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ISSN 2278-4500

A research awareness e-Journal by

2015 | Volume 4, Issue: 2 | Page: 15 - 30

Published by Dr. Saurav Arora

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Table of Contents
A Compendium of Abstracts of Studies on extracts, homeopathy and high dilution published by
Prof. Anisur Rahman Khuda-Bukhsh et al .......................................................................................................... 1
A Compendium of Articles Published in International Journal of High Dilution Research from
2008 2014 ................................................................................................................................................................... 1
Studies to be Read........................................................................................................................................................ 2
Fundamental Research ............................................................................................................................... 2
Sulphur alters NFB-p300 cross-talk in favour of p53-p300 to induce apoptosis in non-small cell
lung carcinoma. .................................................................................................................................. 2
Gas nanobubbles and aqueous nanostructures: the crucial role of dynamization ....................... 2
Hormetic effects of extremely diluted solutions on gene expression ............................................ 3
Clinical Research ......................................................................................................................................... 3
Influence of adjunctive classical homeopathy on global health status and subjective wellbeing
in cancer patients - A pragmatic randomized controlled trial. ....................................................... 3
'Nosodes' are no substitute for vaccines. ......................................................................................... 4
Homeopathy in France in 2011-2012 according to reimbursements in the French national
health insurance database (SNIIRAM). ............................................................................................. 4
Safety and compliance of a complex homeopathic drug (Contramutan N Saft) in the treatment
of acute respiratory tract infections: A large observational (non-interventional) study in
children and adults focussing on homeopathy specific adverse reactions versus adverse drug
reactions. ............................................................................................................................................ 5
Towards improving the reporting quality of clinical case reports in complementary medicine:
assessing and illustrating the need for guideline development. .................................................... 5
Risk in homeopathy: Classification of adverse events and homeopathic aggravations A cross
sectional study among Norwegian homeopath patients ................................................................ 6
Patients' preference for integrating homeopathy (PPIH) within the standard therapy settings in
West Bengal, India: The part 1 (PPIH-1) study ................................................................................. 7
Review ......................................................................................................................................................... 8
Life stories, homeopathy and permanent education: construction of shared healthcare. .......... 8
Time to sensitize medical graduates to the Indian Systems of Medicine and Homeopathy ........ 8
Hormesis: umbrella mechanism only for agents present in the environment. ............................. 8
Hormesis: principles and applications .............................................................................................. 9
Historical foundations of hormesis ................................................................................................... 9
Hormesis within a mechanistic context ............................................................................................ 9

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Unequal brothers: are homeopathy and hormesis linked? ............................................................ 9


Enhancement of adaptive biological effects by nanotechnology preparation methods in
homeopathic medicines................................................................................................................... 10
Cell sensitivity, non-linearity and inverse effects .......................................................................... 11
A gentle ethical defence of homeopathy. ...................................................................................... 11
Proceedings of the XXIX GIRI Symposium ........................................................................................................12
Upcoming Events........................................................................................................................................................15

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A Compendium of Abstracts of Studies on extracts, homeopathy and


high dilution published by Prof. Anisur Rahman Khuda-Bukhsh et al
For decades, there is a war amongst
homeopathy and skeptics! Numerous
studies have been undertaken which
confirms the efficacy of high dilutions and
homeopathy, but due to lack of repositories
and awareness, many of them go unnoticed.
There is a need to preserve such studies.
The Initiative to Promote Research in
Homeopathy has taken a step ahead in this
line. With the kind help of Prof. Anisur
Khuda-Bukhsh, Professor Emeritus, Dept. of
Zoology, University of Kalyani, West Bengal,
India, who is known for his dedication in
research, has compiled "A Compendium of
Abstracts of Studies on extracts,
homeopathy and high dilution" published

by
him
and
his
team.
Dr. Bukhsh has devoted more than 35 years
in research and has been involved in various
research studies on extracts, homeopathy,
and high dilutions. Dr Khuda-Bukhsh also
proposed Gene Regulatory Hypothesis of
homeopathic remedies almost two decades
back. This compendium covers most of his
publication titles on fundamental and basic
research extracts, homeopathy, and high
dilutions till date. The compendium may be
downloaded
for
free
at
www.researchinhomeopathy.org/compendi
um-arkb. This compendium is a reference
work of pure hard work, dedication, and
insight.

A Compendium of Articles Published in International Journal of High


Dilution Research from 2008 2014

International Journal of High Dilution


Research (IJHDR) has served as an
important platform for the divulgation of
research in the field of high dilution and
homeopathy since its foundation in 2008. It
is an invaluable resource for researchers,
academicians and clinicians being the first
open-access, peer-reviewed, online journal
specialized in this field. IJHDR is hosted by
Groupe International de Recherche sur
lInfinitesimal (GIRI) (www.giriweb.com)
and publishes high-quality articles on
fundamental/basic research in high dilution,
isopathy, biotherapy, nosodes, clinical
research/evidence-based
homeopathy,
veterinary, agronomy, reviews, metaanalyses, systematic reviews, etc. IJHDR
believes in making information freely
accessible and thus provide free full access
to contents as soon as they are published.
The IJHDR is currently indexed in databases
like LILACS/BIREME/PAHO/WHO; EBSCO;
SCOPUS; Qualis/CAPES; Latindex; Google

