You are on page 1of 1

DISEASE EPILEPSY MYASTHENIA GRAVIS MULTIPLE SCLEROSIS GUILLAIN BARRE SYNDROME

S/Sx recurrent seizures ptosis, diplopia (due to weakness of extraocular diplopia, nystagmus, blurry upward weakness, areflexia
(card) muscle) vision, descending muscle others: paresthesia, hypotonia, symmetric
others: symmetrical paralysis, mask-like facial weakness weakness
expression, dysphonia, bulbar symptoms(facial)
Main Epileptogenic Zone(EZ) Antibodies produced by thymus destruction of destruction of SCHWANN CELLS (may be
Culprit OLIGODENDROCYTE due to virus- Epstein Barr or bacteria-
Campylobacter jejuni)
Dx EEG, SPECT(to identify EZ) Tensilon Test (Edrophonium Chloride), an MRI(to reveal plaques), EMG(dec. nerve cond), MRI
Tests anticholinesterase inhibitor and MRI(enlarged Electrophoresis(IgG)
thymus)
Goals promote safety, control seizure improve fxn esp muscle endurance, get rid of promotion of physical mobility maintain adequate ventilation
antibodies
Meds Valium/Phenobarbital-for children Neostigmine Bromide and Pyridostigmine Bromide Interferonβ-1a(AVONEX /REBIF) Anticoagulants,
Fosphenytoin-DOC **both are cholinergics Interferonβ-1b(BETASERONE)
anesthetics-to depress muscle **antidote for OD is Atropine Sulfate Glatiramer Acetate(COPAXONE)
Corticosteroids
(HYDROCORTISONE)
**interferon prevents t-cell
proliferation
Other Transcranial Magnetic Stimulation Plasmapheresis of Plasma Exchange --- Plasmapheresis, Mech Vent, Intubation
Tx Excision of EZ Thymectomy
Vagal Stimulation
Compli Status Epilepticus (ng ix is to start Myasthenic Crisis Cholinergic Pneumonia, UTI, DVT Miller Fisher Syndrome- a clinical variant
an IV Crisis characterized by ataxia, opthalmoplegia and
cause underdose overdose areflexia
cm extreme weakness
weakness
tensilon relief worsen
test
mgt cholinergics atropine
Ng Dx Risk for injury r/t involuntary Fatigue, related to increased energy needs from Impaired physical mobility r/t Ineffective breathing pattern: dyspnea r/t
muscle movements secondary to muscular demyelination of neurons weakness of the muscles needed for
seizure disorder involvement breathing secondary to GBS
Other PHASES OF A SEIZURE an AUTOIMMUNE d/o COURSES OF MS also known as POLYRADICULONEURITIS
Stuff ***prodromal and aural are ng ix include: eye care, nonverbal communication, a. Relapsing-Remitting first discovered this disease Landry-Strohl
considered Pre-ictal in some books maintaining respiration b. Primary Progressive Jean Landry, Georges Guillain, Jean
a. Prodromal-remove stimulus w/c c. Secondary Progressive Alexandre Barré, André Strohl
triggers attack d. Progressive Relapsing
b. Aural-insert padded tongue dep
c. Ictal
d. Postictal-monitor v/s
FAQs
 Common S/sx of the 4: weakness, sensory disturbances, seizures, pain, o Partial-involves only 1 part of brain
dizziness, visual disturbances.  Simple Partial-without loss of consciousness
 Perception refers to senses while coordination refers to motor.  Complex Partial-with loss of consciousness
 The myelin ii the protein covering of the axon.  Unclassified
 The reason while GBS is reversible is that Schwann cells are capable of  Pattern of Tonic-Clonic: Aura, Epileptic Cry,Tonic-contraction of muscle,
regenerating while Oligodendrocytes are not. Clonic-jerking mov’ts
 TYPES OF SEIZURES  Central Sulcus is the landmark of division of motor(anterior, precentral gyrus)
o Generalized-involves the whole brain and sensory(posterion, postcentral gyrus)
 Grand Mal  Seizure is a symptom, Epilepsy is a recurrence and Conulsion is an involuntary
 Petit Mal muscle contraction