UNeMed Corporation 2013 Annual Report

ces Software Research Tools Therapeutics Diagnostics Medical Devices Software Research Too
tartup Technology Transfer Consulting Licensing Patent Protection Material Transfer Intellectual P
Annual Report | FY 2013
UNeMed improves healthcare by fostering innovation, advancing

biomedical research and engaging entrepreneurs and industry to
commercialize novel technologies.
Cover: In 2006, Doctors Dmitry Oleynikov and Shane Farritor developed mini surgical robots that decrease the
size of surgical incisions. The robotic surgical device enters a patients body using a single incision, which should
be much less invasive than traditional surgery
meaning shorter recovery time for patients and reduced-cost
hospital stays. The patented technology is licensed to Virtual Incision (see page 7), a startup company that has
attracted more than $3 million in private investments so far.
(Photo: University of Nebraska-Lincoln Office of Research)
Contents
Watch the UNeMed video here:
Message from the President & CEO

About UNeMed
Facilities
Staff & Board of Directors
Startups
Innovation Week
Education
Outreach
Malaria cure goes global
UNeMed Metrics
New Additions
Featured Technologies
10
11
15
16
Annual Report | 2013
From the President & CEO
Michael Dixon, Ph.D.

President and CEO
It gives me great pleasure to present the UNeMed 2013

Annual Report.
As the technology development and commercialization entity for the University of Nebraska Medical Center
(UNMC), UNeMed Corporation is focused on improving
healthcare by fostering innovation, advancing biomedical
research and engaging entrepreneurs and industry to commercialize novel technologies.
UNeMed was established in 1991 and has amassed a
diverse portfolio of intellectual property that represents
significant advances in biomedical and clinical technology
areas such as therapeutics, diagnostics, medical devices,
research tools and software. However, UNeMed is more
than a technology portfolio. We are a diverse staff with
significant expertise in science, business and law. Our
teaming approach allows us to offer both researchers and
industrial partners unique solutions to complex problems.
As a testament to UNMCs commitment to the development and translation of research into biomedical products,
UNMC consolidated all technology transfer activities into
UNeMed in 2007 along with substantial financial support
which has sparked significant growth in all of our major
metrics.
Biomedical and translational research at UNMC doubled in the last decade. Last year, research spending at
UNMC grew to more than $140 million, generating 66 new
innovations. UNeMed evaluated each invention for patent
and market potential, and worked with inventors to secure
appropriate U.S. and international patent applications.
Through our significant network of marketing contacts, we
ran international marketing campaigns for each technology to help identify the right commercial partners. We
signed a record number of license and option agreements
(22), including four startup companies and three international agreements. Out-licensing, co-research, and/or new
company creation were just a few of the many methods we
employed to encourage development, and ultimately the
sale of new biomedical products based on our technology.
Revenue from these activities is used to fund additional
translational research at UNMC.
As part of our community outreach, UNeMed has also
designed programs to work with the local community of inventors, as well as regional colleges and hospitals, including the Eastern Nebraska and Western Iowas Veterans Administration Hospital and Roosevelt University in Chicago.
We firmly believe the development of new innovations
is essential to our state and national economy, and UNeMed is deeply committed to accelerating economic growth
through creativity and entrepreneurship. We are enthusiastic to connect our research expertise and technology with
the needs of industry, and help advance healthcare while
further developing our economy.
These are the collaborations and partnerships that will
change the world.
Return to Table of Contents

UNeMed
From bench to bedside
UNeMed serves the faculty, staff,
and students at the University of Nebraska Medical Center and helps
them identify problems and develop solutions that promote the general health and welfare of the state.
Whether those solutions are new
drug candidates, medical devices, or
methods for treating diseases, all innovations are evaluated for their scientific and commercial potential by
UNeMeds experienced group of staff,
postdocs and interns.
UNMC employees first disclose
their innovative solutions to UNeMed,
which then works to identify and
MISSION
UNeMed improves healthcare by fostering innovation,

advancing biomedical research and engaging entrepreneurs and industry to commercialize novel technologies.
collaborate with nonuniversity commercial

partners to fully develop
those innovations into
market-ready products
and solutions that improve public health.
These technologies
can be further developed
through
established UNeMed Corporations core function as a technology transfer office
companies, or used as is to help make research and innovation developed at the University
the basis of a new com- of Nebraska Medical Center accessible and available to benefit the
general public.
pany that leads to a robust startup community
for the local economy. This development is supported through various
n Innovative Vision
university, state and federal funding
n Integrity and Stewardship
n Excellence
programs, in addition to private inn Dedication
vestment and research sponsorship.
Throughout the process, UNeMed
works to facilitate the exchange of
information, rights, and assets to imn World-class technology
prove the health of all Nebraskans.
commercialization entity
In the beginning
In 1991 the Board of Regents of the University of Nebraska saw that innovation and discovery needed help
going beyond academic journals and into the hands of
people who could benefit most.
In a move to protect and commercialize world-class
intellectual property created at the University of Nebraska Medical Center, the Regents established UNeMed
Corporation as the licensing arm for UNMC technology.
As a for-profit corporation, UNeMed also administered
other commercial and research contracts for UNMC. The
VALUES
VISION
n Best service to faculty

n Recognized by community as
an entrepreneurial resource
n Help build a strong biomedical
ecosystem in Nebraska
job of evaluating
and managing
new inventions
fell to the Intellectual Property Office.
UNeMed eventually absorbed the Intellectual Property Office in a 2007 restructuring. The restructuring folded
UNeMed into UNMCs research division under the Vice
Chancellor for Research, creating UNeMed as it exists
today a world-leading technology transfer office that
springboards Nebraska innovation from the research
bench to patients bedsides.
The mission today goes far beyond the modest beginnings 22 years ago.
UNeMed has since established itself as a national
leader among technology transfer offices, reaching far
above and beyond the traditional role of licensing technologies and filing patent applications.
UNeMeds progressive approach is infused with an entrepreneurial spirit that places the office at center stage as
a major player in the startup, consulting, and conferencing
communities.
Playing that role is made easier with a partner like
UNMC, which has undergone a transformative period of
growth that has firmly placed a large star over Omaha on
the biomedical research map.
Facilities
Innovation happens here

UNeMeds corporate headquarters in Omaha sits in the northwest corner of the University of Nebraska Medical Center campus
and its world-class research facilities.
In the last 10 years, UNMC has committed more than $670 million toward building new or upgrading to state-of-the-art facilities
that have brought in world leading researchers in fields such as
cancer, drug delivery, nanomedicine, and infectious diseases.
Heres a closer look at some of the more recent facility additions, and a few that are still on the horizon for the near future:
Fred & Pamela Buffett Cancer Center

On May 7, 2013, UNMC broke ground on the Fred
& Pamela Buffet Cancer Center, a $323 million building
project the largest project in the 144-year history of
the University of Nebraska. The facility is expected to
fully plant UNMCs cancer research as the clear leader
in the region and among the national elite.
Projected for completion in 2016, the building will be
divided into 252,000 square feet of research facilities
and 325,000 square feet for a clinical outpatient treatment facility and a 108-bed inpatient hospital. Nearly
100 labs will be dedicated to researching a multitude
of cancers, including breast, brain, pancreatic, prostate
and lung cancers.
UNMC Rendering
Durham Research Center

Fully completed in 2009, the Durham Research Center
is an imposing two-tower facility with half-a-million square
feet and more than 200 lab facilities. Researchers in these
two buildings alone brought in h$177.2 million in research
funding in 2009.
UNMC Photo
Stanley M. Truhlsen Eye Institute

UNMC joined the ranks of elite eye research and care centers such
as those at Johns Hopkins Hospital and Harvard Medical School with
the grand opening of the Stanley M. Truhlsen Eye Institute on May 22,
2013. The $20-million facility features the Ocular Imaging Research
and Reading Center and the Center for Innovative Clinical Trials in Ophthalmology. There are already plans for future expansion with the expected addition of a surgical wing.
UNMC Photo
Lozier Center for Pharmacy Sciences and

Education and Center for Drug Discovery
UNMC Rendering
With construction set to begin in early 2014, the new College of Pharmacy building will house laboratory and research
support space with an emphasis on infectious diseases and
dedicated to three key areas: drug discovery and development, drug delivery, and clinical and translational research.
Completion of the $35 million construction project is expected in 2015.
RESEARCH CENTERS
n Center for Advanced Surgical
Technology
n Center for Biopreparedness
Education
n Center for Clinical and
Translational Research
n Center for Collaboration on
Research Design and Analysis
n Center for Drug Delivery and
Nanomedicine
n Center for Environmental Health
and Toxicology
n Center for Health Services
Research
n Center for Humanities, Ethics and
Society
n Center for Neurodegenerative
Disorders
n Center for Research in Leukemia
and Lymphoma
n Eppley Cancer Center
n Center for Integrative and
Translational Neuroscience
n Nebraska Center for Cellular
Signaling
n Center for Staphylococcal
Research
MAJOR PROGRAMS
n Gastrointestinal Cancer (SPORE)
n Mass Spectrometry in Clinical
Diagnosis of Nerve Agent
Exposure
n The Molecular Biology of
Neurosensory Systems (COBRE)
n Nebraska Center for Cellular
Signaling
n Nebraska Center for
Nanomedicine
n Nebraska Research Network in
Functional Genomics (INBRE)
n Nebraska Regenerative Medicine
Project
n Neural Immunity in HIV Dementia
n Proteomic Strategies for AIDS and
Drug Abuse - HIV and METH
CNS Synergy
n Staphylococcal Biofilm and
Disease
n Chronic HIV Infection and Aging in
NeuroAIDS (CHAIN) Center
People
UNeMed Staff
Michael Dixon
President & CEO
Ph.D., Pathology and Microbiology,

University of Nebraska Medical Center
Joined UNeMed: 2003
Joe Runge
Director of Business Development
M.S., Molecular Biology, University

of Iowa
J.D., Intellectual Property Law,
University of Iowa
Joined UNeMed: 2005
Cori Harsh
Finance Manager
Joined UNeMed: 2009
BOARD OF DIRECTORS
Donald Leuenberger
Chair
Vice Chancellor for Business and
Finance
University of Nebraska Medical
Center
Michael Dixon, Ph.D.
President & Chief Executive Officer
UNeMed Corporation
Richard Spellman, Esq.
General Counsel for Healthcare
University of Nebraska Medical
Center
Mike Pallesen
Board Secretary and General
Counsel
Cline Williams, Wright, Johnson &
Oldfather
Steve Schreiner
Vice President & Director of
Licensing and Marketing
Ph.D., Pathology and Microbiology,

University of Nebraska Medical Center
M.A., Microbiology, University of
Nebraska Omaha
Joined UNeMed: 2006
Matthew Boehm
Senior Licensing Specialist
Jason T. Nickla
Vice President & Director of
Intellectual Property
J.D., Law, Creighton University

School of Law
LL.M., International Intellectual Property Law, Chicago-Kent College of Law
Joined UNeMed: 2009
Jack Mayfield
Contracts Manager
Ph.D., Cancer Biology, University of

Nebraska Medical Center
Joined UNeMed: 2009
J.D., Law, University of Tennessee

M.S., Education-Instructional Media,
Kansas State University
Joined UNeMed: 2012
Valerie Gunderson
Office Manager
Mindy Ware
Patent Associate
Joined UNeMed: 2007
Charlie Litton
Communications Associate
Joined UNeMed: 2013
Qian Zhang
Licensing Associate
Ph.D., Cancer Biology, University of

Joined UNeMed: 2011
Caronda Moore
Licensing Associate
Ph.D., Medial Science, University of

Joined UNeMed: 2013
Deepak Madhaven
Physician in Residence
M.D., University of Nebraska Medical Center

Joined UNeMed: 2013
Joined UNeMed: 2010
Gary L. Madsen
Entrepreneur in Residence
Ph.D., Medical Microbiology, Creighton University School of Medicine

M.S., Medical Microbiology, Creighton University School of Medicine
Joined UNeMed: 2012
Agnes Lenagh
Licensing Associate
Ph.D., Pharmacology and Experimental Science, University of Nebraska

Medical Center
Joined UNeMed: 2012
Anne Rivas
Office Associate
Joined UNeMed: 2013
Jack A. Hartwigsen
Senior Licensing Consultant
Ph.D., Molecular Biology, Iowa St. Univ.