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Scholar; DOAJ; NSDL/NSF; Open J-Gate;


Journal Seek and Portal CAPES.
Since its launching in 2008 until 2014,
IJHDR has published 341 articles across 28
issues, including five proceedings of GIRI
meetings. With the increasing volume of
online published material, the need to
preserve it offline has emerged. The present
compendium aims to organize the articles
published in IJHDR from 2008 2014 in one
single PDF, which might be saved to any
online and offline medium, can be accessed
anytime with a few clicks, is searchable and
might be printed by libraries and
universities for filing in their archives.
To facilitate the access, the articles have
been arranged as per publication date and
hyperlinked to the title. As the present
compendium is open access, you might use
freely, as well as circulate it among
colleagues. The compendium may be
download
freely
from
www.highdilution.org/compendium

#researchinhomeopathy

Studies to be Read
Abstracts of peer reviewed studies published during April June 2015

Fundamental Research
Int J Oncol. 2015 Jun 22.
Sulphur alters NFB-p300 cross-talk in
favour of p53-p300 to induce apoptosis
in non-small cell lung carcinoma.
Saha S, Bhattacharjee P, Guha D, Kajal K,
Khan P, Chakraborty S, Mukherjee S, Paul S,
Manchanda R, Khurana A, Nayak D,
Chakrabarty R, Sa G, Das T.
Abstract
Adverse side effects of chemotherapy
during cancer treatment have shifted
considerable focus towards therapies that
are not only targeted but are also devoid of
toxic side effects. We evaluated the
antitumorigenic activity of sulphur, and
delineated the molecular mechanisms
underlying sulphur-induced apoptosis in
non-small cell lung carcinoma (NSCLC) cells.
A search for the underlying mechanism
revealed that the choice between the two
cellular processes, NFBp65-mediated
survival and p53-mediated apoptosis, was
decided by the competition for a limited
pool of transcriptional coactivator protein
p300 in NSCLC cells. In contrast, sulphur
inhibited otherwise upregulated survival
signaling in NSCLC cells by perturbing the
nuclear translocation of p65NFB, its
association with p300 histone acetylase, and
subsequent transcription of Bcl-2. Under
such anti-survival condition, induction of
p53-p300
cross-talk
enhanced
the
transcriptional activity of p53 and intrinsic
mitochondrial death cascade. Overall, the
findings of this preclinical study clearly
delineated the molecular mechanism
underlying the apoptogenic effect of the
non-toxic homeopathic remedy, sulphur, in
NSCLC cells.

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Homeopathy 2015;104(2):101-15
Gas
nanobubbles
and
aqueous
nanostructures: the crucial role of
dynamization
Jean-Louis Demangeata
Nanobubbles (NBs) have been a subject of
intensive research over the past decade.
Their peculiar characteristics, including
extremely
low
buoyancy,
longevity,
enhanced solubility of oxygen in water, zeta
potentials and burst during collapse, have
led to many applications in the industrial,
biological and medical fields. NBs may form
spontaneously from dissolved gas but the
process is greatly enhanced by gas
supersaturation and mechanical actions
such as dynamization. Therefore, the
formation of NBs during the preparation of
homeopathic dilutions under atmospheric
pressure cannot be ignored. I suggested in
2009 the involvement of NBs in nanometric
superstructures revealed in high dilutions
using
NMR
relaxation.
These
superstructures seemed to increase in size
with dilution, well into the ultramolecular
range (>12c).
I report here new experiments that confirm
the involvement of NBs and prove the
crucial role of dynamization to create
superstructures specific to the solute. A
second dynamization was shown to enhance
or regenerate these superstructures. I
postulate that superstructures result from a
nucleation process of NBs around the solute,
with shells of highly organized water (with
ions and silicates if any) which protect the
solute against out-diffusion and behave as
nucleation centres for further dilution steps.
#researchinhomeopathy

The sampling tip may play an active role by


catching the superstructures and thus carry
the encaged solute across the dilution range,
possibly up to the ultramolecular range. The
superstructures were not observed at low
dilution,
probably
because
of
a
destructuring of the solvent by the solute
and/or of an inadequate gas/solute ratio.
Keywords: Nanobubbles; Nanostructures;
NMR relaxation; water; ultrahigh dilution;
Dynamization
Homeopathy 2015;104(2)116-22
Hormetic effects of extremely diluted
solutions on gene expression
Andrea Dei, Simonetta Bernardini
This paper summarizes the results of
investigations showing how molecular
biological tools, such as DNA-microarrays,
can provide useful suggestions about the
behaviour of human organisms treated with
microamounts of drugs or homeopathic
medicines. The results reviewed here
suggest firstly that the action of drugs is not
quenched by ultra-high dilution and
proceeds through modulation of gene
expressions. The efficacy of drug solutions
seems to be maintained in ultra-highly
diluted preparations, a fact which
constitutes a challenge to the dogma of
quantization of matter.

