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PHARMACOLOGIC MANAGEMENT

DRUG CLASS
EFFICACY
SAFETY
TREATMENT FOR HYPERTENSION
It increases the rate of urine Erectile dysfunction, gout,
DIURETICS
flow, excretion of Na and other hyponatremia,
accompanying ions, usually Cl.
hypercalcemia
and
arrhythmias
Loop

Thiazide

BetaBlockers

ACE
Inhibitors

Increases excretion of water by
interfering
with
chloridebinding cotransport system,
which in turn inhibits sodium
and chloride reabsorption in
the ascending loop of Henle
and distal tubule.
Inhibits Na-K-Cl symporter in
the
distal
renal
tubules,
resulting in increased excretion
of Na, water and K.
Beta blockers primarily block
β1 and β2 receptors and
thereby
and
thereby
the
effects of norepinephrine and
epinephrine. By blocking the
effects of norepinephrine and
epinephrine,
beta
blockers
reduce
heart
rate;
reduce blood
pressure by
dilating blood vessels
Prevents
conversion
of
angiotensin I to angiotensin II,
which
is
a
potent
vasoconstrictor, resulting in
lower aldosterone secretion.

SUITABILITY
Helps our patient to get rid
of excess salt and fluid
helps lower blood pressure
and can make it easier for
the heart to pump.

Hyperuricemia,
hypokalemia, anaphylaxis,
glycosuria.

Scaling eczema, StevenJohnsons syndrome, TEN,
disorder of hematopoietic
structure, hepatotoxicity
Beta blockers should not
be withdrawn suddenly
because
sudden
withdrawal may worsen
angina (chest pain) and
cause heart
attacks or sudden death.

First line treatment for
hypertension.

Used with caution to
patients with congestive
heart failure. Do not use
in
patiens
with
hypersensitivity.
Side/Adverse
effects:
Hyperkalemia,
hypersensitivity reactions,
hypotension, cough, chest
pain,
palpitations,
proteinuria.

It is suitable for the patient
because of its faster
remodeling of the heart. Its
effect is more on
hemodynamic and not on
the structural effect.

It is suitable for the patient
because it can reduce the
patient’s heart rate.

Should be taken on an
empty stomach. Take 1hr
before or 2hr after meals.

Calciumchannel
blockers

It relaxes coronary smooth
muscle and produces coronary
vasodilation which improves
myocardial oxygen delivery.

TREATMENT FOR HIGH TOTAL CHOLESTEROL
Competitively inhibits HMGStatins
CoA reductase, the enzyme
that catalyses the conversion
of HMG-CoA to mevalonate.
This results in the induction of
the
LDL
receptors
and
stimulation of LDL catabolism,

Edema,
pulmonary
edema,
headache,
fatigue,
palpitations,
dizziness,
nausea,
flushing, abdominal pain,
somnolence.

It is suitable for our
hypertensive patient
because it can improve the
myocardial oxygen delivery
and coronary vasodilation.

Adverse Effects:
Chest
pain, face edema, fever,
neck
rigidity,
malaise,
photosensitivity reaction,
generalized edema.

Reduces LDL-cholesterol,
apolipoprotein B &
triglycerides; increases
HDL-cholesterol in the
treatment of
hyperlipidemias.

76/p ack Atorvastati n 10mg/tab P26. hypersensitivity reactions. fatigue. cough. It is suitable for the patient because of its faster remodeling of the heart. pulmonary edema.25/tab P8. abdominal pain.75/tab 100’s P843/pack 100’s P2334. the enzyme that catalyses the conversion of HMG-CoA to mevalonate. TEN. Its effect is more on hemodynami c and not on the structural effect. Scaling eczema. Reduces LDLcholesterol. nausea. flushing. fever. chest pain. P-DRUGS DRUG CLASS DIURETIC Hydrochlorothiazide (Diuzid) 25 mg given 1tab once a day BETA-BLOCKER Atenolol (Tenorvas) 25mg given1/2tab once daily ACE INHIBITOR Captopril (Hartylox) 25 mg 1 tab twice a day LDL- EFFICACY SAFETY Inhibits Na-K-Cl symporter in the distal renal tubules. hypotension. CALCIUM CHANNEL BLOCKER Nifedipine (Cacibloc) 10mg 1cap twice a day It relaxes coronary smooth muscle and produces coronary vasodilation which improves myocardial oxygen delivery. palpitations. disorder of hematopoietic structure. Side/Adverse effects: Hyperkalemia. water and K. hepatotoxicity SUITABILIT Y First line treatment for hypertension . which is a potent vasoconstrictor. This results in the induction of the LDL receptors and stimulation of LDL catabolism. beta blockers reduce heart rate.leading to lowered cholesterol levels. photosensitivity reaction. Adverse Effects: Chest pain. It is suitable for the patient because it can reduce the patient’s heart rate. neck rigidity. Tenorvas tab 50mg Used with caution to patients with congestive heart failure. Beta blockers should not be withdrawn suddenly because sudden withdrawal may worsen angina (chest pain) and cause heart attacks or sudden death. Hartylox tab 25mg It is suitable for our hypertensive patient because it can improve the myocardial oxygen delivery and coronary vasodilation. resulting in increased excretion of Na. COST Diuzid tab 25mg P4. proteinuria.00/filmcoated tab . palpitations. StevenJohnsons syndrome. resulting in lower aldosterone secretion. By blocking the effects of norepinephrine and epinephrine. Do not use in patiens with hypersensitivity. malaise. reduce blood pressure by dilating blood vessels Prevents conversion of angiotensin I to angiotensin II. headache. leading to lowered LDL-cholesterol levels. Edema. generalized edema. Beta blockers primarily block β1 and β2 receptors and thereby and thereby the effects of norepinephrine and epinephrine. Take 1hr before or 2hr after meals. apolipoprotei n B & triglycerides. somnolence. STATINS Atorvastatin (Avamax) 10mg once daily Atorvastatin competitively inhibits HMG-CoA reductase. dizziness. increases HDLcholesterol in the treatment of hyperlipidem Calcibloc cap 10mg Should be taken on an empty stomach. face edema.

ias. .