M.S., Molecular Biology, Iowa St. Univ.
M.B.A., Finance, University of Iowa
Joined UNeMed: 2006
Activities
Featured startups built in FY 2013
Radux Devices, LLC
Startups
Many inventions disclosed to UNeMed are at an
extremely early stage of development, and often industry
partners require additional
research data before entering into formal relationships.
In such a circumstance, new
corporate entities are often
the most appropriate avenue
for product development.
UNeMed works with
entrepreneurs, investors and
consultants to form new companies around disclosed technologies. UNeMed nurtures
these companies identifying
early investors, grant opportunities and potential leaders
while often taking an equity
stake in the business.
In fiscal year 2013, UNeMed helped establish four
new startup companies, including Bohe Biotech, a new
company in China that plans
to develop a UNMC technology that could make things
like mouthwash and toothpaste provide fresh breath all
day long.
Other companies formed
in 2013 are Radux Devices,
LLC, ProTransit Nanotherapy,
LLC, and Trak Surgical, Inc.
(See related story.)
Founded by UNMC interventional radiologist Dr. Greg

Gordon, Radux Devices, LLC
was created in 2012 to develop
two of Dr. Gordons inventions.
Both inventions improve radiation protection and decrease
orthopedic stress for physicians, while also improving
work-flow and operating table
management in endovascular/fluoroscopy suites. Radux
was recently awarded two
Nebraska Department of Economic Development grants for
developing and testing prototypes.
ProTransit
Nanotherapy, LLC
Photo by Jack Mayfield
Gary Madsen (left) and UNeMed president Michael Dixon sign on June 12, 2013,
the licensing agreement that made ProTransit Nanotherapy, LLC a reality. ProTransit
will use technology developed at UNMC to make things like sunscreen more effective barriers against skin cancer.
UNeMeds
entrepreneur
in residence, Gary Madsen,
Ph.D., built ProTransit Nanotherapy, LLC, on a drug delivery nanoparticle developed at the University
of Nebraska Medical Center. ProTransit Nanotherapy will begin operations by perfecting
a targeted system that will deliver powerful
antioxidants to subcutaneous tissue beneath
the skin. The encapsulated antioxidants could
then be added to existing products such as
sunscreen and cosmetics, and improve their
abilities to prevent skin cancer and wrinkles.
Future possible products from this platform
technology include treating cancer and symptoms of stroke.
Trak Surgical, Inc.

Hani Haider, Ph.D., and his team developed
a potentially transformative medical device
and software that could change the way joint replacement surgeries are performed. The device
is a next-generation handheld surgical tool that
uses software and a guidance system that may
completely eliminate the need for expensive jigs
and the specialized staff necessary for current
orthopedic surgeries. Dr. Haider, a mechanical
engineer, founded Trak Surgical Inc., which received a $500,000 matching capital investment
from Invest Nebraska in March 2013.
New startups based on UNMC innovation

6
5
4

6
Activities
Where are they now?
Vireo Resources
Vireo Systems, a Tennessee-based

nutritional supplement manufacturer,
expanded operations to the Omaha
area in 2009.
Vireo
Systems created the
subsidiary Vireo
Resources
in
Plattsmouth, Neb., so it could be closer
to UNMC, the source of its most successful and popular products. In September 2012, Vireo Resources growth
and success continued with expansion into a $1 million facility. UNMC
innovations in the Vireo product line
include Con-Cret, the best selling
creatine HCL product in the country;
AminoActv, a top anti-inflammatory
and painkiller alternative to ibuprofen
and naproxen; and Rejuvenate Plus
an anti-inflammatory product for pets
with joint ailments.
Virtual Incision Corp.
UNeMed Seminars
80
70
60
50
42
37
10
47
30
20
64
40
23
Established in 2002, Prommune

Inc., recently took an option to a patent application covering the use of a
synthetic protein, EP67, to treat microbial infections. Prommune will
initially focus on the development of
EP67 for the animal health market,
and has received $100,000 from the
State of Nebraska to investigate its
use for bacterial infections in pigs.
Prommune was one of 15 companies
selected to present its business plan
at the KC Animal Health Investment
forum in Kansas City, Mo., on Aug. 27,
2013.
developed a new technology, secured

a patent or produced a technology that
resulted in a licensing agreement for
further development.
At the 2012 ceremony, UNeMed presented two major awards, the Most
Promising New Invention and Emerging
Inventor Awards.
Tammy
Kielian,
Ph.D., earned the 2012
emerging
inventor
award for her work
with Staphylococcus
aureus, device-related
biofilms and neurodegenerative diseases in
Dr. Kielian
children.
Gregory Oakley,
Ph.D., earned the 2012
Most Promising New
Invention award for
research that could
lead to greater understanding of damaged
DNA and how it might
be better targeted for
Dr. Oakley
new therapeutic treatments.
UNMC Photo
Prommune Inc.
Every fall, UNeMed sponsors Innovation Week, a popular series of events

that honor innovators at UNMC, and
helps educate and inform faculty, staff,
and students.
In addition to an awards ceremony,
Innovation Week also raises awareness
about technology transfer relevant subjects, including intellectual property,
sponsored research opportunities, collaborating with industry partners, and
research funding opportunities.
The week begins with an open
house, where UNMC employees can
register for giveaways, take home UNeMed T-shirts, Koozies, pens and other
items, and meet with UNeMed staff
all while enjoying a free smoothie or
latte. Various events occur throughout
the rest of the week, including seminars
and workshops presented by both local
and national experts.
The week culminates when more
than 300 people turn out from the wider
Omaha-Lincoln metro area for the Innovation Awards ceremony and reception. The ceremony honors innovators
from the previous fiscal year who have
UNMC Photo
Founded in
2006, Virtual Incision Corp. is
the product of
surgical devices developed at UNL and UNMC. The
company has attracted more than $3
million in private investments, most
recently a $500,000 match from Invest
Nebraska in January 2013. Virtual Incision is developing a product line
of surgical robots including those
depicted on the cover that are expected to make surgical procedures
safer, cheaper and less invasive.
Innovation Week
Activities
Education
Academic research institutions are charged with missions
concerning not only the pursuit
of knowledge through research,
but also with the education of students in areas such as scientific
disciplines and the management
of ideas, money and time so they
may be successful in their future
careers. Many of those careers
will impact public sector areas
such as economic growth and
public health, so the education of
campus investigators in the effects
of developing, marketing, and
transferring novel technologies to
the market falls within UNeMeds
core mission.
Campus education provides
investigators with the knowledge
to contact UNeMed when initial
discoveries are made; and ensures that the University has the
best chance of developing and
successfully licensing a technology that leads to significant and
sustained revenue.
To aid in the education of the
campus community, UNeMed
engages in different types of outreach programs, including those
that aim to educate the campus
in general, and specific programs
focusing on individuals who show
an interest for a career in transferring technologies to the commercial sector. UNeMeds postdoc and intern programs serve to
educate individuals, while open
seminars and UNeMeds Innovation Week activities provide general exposure and education to
all campus personnel.
Through these efforts, UNeMed
seeks to create a culture of innovation, where all UNMC faculty, staff, and students are both
knowledgeable and conscious
of the possibilities of developing
and transferring valuable technologies from UNMC to the private sector.
Win-Win
UNeMed grows with postdocs, interns

There are few opto entertain the ideas,
portunities for stuand see how you can
dents to gain crosshelp the office grow
functional training
at different levels,
and experience in
Dr. Lenagh said.
areas such as sciQian Zhang, anence, law, and marother current postketing critical
doc licensing fellow
functions in technolat UNeMed, is also
ogy transfer, a highfluent in Chinese. A
ly multidisciplinary
cancer biology Ph.D.,
profession that enshe has spent part
compasses technolof her postdoc trainogy evaluation, pating helping UNeMed
ent law, licensing,
broaden its scope to
marketing, contract
include partnerships
Photo by Matt Miller
negotiation, contract UNeMed president and CEO Michael Dixon (left) and in the booming Chienforcement, busi- Bohe Biotech founder Wang Jiang sign a technology nese market.
ness development, licensing agreement earlier this year as Qian Zhang
Its a great oplooks on. Zhang, a UNeMed postdoc, played a critical portunity since Chiand many others.
UNeMeds intern- role to help close the deal.
na is emphasizing so
ship and postdoctormuch on biotech and
al fellowship training programs provide innovation, Dr. Zhang said.
qualified candidates with opportunities to
Since 2007, UNeMed has employed 39
gain exceptional experience in these func- interns from backgrounds such as science,
tions while in a highly collaborative and engineering, systems integration, marketentrepreneurial environment.
ing, law, finance, and business. Interns
Not only have these programs benefit- work closely with experienced staff and
ed students and young professionals, but are typically assigned projects related to
their insights, expertise and perspectives their educational backgrounds while also
have also contributed significantly to op- seeing the whole picture of how technolerations at UNeMed. These programs have ogy transfer works.
also been a means for attracting and trainUNeMed has had seven postdoctoral liing exceptional UNeMed staff.
censing fellows since the program started
Dr. Matthew Boehm, senior licensing in 2008, and six began as an intern, includspecialist at UNeMed, began his career as ing Dr. Lenagh.
an intern before moving up to a postdoc
It was good to work with different
and finally his current position.
people in the office and see the whole proAs postdoctoral fellows, their primary cess, she said.
duty is to use their expertise as technolThis open and collaborative nature of
ogy licensing associates, which involves UNeMed also allows interns to contribute
technology evaluation, marketing, and to various other projects and explore areas
licensing. But postdocs have served mul- outside their expertise to further expand
tiple added functions at UNeMed includ- their horizons and gain a better undering blog writing, website development, standing of where they want their careers
various legal functions, and business de- to go.
velopment.
Agnes Lenagh, a pharmacology and experimental neuroscience Ph.D., joined UNeMed in 2012 as an intern and now serves
Postdoctoral Research Associates since the program began in 2008.
as postdoc licensing fellow. In addition to
n Tara Scrogin, J.D., 2008
typical marketing and licensing work, she
n Russell Nelsen, J.D., 2009-2010
is also using her past experience in web
n Matt Boehm, Ph.D., 2009-2010
development to revamp the UNeMed webn William Hadley, J.D., 2011-2013
n Qian Zhang, Ph.D., 2011-current
site into a much more effective and usern Agnes Lenagh, Ph.D., 2012-current
friendly interface for researchers, industry
n Caronda Moore, Ph.D., 2013-current
partners, and the general public.
If you have other skills, they are willing
Postdoctoral Program
Activities
Services
Sizzling steaks drew a steady stream of vistors to Nebraskas booth during the
international BIO conference in Chicago. UNeMed representatives used the oppotunity to build new relationships in the global biomedical community.
World meets Nebraska at BIO