The second and more important result is


that the different gene expression profiles of
cell systems treated with the same drugs at
different dilutions suggest the existence of
hormetic mechanisms. The gene expression
profiles of cells treated with copper(II)
sulfate, Gelsemium sempervirens and Apis
mellifica, are characterized by the same
common denominator of the concentrationdependent inversion of gene expression,
which can justify at a molecular level the
concept of simile adopted in homeopathy.
The main conclusion we draw from these
results is that these procedures provide new
kinds of information and a tool for
disclosing the mechanisms involved in
hormetic effects. The application of these
effects to modern medicine may allow
researchers to conceive unprecedented
therapeutic applications or to optimize the
currently used ones in the framework of a
low-dose pharmacology based on a reliable
experimental platform.
Keywords: Gene expression; Hormesis;
Microarray;
Homeopathy;
Low-dose
pharmacology

Clinical Research
Complement
Ther
Med.
2015
Jun;23(3):309-17.
Influence
of
adjunctive
classical
homeopathy on global health status and
subjective wellbeing in cancer patients A pragmatic randomized controlled trial.
Frass M, Friehs H, Thallinger C, Sohal NK,
Marosi C, Muchitsch I, Gaertner K, Gleiss A,
Schuster E, Oberbaum M.

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Abstract
Objectives: The use of complementary and
alternative medicine has increased over the
past decade. The aim of this study was to
evaluate whether homeopathy influenced
global health status and subjective
wellbeing when used as an adjunct to
conventional cancer therapy.

#researchinhomeopathy

Design: In this pragmatic randomized


controlled trial, 410 patients, who were
treated by standard anti-neoplastic therapy,
were randomized to receive or not receive
classical homeopathic adjunctive therapy in
addition to standard therapy. The study
took place at the Medical University Vienna,
Department of Medicine I, Clinical Division
of Oncology.
Main Outcome Measures: The main
outcome measures were global health status
and subjective wellbeing as assessed by the
patients. At each of three visits (one
baseline, two follow-up visits), patients
filled in two different questionnaires.
Results: 373 patients yielded at least one of
three measurements. The improvement of
global health status between visits 1 and 3
was
significantly
stronger
in
the
homeopathy group by 7.7 (95% CI 2.3-13.0,
p=0.005) when compared with the control
group. A significant group difference was
also observed with respect to subjective
wellbeing by 14.7 (95% CI 8.5-21.0,
p<0.001) in favor of the homeopathic as
compared with the control group. Control
patients showed a significant improvement
only in subjective wellbeing between their
first and third visits.
Conclusion: Results suggest that the global
health status and subjective wellbeing of
cancer patients improve significantly when
adjunct classical homeopathic treatment is
administered in addition to conventional
therapy.
Paediatr
Child
Health.
2015
May;20(4):219-22.
'Nosodes' are no substitute for vaccines.
Rieder MJ, Robinson JL.
Abstract
A growing antivaccine movement in Canada
and elsewhere is hearing more about an

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unproven homeopathic therapy, 'nosodes',


as an alternative to routine vaccines. The
present statement defines nosodes and
describes limitations for their use in
children. There is scant evidence in the
medical literature for either the efficacy or
safety of nosodes, which have not been well
studied for the prevention of any infectious
disease in humans. Recommendations to
change the labelling on these products to
reflect such limitations are made.
Keywords: Homeopathy; Nosodes; Public
health
Fam Pract. 2015 Apr 28.
Homeopathy in France in 2011-2012
according to reimbursements in the
French national health insurance
database (SNIIRAM).
Piolot M, Fagot JP, Riviere S, FagotCampagna A, Debeugny G, Couzigou P, Alla
F.
Abstract
Background: The use of homeopathic
medicine is poorly described and the
frequency of combined allopathic and
homeopathic prescriptions is unknown.
Objective: To analyse data on medicines,
prescribers and patients for homeopathic
prescriptions that are reimbursed by French
national health insurance.
Methods: The French national health
insurance databases (SNIIRAM) were used
to analyse prescriptions of reimbursed
homeopathic drugs or preparations in the
overall French population, during the period
July 2011-June 2012.
Results: A total of 6,705,420 patients
received at least one reimbursement for a
homeopathic preparation during the 12month period, i.e. 10.2% of the overall
population, with a predominance in females

#researchinhomeopathy

(68%) and a peak frequency observed in


children aged 0-4 years (18%). About one
third of patients had only one
reimbursement, and one half of patients had
three or more reimbursements. A total of
120,110 healthcare professionals (HCPs)
prescribed at least one homeopathic drug or
preparation. They represented 43.5% of the
overall population of HCPs, nearly 95% of
general practitioners, dermatologists and
pediatricians, and 75% of midwives.
Homeopathy accounted for 5% of the total
number of drug units prescribed by HCPs.
Allopathic medicines were coprescribed
with 55% of homeopathic prescriptions.
Conclusion: Many HCPs occasionally
prescribe
reimbursed
homeopathic
preparations, representing however a small
percentage of reimbursements compared to
allopathic medicines. About 10% of the
French population, particularly young
children and women, received at least one
homeopathic preparation during the year.
In more than one half of cases, reimbursed
homeopathic preparations are prescribed in
combination with allopathic medicines.
Regul
Toxicol
Pharmacol.
2015
Jul;72(2):179-84.
Safety and compliance of a complex
homeopathic drug (Contramutan N Saft)
in the treatment of acute respiratory
tract infections: A large observational
(non-interventional) study in children
and adults focussing on homeopathy
specific adverse reactions versus
adverse drug reactions.
Michalsen A, Uehleke B, Stange R.
Abstract
Background: This non-interventional study
was performed to generate data on safety
and treatment effects of a complex
homeopathic drug (Contramutan N Saft).

