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Europisches P a t e n t a m t

(fi) Publication number:

European Patent Office

EUROPEAN

4 0 1

B1

Office europen des b r e v e t s

0 017

PATENT SPECIFICATION

() Date of publication of patent spcification: 24.07.85


Application number: 80300877.0
(22) Date offiling: 21.03.80

Intel.4: A 61
C 09
C09
C 08
C 08

L 15/06, A 61 F 5 / 4 4 ,
J 3/08, C 09 J 3 / 0 2 ,
J 3/14, C 08 L 5 / 0 0 ,
L 35/08, C 08 L 2 3 / 2 2 ,
L 31/04

(m) Articles of manufacture having adhesive properties.

() Priority: 21 .03.79 GB 7909956


(S) Date of publication of application:
15.10.80 Bulletin 80/21
Publication of the grant of the patent:
24.07.85 Bulletin 85/30

(73) Proprietor: ADVANCE TAPES (U.K) LIMITED


P.O. Box 122 Vantage Works
Abbey Meadows Leicester, LE4 5RA (GB)
(7?) Inventor: Potaczek, Jan J.
57, Bath Street
Leicester, LE47QEIGB)
(74) Reprsentative: Deans, Michael John Percy et al
Lloyd Wise, Tregear & CO. Norman House
105-109 Strand
London WC2R OAE (GB)

(M) Designated Contracting States:


AT BE CH DE FRITIMLSE
() Rfrences cited:
DE-A-2 441626
GB-A-1 307 968
FR-A-2 277 597
US-A-3339 546
FR-A-2 392 076
US-A-3 805 789
FR-A-2 393 566
US-A-3 906 951
O
FR-A-2 396 542
US-A-3 908 658
CHEMICAL ABSTRACTS, vol. 81, no. 12, 23rd
September 1974, page 119, no. 65513m,
o
Columbus, Ohio, U.S.A.
The file contains technical information
submitted after the application was f iled and
not included in this spcification
a.
LU

Note: Within nine months from the publication of the mention of the grant of the European patent, any person may
give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall
be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been
paid. (Art. 99(1 ) European patent convention).
Courier Press, Leamington Spa, England.

This invention relates to articles of manufacture


having adhesive properties, and useful, for
example, as protective plasters or dressings or as
rings, washers or the like in surgical appliances
such as ostomy appliances.
Conventional pressure-sensitive plasters comprise an adhesive based on a rubber/resin mixture. Such plasters adhere with difficulty to moist
body surfaces and, even then, under movement
of the body they may easily detach from the skin.
There is a particular need for improved protective
plasters which may be used in the management
of colostomies and ileostomies and similar surgical operations. The ostomy appliances provided
for patients who have had such an operation have
generally included a sealing ring supposedly for
preventing draining waste material which
commonly includes active gastric juices from
coming into contact with the patient's skin
surrounding the stoma, and thereby attacking the
skin, or from leaking, thereby producing embarrassing odour and soiling of the patient's
clothing. Such ostomy sealing rings have not
always proved reliable and additional sealing
compositions in paste form which may be
squeezed from a toothpaste-like tube have been
suggested to overcome this problem but have not
found wide application, being difficult for the
patient himself to use.
Marsan in Example II of U.S. Patent 3908658
describes the manufacture of a ring-like seal suitable for ostomy appliances composed of a gel
consisting essentially of a mixture of mineral oil,
styrene-isobutylene copolymer and ethylene-vinyl acetate copoplymer. As described in Example
II, these components are blended at about 300F.
The temperature is then said to be lowered to a
temperature a little above 200C. Since 200C is
substantially higher than 300F, this is clearly a
clerical error. Both in view of the fact that Fahrenheittemperatures are otherwise used consistently
throughout U.S. Patent 3908658, and by comparison with Examples IV and V, it is clear that 200F is
intended. At this lower temperature a quantity of
pre-gelatinised starch is added and the fluid
mixture is then poured into moulds to form ringlike seals with the starch held in the plastics
matrix. The starch is present solely to act as a
slow release agent in use, and it is suggested that
other so-called "water sensitive agents" can be
used as substitutes for the starch. Included in the
list as alternatives for the starch are naturally
occurring high molecular weight polysaccharide
gums and, separately, polyvinyl alcohol. The seal
is said to possess adhesive properties, resulting
from the mixture of the two copolymers and the
mineral oil in the plastics matrix, but it is further
disclosed that due to irregularities of the stoma or
scar tissue, it is desirable to use a pasty like putty
material for filling voids.
Marsan further discloses in column 1 of U.S.
Patent 3908658 that karaya-glycerol seals are unsatisfactory due to breakdown and dissolution.