UNeMed joined 13,594 biomedical industry leaders from 62 countries for the massive,
weeklong BIO conference in Chicago. UNeMed staff that attended the international
conference used the opportunity to interact
face-to-face with potential industry partners
while showcasing the world-class research
at the University of Nebraska Medical Center. Among the more valuable features at BIO
2103 was the business-partnering program
that gave UNeMed access to more than 2,800
participating companies. UNeMed scheduled
many partnering meetings during the convention, which generated no less than 19 new opportunities.
Consulting services
offered at Roosevelt University
UNeMed uses existing personnel and capabilities to provide outside institutions with
invention evaluations, market potential analysis, intellectual property landscape analysis,
and marketing efforts, if applicable.
Most recently, UNeMed has worked with
Roosevelt University, a sprawling campus
of 6,343 students in downtown Chicago and
nearby Schaumburg, Ill. UNeMed will serve
as Roosevelts back office for technology
transfer, helping them establish intellectual
property policy and procedures, evaluate new
inventions and establish and pursue a marketing plan to discover industry partners.
UNeMed leads Intersect 2013
Ben Yoskovtiz (left), author of Lean Analytics and a featured

speaker at Intersect 2013, meets with a conference goer during
a short break at the all-day event.
UNeMed assumed a leadership role for

Intersect 2013, one of the largest entrepreneur
networking conferences in the state.
UNeMed personnel helped plan the conference, aligned financial sponsors, produced
promotional materials, issued press releases,
built a new website, managed social media
interactions and volunteered as conference
staff on the day of the event.
With more than two dozen speakers, many
of them highly regarded in the national startup community, Intersect 2013 proved to be a
valuable experience to the nearly 400 people
who attended.
As a regional leader
in technology transfer, UNeMed is establishing itself as
more than a mere extension
of the University of Nebraska
Medical Center.
In addition to consulting
services for smaller institutions, UNeMed also expends
a fair amount of energy
building and maintaining its
reputation as a valuable resource within the intellectual
property, small business and
biotechnology communities.
UNeMed has executed
agreements with external institutions, takes a leadership
role in the local entrepreneur
and startup community, offers educational seminars
and is a visible member of
the international biotechnology industry.
UNeMeds effectiveness
in these services is largely
due to the make-up of its talented staff and personnel. In
addition to a staff of biomedical and intellectual property
experts, UNeMed has also
added the business and clinical perspective with a physician- and entrepreneur-in-residence. (See page 15.)
Expanding reach
Breakthough malaria
drug will treat millions
n UNMC, UNeMed gift
cutting edge treatment
to developing world
College of Pharmacy.
Dr. Vennerstrom is now working
on improving the already powerful
compound, which now requires malaria sufferers to undergo a threedose regimen over three days.
Currently in Phase II studies, the
improved version could reduce the
number of treatments to one, effectively curing a malady that strikes
200 million people worldwide with a
single pill.
One of UNMCs greatest achievements in recent memory splashed

across international headlines in
July 2012.
In the last days of the fiscal calendar, UNMC announced the approval
of a new breakthrough treatment for
malaria, which kills an
estimated 655,000 people every year.
Before the drug could
be developed into the
life-saving treatment it
is today, UNeMed facilitated the transfer of the
discovery to Medicines
for Malaria Venture,
which is mostly backed
by the Bill and Melinda
Gates Foundation.
The new drug, Synriam, was developed
by Indian firm Ranbaxy
Pharmaceuticals Limited, but was invented
UNMC Photo
by a team researchers Jonathan Vennerstrom, Ph.D., continues to work on his ground-breakled by Jonathan Venner- ing malaria treatment, and hopes to have a one-dose version ready
strom, Ph.D., at UNMCs before the end of fiscal 2014.
Licensing & Sponsored Research Agreements

28
24
2
20
2
16
1
10
19
17
14
22
12
2009
2010
2011
2012
2013
THE WOR
UNeMeds grasp re
In fiscal 2013, UNe
foreign countries.
Australia
Belgium
n Canada
n China
n Czech Republic
n Denmark
n England
n
n
The process: Fro

UNeMed receives an annual average of 78 new
invention disclosures, and evaluates them for scientific and commercial potential.
In fiscal 2013, UNeMed received 66 notices of
new inventions, down from a peak year in 2012,
which saw 106. Despite the lower number, UNeMed
filed 29 United States patent applications, a fiveyear high. And international patent applications
reached an all-time high at 18, eight more than in
the previous year (see graphs.)
For a certain set of these inventions, the appropriate form of intellectual property protection
is established whether its a patent, copyright, or
trademark. The technology is then marketed nationally and across the planet as UNeMed expands
its reach beyond the United States and into foreign
UNeMed Metrics
UNMC Patents
A look at the cumulative number of patents from research
at the University of Nebraska Medical Center.
U.S. Patents...............................345
Pending................................ 228
Foreign Patents.........................157
Pending................................ 90
2013 BY THE NUMBERS
$141.62 million
research expenditures in 2012
$1.46 million
gross revenue
RLD IS FLAT
299material transfer requests
eaches far beyond Nebraskas borders.

eMed pursued opportunities in 21
Finland
France
n Germany
n India
n Ireland
n Israel
n Italy
66
Japan
Malaysia
n North Korea
n Russia
n South Africa
n Spain
n Switzerland
104
confidential disclosure requests

new inventions
educational seminars
22licensing agreements
6sponsored research deals
5U.S. patents issued
4 startup companies formed
3 foreign patents issued
64
om bench to bedside
strongholds such as Europe, China and Japan.
Once UNeMed finds a commercial partner that
can continue to support the development of the
technology, UNeMed negotiates a licensing agreement to ensure that the innovation is developed,
and that UNMC is compensated for its support in
the development of the technology.
Compensation may include licensing fees, equity, running royalties, milestone fees and other
contractual obligations. In the case of Synriam,
the malaria treatment featured on page 10, UNeMed waived compensation to ensure the technology would reach its full potential and benefit those
who need it most.
In addition, commercial partners often continue
to work with UNMC through the use of sponsored
research or collaborative development agreements designed to pursue advanced development

activities by using the expertise found on campus.
UNeMed has historically out-licensed 15-20 technologies annually over recent reporting periods.
Despite the lower number of invention disclosures, UNeMed increased the number of sponsored research agreements threefold in 2013; and
increased the number of licensing aggreements to
22, compared to the 19 agreements signed in 2012.
Other collaborative metrics (Confidental Disclosure Agreements and Material Transfer Agreements) and patent applications all show that UNeMed is actively moving UNMC research toward
the marketplace.
11
UNeMed Metrics
Stretching the research dollar
A strong testament to the amount and quality of research at
the University of Nebraska Medical Center can be seen with a
careful look at data provided by the Association of University
Technology Managers or AUTM. In fact, UNMC is dollar-fordollar one of the most creative and innovative universities in
the nation, if not the world.
In 2012, UNMC accounted for $141.62 million of the $394.74
million the University of Nebraska spent on research. Research
heavyweights such as Johns Hopkins University and Stanford
University spend five to 10 times more on research, yet UNMC
compares favorably across the board when research activities
are viewed in proportion to the amount of money spent. UNMC
leads a group of selected peers and even the national elite
by most measures.
For example, UNMC researchers developed 7.48 new inventions for every $10 million spent in 2012, well beyond the
peer group average of 4.05, and more than double the national
average of 3.56.
Elite schools and other selected notable institutions including Stanford, Johns Hopkins, Harvard, Columbia and most
Big Ten schools reported an average of just 0.16 new inventions for every $10 million spent.
UNMCs trend as a research leader can also be seen by using the same approach to view licensing agreements.
UNeMed helped secure 1.34 licensing deals for every $10
million in research spent, more than five times the national
average (0.24). The peer group averaged 0.94 licensing agreements for every $10 million spent.
How UNMC compares to the peer group average per $10 million in research expenditures in 2008-2012, according to data provided by the Association of University Technology Managers.
New Inventions/$10 million in research (2012)

8
7
6
Selected Peer Group
2011
n
n
n
n
n
n
n
n
n
n
n
n
n
n
4.05
2010
3.67
2009
3.6
2008
4.05
3.92
5.18
4.09
6.11
7.48
7.37
2012
Kansas University
Northwestern University
Ohio State University
Oklahoma University
Oregon Health & Science University
University of Arizona
University of Cincinatti
University of Colorado
University of Florida
University of Illinois (Chicago-Urbana)
University of Iowa
University of Kentucky Research Foundation
University of Tennessee
University of Utah
Licenses/$10 million in research (2012)

1.5
1.2
0.9
2011
.94
1.34
.85
2010
.6
2009
.85
1.23
12
2008
.8
1.13
0.3
.86
1.06
0.6
2012
UNeMed Metrics
UNeMed Licensing Agreements
(1999-2013)
80
70
60
40
20
18
10
19992003
44
30
80
50
Total Revenue in millions

(1999-2013)
$10
million
$9
million
20042008
20092013
$8
million
10.76
$7
million
$6
million
$5
million
New Invention Notifications

(1999-2013)
$4
million
$3
million
400
146
2.75
150
19992003
257
200
20042008
390
250
50
19992003
20042008
$2
million
300
100
1.29
350
$1
million
20092013
20092013
13
UNeMed Metrics
Material Transfer Agreements

(1999-2013)
1,500
1,200
1213
300
0
20092013
500
400
433
880
20042008
600
354
511
19992003
900
Confidential Disclosure Agreements

(1999-2013)
20042008
20092013
300
200
U.S. Patent Applications
146
100
19992003
70
40
50
29
Foreign Patent Applications
13
60
50
18
4 7
17
2009
2010
2011
29
6 6 7
Foreign
Patents Issued
10
Non-Provisional
Patent Applications
21
20
10
Provisional
Patent Applications
5 8
29
12
Patents
Issued
14
30
15
16
10
44
20
8 14 10
26
30
39
40
2012
Patent Cooperation
Treaty Applications
2013
Foreign Patent
Applications
New Additions
Entrepreneur-in-residence
UNeMed has enjoyed the benefits of
an entrepreneur-inresidence since Gary
Madsen, Ph.D., joined
the staff in June 2012.
He was brought in
to help identify promising UNMC technologies that have the
potential to form the
basis of new startup companies.
Dr. Madsen recently signed a one-year
extension, and also established ProTransit Nanotherapy, LLC, a company based on
technology invented at UNMC. (See page 6)
He joined UNeMed following a successful, three-decade career in biotechnology
product and business development. Previously, he worked in several biotech companies in Madison, Wisc., including Gilson,
Third Wave Technologies (Hologic), Promega and EraGen Biosciences. He began
his biotechnology career at Abbott Laboratories, then served as vice president of
research and development at IDEXX Labs
in Westbrook, Maine.
Physician-in-residence
In May 2013, UNeMed created a physician-in-residence position, and signed Deepak
Madhavan, M.D., to the
role.
Dr. Madhavan is
the director of The Nebraska Medical Centers comprehensive
epilepsy program and
an assistant professor at UNMCs Department of Neurological Sciences.
As researchers develop new ideas on
campus, Dr. Madhavan will bring his rare
experience as a businessman and practicing physician to help get those innovations
closer to patient bedsides.
Before joining UNMC, Dr. Madhavan
founded in 2009 a private practice focused
on treating epilepsy, Midwest Regional
Epilepsy Associates. He is also the president of Lifestyle Innovations for Epilepsy,
or LIFE, an Omaha-based nonprofit dedicated to the wellbeing of people living
with epilepsy.
Media specialist joins UNeMed roster

