valve Replacement in Children and Young Adults: Results from a National Database. Presented
at the AATS Cardiovascular Valve Symposium. Istanbul, September 2014.
6. Fudulu DP, Dorobantu DM, Sharabiani MT, Angelini GD, Caputo M, Parry AJ, Stoica SS. Surgical
outcomes following repair of anomalous origin of coronary artery from the pulmonary artery: results
from a national audit. Presented at the EACTS/ESTS Joint Annual Meeting. Milan, September 2014.
7. Dorobantu DM, Sharabiani MT, Hayes A, Martin R, Angelini GD, Parry AJ, Caputo M, Stoica S.
Predictors for survival and reintervention in simple and complex subaortic stenosis: results from a
prospective, procedure-based national database. Presented at the Annual Meeting of AATS. Toronto,
April 2014.
8. Caputo M, Mohktari A, Miceli M, Ghorbel M, Suleiman MS. Controlling Reoxygenation During
Cardiopulmonary Bypass Reduces Inflammatory and Stress Response in Patients with Single
Ventricular Physiology Undergoing Heart Surgery. Presented at the Annual Meeting of AATS. Toronto,
April 2014.
9. C. Fino, A. Iacovoni, P. Ferrero, E. DElia, M. Merlo, A. Miceli, M. Senni, L. Galletti, M.Caputo, J.
Magne. Determinants of long term functional capacity in patients undergoing mitral valve annuloplasty
or mitral valve replacement for ischaemic mitral regurgitation. Presented at the Annual Meeting of the
American Heart Association, Dallas, November 2013.
10. Zebele C, Chivasso P, Bruno D, Sedmakov C, Angelini G, Caputo M, Parry A, Stoica S. The Ross
operation in children and young adult from the UK National Database. Presented at the EACTS/ESTS
Joint Annual Meeting. Vienna, 2013.
11. Chen Q, Kia M, Caputo M, Stoica S, Tulloh R, Parry A. Does forward pulmonary flow influence the
outcomes of the bidirectional Glenn procedure? Presented at the EACTS/ESTS Joint Annual Meeting.
Vienna, 2013.