The present invention adopts a new and different approach, namely that of using a plastics
matrix as a vehicle for a selected gelatinous
adhesive composition, which composition, when
held in the matrix enables the resultant article to
adhere firmly to moist human body surfaces over
long periods.
In accordance with the present invention we
provide an article of manufacture, having adhesive properties, and comprising a plastics matrix
in which is dispersed from 30 to 55 per cent by
weight of a gelatinous adhesive composition
comprising the product resulting from heating
together for an extended period at a temperature
of 80C or more, and in the absence of added
solvent:
(a) one or more polyhydric alcohols (as herein
defined), and
(b) gelatin, and/or a naturally occurring high
molecular weight polysaccharide gum, and/or a
resin which is a copolymer of a vinyl ether and an
organic acid anhydride and/or its corresponding
free acid,
so as to promote chemical reaction between
components (a) and (b) to form esters.
We believe many of the said adhesive compositions to be novel, and certain of the said novel
adhesive compositions comprise one aspect of
our co-pending European Patent Application No.
80300878.8 (Publication No. 18093 "Gelatinous
Articles and Compositions"), filed the same day
as this Application and which claims priority from
our earlier British Patent Application No. 7909957,
to which reference may also be made.
The gelatinous adhesive compositions described herein may be regarded as means relating
to an essential element of the present invention
for putting that invention into effect.
The preferred polysaccharide gum is Karaya, a
natural substance occurring in the bark of certain
trees and which appears to be a high molecular
weight polysaccharide formed by the condensation of certain anhydro-monosaccharide
units, of which those derived from D-galacturonic
acid, D-galactose and L-rhammose are the most
important. Other naturally occurring high molecular weight polysaccharide gums which we have
found to be useful include gum Tragacanth and
gum Arabic.
The preferred resin is a methyl vinyl ether/
maleic anhydride copolymer of which a range of
suitable resins is available under the trade name
Gantrez from Gaf (GB) Limited and under the
trade name Viscofas from Imperial Chemical Industries Limited. We prefer to use GantrezAN139,
or Viscofas L.30.
By the term 'polyhydric alcohol' as used herein
we intend to refer to a polyhydroxy compound
without any other functional groups. Suitable
polyhydric alcohols include but are not limited to
glycerol, sorbitol, pentaerythritol and polyvinylalcohol.
Our gelatinous adhesive compositions have
inherent tack and water swelling (absorbing) purposes. The resultant article of manufacture in

which the adhesive composition is dispersed in a


suitable plastics matrix must retain these
properties. Any of the conventional film forming
elastic binder plastics materials which are compatible with skin tissue may be employed, though
we have found that best results are obtained
when at least the major part of the plastics matrix
material comprises one or more copolymers of
ethylene and vinyl acetate. A range of such
copolymers is available from Bayer AG. under the
trade name Levapren. We have obtained good
results from employing a blend of a high molecular weight such copolymer, Levapren L452, and a
low molecular weight such copolymer, Levapren
KH8160. Other film forming plastics such as polyisobutylene may optionally be added to the blend
or substituted.
The gelatinous adhesive composition can be
made either in a heated reaction vessel or preferably in situ during blending with the other ingredients forming the article in a heated Z-blade
mixer, the blend being subsequently allowed to
solidify, suitably in a mould.
The specific gel content of the gelatinous adhesive composition may readily be adjusted to
obtain a desired degree of water swelling (absorbing) capability. The gel structure may be
altered by varying the proportions of the reacting
ingredients and by employing a cross-linking
resin such as glyoxal or citric acid. Melamine
resin is also an effective crosslinking agent for the
composition but may sensitise the skin of some
people and is therefore less preferred.
Our gelatinous adhesive compositions have
useful
inherent
pressure-sensitive
very
properties, enabling them to act as the sole or
main tackifying agent in adhesive articles in
accordance with this invention, such as protective
plasters or dressings, or rings, washers, or the
like, in surgical appliances such as ostomy appliances. The resultant articles adhere readily to
dry or moist human body surfaces.
The physical characteristics of the adhesive
articles, such as tack, plasticity, cohesive strength
and moisture absorbency, may be modified by
admixing other substances such as: viscosity
modifiers, e.g. micronised silica; tack modifiers,
e.g. polyvinylpyrrolidone resin (which in glycerol
forms a tacky viscous compound); fillers e.g.
calcium carbonate; crosslinking agents, e.g. glyoxal or citric acid; antimicrobial agents; and
plasticisers, e.g. paraffin oil. Selection of the polyhydric alcohol may also be used to adjust the
physical properties of the articles. Thus when the
polyhydric alcohol is glycerol the article has substantial water absorbing properties, and may
eventually swell unduly or even begin to dissolve;
substitution of glycerol wholly or partially by
sorbitol may avoid this. Pentaerythritol is not
soluble to any great extent. The presence of polyvinylalcohol enhances adhesion to the skin.
We have found that particularly satisfactory
ostomy plasters result when the gelatinous adhesive composition is present in an amount from 30
to 55 per cent by weight.

