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Question 1

1.

Which is a component of cocktail therapy vs.


AIDS?
Answer
Amantadine
Zidovudine
Acyclovir
Vancomycin
Ribavirin (virozole)

1 points

Question 2
1.

Atropine can induce


Answer
"tachycardia, dry mouth"
"bradycardia, miosis"
"tachycardia, salivation"
"tachycardia, miosis"

"bradycardia, salivation"

1 points

Question 3
1.

Lugols Solution (Iodine) can be used to


treat
Answer
hyperthyroidism
hypogonadism
allergy
diabetes
hypothyroidism

1 points

Question 4
1.

After long-term use of Glucocorticoids,


rebound phenomenon will occur if the dosage
is reduced rapidly, it is because
Answer

adrenal suppression
iatrogenic Cushing syndrome
glucocorticoid dependence
increased ACTH secretion
decreased pituitary function

1 points

Question 5
1.

Which drug is addictive antitussive


Answer
Ammonium chloride
Dextromethorphan
Benzonatate
Codeine
Pentoxyverine

1 points

Question 6
1.

Pharmacological mechanism of Cardiac


Glycosides is
Answer
Inhibition of cAMP
Inhibition of H+-K+-ATPase
Inhibition of Na+-K+-ATPase
Inhibition of P-450
Inhibition of Phosphodiesterase

1 points

Question 7
1.

Which drug can be used for abortion


Answer
Prostaglandins
Ritodrine
Ergometrine
Oxytocin
Indomethacin

1 points

Question 8
1.

Which of the following drugs can inhibit the


DNA-dependent RNA polymerase?
Answer
Penicillin G
Rifampin
Streptomycin
Chloramphenicol
Cefoperazone

1 points

Question 9
1.

The effect of Cholestyramine on blood lipid


is
Answer
Reduce TC and LDL-C
Reduce TG and HDL
Reduce CE and FFA

Reduce TC and VLDL


Reduce TC and CM

1 points

Question 10
1.

Which one is NOT a main adverse effect of


Streptomycin?
Answer
Nephrotoxocity
Vestibular toxicity
Hepatotoxicity
Neuromuscular Paralysis
Cochlear toxicity

1 points

Question 11
1.

The most active aminoglycoside against


Mycobacterium tuberculosis is
Answer

Kanamycin
Neomycin
Amikacin
Streptomycin
Tobramycin

1 points

Question 12
1.

The H2 receptor antagonists are mainly used


to
Answer
hypertension
asthma
diabetes
intestinal spama
peptic ulcer

1 points

Question 13
1.

Which pathogen is susceptible to


Azithromycin?
Answer
Plasmodium
G coccus
G bacillus
Rickettsia
Anaerobic bacteria

1 points

Question 14
1.

The most important mechanism of


Cephalosporins acquired resistance is
Answer
the change of metabolism pathway
produce the -lactamases
reduction of cell membranes perrmeability
active efflux system
modification of target sites

1 points

Question 15
1.

Which drug has the mucoprotective effect for


ulcer treatment
Answer
Ranitidine
Magnesium trisilicate
Omeprazole
Atropine
Sucralfate

1 points

Question 16
1.

The correct time for alternate-day


adiministration of Glucocorticoids is
Answer
4:00 AM
8:00AM

8:00 PM
4:00 PM
12:00 AM

1 points

Question 17
1.

The common effect of Nitroglycerin and


Propranolol in angina treatment is
Answer
decrease heart rate
decrease peripheral resistance
decrease myocardiac contraction
decrease myocardiac oxygen consumption
decrease ventricular volume

1 points

Question 18
1.

Which of the following effect is the adverse


drug effect of Heparin

Answer
Peptic ulcer
Pypertension
Asthma
Bleeding
Abnormalities of renal function

1 points

Question 19
1.

Which of the following antibacterial agents


can inhibit folic acid metabolism?
Answer
Quinolones
Aminoglycosides
Clindamycin
Cephalosporins
Sulfinamides

1 points

Question 20

1.

Which one is NOT the clinical use of Oxytocin


Answer
induction of labor
induction of abortion
augmentation of labor
promote milk ejection
postpartum hemorrhage

1 points

Question 21
1.

Which one is rapidly effective for acute


asthmatic attack
Answer
oral administration of Aminophylline
Cromoglicate sodium
Aalbutamol inhalation
Beclomethasone
Ketotifen

1 points

Question 22
1.

