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UNIT-I

PHARMACY AND
THERAPEUTICS COMMITTEE

BY
J.JAYASUTHA
LECTURER
DEPT.OFPHARMACYPRATICE
SRMCOLLEGEOFPHARMACY
SRMUNIVERSITY

DEFINITION

THE PHARMACY AND THERAPEUTICS COMMITTEE IS A


POLICY FAMING AND RECOMMENDING BODY TO THE MEDICAL
STAFF AND THE ADMINSTRATION OF HOSPITAL ON MATTERS
RELATED TO THERAPEUTIC USE OF DRUGS.

OBJECTIVEOFPHARMACYAND
THERAPEUTICSCOMMITTEE

Thepharmacyandtherapeuticshavethree
majorrolestoplay.Theseare:
ADVISORY
EDUCATIONAL
DRUGSAFETYANDADVERSEDRUG
MONITIORING.

COMPOSITIONOFPHARMACYAND
THERAPEUTICSCOMMITTEE
Compositionofpharmacyandtherapeutics
committee(PTC)mightvaryfromhospitalto
hospital.Thefollowingschemeissuggestedfor
generaladoption:
ThePTCmaybecomposedof:
Atleastthreephysiciansfromthemedicalstaff
Apharmacist
Arepresentativeofthenursingstaff
Anhospitaladministratorwithhis/herdesignatedan
exofficiomemberofthecommitteeoneofthe
physiciansmaybeappointedasthechairmanofPTC.

MEDICALSTAFFHOSPITAL
PHARMACIST
(CHAIRMAN)ADMINISTRATORS
(SECRETARY)
(DIRECTOR)

PHARMACYANDTERAPEUTICSCOMMITTEE

SUBCOMMITTEES

SUBCOMMITTEE1
Neoplastics
SUBCOMMITTEE2
Antiinfectives
SUBCOMMITTEE3
Cardiovasculardugs
Diuretics
Cardiacglycosides
Hypotensives
Vasodilators
Anticoagulants

SUBCOMMITTEE4
Gastrointestinaldrugs
Autonomic
SUBCOMMITTEE5
CNSagents
Analgesics
Psychotherapeutics
Respiratory&CerebralStimulants
Sedatives&Hypnotics

SUBCOMMITTEE6
Endocrineagents
Antidiabeticagents
Antiinflammatoryagents
Hormones
ThyroidPreparations.

OPERATIONOFPHARMACYANDTHERAPEUTICS
COMMITTEE

Thiscommitteeshouldmeetregularlyatleast
sixtimesinanyearandalsowhennecessary.
Theagendaandthesupplementarymaterials
shouldbepreparedbythesecretaryand
furnishedtothecommitteememberswellin
advancesothatthememberscanstudythem
properlybeforemeeting.
AtypicalAgendamayconsistsoffollowing:

Minutesofthepreviousmeeting
ReviewofthecontentsoftheHospital
Formularyforthepurposeofbringingitupto
date,anddeletingofproductsnotconsidered
foruse
Informationregardingnewdrugswhichmay
havebecomecommerciallyavailable.
Reviewand/oradoptionofinvestigational
drugscurrentlyunderprocessinginthe
hospital.
Reviewofsideeffects,adversedrug
reactions,toxiceffects,druginteractionsof
drugsreportedbyvariousunitsofhospital.

ReviewofDrugSafetyinthehospital.
Reportsofvarioussubcommittees.
Reportofmedicalaudit.
Anyothermatterwiththepermissionof
chair.
Voteofthanks.

ROLEOFPHARMACYAND
THERAPEUTICSCOMMITTEE(PTC)IN
DRUGSAFETY
Drugsafetyisthemoral,legalandprofessional
obligationofpharmacistinwesterncountries.
Itincludesresponsibilityfromdispensingofdrugs
todrugadministration.
Followingguidelinesmaysubserve thecommittee
inascertainingtheadequatesafetyfactorof
hospitalpharmacy:
Thehospitalmustemployaqualified,atleast,a
registeredpharmacistwithatleast B.Pharm degree
asChiefPharmacistandtherestaremaybe
atleast Diplomaholdersinpharmacist.

Shouldnotpermitnonpharmacistpersonnel
todispensedrugsandalliedmaterials.
Mustemployasufficientmembersof
qualifiedconsideringtheworkloadofa
pharmacistandallowforadequate
coverage(7days/week).
Mustprovideadequatesafe,workspace,and
storagefacilities.

Shouldhaveequipmentnecessarytosafely
andadequatelycarryoutthemodernpractice
ofpharmacy.
Musthaveanautomaticstoporderregulation
fordangerousdrugs.e.g:narcotics,
anticoagulantsetc.
Shouldhaveadrugformularywhich
periodicallyrevisedandkeptupto date.