M Caputo/Page 19 of 22

12. Caputo M. Selective Cerebro-Myocardial Perfusion in Hypoplastic Aortic Arch Repair. Presented at
the Annual Meeting of AATS. Minneapolis, May 2013.
13. Damien P. Kenny, Jaimie Polson, Sian Curtis, Ron Hartely-Davies, Massimo Caputo, Rob Martin,
John Cockcroft, Julian Paton, Dirk Wilson, Andrew Wolf, Mark Hamilton. Impact of Local Arterial
Compliance and Shear Stress on Baroreceptor Function in Children with Repaired Coarctation of the
Aorta. Presented at the 61th Annual Meeting of the American College of Cardiology, Chicago, March
2012.
14. Fino C, Magne J Caputo M, et al. Aaemodynamic comparison between mitral valve annuloplasty vs
replacement in patients with ischaemic mitral regurgitaion: an exercise stress echocardiographic study.
Presented at the Annual Meeting of the American Heart Association, Loa Angeles, November 2012.
15. M.T. Ghorbel, G.D. Angelini, M. Caputo. Normoxic cardiopulmonary bypass is associated with
reduced transcriptomic changes in comparison to hyperoxic procedure in cyanotic paediatric patients
undergoing corrective congenital heart surgery. Presented at the Annual Meeting of the European
Society of Cardiology, Paris, August 2011.
16. Caputo M, de Siena P, Patel N et al. The effects of normothermic CPB on renal function in children
undergoing cardiac surgery: a prospective randomised trial. Presented at the Annual Meeting of AATS.
Philadelphia, May 2011.
17. Miceli A, Caputo M. Renal dysfunction after cardiac surgery: assessment of risk factors. Presented at
the Annual Meeting of the American Heart Association, Chicago, November 2010.
18. Miceli A, de Siena P, Fiorani B, Romeo F, Angelini GD, Caputo M. Combined clopidogrel and aspirin
up to surgery increase the risk of post-operative myocardial infarction, bleeding and reoperation in
patients undergoing coronary bypass surgery. Presented at the 59th Annual Meeting of the American
College of Cardiology, Atlanta, March 2010.
19. Miceli A, de Siena P, Fiorani B, Romeo F, Angelini GD, Caputo M. Preoperative anemia increase the
risk of mortality and morbidity after cardiac surgery. Presented at the 59th Annual Meeting of the
American College of Cardiology, Atlanta, March 2010.
20. Miceli A, Bruno V, Fiorani B, Romeo F, Angelini GD, Caputo M. Pre-operative occult renal
dysfunction: a risk factor for mortality and morbidity in CABG surgery. Presented at the Annual
Meeting of the American Heart Association, Orlando, November 2009.
21. Miceli A, Fino C, Narayan P, Bryan A, Angelini GD, Caputo M. The effect of Angiotensin-converting
enzyme therapy on early outcome in patients undergoing coronary artery bypass grafting surgery.
Presented at the 58th Annual Meeting of the American College of Cardiology, Orlando, March 2009
22. Miceli A, Fino C, Fiorani B, Yeatman M, Angelini GD, Caputo M. The effects of preoperative statin
treatment on the incidence of atrial fibrillation in patients undergoing CABG surgery. To be presented
at the 45th Annual Meeting of The Society of Thoracic Surgeons. San Francisco, January 2009.
23. Hazekamp M, Caputo M, Bokenkamp R. Atrial baffle for repair of left atrial isomerism and
atrioventricular septal defect with anomalous systemic and pulmonary venous connections. Presented at
the 3th EACTS/ESTS Joint Annual Meeting. Leipzig, 2004.
24. Caputo M, Reeves B, Rajakaruna C, Alwair H, Santo K, Angelini GD. Incomplete revascularisation
during Opcab surgery is associated with reduced mid-term event free survival. Presented at the 84th
Annual Meeting of the American Association for Thoracic Surgery. Toronto, 2004.
25. Modi P, Suleiman M-S, Pawade A, Parry AJ, Angelini GD, Caputo M. Basal metabolic state of hearts
of patients with congenital heart disease: the effect of cyanosis, age and volume-loading. Ann Thorac
Surg 2004. Presented at the 40th of The Society of Thoracic Surgeons Annual Meeting. San Antonio,
2004.
26. Bays S, Caputo M, Modi P, Sueliman M-S, Angelini GD, Parry AJ. The effect of cyanosis on protein
S100 release and neurological outcomes after paediatric heart surgery. Presented at the 40 th of The
Society of Thoracic Surgeons Annual Meeting. San Antonio, 2004.
27. Narayan P, Caputo M, Alwair H, Mahesh B, Angelini GD, Bryan AJ. Early and mid-term outcome of
surgery of the ascending aorta/aortic arch: is there a relationship with caseload? Presented at the 2nd
EACTS/ESTS Joint Annual Meeting. Vienna, 2003.

M Caputo/Page 20 of 22

28. Caputo M, Modi P, Imura H, Pawade A, Parry A, Suleiman M-S, Angelini GD. Cold blood versus
crystalloid cardioplegia in pediatric heart surgery: a prospective randomized study. Presented at the 38 th
Annual Meeting of The Society of Thoracic Surgeons, Fort Lauderdale, Florida 2002.
29. Lim K, Caputo M, Ascione R, West C, Angelini GD, Bryan AJ. A prospective randomised comparison
of CarboMedics and St Jude Medical mechanical heart valve prosthesis: an interim report. Presented at
the 81th Annual Meeting of the American Association for Thoracic Surgery. San Diego, 2002.
Invitations to advice on an international level

Member of the Research and Evaluation Committee for the University of Milan, Italy (2012)

Invited to establish an academic congenital cardiac unit at the University of Bucharest, Romania (2011).

Charity Cardiostart to establish adult and paediatric cardiac surgery in Arequipe, Peru, 2077
(www.cardiostart.com).