Between FebruUNeMed planned to expand its
staff by redefining a vacant office as- ary and July 2013,
sociate position as a communications more than 50 news
items have apassociate.
As new, cutting edge technology peared in local,
is created, UNeMed is in the unique regional, national
position to help communicate the po- and international
tential of that technology to the world, media that were
UNeMed president and CEO Michael generated from the
Litton
communications
Dixon said.
The new position carries the main associates desk. Most, if not all, meresponsibility of creating and distribut- dia stories also prominently featured
ing information to internal and external UNMC, adding to the universitys alclients, while promoting UNeMed and ready enormous prestige.
Developing an overall communiits marketing and licensing activities.
More specifically, the communica- cations strategy and plan will help
tions associate is expected to create determine the value of these media
press releases of significant events, placements, and is among UNeMeds
develop presentations for entities en- goals for FY 2014.
gaged by UNeMed, and produce an
annual report of UNeMed activities.
MO Building American
MONEY
In addition, the communications
NE
Y Differ
associate position was built to aid the
Vete
enc
e-m
rans
marketing and licensing staff in creatake
r
on fi
rms
ing marketing materials, and any othrada
r
er journalistic materials required.
The communications associate
Insuring
EASIER ON THE JOINTS
long-term
will play a vital role in our office as we
care is a
tough call
work to help publicize the many great
innovations that occur on campus everyday, Dr. Dixon said.
ks
ac
hip
tr
All of these functions were previers
ur
yo
g
artn
in
p
r
ously performed by interns with expeve
esh
Co
a fr
int
rience in these areas.
m
m
UNeMed hired Charlie Litton in
EYChinese fir
N
January 2013 as its first dedicated J
O NMC,
apane
se rm
communications associate. LitU
M
to bac
k UNM
ton recently completed his masC wor
-up
k in b
d
acter
n
ters degree at the University of
y
ia
a
e
IRSoneyes meals,
gh other freebies at tech firms
St utine
M ipt ct t
Nebraska-Lincolns College of After rec
r ffe
c
s
ro
ord h
a
ighs,
Journalism and Mass Communican ances
gas p
fin
rices
slide
cation. He has experience in both
GET FREE
bCHECKING.
ack d
FROM A COMMUNITY
own BANK.
print and broadcast journalism,
with his work appearing in The
Washington Post, ABC News and
MSNBC.
The We Build American campaign promotes the use of
U.S.- made products in home construction to support the
Coming Tuesday
OMAHA WORLD-HERALD
TAX DAY
IS TODAY
If you havent led your 2012 tax

return yet, take note: Today is the
deadline, and returns must be
postmarked or eled by midnight.
There will be no extended retail

