Professional Documents
Culture Documents
Aeromatic-Fielder Technologies
Product Know-How
Process Expertise
of the plant.
Coating.
Safety and the environment
Plants Customised for Success
specific requirements.
Process
Technologies
Drying
Warm air is blown through a perforated distributor to rapidly and gently
dry materials until the required residual moisture content is reached.
Drying
Moisture evaporated from the product is exhausted with the drying air.
Special features
Selection of air distributors
Short process time
Top Spray
Granulator
Special features
One pot process
Selection of air distributors
Spray
Dryer
Special features
Compact unit
Easy scale-up
Batch or continuous discharge
Granulator
Built-in Versatility
Precision-Granulator
A rotating high velocity air stream is established in the central
agglomeration tube. Particles are picked up at the base of the tube
Precision
and accelerated by the air stream. The particles come into contact
Granulator
with liquid droplets produced from the spray nozzle at the base of
the tube \ the relative velocity of air, liquid droplets and particles
are high so wetting is efficient and drying begins almost
immediately. Most of the feed material is in the outer holding
area, where the gas velocity is very low. Attrition is greatly
reduced. The gas humidity is also low in the holding area so the
material is dry not sticky. Individual particles may make repeated
cycles (typically from 10 to 1,000) through the tube, allowing very
large agglomerates to be built up.
Precision-Coater
Used for smaller particles, such as powders, granules, seeds, crystals,
pellets, and small tablets. The product is coated and partially dried by
Precision
Coater
Batch Fluid
Technology
Through-the-wall installation
By positioning the support column at the back of the
fluid bed, a through-the-wall installation is achieved
which ensures that all the auxiliary equipment is
housed outside the process room. This greatly
simplifies compliance with GMP guidelines.
Solvent emission control
External
bag fitter
Normally used in
conjunction with
the particle
retainer to
collect dust from
the fluid bed in
coating
applications.
Open Cycle
Design
Quick
closing valve
HEPA filter
Optimized Designs
Process filters
In granulation, drying, and most pelletizing
applications, a process filter is used to trap
mall particles, which are returned to the bed
Quick closing
valve
Police filters
Suction fan
Pre-heater
3 Blow-back filter
There are multiple filter bag sections in this
Filter
Heater (face
and by-pass)
Cooler/
condenser
Your Process
Understanding
& Controlling
Materials
information
Multivariate
analysis
PAT data
Process
engineering
models
Process
optimisation
Controls
The PLC front panel key-pad and built-in monitor
are used for recipe programming and real-time
process MIMIC display.
For optimum compatibility with existing plant
control strategies, fluid bed systems are available
with a choice of manual or FDA compliant
automated controls. Programmable logic controller
(PLC) and PC-based options offer a wide range of
Lighthouse Probe
Technology
GEA Pharma Systems (GPS) has joined
forces with J&M GmbH to create a
compact and cleanable in-process optical
probe for use in powder processing
equipment.
The result is the novel Lighthouse Probe, which
can be used with a range of spectroscopic
techniques, including NIR and UV/vis, to overcome
the traditional problem of product sticking to
observation windows.
The probe is compact and easy to install and makes
it possible to take a reliable in process measurement
of quality critical product characteristics including:
Material and active content identification
Active content uniformity during high shear
blending operations
Moisture content and end-point during
drying processes
Coat growth during coating processes
Optical methods such as UV/Vis or NIR
spectroscopy can be very powerful tools for
analysing a range of product characteristics, but in
processes involving wet and sticky powders it is
necessary to ensure that the system has a clear view
of the product. Conventional windows used in
process equipment such as fluid bed systems or high
shear granulators, have always suffered from the
risk of window fouling. The new GPS & J&M
Lighthouse Probe has overcome this problem.
Sizes &
Capacities
Meeting Every
Requirement
Standard modules configured into tailor-made plants.
The philosophy behind the design is that a combination of
standardised modules are built together in order to meet the
requirement for a specific duty. Therefore, dryers of equal capacity
may be completely different with respect to design, configuration
and physical size.
To meet the high requirements of the pharmaceutical industry,
Aeromatic-Fielder has a series of fluid bed systems suitable for
formulation, process development, production of clinical material
through to full-scale production.