Invitations to referee journal articles and grant applications


National Insitute Health Research, Medical Research Council, Circulation, Annals of Thoracic Surgery,
Journal of the American College of Cardiology, European Journal of Cardiothoracic Surgery, Journal of
Thoracic and Cardiovascular Surgery, European Heart Journal, Anaesthesiology, British Heart Foundation,
Heart, Cochrane Review, European Journal of Paediatrics, Clinical Chemistry and Laboratory Medicine,
Future Medicine, Pharmacological Research, Clinical Cardiology, Nigerian Journal of Clinical Practice,
Chinese Journal of Physiology, Journal of Postgraduate Medicine, Italian Research Council, Singapore
Heart Foundation, Perfusion, World Journal for Pediatric and Congenital Heart Surgery, European Journal
of Medical Research.
(8) ADMINISTRATION AND MANAGEMENT
I have been responsible for preparing annual reports, calling for committee meetings, and organizing
seminars for basic scientist and clinical doctors in cardiovascular research. I have actively contributed to
visiting research charities and successfully managed a team of researchers and support staff. I have also
helped with major appointments as a member of appointment committees for the University. I have
organized international meetings in Bristol, disseminated knowledge via the media and helped charities by
given talks to laypeople. I have helped and continue to help academics and researchers from third world
countries.
I have recently been nominated Medical Director responsible for the organization of the homograft bank
related to the cardiac surgical services within the Bristol Tissue Bank.
CONTRIBUTIONS WITHIN THE UNIVERSITY
Medical Director of the Bristol Heart Valve Bank
Member of the RAE committee for the 2012-2013 assessment.
Invited to write an Impact Case Study for the recent REF by the School of Clinical Science
Contributions to departmental committees and working groups
o Contributed to the regular meetings of both university and NHS departments (2003-to date)
Positions of responsibility in the department
o Head of Paediatric Surgery Research Group (2003-to date)
Contributions to university committees and working groups
o Acted as member on several appointments committees
Managing research staff
o I have been managing in the last 5 years numerous undergraduate and postgraduate students,
research and clinical fellows, technicians, research nurses and trial coordinators. At the present time I
direct a team of more than 10 people working in my laboratory at the Bristol Heart Institute or running
several of my clinical trials.
Participating in recruitment
o I am the University representative for the appointment committees of the University Hospital Bristol
NHS Trust and have participated to 10 Consultant interview panels.