Valsartan is
Answer
Ca2+ channel blocker
-blockers
Cardiac Glycosides
Angiotensin II receptor blockers (ARBs)
Angiotensin-Converting Enzyme Inhibitor(ACEI)

1 points

Question 23
1.

For the roundwarm and pinwarm infection,


preferred drug is
Answer
Praziquantel
Levamizole
Mebendazole

Piperazine
Pyrantel

1 points

Question 24
1.

Penicillin G is the 1st choice against


Answer
Gbacillus
Hemolytic Streptococcus
Mycobacterium tuberculosis
Enterococci
Shigellosis

1 points

Question 25
1.

The mechanism action of Heparin is


Answer
block the Ca++ action
active the ATIII

counteract to the VitK


antagonize the VitK effect
"inhibit the synthesis of thrombin II , IX, X"

1 points

Question 26
1.

A 35-year-old female complains of itching in


the vulval area. Hangingdrop examination of
the urine reveals trichomonads. What is the
preferred treatment for trichomoniasis?
Answer
Emetine
Metronidazole
Pyrimetamine
Pentamidine
Doxycycline

1 points

Question 27
1.

The mechanism of Glucocorticoids for asthma


treatment is
Answer
stimulate respiratory centre
activate adenyl cyclase
dilate airway smooth muscles
anti-inflammation and anti-allergy
block M-receptor

1 points

Question 28
1.

Adverse Effects of Angiotensin Converting


Enzyme (ACE) Inhibitors are NOT including
Answer
Ventricular bradycardia
Hypotension
Hyperkalemia
Angioneurotic edema
Cough

1 points

Question 29
1.

What is the mechanism action of Zidovudine


Answer
Inhibition of nucleoside reverse transcriptase
Inhibition of DNA synthesis
Inhibition of viral particle assembly
Inhibition of RNA synthesis
Inhibition of viral proteases

1 points

Question 30
1.

Which agents using should be cautious about


or avoided while patient underwent kiney
malfunction?
Answer
Penicillins
Macrolides

Tetracyclines
Aminoglycosides
Chloramphenicol

1 points

Question 31
1.

The mechanism of action of Biguanides is


Answer
increase the glycagon effect
decrease insulin resistance
enhance the glucose uptake and catalyzing by peripheral
tissues
stimulating insulin release from pancreatic cells
promote the glucose to catalyze

1 points

Question 32
1.

Cardiac output is best increased by


stimulation of
Answer

beta1 receptors
muscarinic receptors
beta2 receptors
alpha2 receptors
alpha1 receptors

1 points

Question 33
1.

The Thioureas can be used for


Answer
hypothyroidism
diabetes
hyperthyroidism
hypogonadism
allergy

1 points

Question 34
1.

Which one is NOT a first-line


antituberculosis agents?
Answer
Isoniazid
Ethambutol
Rifampin
Pyrazinamide
Amikacin

1 points

Question 35
1.

The mechanism of action of Sulfonylureas is


Answer
increase the glycagon effect
decrease insulin resistance
inhibit the insulin effect
promote the glucose to catalyze
stimulating insulin release from pancreatic cells

1 points

Question 36
1.

Which description about Generation III


Quinolones is WRONG?
Answer
Levofloxacin is most effective vs. G germs in the family
They act against G germs by inhibiting DNA gyrase
They are chlorine derivatives of Pipemidic acid
They act against G germs by inhibiting DNA topoisomerase IV
They have strong activity against G germs

1 points

Question 37
1.

Which agent act against bacteria mainly by


interfering functions of cell membrane?
Answer
ciprofloxacin
polymyxin B
streptomycin

erythromycin
tetracycline

1 points

Question 38
1.

Which drug is effective against either


systemic or superficial fungal infection?
Answer
Flucytosine
Ketoconazole
Nystatin
Amphotericin B
Ribavirin

1 points

Question 39
1.

Which one in the following drug is best to


treat hypertension crisis
Answer

Spironolactone
Losartan
Sodium Nitroprusside
Captopril
Hydrochlorothiazide

1 points

Question 40
1.

Hypokalaemia occurs with the following drugs


Answer
Captopril
Bumetanide
Nifedipine
Carbonic anhydrase inhibitors
Spironolactone

1 points

Question 41
1.

Prodrug-requires activation by microsomal


enzyme system
Answer
cyclophosphamide (Cytoxan)
chlorambucil (Leukeran)
thiopeta (Thioplex)
mechlorethamine (Mustargen)
semustine (methyl CCNU)

1 points

Question 42
1.