post ofce hours or later collection
pickups today in Omaha, but mail
deposited at the main post ofce,
1124 Pacic St., before midnight will
get an April 15 postmark.
OMAH
A WO
economy and create American jobs.
RL
MONDAY, APRIL 15, 2013D-HOMAHA.COM
ERAL
D
WEDN
ESDA
Y, JUN
E 19
, 20
ONLY IN THE WORLD-HERALD
13
OMAH
A.COM
A fo
rm
Job fa
irs ju
st
one
way
LOOK
INSIDE
FOR:
Classied
Ads
hear er Ne
d wo bras
rldwi kan
de.
he
Com lps th
e
ing
in M Gates
oney Foun
datio
ns vo
ice be
BY
BA RB
ON
LY
AR
IN
Mo
TH E A SO DE
nd re mi
WO
LO
RL D-H RL IN
nologwork litary
OK
at
INSI
ER AL
half y con Belle veteran
veter
FO DE
D
peop the wo tracto vue inf s soon
R:
r
emergan hir
forcesle wh rkforc CSSS ormati could
Classi
o ha
e of .NET, on
been ed in ing ini
ve
Ads ed
200
Ho and
wh tec
the tiativ
rec
og
week lding reserv served alread ere hTh
las
es
MAR
unem e foc nized t few that
in the y are
Om s Hirina stack es.
us
KETW
ah
arm
era ploym has for the years have
Scott a for g Ou of res
ns
con
andat his Scott Technology Center lab are, from
ed
ir effHaider
Dow
ATCH
Hani
ent professor
veter jusWith
have Karlcon
Indust
rate tri
the Theob veter r Heroeumes
buted
Pinto,
Ian ort
Eppenbaugh,
Cordel,
Andres Barrera and Ibrahim
t 2.9Alvaro
s.
at
can
impro ans we left,
for
tracts
s
ald ans,
rials
to
15
pe
Ne
Pamela Yip
Al-Shawi
(on
the
screen).
I am didate was compajob fai last
a
,318.2
An
.
and veme re un rcent bra
fal
ska ling
job other
The Dallas Morning News severa act s qu enthu ny recr in
em
4.5
3 (+1
S&P
percent over plo of the
ve
In
he sai l of ually alicati siasti
38.38
500
ruiter
Bloom
to calfair, Ell emplo
go
the
bene hiring nt in 3.9 peyed in statest)
d.
se pe ing to ons. c abou
berg
had l sev iott Eq yer at
1,651
Th
cre ted veter 2010. rcent 2012, an
t
era
ople
fol
Om e con
.81
from ans,
dit
637.2 Midlands
res inquir
l of uipme the veter
in 201
NASD
for low up
(+12.7
Act s un
ou
em
tax
1 (+4
see aha-areatractor
actua
1
br rces ed abouthe can nt, als ans
AQ
Cru
wi
7)
k
is on of 201 der the incen ploye
ou
de oil
.13)
l job th
rm out ve emplois one
plicat ght bastaffer t work. didate o plann
3,482
bene e rm 1. TheobVOW tives rs have
s,
(NY
strates have teran yers of a nu
.18
an
to
MEX)
a cal ions ck a who att The s who ed
98.44
tha
ts.
tha
(+30.0
OM
mb
wh
rec s wh
hu
t ha ald sai Hire d
Bu
gy
res
AHA.C
er of
ently en hir t act
Kallsel to, that I am ole bu ende man
(+0.67
The
s ma d CS Heroe
erv to
5)
ans t mostl
Ell
Kee
de use SS.NE s
have ists attrac
nc d the
de
ing ively
OM
)
Pag World-He
p up
a fewjust ma y, the
fair
Sh n sai iott HR plann h of
/M
e 2D
joine and mi t and veloped . Some
with
rald
of tho T
ONEY
weldee has d.
mana ing on apthe
150,
view extra ke go compa
d wi
lita ret
a
se
late
ger giving
tors, rs, me20 jobs
th som ry spoain ve forma
chall od em nies
pro
st new TALKS
BU
wo
Me
ter
rkp cess
say
SINE
plo
en
s on
to ha and sai chan to ll,
liss
e of uses.
an l
as the ges du yees, , veter
a
ics
our
SS BR
Fo lace
the
Ot s,
Veter ve the d veter
bus
and includ
de
rin
natio hers
y
ing r Theoblingo
iness
IE
Man
and navig g the spite
nal
the ans maskills ans crane ing
FS
blo
the veteran ald,
ate
ex
int
esp
g.
yw
y
pe
ecialloperaally, compa ke up Elliott
ance have s is ana Marin ctatio civilia erSev
orke
n
of theveter nys wo abou is lookin y ten
need the ski adva e ve ns.
worken out
rs d
ans
d
rkf t 10 pe
nta teran
ed to lls
g
orc
recentor are of 10 wo
T 18-an ma
isen
rce for
fullland secge becau, hirmilitahe tra d-ove ke up abe of 165 nt of .
Americ Gallupactive rkers
gage
uri
the
se
r wo
have
try, ry croining the
com ty cle
of wo an wo sur veyly diseng
d
rkf out 7 ; natio
ch
pany ary ge orce. perce nto be Kallse sses
enthusrkers rkplac . In its aged, ecked
s
nt
Is long-term care insurance
excel n sai over intt from
iasticare we e, Gallup ongoin accord out at
The
the
lent d. W
o
the right choice for you?
fou g sur ing
in 20poll exa about, re eng
emplo e ha our ind
age nd tha vey of to a
Its not an easy question to
three 10 and mined and com
d, or
yees ve fou ust
K E
the
answer, but one things for sure:
The types endingworker mittedinvolv only 30 OO
with nd the
L cenSID
See
m
gre
Everyone will have to confront
30 milrst is of emplo in 20 engage to theed in, per
at
Veter
active
12.
t R:
me
IN
ir
yee
lion
wh
how to pay for their care when
wo
ans:
ich
rkp FO
worke ly eng s wh The sur nt beg
d
going accoun
Page
they get old and frail.
age o hol
vey inning lace.
rs.
sie
2
labele throug ts for The secd, whichd full-timclassi
Generally, Medicare doesnt
Class
es
e
rep
The d ac h the 50 mil ond
pay for long-term care. Meditype resent jobs.
Ad
com se worketively dismotion lion. The
is no s abo
care pays only for skilled
s
pan
ies rs aboengage at work. se em t eng ut
nursing facilities or home health
with
plo
age
d,
their ut 20 d, hates The thir yees
care when your stay is medicalattitud million goi
d typ are
ly necessary. And you must meet
e, acc undng to wo e,
ording erm rk.
strict conditions for Medicare to
to the ine the
pay for these types of care.
report ir
Before deciding whether to
.
k
buy a long-term care insurance
wor
policy, look at your familys
the
health history, your age, your
will
by
health status, overall retirement
id
ted
tech , sa e
goals, income and assets.
lera
Bio ials shar e
Do you have a family tence
e
tr to
th
ac
Lice
dency toward heart disease,
Boh and ds
of
tly
win nse pl
s
ea
cancer, stroke, diabetes, high
inna arch stan sale
gr
s na
ate
hi
blood pressure or dementia?
ho
on its
al
se
be
The
C
tio
.
w tu
,
d
re
nal honori
said Tom Murphy, a certied
mm
Pac Nebraska
an China now ore ntor, en
aw
co perm oth
nancial planner at Murphy
new ics 15
spe
ard ng U.
in For t m inve om ev
es at to to e of
P.
th
us
Licensplate in 0th anncialty lice
& Sylvest LLC in Dallas. If
uc e
t ay re leas to
fr
LD
uc
nd th s
of the e Pla the Un iversa nse pla
so, does that family tendency
RA
co g, ltie
od a w adhe re ing rite
Un te Co ited ry las
the
historically result in the need
-HE
e pr in er e slow lead d pe
Wan roya t.
bes ion Pac llector States t year honorin
ar
wh
th
t
tt
LD
s,
s Ass . The has
new
for either care in the home or
ic
g UnR
o
m
y,
in oduc id ixed be is th ur onge
overallare all plate Railro ociatio Aut won bes
O ion
da
be ucts
sa m to
ho ol
moving to a care facility?
enforc attracover the in the ad Museu n vot omobi
all lar l
E leW t tually prod and pr He ients thol resultveral r pr
If care is needed, do you
cou S O D E Rm
ed
fo
Veh ement tivenes globe,
te
e
the
R Y A N ntr
L Ilice
N / TH
THE
WORLD-H
E
R
A
L
D
say regutica
ed
en en as
icles
have enough money to pay the
h
. The s and voted y. ALP IN nse Friends
ld
gr men. The er se eath
but provides
ev were
&
gi
doe guidance
The hand at right is holding a surgical bone saw with the Trak Surgical Inc. device mounted on top. The laser line
where on
toLY
cutCA
the bone
pla
ou wit aceu e 4
Ne as toleg
additional expenses? If youre
illif this
hy othp
U.P. direof
the amel ol ov br
ctothe sn
the memb
wte
t kee Itbra
son is
al , to
skakill ibil
I w an arm : Pag
a real surgery. Smoke has been added during photography to better show the laser projection. Among the advances
device:
can
the
saws
if the
surgeon
platesve
ers,or
married, do you have enough to
OityN
as motor
hn th
res plates. r Rhond p num Depar
th ph
if
en th minty
deviates from the desired plan. A branch of UNMC aims to get the research out of the lab and into the hands ofide
surgeons.
of the
of oss
a is an older prototypea too
ditidevice.
pay them while allowing your
nts. TheBelow
hina
ow er a
a Jo ding king platesLahm bers on tment ad l forers
men h,
kn long ang,
e of ak law
eC
ash,
spouse to maintain his or her
ine ble ad, spea al hy
are estima org
fress.
ani mMo
Se
, th
tor w
nt pe
W
Ch
ag
issued ted
standard of living?
anthe tozat
ion th .
rysle
im Gam ixon of or
od I do ho said
pl
onlytedre are
ts
mouplamtes
Generally, for the poor or
e
ly
s
Chrys
r to
uc
gu00 ,si r & id D er
ke tochNeasbrag1,0
M
t w ,
od ores
the folks on the lower end of
fix
biggesler on
Sys
ska d ea octe , sa . mak
bu thol
pr
in
CO
,
2.
su
tem
Tue
st
r
the spectrum, (a long-term care
A.
7m
in thr t sho
ew coul Pr ts .S
workf adm
sda
fo ach does tmen
AH B Y P A I G E Y O W E L L | W O util
or uc t U
orce inistra
policy) may not make sense
R LityD ee
- Hdec
E Rwd
A ow
L Dn ySave
T Arte
F F Will
R io
I TnE R ch I
ars re it . A
OM
of 20 tor
son prod inen
SU
ye to if
Aub vehicleades by with U.S d what
because Medicaid provides covof
ts
hn
0 are Bill Mc
Vs
urn
cou the hands
Jo of eir om s. ve ient But pro rest id,
13 When mechanical engineer and biomedicalagreem
Hills, s link
research
outedofagr
the
and
erage for nursing homes, said
peo
eeilab. reg
ulainto ld
have to th o pr tion ke
ed .
ple Quillen Stephen Keller, manager of com20
sa
e the
ent Mich.-b to 51 ng to x tors ove
professor Hani Haider was recruited from Adminissurgeons.
who
cha
bee tw solu ta ingr id
17,
wit
dea
nge
ase
have pensation
2.7
sa in thit in w, he
nof
the
ra
ht the
the e
Nebraska,
a state-funded
venture
and benets at Grant
London to teach at the University of Nebraska
NE
tion h the
Jee traInvest
ser veds backup
e
Na d Ch ths in posmillion recall gien mig
e
Gra to
organization;
a CEO
Silicon
Thornton
LLP.tap
For wealthy
ixonshar aliz follo
Medical Center in 2000, he worked from a with fue pcapital
ler fromt-cr
do tional rys
spo Val- It
Y, JU
in the
ning, D
refu
ly
rt
Highw saiteam
l ley;
ci
ash formed
Cheroa vo
tanksnd
d
UNeMed;
and
have
folks say,
withes
$5fro
million or
small laboratory in the basement of a hospital.
lunHaiders
arm
NDA
res.
ay Tra it rea
ntai na ould mer obab
cov sing
m the they
tar y company
mount keeInc.
ed for
che ed
Trak
over of investable
assets
MO
andThat
lier Surgical
Now, Haider is the director of the Bio-and er Gra ear
fc could
cam
m pr
d change co Chi w
ces ser
nt
g
RD
in Jun edof
Save
beh Jee
R
fety an dby in MC to co ould
the ndthe
can self-fund this without
any ver roo
and
an
p Libpaign insurgery
BA Research
Chbusiness
medical Engineering
and
D
ind replacement
e to joint
TE
ical hAdvanced
ero
Lib making
reserv m
on g an e
ertyto
the
AL
rec andW
it seasier
cheaper
perform.
problem, but you do need liquid
UN pts ld w
HUB F WRI Lab in
Surgical Technologies
6,000itsquare
feet ert
as
y in kee
veh
rear w
th
es. at CSSS
Med
an
ER
in mo all the
w
m
yea
LL
icle
.
or
e
axl
The
conventional
method
of
performing
W
a
AF
assets for that.
te w
.NET, -H
rs
s e urs,
at the Scott
Centerpin Aksarben
SE Technology
del es m.tive
iz Ob
ST
g
us
Theones,
LD
nijoint
years replacements
BY E
02and
hip
Its consumers in the middle
rask hi al rea ama successful 20
RUS ALD
the
ca r relies
ho al
recallafte
WO
Village.
-2007
MIL
OR a Bellevue
eb ners erci mah
RLD
ri.va 19D93
hintmechanical
ER
mpade
no
BYHe and
st cor-tion to
align
the
YN
who may benet from long-term
A
at will
-HE
rt mmandOresearchers
-H a teamN
er to
of surgeons
la
co instruments
th- min on
info
OH
AW
RAL
th-20
pany Japan
ns placement
en g
04implant,
LD
ch
R
rmati J A M E S
rect
news joint
or
heith tholof the
ousidjoint
D
care insurance, he said.
k
atxo
y of a pa
AH
have
on aco
wayth
toesimplify
nv rdin
OR beenitworking
mPre
e Be
wis w
t to coIncorrect
on tec R . B U
res has agese ph STAFF WR
W
nt than
sear ie
ren
onre
en
much
easier
said
tofor at
In that middle band, which is OM
worent Ba Di which
rs ed
ear
en done.
RN
om
h
co
replacement
morees
thants10
t
m
ips rn
hno
ch by reed armace ITER
ve rmsurgery
ka
ET
inate rack sh
ag surgery
ed
of the years.
acdown
an
placement
can result
logy
T
a wide swath of the population,
wit
ninow
to
uc
makodhas
gr ingmore
storloped commercialization
the universitys
ueBen Obam
The NMCke
con / T HAnd
Federa
who Medic a Un nan utical
EU
es goes
s fo
W
a sug s in enin utSee
Be
tractohebranch,
al
alrepurs
inve ve is aiming
R L UNeMed,
ON (insurance companies) can make
to get
UNeMed: Page 3
l Re rnankeU
that e pr
com may be Centeiversityce addit comT r whr Oha
plaHaiders
ges sh min hing
D
ady nted
ser
nne
te ere se - HdE Rde
WO LY aINstrong case that this makes
for
re he to
ploy -fted
Obam
willd.inInve stayed
teria.bating on to r mi of Ne ional
inve,by
A L ex gien
RLD- THE
halun
d mighteryt
- thesay
Cen Chinepo
eming aththir
a did aonPBS in
antib a ne crobio brasf themplD hy
See Yip: Page 3
chael
dseter
whch
ly
te
HERA
eathe cen
eth
not
co al
Ta
m ev
inte
not prod
job
iotic- w sol
wer
log
ioas
a com
brlonoppo
Di
as cha
UN
mm
or
. If
spo isho
tra
LD
cha cohe
res ution ist
eM xon,
ger ns
e B a ne
woeulddirectly
t ofrvie
nso
Pharm
irmanen
istan
- w tha
a
arch and
ed.
than l bank irman
ast aire
pre
io
for
oh r Be
ans
Yip News
anke
en
ass
rna
pe
UN
ren
se
de
B
sid
s
gi
rs
a
chi
t
we
id
,
orig
end
istanr more
pti
fo Muolelle hyand es s Comina
bacef
ent
re he
el ning
nolog eMed
Wang t pro res aceutical
ed
sys des are
in Jan intote r a ve
que d late ina
and
th alr, wh prcomNM
tem
Berna stion Mondally
deal y tra , which
was er. -bas uses en12
Pams Mor
fessorearch
rec , wh
yea
CEO
rus
s
or rs on,o is U pared
ch uarney.r-Ins
alread
lla
o
ord
nke about y,
by Co. wi
Prog along nsfer of is UN
of pe es an rst
longChina cial of m Bo
quen
him
inb Mu ix on thee stese
ppiar
a UN ll
and has de , Dr.
y thee Da
d ba
de
ngpart to tead, , whose
ram with
er
pti
THE
MC
d el Delleisr, th
job
ce, PERKS
re . Be
res ces in catalo velop Guan MC
s Ad
lates de ins cteria fense Th immu
Di
g down in FBI Dir Obama term
bro s tec
UN
t the
ult
mm ve un
rnheain
gsh
minis MC
With theke
notable
of Apple,
again
one xon
ulin,
h, an
in ne a da g new ed a wa un
Septe ector praise
blood whose
co rivati fo icha Tha statuyedrm
red exception
ne
d n Be
s
Mpay
the must
w me tabase pepti y to
reportedly
a lot of the rnanke mb Rober d
becauthat necalled traemployees
sugfoodfor exd the famst vition. Sponsor
de edient id Morp. ies to fo
anyfor their
T
be
ar.
was longer FBI, wh s a littler afte t
dicati tha de seample
of us
at work,
a number
their
ed of technerms
issue se he eds a Wang
ilia
r
(the he ke
ciaroffer
gr ts, sa C at tr ts by
sup
are
ons, t cou
s
y
, reg r
pos than heere he e bit like
ed
employees
freebies.
areare
some
tha of an s foc comme
y fac
da a slew ofthi
no Here
no of
get produ is rea
said ld
ed
s alre
uc eM t th uc
ut
wanteto
rci tabase
ts be t aware
ct).)
lly
ng t sic
od techteria could tibiotic-using them:
en prValley
Miof Silicon
It wouldto,
be Ob
stupid
taxady
this food,
Great social things aside, the debate
THE Sthe
AN Jit
OSE
de(C
into
to job descriptionUN
on al outle
veALIF
cau
good s, jus k we are
ama d or he
of the
lop
perfe
rtmpampered
sistan are leslead to resist >> the
the sta
e
NEWS
MERCURY
workers
nearly said Sanjeev Agrawal,
ran prod- is growing within the IRS and among
rt to that they
saiwho
t gourmet
lik snacks, yogase
meals tand
pa be bl
gra Free
ant Google:
tha con
d.
su
pip
ct pa ed, he
s
ce
The
dition e wh pursu when se
la But now the IRS uct marketing
getwith perks.
ve membership,
t yo cooking
bactegym
eli
to ne
death
for Google from 2003 tax experts over whether employees
to pe likely perbu
sai
rtn
classes,
classes
en
we
For
the
thousands
blessed
to
be
ing
St
de
sa
pa
ing
ur
d.
er
rtners al com
and
, Wa tire you do your working
oth
ptide to de gs. ria
is ish
reportedly
examining whether free to 2005 ar
andbu
whose Googler-wife still should be taxed for these freebies, or
to do Ta
benevolent
behemoths
er forCh
Bac- Free It
andPark, Calif.,
car
men
Facebook:
food at ng
its sai
Menlo
s. An ve>>lop
es on like
ckstoday. Free meals whether the perks should be considinese hip there
o
is in and
theuperks
mu nt appreGoogle
UN could
Facebook,
betha food
a
timheadquarters,
a com
d. cafes,
with.isand the other free perks pro- enjoys
res ma
fe a
in not
which
main
plus
inv
MC the he tvided
be ye
icrob reciaend
earhasytwo
r
bebo
taxed
because theyre not ered noncompensatory and thereards
estor
by Silicon Valley tech companies shouldcl
an
the free
lunch.
And the
ud
te toma
forfree els
ch
poun
buta pizza
barbecue
burrito bar andare wo
ial shack,
BY J
Sta
e ca
is aars
kes And
of a as a fringe benet on which compensation.
Dixo shop,
to comme
be
Theyreto
a phenomenal fore nontaxable, according to the Wall
dmaybe
WO
rk- to
shuttle
thed wiqualies
AY
lonwork.
deve even
a 1950s-styleWa
burger
RLD
lori motivator
to warbucks
WITH
n sai develop fore the
ngs joint
th
ge oral
-HE
merci employees
should pay additional tax.
convenience,
and a Street Journal.
free haircut.
Ga
ke up has aa terric
es
d
a
RO
ed
RAL
sho
UN r. Dixo hygie loped
W
Some experts say companies like
int pepti
Iow soline
D STA
newbecause it gives emwing social
alize
>> Twitter: Three freeres
meals
day at its San
ear athe
MC on nbenets
ne to attract
its cus
And that set off a great grumblingdringreat
thing
ch gopartners o a dru deAs rms
way
pro here
s go
FF WR
when pile
sai
Google are dodging the rules and that
ks. thean
froma contin prices
tom
Francisco ofce
?be heard from San Jose tocof ployees
ducts tha
calorie
that
easy
way
and
the bright,
al to dofbo
ing
ITE
hip
ers: to meet and pass
g, retain
see brightest
t could
fee The Se
to comthe
R
th
forwa
rep a mo ue to in Ne
keepit
ript
kin been
sforth.
pos ideas
cha backattand
in its
has increasingly
part are
of the woSan
Source: The San Jose Mercury News
See Perks: Page 3
Francisco.
AAAs
of
orted nth
move bra
rk sc
g de searc
le-b
s
in
ting
me
rd.
pa
ska
t
ck on
unsur
me
ase
rciali velop h the
rt ofey no
cal said it Ke
Ne
Ro
Tu ago
dow
Con
d
on
. nwill sits
for braska esday. , AAA
nw and
next nu boardsorie couon
ze me ment
tact
globe
are e wh se Wh
402sta ll
a gal
.
Nebra ard
m But is
ich
a
ite sai
week,
444- the writ
ar nts
dical pa
regula
$3.60,
nat
loc
1192
est were
lon s averag
ellion rtba d
er:
urrtnerse. hat it uncooney
Sh in
ska
, emi
sellin ations d she
pri
res
of un
wide cise an at
it to tion ahead ion
yo s on
age the sam
ly.no
ur m
w
sk
oflsa exer
g gas in the was
lea e pri
. Iow
hr@
ts ear
Pr ces.
yo out d in ha ch. s
that do so. that wo Po
owh
T H E N E B R A S K A W AY
fed r de d th ys
e as ded ce Tu
oline
is too ices are
Som as
.com
Om
Wha one knows are ab lope nan
info it alreadyStarbu uldanreqheera
leaded
Nebra e of averag the natregula esday
at the aha
fol un w pa ion
rma
difcu cha
fs
uire
cks
ry
hav
at
ve
r
pt
s
ne
thr
the
e.
pro
tion
e wa ional was
not ha
ng
e
ska
low
a
are
Om
Eveeryo scri belielly deInyour lif prin ough its on its vides ed
e no tent hen
s
E10 seen lt to say ing dai
a,
can low
ave
aha week
ap
ted
ut
pri
age where be est gas $3.64.
rev oney core pica ive fla
brochuiPhone websi nutritioshore at e w in a
W , $3.57; ago: Ne
ur to
may ethano ces as , Wh ly, so
d
drU.Sugho tio
n stur ts
t
locati $3.44 unlea found in prices
l ble
ite sai it
yo
app te,
n
ing ith so
m
and
off
bra
res
d
M
ty
ng
low
I
us
st
g
si
ro . con
er it
pri
nds.
e ay,
ska
in caf and
r. .
Iow
yi aray
po e
Ne
in sum
were ons in a gallonded reg the Omin
with ces, many var
a, $3. , $3.
scio yre od anor theneer
Som as $3.24 d. I
ed
es. with to sh chai ck .
price braska for a
d tr erupric
its
68;
t w ermild
smidallrgyan
e
$3.39 sellin the me Tuesd ular ave aha
cos
72.
few
for
iab
go, certai
too
Theildho havi ns
lar my ba ch
ts yo
id
ghes ros
gallon a mo s averag cen stations
difcu les
weri
a gal g unlea tropol ay. Som rWh
con And
eyincw
in M
ay
ns
nth
rea
re par
An
This
hite
is isnty
a new
forim
her.
New streets. This is a new place
call home.
this
is
how town
regu lps t slouw its
ch to be
sum
pacA new job.
n co0.1
lon.
se
e mo ts low
Th Th
ita
co tly e slightly
ded
nation , among ago
sai
ay
also increa
theund
tmon
low lt to
he don ho k,
er.
st id
hig
theera pric
reg n area e
largel e ho
offs
pre Pinnacle
cialWhe
owh shed.got started.
With
Banks Free Checking with Online Banking.
Allto
this
from
bank
how
per
is
prices
in
gallon . Om
the was $4. tor fue
cial
ular
if
e r ers
I like thin id.
cen
et
dic
she helpin se in sup
sacoran
prices
eyt las
een
ch sev
es t by che May as
closur y tha
tot ind,
driaven
g to peopleply
ex
for
sai
ts been
helping
the
she now calls neighbors.
thats
I me sa
will t
innsu
monthul
for ahas avehighes 01 per l
ago
oa Co
n estha
inaround for generations,
ey tick
push
ter
mon
reg
t
Last d.
e
ck
in aper higher
serve es at
pr term
by ma May
ef s, the
onmonth
ed onled
dec g me
lv uprd
gallonwas $4. ular rage in the
priceslevels
Inform
week,
were
a ation is food. The
mad Ke
linlineninusr pricm
the a few
pri
Lab&, Sy
int CHECKING
un
de nd
09,
rti
hav
e son mild.
the sea
.
GET
AT PINNBANK.COM
Th
or Dehy ha
low is
Mi
ew es
oil FREEena
and leaded ce per
por
ation White
fou
e te
cefell y
second
Avera
us
inc
er,
ally
MEMBER
FDICvi ry,yea
of
haelectri
ted
cha e dem dwest rener nce
Iow
uc parca
ph0.4mper
adj The
is cityureased
ng
were tha Admi said,
as wa a month
ge pri
ph 1.4
ies
be tme
urrs. In
it
Gas w yo
t
T H E W AY B A N K I N G S H O U L D B E
dim ed, buand for .
e increaseusted
k cen
s ofntwsai
ur M
that
ces
s $4
s is the
with up abo proces nistratiothe En
inishe t sup gas
pric Mcos
d Tue
ts
pasewt in Apr
groho
in
for
hiper
n
erg
sup
a
sed
cen
thin
a
ut
cer es r at pus
n
ply oline
vi t 12
d
reg
y
pli
T hed
hemo il, the eysday.
t.rHig
years.Toympricneweres.at
ht
The year ago 8 per fuel reular
w
Coast es arr as a res concer has not
larg
up
on
her
sup
nthms,
cen
es la
sav
sho
, oueneed
unOuan
Foo
core pl
m. ig
natura
drouppe
t com plies
ns
states iving ult of
ings .
uld
tsid
pric est
rgy pric
ery
usd cos
Dal
rm
e the
es
with
pro
fro
add hav
par
the prices
d by fo
s of l gas
yo t of
tsg.fell
vide in motor
Wh in Joliet , combin m the itio e
ed
pas in ros
peesnt0.4
z, a co
and
leisur a few
inatio
ite sai
osvolatilereetheun
t 12thane m
ty0.1
, Ill.
Gulf nal
0.2
per
mo vacati fuel
w efoo
st in Kloper
yo mour
, com ed wit
e
n tar month
per
r
d.
who cent. ith
cen
almst, cen
To activi re dol oning costs
and d
it t inedfo
getfo ons,ey
ing h a re
ost pit,c:asle w
lars
tie
fam
ofm2 inqu
70 cen day,
bac
line ar
MaByragas
tofouop
to spe ilie
Freq
with s.
is
cateego
logi
perecen
k onl nr
withid
and
re
ts
s
er
nea
ho
ey
fue
ine,
th Pe
nd on
dy
ries
w The t. sa theycFed 1.7
uent
rly low
e: cenm,on gree
United
tank, $10 er, mo l approx
era ncper
-flie ripts, al ps y on
at t ine e
higher Airline
Wh less to torists imate
ud dal Reser
ci
r sc
Con
ar rv
ite sai ll
polic
tact
an a st avoi ve th leves
require freq s is ma
a 15- are pay ly
the
se
uen
d.
s
writ
y tig
gallon ing
ey belie peop t de
add
yin t-ier king n rote
er: 402folk ey
t ench
444n
too, ing a reqg 25,00 status it awlittlMon aiht
1259
se on s,
do
, jay.w
hartr at ri ed
Most to qua uireme 0 miles . That eis
ithro
The e m m
lify for nt
sta der
th get
they
w@
per th
if the frequen
ip: mor oble ough
owh
d, useto
at
year. tus
sta for
.com
sh
discouy are ear t iers tus inat least ba
Nod th d.to awor that r pr en er
nted ning would its Mil $2,50
d thei r be w
eyitedey
an w, Un
Fro
0on on
tickets 25,00 spe eag m
is ince l of ve gs po
ePl inM
spe nv
m sta
rs t
mig 0 mil nd tha us pro
e alwill ne brin
ht be es.
t mu
ff and
conding,
gra
love es
lv
e
m.
affe But tho ch ar
ey
wire
e
anywayso er
us new .
cted.
se wh ill
report
th moness. : Stat the status ith
w
o buy
s
w
at at
s
com
pani
es at
tract
and
retain
worke
rs with
milita
ry tie
s
or ke
ng ma
spyi ke to
t to ta
jec can
sub you
are teps
fe
s
li
ily are e 5D
da
of there . Pag
ects but ops
asp nce, e sno
ny
Ma rveilla on th
su rder
ha
it
Simpler replacement surgery spawns company aiming to get system on market
hair
ir c
the wor
ade mill
rs tr tread eir he
rke
wo esks, to th
e
r
d
Mo ding balls
stan rcise
exe
199
2!
Residence Programs
UNMC researcher
Dan Anderson (center)
interviews with a local
television reporter in
early July about a
new coronary artery
disease blood test he
and his co-inventors,
Dr. Geoff Thiele and
Michael Duryee, are
developing.
th d th ppin atus ning er