The most satisfactory blends for forming ostomy plasters are those comprising 40 to 50 per
cent by weight of an adhesive composition resulting from the chemical reaction between sorbitol
and/or glycerol and Karaya gum. The ostomy
plasters we have made from this blend are soft
and pliable, have good adhering qualities to dry
and moist skin, are resistant to plastic flow at
body temperature and, owing to the Karaya gum
content, also possess skin healing properties.
When an adhesive article in accordance with
this invention is embodied as a protective plaster
or dressing, it preferably has a backing sheet to
prevent the tacky plaster or dressing from sticking
to clothing etc. A thin, suitably water impermeable, plastics film, for example of polyethylene
may be employed. The film is suitably provided
with perforations which assist in getting rid of
occluded air bubbles during the lamination process. The plasters may be formed as a sheet
which may be cut into desired shapes and sizes in
a subsequent operation.
The following examples will illustrate the invention:Example 1
300 grams of high molecular weight ethylene/
vinyl acetate copolymer, manufactured under the
trade name Levapren L452, and 100 grams of low
molecular weight ethylene/vinyl acetate copolymer, manufactured under the trade name Levapren KH 8160, were placed in a Z-blade mixer
heated at 80-90 and mixed until a uniform
dough was obtained. Then 85 grams of glycerine,
80 grams of Karaya gum and 2 grams of Nipastat
(a mixture of p-hydro-benzoic acid esters produced by Nipa Laboratories Limited and having
anti-microbial properties) were added and mixed
for one hour at 80-90C, when at the end of this
period a uniform dispersion of the gelatinous
adhesive composition was obtained in the plastics matrix. Part of the dispersion was pressed to a
thin sheet in an hydraulic press maintained at
130C. The thus formed adhesive sheet was laminated to a perforated thin polyethylene film and
then cut into plasters of desired shapes and sizes.
The remainder of the dispersion was moulded to
produce a solid mass.
Example 2
The procedure of Example 1 was repeated but
with the quantity of Nipastat reduced to 1 gram.
Comparison of the products of the two examples
showed that the reduced Nipastat content products were less likely to sensitise skin.
Example 3
300 grams of Levapren L452 and 300 grams of
Levapren KH 8160 were placed in a Z-blade mixer
heated at 80-90C and mixed until a uniform
dough was obtained. Then 450 grams of glycerine, 60 grams of Kollidon 90 (polyvinyl
pyrrolidone resin manufactured by BASF Limited), 150 grams of Gantrez AN 139 (methyl
vinyl ether/maleic anhydride copolymer resin