Why the clinical use of Choloramphenicol is


limited in infectious disease?
Answer
Severe adverse effects such as irreversible marrow inhibition
Low bioavailability
Most bacteria have developed drug resistance
Low efficiency in suppressing bacteria
Severe allergic shock

1 points

Question 43
1.

Which one does NOT have the effect of


antiplatelet aggregation
Answer
Aspirin
Wafarin
Dipyridamole
Ridogrel
Epoprostenol

1 points

Question 44
1.

Which of the following is NOT the adverse


effects of Glucocorticoid ?
Answer
poor wound healing
asthma

"buffalo hump, moon face"


osteoporosis
hypertension

1 points

Question 45
1.

Omeprazole is belonged to
Answer
H1 receptor antagonists
H2 receptor antagonists
M receptor antagonists
Mucosal protective agents
H+-K+-ATPase (Proton pump) inhibitor

1 points

Question 46
1.

A 25-year-old female post-renal transplant


shows signs of acute renal allograph

rejection. Of the following agents, which


should be administered?
Answer
Acyclovir
Interleukin-2
Levamisole
Interferon
Cyclosporin A

1 points

Question 47
1.

By which target Aminoglycosides interfered


with protein synthesis of bacteria?
Answer
stage of peptide strands exfliation
stage of termination
all stages of protein synthesis
stage of initiation
stage of peptide strands elongation

1 points

Question 48
1.

The phase of the cell cycle that is resistant


to most chemotherapeutic angents and
requires increased dosage to obtain a
response is the
Answer
S phase
M phase
G0 phase
G1 phase
G2 phase

1 points

Question 49
1.

Which one in the following drugs is


preferable to use to treat Paroxysmal
supraventricular tachycardia
Answer

Amiodarone
Verapamil
Procainamide
Lidocaine
Atropine

1 points

Question 50
1.

Competitive inhibitor of
3-hydroxy-3-methylglutaryl coenzyme A
(HMG-CoA) reductase is
Answer
Cholestyramine
Ezetimibe
Simvastatin
Acetazolamide
Nicotinic acid

1 points

Question 51

1.

The effect mechanism of expectorant


Acetylcystein is
Answer
breakdown the viscous component of the sputum
decrease the protein secretion in the airway
increase airway fluid secretion
increase airway ciliary movement
decrease sputum secretion

1 points

Question 52
1.

Which of the following description about the


clinical uses of Glucocorticoid is WRONG
Answer
inhibit the growth of bacteria
anti-shock
anti-inflammatory effects
immunosuppressive effects

anti-allergic effect

1 points

Question 53
1.

Which drug can Increase nitric oxide (NO)


Answer
lonidine
Aldosterone Antagonists
Nifedipine
Methyldopa
Nitroprusside

1 points

Question 54
1.

Which drug is most effective against systemic


fungal infection?
Answer
Terbinafine
Nystatin

Clotrimazole
Amphotericin B
Griseofulvin

1 points

Question 55
1.

Which of the following drugs is the first


choice for the treatment of type I diabetes?
Answer
Angiotensin Converting Enzyme (ACE) Inhibitors
Insulin
Sulfonylureas
Acarbose
Biguanides

1 points

Question 56
1.

Which one in the following drugs is highly


efficacious diuretics

Answer
Spironolactone
Acetazolamide
Hydrochlorothiazide
Triamterene
Furosemide

1 points

Question 57
1.

To treat bleeding induced by Warfarin, which


drug can be used
Answer
Urokinase
Vit K
Vit B12
Dipyridamole
Protamine

1 points

Question 58

1.

Which agent is The 1st choice against MRSA?


Answer
Amoxicillin
Generation 1 Cephalosoprins
Vancomycin
Penicillin G
Erythromycin

1 points

Question 59
1.

Gentamicin inhibit bacterial protein


synthesis by binding
Answer
30S ribosomal particles
Messenger RNA
RNA polymerase
Peptidoglycan units in the cell wall
DNA polymerase

1 points

Question 60
1.

The most effective drug to inhibit gastric


acid secretion is
Answer
Calcium carbonate
Cimetidine
Proglumide
Pirenzepine
Omeprazole

1 points

Question 61
1.

Compare antibacterial characteristics of 4


generations of Cephalosporins.
Answer

Question 62
1.

What is the clinical uses of Calcium Channel


Blockers(CCBs).
Answer

Question 63
1.

List the adverse drug reactions (adverse


effects) of Glucocorticoids in long-term
use.
Answer

Question 64
1.

Please describe the therapeutic strategies


and drugs for Peptic Ulcer.
Answer