You are on page 1of 2

ANTINEOPLASTIC

DRUG
EFFICACY
NAME
Doxorubic
Highly destructive to
in
rapidly proliferating
cells and slowly
developing
carcinomas

Bleomycin

Vinblastin
e

Dacarbazi
ne

blocks DNA, RNA, and
protein synthesis. A
cell cycle-phase
nonspecific agent.
Widely used in
combination with
other
chemotherapeutic
agents because it
lacks significant
myelosuppressive
activity.
Interferes with nucleic
acid synthesis by
arresting proliferating
cells in metaphase.
Exhibits potent
myelosuppressive and
immunosuppressive
properties, but
produces less
neurotoxicity
. Interferes with
purine metabolism
and with RNA and
protein synthesis in
rapidly proliferating
cells

ANTI-GOUT AGENT
Allopurino
reduces endogenous
l
uric acid by
selectively inhibiting
action of xanthine
oxidase

SAFETY

SUITABILITY

Hypersensitivity, fever,
chills, anaphylactoid reaction,
myocardial toxicity with delayed CHF,
ventricular arrhythmias hypertension,
Stomatitis, anorexia, inanition, diarrhea,
Severe myelosuppression; leucopenia,
thrombocytopenia, anemia, rash, recall
phenomenon
Dizziness, fatigue, diaphoresis,
anaphylaxis,
mucositis, anorexia, hepatotoxicity
,diarrhea, Leukopenia, neutropenia,
thrombophlebitis, interference with
normal healing, Severe hyperkalemia,
hyperuricemia, Pulmonary emboli and
edema, interstitial pulmonary fibrosis,
Alopecia (reversible), , toxic epidermal
necrolysis, nephrotoxicity.

produce
regression in
neoplastic
conditions,
including
lymphomas

Peripheral neuropathy, ataxia, loss of
deep tendon reflexes, muscle atrophy,
dysphagia, weakness in larynx and
extrinsic eye muscles, photophobia,
Stomatitis, anorexia, severe
constipation, hepatotoxicity, Urinary
retention, polyuria, dysuria, SIADH uric
acid nephropathy, Urticaria, rash,
alopecia, cellulitis and phlebitis

Acute
lymphoblastic
and other
leukemias,
Hodgkin's disease

Hypersensitivity; facial paresthesia and
flushing, flu-like syndrome, myalgia,
malaise, anaphylaxis. CNS: Confusion,
headache, seizures, blurred vision. GI:
Anorexia, nausea, vomiting.
Hematologic: Severe leukopenia and
thrombocytopenia, mild anemia. Skin:
Alopecia.

As single agent or
combination with
other
antineoplastics in
treatment of
refractory
Hodgkin's disease

Drowsiness, headache, vertigo,
diarrhea, malaise Agranulocytosis,
aplastic anemia, bone marrow
depression, thrombocytopenia, pruritus,
toxic epidermal necrolysis,
Hepatotoxicity, renal insufficiency.

reduce severity of
hyperuricemia
associated with
antineoplastic

Body as a Whole: Fever, fatigue, pain,
chills or shivering. CNS: Headache,
dizziness, drowsiness. CV: Hypertension.
GI: Diarrhea, increased LFTs, abdominal
pain. Genitourinary: Urinary retention.

prevention of
nausea and
vomiting from
emetogenic
chemotherapy

Rash, acute poisoning: Anorexia,
nausea, vomiting, dizziness, lethargy,
diaphoresis, chills, abdominal pain,
diarrhea; onset of hepatotoxicity—
elevation of serum transaminases (ALT,

Fever reduction.
Temporary relief
of mild to
moderate pain.

As single agent or
in combination
with other
chemotherapeuti
c agents in
treatment of
Hodgkin
lymphoma

ANTIEMETIC
Dolasetro
ne

selective serotonin (5HT3) receptor
antagonist has
antiemetic properties

ANTIPYRETIC
PARACETAMOL

Reduces fever by
direct action on
hypothalamus heatregulating center
with consequent

It is used as iron source as it replaces iron found in hemoglobin. and dissipation of heat. . Used for prevention and treatment for iron deficiency.peripheral vasodilation. Iron Supplementation Ferrous Facilitates O2 fumarate transport via hemoglobin. myoglobin AST) and bilirubin Gastric irritation. sweating.