sold by Gaf (GB) Limited) and 2 grams of Nipastat


were added and mixed for one hour at 80-90C.
Part of the dispersion was pressed to a thin sheet
in an hydraulic press maintained at 130C, and the
resultant adhesive sheet laminated to a perforated thin polythene film. Satisfactory ostomy
plasters were obtained.
Example 4
The procedure of Example 3 was repeated but
with the Nipastat content reduced to 1 gram.
Comparison of the resulting ostomy plasters
showed that those of Example 4 exhibited less
likelihood of sensitising skin as compared with
those of Example 3.
Example 5
The process of Example 1 was followed except
that 20 grams of the Karaya gum was replaced by
20 grams of Gantrez AN 139.
Example 6
200 grams of Levapren 452 and 200 grams of
LM-MH
(Vistanex
manupolyisobutylene
factured by Esso Co. Ltd) were blended in a Zblade mixer at 90C. Then were added: 2 grams of
Nipastat, 100 grams of micronised amorphous
silica (Syloid 244 manufactured by Grace GnbH),
50 grams of Kollidon 90, and 110 grams of Karaya
gum. The blend was mixed to obtain uniform dispersion. Next 150 grams of glycerol and 100
grams of paraffin were added, followed by mixing, still maintaining a temperature of 90C, for
one hour. The further stages were as per
Example 1.
Example 7
Example 6 was repeated with 1 gram only of
Nipastat and the results compared. The reduced
Nipastat content plasters of Example 7 were
found less likely to sensitise skin.
Example 8
1500 grams of Vistanex LM-MH and 50Q
grams of Levapren 452 were placed in a Z-blade
mixer heated at 90-100C and mixed until a
uniform plastics dough was obtained. Then 900
grams of Karaya gum, 600 grams of glycerol, 400
grams of sorbitol and 2 grams of Nipastat were
added and mixed for one hour at 90-100C,
when at the end of this time a uniform dispersion
of the hydrocolloid gelatinous adhesive composition in the plastics matrix was obtained. Part
of the dispersion was pressed to a thin sheet in a
hydraulic press maintained at 120C. The resulting adhesive sheet was laminated to perforated
thin polyethylene film and then converted into
plasters of desired shapes and sizes. Satisfactory
ostomy plasters were obtained.
The above Examples all involve production of
the gelatinous adhesive composition in situ in the
plastics matrix. We shall now describe below
further Examples in which production of the

gelatinous adhesive composition is performed as


a first step.
Example 9
200 grams of sorbitol and 200 grams of Karaya
gum were placed in a glass container and heated
at 120C in an oven for one hour, stirring the
contents every 15 minutes. After cooling to room
temperature, a brittle mass resulted. Test showed
that this mass was a gelatinous hydrocolloid
adhesive composition. It was found to swell and
eventually break up into gel particles in water at
ambient temperature, but it did not completely
dissolve.
200 grams of the sorbitol/Karaya gum hydrocolloid adhesive composition was blended with
150 grams of Vistanex LM-MH and 50 grams of
Levapren 452 and moulded in an open dished
mould at 120C to produce an ostomy sealing
ring.
Example 10
The procedure of Example 9 was repeated first
with 200 grams of pentaerythritol and second
with 200 grams of polyvinylalcohol substituted
for the sorbitol and the results compared. The
ostomy sealing rings formed using pentaerythritol tended to remain relatively hard and not
greatly to swell absorbing moisture when in
contact with the skin and are therefore in our view
less preferable. The rings formed with polyvinylalcohol exhibited particularly good adhesion to
skin.
Example 11
40 grams of glycerine and 30 grams of gelatin
were placed in a glass jar and heated at 110C in
an oven for 2 hours, stirring the contents every 15
minutes. At the end of the curing cycle a thick
viscous mass resulted. Part of this glycerine/
gelatin adhesive composition was blended with
about the same weight of a mixture of equal parts
of Levapren L452 and Levapren KH 8160 and
moulded in an open dished mould at 120C to
produce an ostomy sealing ring or washer.
Example 12
The process of Example 11 was followed except
that instead of 30 grams of gelatin 35 grams of
gum Tragacanth was used.
Example 13
The procedure of Example 11 was followed
except that instead of 30 grams of gelatin, there
was substituted a mixture of 27 grams of gum
acacia and 2 grams of Madurit 5458 (a melamine
resin manufactured by Hoechst of Germany).
Example 14
The procedure of Example 13 was repeated first
with 2 grams of citric acid substituted for the
Madurit 5458 and second with 2 grams of glyoxal
obtained from BDH Chemicals Ltd. substituted for
the Madurit 5458. The products resulting were
found superior in each case to those of Example

13 in being less likely to induce sensitivity in skin.