le the
an d ha ey st ow conf Peop ity, ing
an Mon that ings nce: ugal d be ey
ve th gila e fr an h th
lie st
t
be d be ey vi bracsavingmuc
ou ,
an Mon t em of how
me
co scales
trai ance out
le
this port et ab e. peop ose ly,
im re mak es l of th ical mes
discve or etim ra typat co the
ha Som seve . But e th than
on said scal em
p. t
high ntz one for th
erla a lo le
Kloeres er
n ov ve peop d
s cawe haeen e an ,
th t high.
pt
ou rs scri es tw danc pers to
otheThe etimion be avoi ship seem es
ch
or
om at
S rrel oney w y mayproa ink es
co are m oney he ap u th it do
of
,
e m . T te yo
who ar said posi hen cally
u
also ntz lly op t w listi
, yo you
Klo tota ey, bu e ho
said g
be mon more.
he thin
aad if
to out it ns ple, very
,
so
ab e seexam the
are ople them
ak
m For vet
who pe ith
co
le rich n w to be simayspise. peop nst dow like have liefs
de The agai sit ould e
be
tly tually ly w id. W ting
n by
manu ac tual z sa nic
ow ey
yo ey ac lont sly co
e kn on
th , K ou ey. s ar m ver
as
ch
ne
on
pt
ri ta m ri ch hate ve an
at
mulound ey sc , su ut w ha
e thrar Mon mes s. B , they:
dg
r naalitie by sage owle inte ng
otherson ey gomes kn may anni ied
pe l th ding mon aits al pl cert al s
labeerri com cal tr anci z, a rson ha
ov It is logi e n lont ith Pe hich aii.
w aw
th id K w
ho
r
ts, H n
yc ith
ps re w s, sa anne ltan and ns ca - fe oces al pl onsu nia tter ey bedel
pr anci ial C alifor pa mon al in on nanc in C script ed anci path e
Fi ces ey rder n ng, lsiv ce
of Mon t diso ch as buyi mpu nden id.
e
co pe he sa t
ic
ed s, su iv g, de
o
pr vior puls blin cial g, wha
ing
ha com gam an ablin tifyscripts
erat Sc
op e,
ity, cal ng, nal en iden ey er it ing
ief r m
logiardi anci is to mon heth ov
ch fo
arz, orks
ho d n trick ular e w impr
S
hw w
an The rtic rmin om
Sc his
of ng
TION v
pa te u fr
Jeff sk. T
are aski is
ur de
E OP s can
de
yo and ing yo s. g aw en t th your ,
TH
sk
er ance min d thd I ge ting self
is
de e.
ING
nd
IC
an
ng
co
n
ur
di
hi ur be are
di mor
w
PR
alua yo or
sks
yo Its ey here ev ng ed
Stan or
de ,50
>> ,000
t th lf, W then aski help
mill
$3
ad d $4
whaurse and and lief id. moTre an or s
yo lief? t life is bentz saaha u ain t
>> ,000
e, $5
be rren s th Klo , an
n yo cert edic
cis
$1
cu ow hae? ce r wheve a pr
Exer 5 to
>> m $1
H rt m instanoccu ha ould less he
fro
hu For ay you at w have th,
t m that n th g to wor
vice
menalize patter goin net
a
ad
ss
f
c
re
h
re lie u
le
it
i
ec e w
be at yo and
s sp erat : hen
th me
ha
pt
incoid. phy ho op scri W get
sa Mur e w ey nce: way give le
on
thosc m oidathis it or ssib be
po t to .
for eci ey avfeel end
sp kly as wan said ly
sp Mon ho
e w , they ic not phy ular
e4
thos ey as quey do Mur rtic
Pag
mon ay e th evil, is pa Yip:
e
it awcaus as ency
Se
ed nd
be
viewhis te
T
15
Double Threat
Vitals
Diagnose, kill cancer with one compound
Photo: UNMC
Two of the most prevalent