with the medication for 8days. The study


was conducted in 64 outpatient practices of
medical
doctors
trained
in
CAM.
Tolerability, compliance and the treatment
effects were assessed by the physicians and
by patient diaries. Adverse events were
collected and assessed with specific
attention to homeopathic aggravation and
proving symptoms. Each adverse effect was
additionally evaluated by an advisory board
of experts.
Results: The physicians detected 60
adverse events from 46 patients (4.4%).
Adverse drug reactions occurred in 14
patients (1.3%). Six patients showed
proving symptoms (0.57%) and only one
homeopathic aggravation (0.1%) appeared.
The rate of compliance was 84% in average
for all groups and the global assessment of
the treatment effects attributed to "good"
and "very good" in 84.9% of all patients.
Conclusions: The homeopathic complex
drug was shown to be safe and effective for
children and adults likewise. Adverse
reactions
specifically
related
to
homeopathic principles are very rare. All
observed events recovered quickly and
were of mild to moderate intensity.
Keywords:
Acute
respiratory
tract
infection;
Adverse
events;
Dosage;
Echinacea
angustifolia;
Eupatorium
perfoliatum; Homeopathic aggravation;
Mother tincture; Non-interventional study;
Proving symptoms; Safety
Complement
Ther
Med.
2015
Apr;23(2):141-8.
Towards improving the reporting quality
of clinical case reports in complementary
medicine: assessing and illustrating the
need for guideline development.
van Haselen RA.

Patients and Methods: 1050 outpatients


suffering from common cold were treated
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Abstract
Background: Case reports have had a
varying level of recognition as a source of
evidence throughout the history of
medicine. In recent years, there has been a
revival of interest in clinical case reports in
both conventional and complementary
medicine. There is a need to further
improve the reporting quality of clinical
case reports of different Complementary
and Alternative Medicine (CAM) therapies.
Objectives: To provide an overview of the
different objectives for clinical case reports,
identify those that are most relevant for
CAM, and to develop a conceptual
framework for purpose orientated clinical
case reporting guidelines for CAM therapies.
To practically illustrate the chosen
approach by developing a clinical case
reporting guideline for homeopathic cases.
Methods: The various objectives of clinical
case reports were described by Prof. Milos
Jenicek, and the potential relevance of these
objectives for CAM were discussed and
graded by a mixed panel of experts. A
conceptual framework for developing
clinical case reporting guidelines for CAM
treatments with specific objectives is
proposed. The aim is to integrate both
'generic' and 'CAM therapy specific' quality
items. This framework has been practically
applied to the development of a reporting
guideline for clinical case reports in
homoeopathy which will be reported in a
second article.
Results: An overview is given of the clinical
case reporting literature. The conceptual
framework for the development of purpose
orientated CAM clinical case reporting
guidelines is presented. This framework is
based on alignment with the recently
published 'generic' CARE guideline for
reporting of clinical case reports, whilst

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addressing the CAM specific elements at the


same time.
Conclusions: The scope and importance of
clinical
case
reporting
guideline
development in CAM is illustrated. A
conceptual framework for developing CAM
specific clinical case reporting guidelines
was established. It has been implemented
using homoeopathy as an illustration, and
this will be reported in a separate article.
Further improvements in clinical case
reporting in CAM will greatly contribute to
CAM research and education, as well as to
improved patient care.
Keywords: Clinical case reports; Reporting
guideline development
Complementary Therapies in Medicine
2015;23(4):53543
Risk in homeopathy: Classification of
adverse events and homeopathic
aggravations A cross sectional study
among Norwegian homeopath patients
Trine Stuba, Agnete E. Kristoffersena, Terje
Alrka, Frauke Musiala, Aslak Steinsbekkb
Abstract
The registration of adverse events is
important to identify treatment that might
impose risk to patients. Homeopathic
aggravation, a concept unique for
homeopathy may impose a particular risk,
as it is tolerant towards a worsening of the
patients symptoms. The aim of this study
was to explore the classification of patient
reported
reactions
as
homeopathic
aggravations or adverse drug reactions.
Design and setting
In a cross sectional survey, patients were
asked to register any reactions they had
experienced 14 days after taking
homeopathic remedies. Worsening of
symptoms was classified as homeopathic
aggravation if it was (i) an increase of the

#researchinhomeopathy

patients existing symptoms (ii) and/or a


feeling of well-being that emerged 13 days
after taking the remedy (iii) and/or
headache and/or fatigue accompanying
these symptoms.
Results
A total of 26% of the participants reported
worsening of symptoms. One third was
classified as adverse events. Half of these
were graded as minor and the other half as
moderate according to the Common
Terminology Criteria for Adverse Events.
Two thirds were classified as homeopathic
aggravations. Of these, 73% were classified
as minor and 27% as moderate, giving a
tendency towards milder severity for those
classified as homeopathic aggravations (p =
0.065).
Conclusion
Patients reported a substantial part of the
short-term
reactions
after
taking
homeopathic remedy as a worsening of
symptoms. These reactions were classified
as mild and moderate. Hence, the risk
connected to homeopathic treatment is
minor. More studies are needed to confirm
the existence of homeopathic aggravation
and how to classify the concept in a
clinically meaningful way.
Keywords
Adverse events; Homeopathic aggravations;
Healing crisis; Risk assessment; Safety;
Homeopathy; Cross sectional survey
Journal of Traditional and Complementary
Medicine. In press
Patients' preference for integrating
homeopathy (PPIH) within the standard
therapy settings in West Bengal, India:
The part 1 (PPIH-1) study
Munmun Koley, Subhranil Saha, Jogendra
Singh Arya, Gurudev Choubey, Aloke Ghosh,
Kaushik Deb Das et al.