Pressure-sensitive plasters produced in accordance with this invention are useful in the management of colostomies and ileostomies. We have
found that the specific plasters described adhere
firmly and for extended period of time to moist
human body surfaces. Unlike conventional
pressure-sensitive plasters comprising an adhesive based on rubber-resin mixture, our plasters
will adhere firmly over long periods of time. They
are soft and pliable, conform to the contours of
the body surface and do not peel or detach even
from moist skin during the normal activities of the
person wearing them. Indeed moisture seems to
assist adhesion.
Articles having inherent pressure-sensitive
characteristics can readily be moulded in a variety
of shapes and configurations by following our
techniques. The specific examples given are not
intended to be limiting.
Protective plasters and dressings and ostomy
rings and washers produced in accordance with
the present invention possess one notable advantage as compared with those ostomy rings,
washers, and plasters of which we are aware and
which are on general use in the United Kingdom
at the date of this Application: namely, our plasters, dressings, rings and washers are markedly
less liable to y-radiation embrittlement or softening and so can readily be sterilized by subjection
to y-radiation.
When rings or washers in accordance with this
invention are to be used in ostomy appliances, a
base such as aluminium hydroxide may be added
to the blend prior to moulding to neutralize acid
present in the drainage into the appliance.

1. A article of manufacture, having adhesive


properties, and comprising a plastics matrix in
which is dispersed from 30 to 55 per cent by
weight of a gelatinous adhesive composition
comprising the product resulting from heating
together for an extended period at a temperature
of 80C or more, and in the absence of added
solvent:
(a) one or more polyhydric alcohols (without
any other functional groups), and
(b) gelatin, and/or a naturally occurring high
molecular weight polysaccharide gum, and/or a
resin which is a copolymer of a vinyl ether and an
organic acid anhydride and/or its corresponding
free acid,
so as to promote chemical reaction between
components (a) and (b) to form esters.
2. An article according to Claim 1, wherein the
one or more naturally occurring high molecular
weight polysaccharide gums comprise gum
Karaya and/or gum Tragacanth and/or gum
Arabic (gum Acacia).
3. An article according to Claim 1 or Claim 2,
wherein the one or more polyhydric alcohols are
selected from glycerol, sorbitol, pentaerythritol
and polyvinylalcohol.

4. An article according to any preceding Claim


wherein the said copolymer resin comprises a
copolymer of a methyl vinyl ester and maleic
anhydride or its free acid.
5. An article according to any preceding Claim
wherein the physical characteristics of the said
article including tack, plasticity, cohesive strength
and moisture absorbency are modified by the
incorporation into said article of one or more
viscosity modifiers and/or tack modifiers and/or
fillers and/or crosslinking agents and/or antimicrobial agents and/or plasticisers.
6. An article according to Claim 5, wherein
micronised silica is present as a viscosity modifier.
7. An article according to Claim 5, wherein polyvinylpyrrolidone resin is present as a tack modifier.
8. An article according to Claim 5, wherein
glyoxal and/or citric acid and/or melamine resin is
present as a crosslinking agent.
9. An article according to Claim 5, wherein
paraffin oil is present as a plasticiser.
10. An article according to any preceding Claim,
wherein the gelatinous adhesive composition is
formed in situ in the plastics matrix.
11. An article according to any preceding Claim,
wherein the plastics matrix material is selected
from elastic binder plastics materials which are
compatible with skin tissues.
12. An article according to Claim 11, wherein at
least the major part of the plastics matrix material
comprises one or more copolymers of ethylene
and vinyl acetate.
13. An article according to Claims 11 or 12,
wherein the plastics matrix material includes
polyisobutylene.
14. An article according to any preceding Claim
when moulded to form a component of a surgical
appliance or the like.
15. An article of manufacture according to any
of Claims 1 to 13 moulded to form an ostomy ring
or washer.
16. A plaster or protective dressing consisting
of an article of manufacture according to any of
Claims 1 to 13 which has been pressed to a thin
adhesive sheet in an hydraulic press and then cut
into required shapes.
17. A plaster or protective dressing according to
Claim 16 provided with a backing sheet in the
form of a thin water impermeable plastics film, for
example of polyethylene.