forms of cancer are prostate
cancer and breast cancer, accounting for more than 60,000
U.S. deaths each year. As a result they have become a major
focus of both diagnostic and
therapeutic development.
As with all diseases, the
main goal is to develop more
accurate forms of diagnosis Dr. Baranowskaand disease tracking along Kortylewicz
with safer and more effective
therapies.
Researchers at UNMC have developed a way
to accomplish both goals with one compound. The
compound can be used to image a patients cancer
and treat it at the same time.
Compounds are tagged with a radioactive iso-
Rundown
n Novel compound
n Accurate diagnostic
n Track cancer growth
n Image and kill cancer cells
n Effective against prostate cancer
n Comprehensive, successful cellular and
animal studies
tope that can

be used to kill,
see, or track a
tumor.
The
compounds specifically target a
cellular protein
Inventors
called the ann Janina Baranowska-Kortylewicz, Ph.D.
drogen receptor,
n Zbigniew P. Kortylewicz, Ph.D.
which is commonly found in
a variety of cancers, including breast and prostate cancer.
These compounds have undergone extensive
cellular and animal studies and an Investigation
New Drug application has been filed with the FDA.
UNMC plans to start a clinical trial in prostate cancer patients in the near future.
Investigation New Drug application has been filed with the FDA.
UNMC plans to start a clinical trial in prostate cancer patients soon.
New treatment for old foe

n Wage war against
pancreatic cancer with
minimal side effects
Vitals
Inventors
n Amarnath Natarajan, Ph.D.
n Qian Chen, Ph.D.
n Vashti Bryant, Ph.D.
n Rajkumar Rajule
16
Photo: UNMC
Rundown
n Novel drug
n Orally Available
n Few side effects
n Potent inhibitor of cancer
cell proliferation
n Effective in pancreatic
cancer animal model
n Treat other forms of cancer
n Treat diabetes, other
diseases
There may finally be an

answer to pancreatic cancer.
Every year, roughly
45,000 people are diagnosed with pancreatic cancer, the most lethal form of
cancerous disease. With
current treatment options,
almost 43,000 of them will
die within five years of diagnosis.
The few treatments that
exist are too soon rendered
impotent as patients quickly develop resistance to the
drugs.
But researchers at the
University of Nebraska
Medical Center may be
Dr. Natarajan
able to increase the odds for those who receive the grim
news. Researchers at UNMC are working on a novel drug
called 13-197 that has shown promise in mouse models
with relatively few side effects.
13-197 is still in preclinical development for pancreatic cancer, and may be useful in the treatment of other
forms of cancer and other diseases such as diabetes.
UNMC is interested in partnering with a pharmaceutical company to further develop 13-197 and future analogs for clinical use.
Novel Biofilm Therapy
Fight device-related infections

More than a million cases of
hospital-acquired infections can be
traced to biofilm, a slimy coating of
microbes that settle on medical devices and implants.
Biofilm infections are notori-
Vitals
Rundown
n Innovative therapy
n Personalized meds
n Use patients cells
n Prevent biofilm formation
n Treat established infections
n Reduce risk of developing
antibiotic resistant bacteria
ness. By using a patients own immune system rather than anitibiotics, this approach also decreases the
likelihood of developing antibiotic
resistant bacteria.
Photo: UNMC
Inventors
n Tammy Kielian, Ph.D.
n Mark Hanke, Ph.D.
ously difficult to treat without removing or replacing the medical device. Treatment is further hindered
by the development of antibacterialresistant strains of microbes. But
researchers at the University of Nebraska Medical Center discovered
a new way to combat device-related
infections.
Rather than pursue traditional
routes of treatment with antibiotics,
UNMC researchers developed a novel
method that treats, controls and even
prevents biofilms.
The method is a cell-based therapy that uses a patients own immune
cells, specifically macrophages. The
immune cells are isolated and activated outside the body, then used as
needed to prevent or treat a biofilm
infection.
The cell-based therapy has been
tested to show significant effective-
Dr. Kielian
Intuitool
Do More through the Keyhole
Photo: The Nebraska Medical Center
As the world pushes to make

minimally invasive surgery easier
and safer, surgical procedures need
smaller and smaller incisions.
Engineers and surgeons at the
University of Nebraska Medical Center found a way to meet those needs,
while making those procedures safer
for patients and easier for surgeons
a groundbreaking new surgical tool
called Intuitool.
Minimally invasive, or laparoscopic, surgery is difficult for any surgeon.
During a procedure, a surgeon must
hold the instrument, often at awkward
angles, for hours at a time. The surgeon
cant see the tools directly, instead relying on two-dimensional video displays. And everything must fit through
an opening about the size of Abraham
Lincolns head on a U.S. penny.
Intuitool is the next generation
of laparoscopic tools, with robust articulation and superior ergonomic
design and feel. Its rod-driven system conveys the maximum amount of
Dr. Oleynikov
power with minimal exertion. Multiple publications over eight years

demonstrate how Intuitool is safer,
easier, and quicker to learn.
UNeMed is seeking a partner to license a portfolio of international patent applications teaching multiple
aspects of the Intuitool; or an entrepreneur eager to arm surgeons with
better tools.
Vitals
Rundown
n Intuitive interface
n Ergonomic design
n Shorter learning curve
n Shorter procedures
n Shorter patient recovery
n Better Patient Care
Inventors
n Dmitry Oleynikov, M.D.
n Susan Hallbeck, Ph.D.
17
Cancer Vaccine
Use the immune system to treat prominent cancers
Photo: UNMC
Cancers of the colon, breast, ovary, lung and

pancreas have at least one thing in common: A
lack of treatment.
Researchers at the University of Nebraska
Medical Center have found another common
problem, a protein known as MUC1. Certain
cancers produce too much MUC1, which causes
rapid growth in cancer cells, and puts the brakes
on the bodys natural immune cells, preventing
them from attacking the tumor.
But those same immune cells react differently when short MUC1 fragments are used for
treatment. The fragments trigger an anti-tumor
response, making vaccination against tumor formation an effective cancer treatment option.
Vitals
Rundown
n Tumor-specific immunity
n Vaccine for all MUC1 cancers
n Increase anti-tumor response
n Use the bodys own immune cells
n Halts tumor growth
n Will not create an
autoimmune response
n Extend patient survival
Inventors
n Tony Hollingsworth, Ph.D.
n Karl Kohlgraf, M.D.
n Tom Caffrey
Dr. Hollingsworth
Develop new, better antimicrobial agents with peptide database

Vitals
Rundown
n Search over 2,000 peptides
n Broadly effective
antimicrobials
n Fight antibiotic
resistant bacteria
n Peptides from bacteria,
fungi, plants, and animals
n Work with UNeMed to
develop your own molecules
the Antimicrobial Peptide Database and

data analysis system.
The database is a comprehensive online
resource with detailed information on more
than 2,000 antimicrobial peptides. The database, which continues to grow,
can be used for naming, classification, statistical analysis,
search, prediction, and design
of antimicrobial peptides covering all life kingdoms.
Guided by the database,
Dr. Wang has already developed novel peptides against
specific organisms, including
methicillin-resistant Staphylococcus aureusa potentially
dangerous bacterial infection
that is resistant to most antibiotics.
Photo: UNMC
Inventor
n Guangshun Wang, Ph.D.
Guangshun Wang of the University of