M Caputo/Page 21 of 22

PROFESSIONAL ACTIVITIES OUTSIDE THE UNIVERSITY


Membership of professional societies
Member of The European Society of CardioThoracic Surgery (2000).
Member of The Society of CardioThoracic Surgeons of UK and Ireland (2005).
Member of The British Society for Cardiovascular Research (2000)
Member of The British Congenital Cardiac Association (2004)
Member of the British Medical Association (2010)
Organisation of major conferences
PICS Chicago, 2014.
Co-organizer of international workshop Off-pump myocardial revascularization -live surgery Bristol
1998, 2000 and 2002.
Main organizer of international workshop The developing heart: from basic science to bed side
Bristol 2002.
Media & Fund-raising activities (community service)
2011: Collaborating with the ALUMNI University of Bristol for fundraising (more than 300,000 to date)
2007: Article on the Bristol Evening Post (6.8.2007) regarding my heart surgery outcomes.
2006: Cardiostart mission to Peru, performing the first adult and paediatric heart operations in Arequipe and
in the whole south of Peru; article in the Bristol Evening Post 25.7.06 with editorial comments.
2005: The outcome of my surgical performance in Coronary Artery Bypass Grafting (together with that of
all UK cardiac surgeons) was covered in The Guardian, Wed March 16 2005.
2004: Featured in the British Heart Foundation founded educational movie on GUCH cardiac operations in
patients with learning difficulties.
2004: National Heart Research Fund Campaign.
2003: Featured in British Heart Foundation national circular during the Heart Week.
2003: Featured in British Heart Foundation national report describing our research.
2000: Contribution to British Heart Foundation fund raising activities in Bristol.
(9) CLINICAL DUTIES
My performance in clinical activity has been excellent. My job plan is divided between adult and paediatric
cardiac surgery. Up to date I have performed around 3000 cases from routine adult to a wide range of congenital
heart pathologies and grown up congenital heart diseases (average of 4 sessions a week and on call rota for
emergencies 1:2). My clinical outcomes are excellent with an overall mortality of <1% with 15 deaths among
the congenital cases in more than 1500 operations performed including the very complex and high risk neonates
(TGA, HLHS, TAPVD) and infants (<1%). Assessment of outcome against national standards shows that since
my appointment I am performing well above the standards of the national mortality rate for coronary and aortic
valve surgery (no mortality), and at one third the national mortality rate for all inclusive procedures.
Another major contribution in the clinical service has been in the field of the Grown Up Congenital Heart
(GUCH) Surgery Service. I have been responsible for the development of the complex aortic root reconstructive
surgery in Bristol (Ross and Marfan Syndrome Surgery) and the Ebstein Tricuspid Valve Repair
(www.ebsteins.org). I was the first in UK to perform minimally invasive pulmonary valve replacement (inject
able pulmonary valve) and awarded funding for the first multicentre randomised trial using this technique
(NIHR). I have been routinely invited in several UK (Glasgow, Manchester, Leicester) and European Cardiac
Units (Milan, Naples) to perform and teach these new surgical techniques as leading expert. At the same time,
surgeons from UK and abroad come to Bristol or send their patients to us because of the expertise we have
developed.
As a result of my clinical activity I have received recognition of excellence of clinical skills at national and
international level through regular invitations to courses and meetings. I have been appointed as an Honorary
Surgeon at The University of West Indies (Trinidad and Tobago), the charity organization CardioStart Medical
Missions (Peru), and the Al-Dir Charity Hospital (Homs University, Syria), to establish their congenital cardiac
surgical program (more than 500 paediatric operations performed with UK standard clinical outcomes).
Recently, I have been invited to establish the Paediatric Cardiac Unit at the University Hospital in Bucharest,

M Caputo/Page 22 of 22

Romania. Finally from May 2014 I have been invited as visiting Professor to develop the Congenital Heart
Surgery program at the RUSH University Medical Center in Chicago.
(10) CONCLUSIONS
Overall these last 10 years my research and clinical activity in congenital heart surgery have been a complete
success. They have provided vital data regarding CPB and myocardial protection strategies in a very vulnerable
and high risk group of patients. They have demonstrated the real possibility of conducting randomised studies in
children despite all the difficulties in enrolling this group of patients and the related lack of such studies
internationally. They have also given the Bristol Heart Institute and the Bristol Royal Hospital for Children an
international reputation in the field of paediatric cardiac surgery launching the base for vital international
collaboration. Finally and more importantly the results of all these studies have changed our clinical practice
and have greatly contributed to the outstanding clinical outcomes that the Bristol Royal Hospital for Children
has achieved in the last 5 years, putting this Unit one of the best in the country. These past achievements and
innovative projects have played a major part for securing the 14M award achieved at the University of Bristol
and the University Hospitals Bristol NHS Foundation Trust to fund the Biochemical Research Unit (BRU) for
Cardiovascular Disease with congenital heart disease chosen as a major research area under my direct
leadership.
My research activity and its translation into the clinical arena has played a vital part in our recent application for
the Safe and Sustainable process aiming at reducing the number of congenital cardiac centres in UK from 11 to
7. Bristol Royal Hospital for Children was selected as one of the 7 Units and will therefore became the central
hub in the South West for congenital cardiac surgery, performing around 500-600 cases per year. This will give
me an incredible opportunity to carry on and expand all clinical trials and translational research under the
support of the British Heart Foundation and the Bristol NIHR Cardiovascular BRU.
For all my past and recent achievements I have been granted in 2012 the Chair in Congenital Cardiac Surgery at
the University of Bristol.