1. Un article manufactur, ayant des proprits


adhsives, caractris en ce qu'il comprend une
matrice en matire plastique dans laquelle sont
disperss de 30 55% en poids d'une composition adhsive glatineuse comprenant le produit obtenu en chauffant ensemble pendant une
dure prolonge une temprature de 80C ou
plus, et en l'absence de solvant:
(a) un ou plusieurs polyalcools (sans autres
groupes fonctionnels), et

(b) de la glatine, et/ou une gomme naturelle de


polysaccharide de poids molculaire lev, et/ou
une rsine qui est un copolymre d'un ther
vinylique et d'un anhydride d'acide organique et/
ou son acide libre correspondant,
afin de provoquer une raction chimique entre les
composants (a) et (b) pour former des esters.
2. Un article selon la revendication 1, caractris en ce que la ou les gommes naturelles de
polysaccharides de poids molculaire lev comprennent la gomme karaya et/ou la gomme adragante et/ou la gomme arabique (gomme acacia).
3. Un article selon la revendication 1 ou la
revendication 2, caractris en ce que le ou les
polyalcools sont choisis parmi le glycrol, le
sorbitol, le pentarythritol et l'alcool polyvinylique.
4. Un article selon l'une quelconque des revendications prcdentes, caractris en ce que ladite rsine copolymre comprend un copolymre
d'un ther vinylmthylique et d'anhydride
malique ou son acide libre.
5. Un article selon l'une quelconque des revendications prcdentes, caractris en ce que les
caractristiques physiques dudit article comprenant l'adhsivit, la plasticit, la force de
cohsion, le pouvoir d'absorption de l'humidit
sont modifies par l'incorporation dans ledit article d'un ou plusieurs modificateurs de viscosit
et/ou de modificateurs d'adhsivit et/ou de
charges et/ou d'agents rticulants et/ou d'agents
bactricides et/ou de plastifiants.
6. Un article selon la revendication 5, caractris en ce qu'il contient de la silice micronise
comme modificateur de viscosit.
7. Un article selon la revendication 5, caractris en ce qu'il contient de la rsine de polyvinylpyrrolidone comme modificateur de l'adhsivit.
8. Un article selon la revendication 5, caractris en ce que le glyoxal et/ou l'acide citrique et/
ou la rsine de mlamine est prsent comme
agent rticulant.
9. Un article selon la revendication 5, caractris en ce qu'il contient de l'huile de paraffine
comme plastifiant.
10. Un article selon l'une quelconque des revendications prcdentes, caractris en ce que la
composition adhsive glatineuse est forme in
situ dans la matrice en matire plastique.
11. Un article selon lune quelconque des revendications prcdentes, caractris en ce que la
matire plastique de la matrice est choisie parmi
des matrires plastiques liantes lastiques qui
sont compatibles avec les tissus de la peau.
12. Un article selon la revendication 11, caractris en ce que la partie principale au moins de la
matire plastique de la matrice comprend un ou
plusieurs copolymres de l'thylne et de l'actate de vinyle.
13. Un article selon la revendication 11 ou 12,
caractris en ce que la matire plastique de la
matrice comprend du polyisobutylne.
14. Un article selon l'une quelconque des revendications prcdentes, caractris en ce qu'il est

moul pour donner un composant d'un dispositif


chirurgical ou similaire.
15. Un article manufactur selon l'une quelconque des revendications 1 13, caractris en
ce qu'il est moul pour donner un anneau ou une
rondelle pour anus artificiel.
16. Un empltre ou un pansement de protection
compos d'un article manufactur selon l'une
quelconque des revendications 1 13, caractris
en ce qu'il a t press dans une presse hydraulique en une feuille adhsive fine puis dcoup
selon les formes requises.
17. Un empltre ou un pansement de protection
selon la revendication 16, caractris en ce qu'il
prsente une feuille de renfort de la forme d'un
film mince en matire plastique impermable
l'eau, par exemple le polythylne.