Thepoisonousmaterialsareseparatedfrom
nonpoisonousmaterialsinthepharmacy.
Theexternalusedpreparationsshouldbe
separatedfrominternalusedmedications.
Musthaveadequatequalitycontrolmeasures
andfollowgoodmanufacturingpractices.
Shouldprovideateachingprogrammeto
teachstudents,nursesthebasiccourseof
pharmaceuticalmathematicsand
pharmacology.

Shouldbeperiodicallyinspectedinorder
toremovedeterioratedandoutdateddrugs
aswellastocheckalllabelsforlegibility.
Shouldhaveanadequatereferencelibrary
whichcontainstextsonpharmacology,
toxicology,posology,andjournals
containinginformationonnewer
developmentsinthepharmaceuticalworld.

ROLEOFPTCINADVERSEDRUGREACTION
MONITORINGPROGRAMME:

Anadversedrugreactionisdefinedasanyusual
ofunexpectedharmfulreactionincludingacute
poisoningsbynarcotics,barbiturates,and
amphetemines aswellasindustrialpoisonings.
Thereisaproportionateincreaseinthedrug
reactions.Inordertogainanunderstandingof
theseproblemsandtoformulatecompetent
opinionsastothebesttypeofpreventionand
treatment,thePTCmustassumethe
responsibilityforthedevelopingandinstituting
aprocedureforthepurposeofcommittee.

AUTOMATICORDERSFORDANGEROUSDRUGS

AllDrugordersfornarcotics,sedatives,
hypnoticanticoagulants,andantibiotics
(adminstered orallyorparenterally)shallbe
automaticallydiscontinuedafter48hours
unlesstheorderindicatesanexactnumberof
dosestobeadminstered,ortheattending
physician,reordersthemedication.
Allordersfornarcotics,sedativesand
hypnoticsmustberewrittenevery24hours.

ROLEOFPTCIN

EMERGENCYDRUGLISTS
TheTimeFactorisnecessaryforthe
PharmacyandTherapeuticsCommitteeofa
hospitaltogetpreparedboxescontaining
emergencydrugswhichshouldbealways
availablereadilyforuseatthebedside.Listof
suchdrugsandothersuppliesshould
compiledbyCommittee,anditshouldfind
theirplaceinEmergencyKits.

Aftertheemergencyboxeshavebeen
placedinthewards,itisveryessentialand
compulsorythatasystemisdeveloped
wherebytheyarecheckeddailyeitherby
thehospitalpharmacistsorbynursing
supervisorresponsiblefortheward.

Followingisthelistofsuggesteddrugsand
otherarticlesmaintainedinEmergencyBox:

SUPPLLIESTOBEMAINTAINEDIN
EMERGENCYBOX:
Syringesofvariousrange
Needles
Filesforbreakingtheampoule
Airwayequipment

DRUGSFOREMERGENCYBOX:
Thesemaybeselectedinconsultationwiththe
physician.
Atropinesulphate0.4mg/ml
Digoxin 0.25mg/ml
Heparin10.000units/ml
Neostigmine methylsulphate0.25mg/ml
Mannitol injection25%
Salineforinjection09%30ml
Waterforinjection20ml.

SUPPLIESFORCABINETUTILITYROOM
Oxygencatheters
Razorwithblades
Resuscitationtube.
OTHEREMERGENCYSUPPLIES
Burnsheets
Dextran andtubing
Resuscitationcarts.

ROLEOFPHARMACYANDTHERAPEUTIC
COMMITTEEINDRUGPRODUCTDEFECT
REPORTINGPROGRAMME

Thedrugspurchasedbyhospitalmaybe
defectiveinquality.
Itisforthecommitteetogetinformationabout
thedefectivedrugproductsandtoinformit
firsttothemanufacturerforappropriateaction.
Ifsatisfactoryanswerisnotobtainedfromthe
manufacturer,itshouldbereportedtothe
FoodandDrugControlAdminstration.

ROLEOFPHARMACYANDTHERAPEUTICS
COMMITTEEINDRUGUTILISATION
REVIEW
Drugutilisationincludesprescribing,
dispensing,adminstering andingestingof
prescriptionofdrugs.
Hospitalpharmacistshouldtakemedication
historythatshouldincludefollowing
information:
Medicationbeingtakenatthetimeof
admission,duringadmission,homeremedies
(OTCdrugs).

Drugallergiesandidiosyncrosy towardsfood
productsetc.
Patentmedicationprofiletobemaintainedfor
eachpatient.Thiswillservethefollowing
purposes:
Tohelpimproveddrugprescribingpracticesby
promotingthesafeandrationaluseofdrugs.
Todetectandhelppreventdruginteractions.
Todetectandpreventadversedrugreactions
insensitivepatients.
TodetectandpreventsIVadditive
incompatibilities.

Todetectdruginduceddiseases.
Tohelpdetectandpotential drugtoxicities.

ThankYou