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Running head: Risperdone

The Effects of Risperidone on Cognitive Processes in Children with Autism and


Irritable Behavior
Marion Thomas
PSY 325 Statistics for the Behavioral & Social Sciences
Instructor: Ioannis Papazafiropoulos
02/23/2015

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The Effects of Risperidone on Cognitive Processes in Children with Autism and Irritable
Behavior

The objective of the following research was to help determine what effects risperdone would
have on the cognitive process of children that had autism and irritable behavior. Favorable effects
were found on children who received risperdone according to Cognitive effects of risperidone in
children with autism and irritable behavior. Repeated ANOVA testing was done after t-test were
used to determine if participants were comparable. According to eta squared results that ranged
from .16 to .46, sand independent variables showed that risperdone helped without showing any
deterioration on cognitive process. These test showed that risperdone may be a viable drug to
help children with autism and irritable behavi0ors and warrant further testing.
In all test, p values were <= .o5 to evaluate statistical significance. According to Tanner, D.
(2011). Statistics for the Behavioral and Social Sciences. (pg.199) The Excel output also
indicates results for one-tailed and two-tailed tests. At p = .05, the outcome is statistically
significant in either case. The t-test was used to determine whether the matched pairs were
closely matched according to Tanner D. (2011) (pg.201) The before/after and matched-pairs
approaches to calculating a dependent-groups t-test each have advantages. The before/after
design provides the greatest control over the extraneous variables that can confound the results in
a matched-pairs design. According to Cognitive effects of risperidone in children with autism
and irritable behavior. This study used an acute, double blind, placebo controlled, parallel
groups design. The dependent factors included the number of words recalled immediately after
hearing them and then with ten minute delay and then with a long delay. These are part of the
reason that the AVENO was the proper test to use for this study.

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The study produced positive results according to Cognitive effects of risperidone in children
with autism and irritable behavior.
No declines, significant or otherwise, were indicated in the
measures of attention (i.e., Cancellation Task, timed math
test), hand-eye coordination (Purdue Pegboard), or short
term verbal memory (verbal learning task). Conversely, significant
improvement occurred with risperidone in two areas
of cognitive processing, namely on the Cancellation Task
(correct detections) and on the Verbal Learning Task (correct
recognitions); improvement occurred equivocally on the
Spatial Memory Task (Dot Test, difference score). Whereas
this stability of cognitive performance may appear to be at
odds with reported tiredness with risperidone (Aman et al.,
2005), the two are not necessarily inconsistent. For example
risperidone caused a large reduction in irritable/disruptive
behavior (E.S. 1.20) and hyperactivity (E.S. 1.00), which
may have enabled the participants to perform as well or better,
even if somnolence were present.

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They are limitations to this study. The test group was small and may of the candidates
were not able to participate in cognitive test. They have been no long term tests that can
prove or disprove possible side effects of long term use of risperdome.
The objective of the following research was to help determine what effects risperdone
would have on the cognitive process of children that had autism and irritable behavior.
Favorable effects were found on children who received risperdone according to Cognitive
effects of risperidone in children with autism and irritable behavior. Repeated ANOVA
testing was done after t-test were used to determine if participants were comparable.
According to eta squared results that ranged from .16 to .46, sand independent variables
showed that risperdone helped without showing any deterioration on cognitive process.
These test showed that risperdone may be a viable drug to help children with autism and
irritable behavi0ors and warrant further testing.

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References:

Tanner, D. (2011). Statistics for the Behavioral and Social Sciences Bridgepoint Education

Cognitive effects of risperidone in children with autism and irritable behavior. Journal of Child
and Adolescent Psychopharmacology, 18(3), 227-36.
doi:http://dx.doi.org/10.1089/cap.2007.0133