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Abstract
There is lack of studies assessing the
preference of Indian patients for integration
of homeopathy into standard therapy
settings. The objectives of this study were to
examine the knowledge, attitudes, and
practice of homeopathy among Indian
patients already availing homeopathy
treatment and its integration into
mainstream healthcare.
A cross-sectional survey was conducted
among adult patients attending the outpatients
of
the
four
government
homeopathic hospitals in West Bengal,
India.
A
self-administered
24-items
questionnaire in local vernacular Bengali
was developed and administered to the
patients.
A total of 1352 patients' responses were
included in the current analysis. 40%
patients
thought
that
homeopathic
medicines can be used along with standard
therapy. 32.5% thought that homeopathic
medicines might cause side effects, while
only 13.3% believed that those might
interact with other medications. Patients'
knowledge ranged between 25.1 and 76.5%
regarding regulations of practicing and
safety of homeopathic medicine in India and
abroad; while positive attitude towards the
same ranged between 25.4 and 88.5%.
88.6% of the patients had favorable attitude
toward integrated services. 68.2% of the
patients used homeopathic medicines in any
acute or chronic illness for themselves and
76.6% for their children. Preference for
integrated services was significantly
associated with better knowledge (P =
0.002), positive attitudes toward safety and
regulations (P < 0.0001), and integration (P
< 0.0001), but not with the level of practice
(P = 0.515).
A favorable attitude toward integrating
homeopathy into conventional healthcare
settings was obtained among the patients

#researchinhomeopathy

attending the homeopathic hospitals in


West Bengal, India.

Review
Cien Saude Colet. 2015 Jun;20(6):17951803.
Life stories, homeopathy and permanent
education: construction of shared
healthcare.
[Article in English, Portuguese]
Slomp Junior H1, Feuerwerker LC2, Merhy
EE3.
Abstract
Taking its inspiration from the homeopathic
method of collecting data, and acting in a
context of permanent education in health,
this study aimed to analyze the possibilities
that can be offered for healthcare by
construction of Life Histories, in organized
encounters for collective elaboration of
shared therapeutic projects. Some changes
that arose from the use of this strategy are
discussed: health workers and users
changed their stances in relation to each
other; teams looked at cases with a new
approach; and both these developments
appeared to have created stronger and
more effective encounters to produce care.
It is concluded that, in the ambit of this
study, Life Histories, by intensifying the
collective operation of soft technologies, in
an invitation to the shared therapeutic
project, increased the porosity of the teams,
and the recognition of the user as a valid
interlocutor.
The
conclusion
favors
reorientation of approach to the other
technological levels in health work, and
recognition of Life Histories as powerful
elements for production of effective
healthcare.

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Indian J Pharmacol. 2015 Jan-Feb; 47(1):


13.
Time to sensitize medical graduates to
the Indian Systems of Medicine and
Homeopathy
Vandana Roy
Traditional medicine is a system of
medicine that has been practiced in its
country of origin for many years, while
complementary and alternative medicine
(CAM) refers to a traditional system of
medicine that is practiced in a country other
than the country of its origin, like Tibetan
medicine when practiced in India.[1]
Traditional medicine includes diverse
health practices, approaches, knowledge
and beliefs. It often integrates indigenous
plant, animal and mineral based medicines.
It may involve spiritual healing practices,
manual techniques and exercises. These are
used to treat or prevent illness. In India,
Traditional medicine and CAM has been
used for thousands of years for prevention,
diagnosis and treatment of a wide variety of
illness. It now provides an important health
care service to patients, especially those
with limited geographic or financial access
to the Modern System of Medicine
(allopathic medicine).
Hum Exp Toxicol. 2015 Apr;34(4):43941.
Hormesis: umbrella mechanism only for
agents present in the environment.
Jargin SV.
Hormesis is a concept of biphasic dose
response to different toxicological and
pharmacological stimuli. According to this
concept, a noxious agent at a small dose can
exert a beneficial action. Among the known

