Publications

Thompson AA, Walmsley SR, Whyte MK. A local circadian clock calls time on lung inflammation.
Nature Medicine 2014; 20:809-811.
Walmsley SR and Whyte MKW. Neutrophil energetics and oxygen sensing. Blood 2014;
123:2753-2754.
Robertson AL, Holmes GR, Bojarczuk AN, Burgon J, Loynes CA, Chimen M, Sawtell AK, Hamza
B, Willson J, Walmsley SR, Anderson SR, Coles MC, Farrow SN, Solari R, Jones S, Prince LR,
Irimia D, Rainger E, Kadirkamanathan V, Whyte MKB, Renshaw SA. Modulation of reverse
migration as an anti-inflammatory mechanism identified by an in vivo zebrafish inflammation
screen. Science Translational Medicine 2014; 6:225-229.
Harris AJ, Thompson AAR, Whyte MKB, Walmsley SR. HIF-mediated innate immune responses:
cell signaling and therapeutic implications. Hypoxia 2014; 2:47-58.
Elks P, Brizee S, van der Vaart M, Walmsley SR, van Eeden FJ, Renshaw SA, Meijer AH.
Hypoxia Inducible Factor signaling modulates susceptibility to mycobacterial infection via a nitric
oxide dependent mechanism. PLoS Pathogens 2013;e1003789. doi:
10.1371/journal.ppat.1003789.
Thompson AA, Elks PM, Marriott HM, Eamsamarng S, Higgins KR, Lewis A, Williams L,
Parmar S, Shaw G, McGrath EE, Formenti F, Van Eeden FJ, Kinnula VL, Pugh CW, Sabroe I,
Dockrell DH, Chilvers ER, Robbins PA, Percy MJ, Simon MC, Johnson RS, Renshaw SA,
Whyte MK, Walmsley SR. Hypoxia-inducible factor 2alpha regulates key neutrophil
functions in humans mice and zebrafish. Blood 2013; 123:366-376
Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C,
Bernard NJ, Kelly B, Foley NH, Zheng L, Gardet A, Tong Z, Jany SS, Corr SC, Haneklaus M,
Caffrey BE, Pierce K, Walmsley S, Beasley FC, Cummins E, Nizet V, Whyte M, Taylor CT, Lin H,
Masters SL, Gottlieb E, Kelly VP, Clish C, Auron PE, Xavier RJ, O'Neill LA. Succinate is an
inflammatory signal that induces IL-1β through HIF-1α. Nature 2013; 496:238-242.
Luong, LEA, Fragiadaki M, Smith J, Boyle J, Lutz, J, Dean JL, Harten S, Ashcroft M, Walmsley
SR, Haskard DO, Maxwell PH, Walczak H, Pusey C, Evans PC. Cezanne regulates inflammatory
responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination. Circ Res. 2013;
112:1583-1591
Thompson AA, Binham J, Plant T, Whyte MK, Walmsley SR. Hypoxia, the HIF pathway and
neutrophilic inflammatory responses. Biological Chemistry 2013; 394:471-477.
Juss JK, Hayhoe RP, Owen CE, Bruce I, Walmsley SR, Cowburn AS, Kulkarni S, Boyle KB,
Stephens L, Hawkins PT, Chilvers ER, Condliffe AM. Functional redundancy of Claas I
phosphoinositide 3-kinase (PI3K) isoforms in signaling growth factor-mediated human neutrophil
survival. PLoS One 2012; 7:e45933.
Basran A, Jabeen M, Bingle L, Stokes CA, Dockrell DH, Whyte MK, Walmsley SR, Higgins KR,
Vogel SN, Wilson HL, Prince LR, Prestwich EC, Sabroe RA, Parker LC, Sabroe, I. Roles of
neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and
clearance of chemokines.. Journal of Leukocyte Biology 2012; 93:7-19.
Kiss J, Mollenhauer M, Walmsley SR, Kirchberg J, Radhakrishnan P, Niemietz, T, Schneider, M.
Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis.
Journal of Immunology 2012; 189:1955-1965.
Santhakumar K, Judson EC, Elks PM, McKee S, Elworthy S, van Rooijen E, Walmsley SR,

Renshaw SA, Cross SS, van Eeden FJ. A zebrafish model to study and therapeutically manipulate
hypoxia signaling in tumorigenesis. Cancer Research 2012; 72:4017-4027.

Marriott, HM, Daigneault M, Thompson AA, Walmsley SR, Gill SK, Witcher DR, Wroblewski VJ,
Hellewell PG, Whyte MK, Dockrell DH. A decoy receptor 3 analogue reduces localised defects in
phagocyte function in pneumococcal pneumonia. Thorax 2012; 67:985-992.