Production capacities
150
300
400
400
600
800
1200
1800
2400
3000
(Size 3)
(Size 4)
(Size 5)
(Size 5) K3
(Size 6)
(Size 6) K3
(Size 7)
(Size 8)
(Size 9)
(Size 10)
30 to 100 L
60 to 200 L
90 to 300 L
90 to 400 L
120 to 400 L
120 to 600 L
240 to 800 L
360 to 1200 L
480 to 1600 L
600 to 2000 L
15 to 50 kg
30 to 100 kg
45 to 150 kg
60 to 200 kg
60 to 200 kg
90 to 300 kg
120 to 400 kg
180 to 600 kg
320 to 1200 kg
125 L
225 L
355 L
450 L
600 L
650 L
900 L
1350 L
1800 L
2250 L
Typical working
capacity
Typical batch
capacity
(average product density 0.5kg/l)
Maximum
working volume
Values are process and product specific and may vary from those shown above.
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Integration
Optimum
Process Efficiency
System integration
GEA Pharma Systems specialises in the design and
manufacture of fluid bed and high-shear granulation
technology and is uniquely qualified to provide
state-of-the-art integrated high shear mixergranulator and fluid bed drying technology. Drawing
on its world-class expertise, GPS Pharma Systems
offers fully integrated turnkey installations. The
service includes: design, installation assistance,
commissioning, process validation, as well as
training, and technical support. Installation,
operation qualification and documentation are
carried out according to FDA/GAMP guidelines.
Integration by design
Aeromatic-Fielders entire range of process
equipment is designed with system integration in
mind. A modular approach allows customers to
select standard process modules to suit project
needs. Fluid bed dryers and coaters can be combined
with top-drive and bottom-drive high shear mixergranulators, wet and dry milling facilities, product
handling systems, binder and coating preparation
units, filtration units, all designed for fully
integrated systems. Safety, containment, product
flow and building requirements are in-built for full
integration for optimum process efficiency
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Design
Cleanability &
Maintenance
Process optimisation depends on efficient, effective
cleaning. Automation of the cleaning process ensures
repeatability, allows validation and minimises down-time.
In recognition of the fundamental role played in todays
advanced powder processing industry by automated cleanin-place procedures Aeromatic-Fielder has developed a
unique approach to CIP.
wash-
CIP Kitchen
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Safety &
the environment
Continuous
Improvement
increase in pressure.
10 bar PSR
design (no
relief duct
neccessary)
Explosion
suppression
system (no relief
duct neccessary)
2 bar PSR
design with
explosion
relief duct
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The Complete
Partnership
Working with you
Entering a partnership with Aeromatic-Fielder means entering a partnership that does
not end until you are completely satisfied. From the moment you have specified your
user requirements and until the plant has been put into service and has been
qualified, our trained staff stays with you at every step of the process, working in
close co-operation with your own staff creating the components and systems that will
result in a finished plant.
Client Verification
Customer
responsibilty
User Requirements
Process Qualification
Functional Specification
Aeromatic-Fielder /
Client Verification
Operational Qualification
Joint tasks
Software
design
Aeromatic-Fielder
responsibilty
Hardware
design
Mechanical
design
Installation Qualification
FAT testing
Hardware manufacturing
Integrated testing
Software Configuration
Bench testing
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Service
for Life
Project Management
The expertise of the Aeromatic-Fielder engineering
team is available to help customers find the
optimum solution for their individual processing
needs. The company assists with single phases of a
project, or takes full responsibility for design and
installation of a complete turnkey plant.
Training
Operators of Aeromatic-Fielder equipment can
undergo training to help them maximise efficiency,
either at the time of installation or periodically as
required.
After Sales
Regular maintenance is essential to ensure
equipment operates to maximum efficiency. Fully
trained engineers can carry out on-site servicing and
calibration of equipment, either as part of a planned
maintenance programme or in response to customer
need. Replacement parts can be supplied from stock
or manufactured to order.
To avoid the expense of equipment replacement
Aeromatic-Fielder can upgrade existing systems and
plant to meet different operational parameters, to
comply with changing regulations, or to modify for
use at another location.
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GEA Pharma Systems 2008 Specifications subject to change without notice All trademarks recognized