#researchinhomeopathy

hormetic agents are pro-oxidants, heavy


metals, heat, radiation, exercise, food
restriction and different kinds of stress. All
these agents are present in the environment
so that the hormetic effect can be explained
from the evolutionary viewpoint as living
organisms have adapted to a certain level of
the impact. For antibiotics, hormetic effects
develop secondarily along with the positive
selection of resistant microorganisms.
Another example is that the adaptation of
certain human populations to ethanol for
over 1000 years apparently resulted in
hormesis; moderate alcohol consumption
was reported to be associated with a
reduced risk of coronary heart disease and
other health benefits. Read more.
Homeopathy 2015;104(2):69-82
Hormesis: principles and applications
Edward J. Calabrese
Hormesis has emerged as a central concept
in biological and biomedical sciences with
significant implications for clinical medicine
and environmental risk assessment. This
paper assesses the historical foundations of
the doseresponse including the threshold,
linear and hormetic models, the occurrence
and frequency of the hormetic dose
response in the pharmacological and
toxicological literature, its quantitative and
temporal
features,
and
underlying
mechanistic bases. Based upon this
integrative foundation the application of
hormesis to the process of risk assessment
for non-carcinogens and carcinogens is
explored.
Keywords: Dose response;
Biphasic; Adaptive response

Hormesis;

Homeopathy 2015; 104(2): 8389


Historical foundations of hormesis
Edward J. Calabrese

The present paper provides an historical


assessment of the concept of hormesis and
its relationship to homeopathy and modern
medicine. It is argued that the dose
response
concept
was
profoundly
influenced by the conflict between
homeopathy and traditional medicine and
that decisions on which doseresponse
model to adopt were not based on science
but rater on historical antipathies. While the
historical dispute between homeopathy and
traditional medicine has long since
subsided, their impact upon the field has
been enduring and generally unappreciated,
profoundly adversely affecting current drug
development, therapeutic strategies and
environmental risk assessment strategies
and policies.
Keywords: Hormesis; Adaptive response;
Biphasic; Homeopathy; U-shaped
Homeopathy 2015;104(2) 9096
Hormesis within a mechanistic context
Edward J. Calabrese
This paper provides an assessment of the
mechanistic foundations of hormesis and
how such understandings evolved over the
course of the past century. Particular
emphasis is placed on recent developments
particularly with respect to receptor-based
and cell signaling-based pathways. Of
particular importance is that the
quantitative feature of the hormetic dose
response are independent of mechanism.
Keywords:
Hormesis;
Doseresponse;
Biphasic; U-shaped; Adaptive response
Homeopathy 2015;104(2): 97100
Unequal brothers: are homeopathy and
hormesis linked?
Menachem Oberbaum, Michael Frass,
Cornelius Gropp
The debate between those who believe
homeopathy and hormesis derive from the

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same root and those who believe the two


are different phenomena is as old as
hormesis. It is an emotionally loaded
discussion, with both sides fielding
arguments which are far from scientific.
Careful analysis of the basic paradigms of
the two systems questions the claim of the
homeopaths, who find similarities between
them. The authors discuss these paradigms,
indicating the differences between the
claims of homeopathy and hormesis.
It is time for thorough and serious research
to lay this question to rest. One possible
approach is to compare the activity of a
hormetic agent, prepared in the usual way,
with that of the same agent in the same
concentration prepared homeopathically by
serial dilution and succussion.
Keywords:
Homeopathy;
specificity; repeatability

Hormesis;

Homeopathy 2015;104(2):123-38
Enhancement of adaptive biological
effects by nanotechnology preparation
methods in homeopathic medicines
Iris R. Bell, Gary E. Schwartz
Multiple studies have demonstrated that
traditional homeopathic manufacturing
reagents and processes can generate
remedy source and silica nanoparticles
(NPs). Homeopathically-made NPs would
initiate adaptive changes in an organism as
a complex adaptive system (CAS) or
network. Adaptive changes would emerge
from
several
different
endogenous
amplification processes that respond to
exogenous danger or threat signals that
manufactured
nanomaterials
convey,
including (1) stochastic resonance (SR) in
sensory neural systems and (2) timedependent sensitization (TDS)/oscillation.
SR is nonlinear coherent amplification of a
weak signal by the superposition of a larger
magnitude white noise containing within it

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the same frequencies of the weak signal.


TDS is progressive response magnitude
amplification and oscillatory reversal in
response direction to a given low dose at
physiological limits with the passage of
time.
Hormesis is an overarching adaptive
phenomenon that reflects the observed
nonlinear
adaptive
doseresponse
relationship. Remedies would act as
enhanced micro- and nanoscale forms of
their source material via direct local ligandreceptor interactions at very low potencies
and/or by triggering systemic adaptive
network dynamical effects via their NPbased
electromagnetic,
optical,
and
quantum mechanical properties at higher
potencies.
Manufacturing
parameters
including
dilution modify sizes, shapes, and surface
charges of nanoparticles, thereby causing
differences in physico-chemical properties
and biological effects. Based on surface area,
size, shape, and charge, nanoparticles
adsorb a complex pattern of serum proteins,
forming a protein corona on contact that
constitutes a unique biological identity. The
protein corona may capture individualized
dysfunctional
biological
mediator
information of the organism onto the
surfaces of the salient, i.e., resonant, remedy
nanostructures.
SR would amplify this weak signal from the
salient remedy NPs with protein corona
adsorbed, leading to sensitized nonlinear
dynamical modulation of gene expression
and associated changes in biological
signaling pathways. When the system
reaches its physiological limits during a
homeopathic aggravation or the natural
disease state, the amplified remedy signal
triggers a nonlinear reversal in dynamical
direction back towards health.