McGrath E, Lawrie A, Marriott HM, Mercer PF, Cross SS, Arnold N, Singleton V, Thompson AAR,
Walmsley SR, Renshaw SA, Sabroe I, Chambers RC, Dockrell DD, Whyte MKB. Deficiency of
TNF-Related Apoptosis Inducing Ligand (TRAIL) exacerbates lung injury and fibrosis. Thorax
2012; 67:796-803.
Elks PM, van Eeden FJ, Dixon G, Wang X, Ingham PW, Whyte MKB, Walmsley SR, Renshaw
SA. HIF-1alpha delays inflammation resolution by promoting neutrophil persistence in a
zebrafish inflammation model. Blood 2011; 118:712-722.
Walmsley SR, Chilvers ER, Thompson AAR, Vaughan K, Marriott HM, Parker LC, Shaw G,
Parmar S, Schneider M, Sabroe I, Dockrell DH, Milo M, Taylor CT, Johnson RS, Pugh CW,
Ratcliffe PJ, Maxwell PH, Carmeliet P, Whyte MKB. Prolyl hydroxylase PHD3 is essential for
hypoxic regulation of neutrophilic inflammation in humans and mice. J. Clin. Invest. 2011;
121:1053-1063.
McGovern NN, Cowburn AS, Porter L, Walmsley SR, Summers C, Thompson AAR, Anwar S,
Willcocks LC, Whyte MKB, Condliffe AM, Chilvers ER. Hypoxia selectively inhibits respiratory
burst activity and killing of staphylococcus aureus in human neutrophils. J. Immunol.
2011;186:453-463.
Webster SJ, Daigneault M, Bewley MA, Preston JA, Marriott HM, Walmsley SR, Read RC, Whyte
MKB, Dockrell DH. Distinct cell death programs in monocytes regulate innate responses following
challenge with common causes of invasive bacterial disease. J. Immunol. 2010; 185:2968-2979.
Walmsley SR, Chilvers ER, Whyte MKB. Hypoxia, hypoxia inducible factor and myeloid cell
function. Arthritis Res. Ther. 2009; 11:219-226.
Prince LR, Bianchi SM, Vaughan KM, Bewley MA, Marriott HM, Walmsley SR, Taylor GW, Buttle
DJ, Sabroe I, Dockrell DH, Whyte MKB. Subversion of a Lysosomal Pathway Regulating
Neutrophil Apoptosis by a Major Bacterial Toxin, Pyocyanin. J. Immunol. 2008; 180:3502-3511.
Walmsley SR, McGoven NN, Whyte MK, Chilvers ER. The HIF/VHL pathway: from oxygen
sensing to innate immunity. Am J Respir Cell Mol Biol. 2008; 38:251-255.
Walmsley SR, Cowburn AS, Clatworthy MR, Morrell NW, Roper EC, Singleton V, Maxwell P,
Whyte M, Chilvers ER. Neutrophils from patients with heterozygous germline mutations in
the von Hippel Lindau protein (VHL) display delayed apoptosis and enhanced bacterial
phagocytosis. Blood 2006; 108:3176-3178.
Walmsley SR, Cadwallader K, Chilvers ER. The role of HIF-1α in myeloid cell inflammation.
Trends in Immunology 2005; 26:434-439.
Walmsley SR, Print C, Farahi N, Peyssonnaux C, Johnson RS, Cramer T, Sobolewski A,
Condliffe A, Cowburn AS, Johnson N, Chilvers ER. The role of HIF-1α and NF-κB in
hypoxia-induced survival in human and murine neutrophils. J. Exp. Med. 2005; 201:105-115.

Cowburn AS, White JF, Deighton J, Walmsley SR, Chilvers ERC. Z-VAD-fmk-augmentation of
TNF-α stimulated neutrophil apoptosis is compound specific and does not involve the generation of
reactive oxygen species. Blood 2005; 105:2970-2972.
Walmsley SR, Cowburn AS, Sobolewski A, Murray J, Farahi N, Sabroe I, Chilvers ER.
Characterisation of the survival effect of tumour necrosis factor-α in human neutrophils. Biochem.
Soc. Trans. 2004; 32:456-460.
Walmsley SR, Sheares KKK, Sobolewski A, Morrell NW, Chilvers ER. New insights into oxygen
sensing at a cellular level. Thorax 2004; 59:90-92.
Mecklenburgh KI and Walmsley SR, Greening AP, Wiesener M, Reed BJ, Cowburn AS,
Chilvers ER. Involvement of a ferro-protein sensor and hypoxia-inducible factor (HIF)-1α in
hypoxia-mediated inhibition of neutrophil apoptosis. Blood 2002; 100:3008-3016.