Nebraska Medical Center spends his time
developing the next generation of antibacterial molecules, and he finds them in some
unlikely places.
Dr. Wang uses naturally occurring proteins in everything
from bacteria and fungi to plants
and animals to find promising
protein fragments. He then engineers the fragments for greater
antimicrobial activity. These protein fragments are known as antimicrobial peptides, which act as
broadly effective antibiotics that
fight infections.
To share his knowledge and
promote research, education,
and information exchange, Dr.
Wang created and manages Dr. Wang
Reduce diabetic brain complications
Photo: UNMC
An exciting new development

at the University of Nebraska
Medical Center helps mitigate the
disastrous effects of diabetes
particularly degenerative and
destructive brain complications
more often seen in the elderly.
Research on diabetic animals show that an enzyme, Glyoxalase-1, could be used to treat
common diabetes complications Dr. Bidasee
such as blindness, heart disease,
kidney failure, and erectile dysfunction.
Even more promising, the therapy also helps improve
brain function and minimizes the amount of brain tissue
affected by a stroke, all while significantly helping reduce
blood sugar levels.
18
Glyoxalase-1 targets
and degrades the suspected cause of these
complicationsa
naturally occurring chemical,
methylglyoxal, which is
created by damaged cells
when blood sugar levels
are high.
Currently there are no
FDA-approved treatments
that target brain complications in diabetes and also
help manage blood sugar
levels. But with a committed partnership, Glyoxalase-1 could be the first.
Vitals
Rundown
n Prevent cognitive
dysfunction
n Reduce cerebrovascular
complications
n Minimize affected brain
tissue following stroke
n Treats other diabetic
complications
n Reduce brain complications
n Manage blood sugar
n Targets damaged cells
Inventor
n Keshore Bidasee, Ph.D.
Research from Dr. Dong Wang
Detect, stop brain injury
immediately after head trauma
Diagnosing and effectively
treating a traumatic brain injury has been nearly impossible.
But thanks to researcher
Dong Wang, Ph.D., at the University of Nebraska Medical
Center, the 1.7 million people
who suffer head trauma each
year might finally receive effective treatment.
Sooner or later, patients
with traumatic brain injuries
develop irreversible neurodegenerative disease, which
can include memory problems,
mental decline, and full cognitive dysfunction leading to
dementia. Traumatic brain injury can also lead to significant
personal, social and economic
losses.
Unfortunately, there is no
way to detect and stop a traumatic brain injury after the actual head trauma occurs.
But the novel prodrug PDex carries imaging agents
and potent anti-inflammatory
Vitals
Rundown
n Diagnostic imaging
prior to symptoms
n Minimizes permanent
brain injury
n Delivers antiinflammatory to injury
n Image, treat
simultaneously
n Safe, non-toxic
n Proof of concept
in animal models
n Comprehensive
patent rights available
drugs into the brain to help visualize and treat the affected
area.
Both imaging and therapeutic agents are directed to
the precise area of inflammation and injury by the systems
unique targeting chemistry.
Kill bacteria, enjoy

fresh breath all day
Dr. Wang has developed a
particle that binds to the tooth
surface for an extended release of
Rundown
antibacterial agents that results
n Chinese rights unavailable
in less oral bacteria and longern Prolonged protection
lasting fresh breath.
against oral bacteria
In current applications, antin Prolonged fresh breath
bacterial agents are commonly
n Single daily use
added to toothpaste and mouthn Versatile
wash to help control the bacteria
that cause gingivitis and cavities.
n Comprehensive patent
The added agents coat the tooth
protection
surface and are effective for short
n Proof of concept studies in
periods of time, but the effect is
tooth & saliva models
temporary.
The antibacterial agents are
quickly washed away by food,
drinks and saliva. This leaves teeth vulnerable to bacterial buildup and bad breath.
UNMCs long-lasting formulation solves that problem.
It is non-toxic, and can be modified to have additional agents
including fragrances, whiteners, analgesics, and tooth strengthening compounds such as fluorides.
Vitals
Photo: UNMC
Improve treatment for lupus

and drastically reduce side effects
Nearly 2 million people
suffer an incurable disease
where the bodys immune
system attacks itself: Systemic lupus erythematosus.
Treatment often involves
inefficiently managing the
symptoms, but research by
Dr. Wang at the University
of Nebraska Medical Center
has found a new, targeted
approach that promises to be
more effective over a longer
period of time.
Current lupus treatments only help control
symptoms that grow more
severe over time. And treatments can only be used for a
short time because the risks
of adverse side effects grow
with increasingly larger
doses.
Dr. Wang recently developed a novel polymer
that releases an anti-inflammatory drug at the site
of inflammation.
The polymer, or P-Dex,
improves the effects of a
common lupus treatment,
dexamethasonea synthet-
ic version of a steroid that

is usually produced by the
human adrenal gland. The
polymers unique targeting
mechanism allows special
delivery to specific areas of
inflammation and minimizes the effects on the whole
body.
The result is a more potent therapy with fewer side
effects.
Proof of concept studies have been completed in
animal models, and comprehensive patent protection is
in place. Exclusive rights are
available for lupus and other
inflammatory diseases.
Vitals
Rundown
n Novel composition
n Reduce dexamethasone
side-effects
n Reduce renal damage
n Better efficacy
n Less frequent dosing
n Less expensive
19
Neuronal Freezing Media Kit

Vitals
Inventors
n Jyothi Arikkath, Ph.D.
n Dipika Singh
When researchers need primary rat or

mouse brain cells, they typically isolate
new cells each time, a long and expensive
process.
When a researcher obtains more
cells than needed, there is no good way
to store the surplus. Often the extra cells
are discarded, because current methods
of storing brain cellsfreezing in liquid
nitrogendestroy as much as 70 percent
of the neurons.
Inventors at the University of Nebraska Medical Center found a way to
preserve as much as 90 percent of frozen
mouse and rat brain cells with a novel
freezing medium, the Neuronal Freezing
Media Kit.
Studies show neurons frozen in this
unique formulation maintain

70-90
percent
viability upon
thawing. The
thawed brain
cells show all
the
expected
characteristics
of primary neurons, including
appropriate cell
structure and
intact markers.
The
NeuDr. Arikkath
ronal Freezing
Media kit is a proprietary combination of
four components that are mixed on site.
The kit can be used to freeze and preserve
primary neurons of rats and mice for longterm storage. Recommended freezing and
thawing protocols are also included.
Photo: UNMC
Rundown
n Novel formulation
n Maintain high viability
(75-90%) upon thawing
n Freeze primary hippocampus
and cortical neurons
n Works with rat and
mouse neurons
n Save cells from wild type or
genetically-engineered animals
n Never again
waste leftover cells
n Reduce costs
n Retain up to 90 percent
viability in frozen brain cells
Lifespace Monitoring System

Cost-effective, reliable care for independent elderly
20
Vitals
Photo: UNMC
One of the largest challenges facing elderly care is striking the proper
balance between monitoring health
while maintaining independence.
Solutions exist, but they are generally expensive and have limited applications.
Stephen Bonasera, a researcher at
the University of Nebraska Medical
Center, found an elegant solution: A
wireless system that caregivers can
use remotely to track patients around
the clock with little more than a modern cell phone and a few well-placed
transmitters in the home.
The cost-effective solution, called
the Lifespace Monitoring System,
measures a persons movement patterns around the home to develop a
baseline of regular activity.
With minimal intrusion, Lifespace
can then detect minor changes in activity, which could indicate the onset of
several mental or physical conditions.
Dr. Bonasera
The system allows caregivers to

immediately intervene when a change
in routine is detected.
Because the system monitors the
movement patterns of an individual,
it can easily be adapted to other applications, such as patients with mental or psychiatric limitations.
Rundown
n Novel
n Inexpensive
n Accurate, non-intrusive
collection of patient info
n Real-time information
n Reduce intervention costs
n Better information,
better results
n Constant and continuous
monitoring
n Improve response times
Inventor
n Stephen Bonasera, M.D.
UNeMed improves healthcare by fostering innovation, advancing

biomedical research and engaging entrepreneurs and industry to
commercialize novel technologies.
UNeMed VISION
UNeMed VALUES
n Innovative Vision
n Integrity & Stewardship
n Excellence
n Dedication
n World-class technology commercialization entity

n Best service to faculty
n Recognized by community as entrepreneurial resource
n Help build a strong biomedical ecosystem in Nebraska
Physical Address:
4460 Farnam Street, Suite 3000
Omaha, NE 68198-6099
Mailing Address:
986099 Nebraska Medical Center
Omaha, NE 68198-6099
402-559-2468
unemed@unmc.edu
http://www.unemed.com
Diagnostics Medical Devices Software Research Tools Therapeutics Diagnostics Medical Devic
Transfer Consulting Licensing Patent Protection Material Transfer Intellectual Property Business St
402-559-2468 | unemed@unmc.edu | http://www.unemed.com
986099 Nebraska Medical Center | 4460 Farnam St., Ste. 3000 | Omaha, Nebraska 68198-6099
It is the policy of the University of Nebraska not to discriminate based upon age, race, ethnicity, color, national origin, gender,
sex, pregnancy, disability, sexual orientation, genetic information, veterans status, marital status, religion or political affiliation.

UNeMed Corporation 2013 Annual Report

Uploaded by

Document Information

Copyright

Available Formats

Share this document

Share or Embed Document

Sharing Options

Did you find this document useful?

Is this content inappropriate?

Copyright:

Available Formats

UNeMed Corporation 2013 Annual Report

Uploaded by

Copyright:

Available Formats

ces Software Research Tools Therapeutics Diagnostics Medical Devices Software Research Too

Annual Report | FY 2013

UNeMed improves healthcare by fostering innovation, advancing

Message from the President & CEO

Annual Report | 2013

From the President & CEO

Michael Dixon, Ph.D.

It gives me great pleasure to present the UNeMed 2013

Return to Table of Contents

UNeMed improves healthcare by fostering innovation,

collaborate with nonuniversity commercial

n Best service to faculty

Annual Report | 2013

Return to Table of Contents

Innovation happens here

Fred & Pamela Buffett Cancer Center

Durham Research Center

Stanley M. Truhlsen Eye Institute

Lozier Center for Pharmacy Sciences and

Annual Report | 2013

Ph.D., Pathology and Microbiology,

M.S., Molecular Biology, University

Joined UNeMed: 2009

Ph.D., Pathology and Microbiology,

J.D., Law, Creighton University

Ph.D., Cancer Biology, University of

J.D., Law, University of Tennessee

Joined UNeMed: 2007

Ph.D., Cancer Biology, University of

Ph.D., Medial Science, University of

M.D., University of Nebraska Medical Center

Joined UNeMed: 2010

Ph.D., Medical Microbiology, Creighton University School of Medicine

Ph.D., Pharmacology and Experimental Science, University of Nebraska

Joined UNeMed: 2013

Ph.D., Molecular Biology, Iowa St. Univ.

Annual Report | 2013

Founded by UNMC interventional radiologist Dr. Greg

Photo by Jack Mayfield

Trak Surgical, Inc.

New startups based on UNMC innovation

Return to Table of Contents

Annual Report | 2013

Vireo Systems, a Tennessee-based

Virtual Incision Corp.

Established in 2002, Prommune

developed a new technology, secured

Every fall, UNeMed sponsors Innovation Week, a popular series of events

Annual Report | 2013

Annual Report | 2013

Return to Table of Contents

UNeMed grows with postdocs, interns

World meets Nebraska at BIO

UNeMed leads Intersect 2013

Ben Yoskovtiz (left), author of Lean Analytics and a featured

UNeMed assumed a leadership role for

Annual Report | 2013

One of UNMCs greatest achievements in recent memory splashed

Licensing & Sponsored Research Agreements

Annual Report | 2013

Return to Table of Contents

The process: Fro

2013 BY THE NUMBERS

299material transfer requests