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Keywords: Nanoparticles; Homeopathy; Top


down; Bottom up; Nanotechnology;
Complex adaptive system; Nonlinear
dynamics; Stochastic resonance; Time
dependent sensitization; Hormesis
Homeopathy 2015;104(2):139-60
Cell sensitivity, non-linearity and inverse
effects
Paolo Bellavite, Andrea Signorini, Marta
Marzotto, Elisabetta Moratti, Clara Bonafini,
Debora Olioso
It has been claimed that the homeopathic
principle of similarity (or similia) and the
use of individualized remedies in extremely
low doses conflicts with scientific laws, but
this opinion can be disputed on the basis of
recent
scientific
advances.
Several
mechanisms to explain the responsiveness
of cells to ultra-low doses and the similarity
as inversion of drug effects, have again been
suggested in the framework of hormesis and
modern paradoxical pharmacology. Low
doses or high dilutions of a drug interact
only with the enhanced sensitivities of
regulatory systems, functioning as minute
harmful stimuli to trigger specific
compensatory healing reactions. Here we
review hypotheses about homeopathic drug
action at cellular and molecular levels, and
present a new conceptual model of the
principle of similarity based on allosteric
drug action. While many common drugs act
through orthostatic chemical interactions
aimed at blocking undesired activities of
enzymes or receptors, allosteric interactions
are associated with dynamic conformational
changes and functional transitions in target
proteins, which enhance or inhibit specific
cellular actions in normal or disease states.
The concept of allostery and the way it
controls physiological activities can be
broadened to include diluted/dynamized
compounds, and may constitute a working
hypothesis for the study of molecular

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mechanisms underlying the inversion of


drug effects.
Keywords: Homeopathy; High-dilutions;
Hormesis; Cell biology; Systems biology;
Similia rule; Energy landscape; Allosteric
regulation; Pharmacodynamics; Receptors
J Bioeth Inq. 2015 Jun;12(2):203-9.
A gentle ethical defence of homeopathy.
Levy D, Gadd B, Kerridge I, Komesaroff PA.
Abstract
Recent discourses about the legitimacy of
homeopathy have focused on its scientific
plausibility, mechanism of action, and
evidence base. These, frequently, conclude
not only that homeopathy is scientifically
baseless, but that it is "unethical." They have
also diminished patients' perspectives,
values, and preferences. We contend that
these critics confuse epistemic questions
with questions of ethics, misconstrue the
moral status of homeopaths, and have an
impoverished idea of ethics-one that fails to
account either for the moral worth of care
and of relationships or for the perspectives,
values, and preferences of patients.
Utilitarian critics, in particular, endeavour
to present an objective evaluation-a type of
moral calculus-quantifying the utilities and
disutilities of homeopathy as a justification
for the exclusion of homeopathy from
research and health care. But these critiques
are built upon a narrow formulation of
evidence and care and a diminished
episteme that excludes the values and
preferences of researchers, homeopaths,
and patients engaged in the practice of
homeopathy. We suggest that homeopathy
is ethical as it fulfils the needs and
expectations of many patients; may be
practiced safely and prudentially; values
care and the virtues of the therapeutic
relationship; and provides important
benefits for patients.

#researchinhomeopathy

Proceedings of the XXIX GIRI Symposium


Editorial
Proceedings of the XXIX GIRI meeting
Saurav Arora

PDF
1-2

Conference Presentation
Informational paradigm, practice and basic research
Richard Blostin

ABSTRACT PDF
3

Intoxication of wheat seedlings with 50 mM NaCl and follow-up


attempt to cure by extremely diluted NaCl (30cH)
P.C. Endler, Pia Lamest, Elke Liebig

ABSTRACT PDF

Reproducibility of effects of homeopathically potentised Argentum


nitricum on the growth of Lemna gibba L. in a randomized and
blinded bioassay
Vera Majewsky

ABSTRACT PDF

The effect of ultra high-diluted drugs on plant-nematode


interaction
Natalia Rodiuc

ABSTRACT PDF

The potential of homeopathic phenomenon in plant growth


Tatiana Vladimirovna Novosaduyk, Victoria Tsvetkova, Victoria
Tsvetkova, Anatolii Komissarenko, Anatolii Komissarenko

ABSTRACT PDF
11-12

In vitro studies of Psorinum 6x on several human cancer cell lines


reveal its anti-cancer potential
Anisur Rahman Khuda-Bukhsh

ABSTRACT PDF

Evaluating Subtle Field Imprints in Water by Droplet Evaporation


Method
Igor Jerman, Petra Ratajc, Bernhard Pollner

ABSTRACT PDF

Preliminary study on force-like effects between As45x, water, and


wheat seeds performed by means of the droplet evaporation
method
Maria Olga Kokornaczyk, Stephan Baumgartner, Lucietta Betti

ABSTRACT PDF

In vitro study of homeopathic medicines in macrophages co-cultured with


Leishmania (L.) amazonensis
Leoni Villano Bonamin, Fabiana Rodrigues de Santana, Fabiana Toshie
de Camargo Konno, Luciane Costa Dalboni, Amarylis T. Cesar, Cideli de
Paula Coelho, Dorly Buchi, Mrcia Dalastra Laurenti, Elizabeth Cristina
Perez Hurtado