1. Herstellungsartikel, der Klebeeigenschaften


aufweist und eine Kunststoffmatrix besitzt, in
welcher eine gelatinse Klebemischung zu 3 0 - 5 5
Gew.-% verteilt vorliegt, die durch Erhitzen ber
eine lngere Zeit bei einer Temperatur von 80C
oder mehr und in Abwesenheit eines Lsungsmittels gebildet wird aus:
a) einem oder mehreren Polyalkoholen (ohne
weitere funktionelle Gruppen) und
b) Gelatine und/oder einem natrlich vorkommenden, hochmolekularen PolysaccharidKlebstoff und/oder einem Copolymerisat
gebildet aus einem Vinylether, einem organischen
und/oder
der korSureanhydrid
respondierenden freien Sure,
um so die chemische Reaktion zwischen den
Komponenten (a) und (b) zur Bildung von Estern
zu frdern.
2. Herstellungsartikel nach Anspruch 1, bei dem
der oder die natrlich vorkommenden, hochmolekularen Polysaccharid-Klebstoffe aus Gummi Karaya und/oder Gummi Tragacanth und/oder
Gummi Arabicum (Gummi Acacia) bestehen.
3. Herstellungsartikel nach Anspruch 1 oder 2,
bei dem der oder die Polyalkohole aus Glycerin,
Sorbit, Pentaerythrit und Polyvinylalkohol ausgewhlt sind.
4. Herstellungsartikel nach einem der vorangegangenen Ansprche, bei dem das Copolymerisat
ein Copolymer eines Methyl-Vinylesters mit
Maleinsureanhydrid oder ihrer freien Sure ist.
5. Herstellungsartikel nach einem der vorangegangenen Ansprche, bei dem die physikalischen
Eigenschaften dieses Artikels einschlielich Haftkraft, Plastizitt, Kohsionskraft und Feuchtigkeitsabsorptionsvermgen modifiziert sind durch
Einbau von ein oder mehreren Viskosittsnderungsmitteln und/oder Haftkraftnderungsmitteln und/oder Fllmitteln und/oder Vernetzungsmitteln und/oder antimikrobielle Zustze
und/oder Weichmacher.
6. Herstellungsartikel nach Anspruch 5, bei dem
mikronisiertes
Siliziumoxid
als Viskosittsnderungsmittel vorhanden ist.
7. Herstellungsartikel nach Anspruch 5, bei dem

Polyvinyl-Pyrroeidonharz als Haftkraftnderungsmittel vorhanden ist.


8. Herstellungsartikel nach Anspruch 5, bei dem
Zitronensure
und/oder
und/oder
Glyoxal
Melaminharz als Vernetzungsmittel vorhanden
ist.
9. Herstellungsartikel nach Anspruch 5, bei dem
Paraffinl als Weichmacher vorhanden ist.
10. Herstellungsartikelnach einem der vorhergehenden Ansprche, bei dem die gelatinse
Klebemischung in der Kunststoffmatrix in situ
gebildet wird.
11. Herstellungsartikel nach einem der vorhergehenden Ansprche, bei dem das Material der
Kunststoffmatrix aus einem elastischen Binderkunststoff besteht, der hautvertrglich ist.
12. Herstellungsartikel nach Anspruch 11, bei
dem zumindest der grere Teil des Kunststoffmatrixmaterials aus ein oder mehreren Copolymeren von Ethylen und Vinylacetat besteht.

13. Herstellungsartikel nach Anspruch 11 oder


12, bei dem das Kunststoffmatrixmaterial Polyisobytylen mitenthlt.
14. Herstellungsartikel nach einem der vorhergehenden Ansprche, der im geformten Zustand
einen Teil eines chirurgischen Hilfsmittels oder
dergleichen bildet.
15. Herstellungsartikelnach einem der Ansprche 1 bis 13, geformt als Ring oder Dichtungsscheibe fr eine knstliche Krperffnung.
16. Plastische Masse oder Schutzausrstung,
bestehend aus einem Herstellungsartikel nach
einem der Ansprche 1 bis 13, welcher in einer
hydraulischen Presse zu einer dnnen Klebeschicht verpret und danach in die gewnschte
Form geschnitten ist.
17. Plastische Masse oder Schutzausrstung
nach Anspruch 16, welche mit einer Unterlage in
Form eines dnnen, wasserundurchlssigen
Kunststoffilms, z.B. aus Polyethylen, versehen ist.