ABSTRACT PDF

Malaria treatment compared for homeopathic medicines and


Coartem in homeopathic clinics in Kenya A multicentre,
pragmatic, randomized, double-blind, double-dummy, ongoing trial
Martien Brands, Mauro Saio, Suzanne van Berkel

ABSTRACT PDF

Biological activity of interferon gamma and lipopolysaccharide on


the nitric oxide production in C6 astroglioma cells and some

ABSTRACT PDF

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unexpected effects of potentization


Clara Bonafini, Marta Marzotto, Debora Olioso, Paolo Bellavite

23-27

Highly diluted medication reduces tissue parasitism and inflammation in


mice infected with Trypanosoma cruzi
Carina Ribeiro Lopes, Gislaine Janaina Falkowski, Camila Fernanda
Brustolin Fernanda Brustolin, Paula Fernanda Massini, Erika Cristina
Ferreira, Neide Martins Moreira, Denise Lessa Aleixo, Silvana Marques de
Arajo

ABSTRACT PDF

Modulation of experimental cystitis induced by uropathogenic E. coli


(UPEC) JJ079 by homeopathic and isopathic remedies
Cideli de Paula Coelho, Vania Maria Carvalho, Renata de Oliveira
Iovine, Luana de Ramos Soares, Luciene Costa Dalboni, Fabiana
Rodrigues Santana, Leoni Villano Bonamin

ABSTRACT PDF

Assessment of the effects of maternal deprivation in offspring treated with


ultra-high diluted Zincum metallicum in rats
Larissa Cristina Ares Silveira da Motta, Victoria Arrifano Moraes,
Patricia Tahan, Maria Martha Bernardi, Kleber Peixoto da Cunha Junior,
Leoni Villano Bonamin, Fabiana Rodrigues Santana, Cideli de Paula
Coelho

ABSTRACT PDF

Effect of Zincum metallicum and LPS treatments on femoral bone density


in pregnant mice
Silvio Leite Monteiro da Silva, Maristela Dutra Correa, Claudio Costa,
Vanessa Gallego Arias Pecorari, Emiko Saito Arita, Maria Martha
Bernardi, Carla Holandino, Leoni Villano Bonamin

ABSTRACT PDF

Nanoscale cluster structure of O2 gas-filled nanobubbles in O2 gassupersaturated alkaline solution


Ichiro Otsuka

ABSTRACT PDF

Detection of nanostructures in solutions of Zincum metallicum and the


vehicle lactose
Marta Marzotto, Clara Bonafini, Debora Olioso, Carla Holandino,
Leoni Bonamin, Davide Prosperi, Maria Marinozzi, P Bernardi, Paolo
Bellavite

ABSTRACT PDF

A systematic review about animal models in homeopathic research:


the last five years of PubMed indexed papers
Leoni Villano Bonamin, Thayna Neves Cardoso, Aloisio Cunha
Carvalho, Juliana G Amaral

ABSTRACT PDF

Immunological research about ultra-high dilution and Homeopathy:


From 1994 to 2014
Leoni Villano Bonamin

ABSTRACT PDF

Ultra-high Dilution 1994 revisited 2014: Follow up of


experiments and theories
PC Endler, Jurgen Schulte, Beate Stock Schroeer

ABSTRACT PDF

Constitutional types of horses and resources for their homeopathic


correction
Victoria Tsvetkova, Tatiana Vladimirovna Novosaduyk

ABSTRACT PDF

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Role of high dilutions in anesthetic recovery in dogs


Djair Teixeira Santos, Veronika Wittmann, Victoria Arrifano Moraes,
Debora Koffke Alves, Kleber Peixoto da Cunha Junior, Leoni Bonamin,
Fabiana Rodrigues Santana, Daniele Di Marco, Cideli de Paula Coelho

ABSTRACT PDF
51

Viscum album (L) extracts in cancer treatment: a systematic review


of in vitro and in vivo studies
Aloisio Cunha de Carvalho, Leoni Villano Bonamin

ABSTRACT PDF

Antitumoral activity of homeopathic and anthroposophic Viscum albums


preparations: an in vitro assay
Joao Vitor da Costa Batista, Michelle Nonato de Oliveira Melo, Adriana
Passos Oliveira, Ezequiel Paulo Viriato, Stephan Baumgartner, Carla
Holandino Quaresma

ABSTRACT PDF

Two cases reports comparing histopathological features of canine


transmissible venereal tumor after treatment with decimal
potencies of Viscum Album and Vincristin
Leoni Villano Bonamin, Gisela Novaes Fontao Lefebvre, Thayna
Neves Cardoso, Marcus Reif

ABSTRACT PDF

Action of methicillin on the in vitro growth of bacteria


Staphyloccocus aureus methicillin-resistance previously treated
with homeopathic dilutions
Tania Aguiar Passeti, Leandro Ribeiro Bissoli, Registila Libania
Beltrame e Fernando Fonsceca

ABSTRACT PDF

Mechanisms of medicine-induced effect on organism


Anatoly Alekseyevich Komissarenko

ABSTRACT PDF
59

The possibility of using Trichinella spiralis as an experimental model


in the field of high dilutions
Olga Borisovna Zhdanova, Amina Aslanovna Haidarova, ludmila
Alexandrovna Napisanova, Dimitri Rossohin, Olga Lozhenicina

ABSTRACT PDF

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