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[Scurvy, a serious and rare form of avitaminosis, easily diagnosed

and treated. Presentation of a case].
[Article in Spanish]
Gil Llano JR1, Grespo Rincón L, Ruiz Llano FC, Costo Campoamor A, Mateos Polo L, González MA.

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Servicios de Medicina Interna, Hospital San Pedro de Alcántara, Cáceres.


We report a 66 years-old man case that was admitted with abdominal wall hemorrhagic swelling
ecchymosis on inferior extremities and perifollicular purpura with hyperkeratosis of the follicles, which
gives it an appearance of palpable purpura, together with gingival hemorrhage and moderate anemia.
He was a well-nourished sick man but who made a peculiar diet, practically free from fruit and
vegetables which developed a pure and serious form of scurvy. We report this case because we
consider that the features which appear are illustrative to provide the immediate clinical diagnosis of
this uncommon disease, potentially mortal, but easy to diagnose, if we think about it in the adequate
clinical contexts, and which it is quickly curable with the administration of ascorbic acid.

Comment in

[Vitamin C deficiency: scurvy. Report of a case]. [An Med Interna. 1996]

Prevalence of Vitamin D Insufficiency and Deficiency among Young
Physicians at University District Hospital in San Juan, Puerto Rico.
Ramírez-Vick M1, Hernández-Dávila L1, Rodríguez-Rivera N1, López-Valentín M2, Haddock L1,
Rodríguez-Martínez R3, González-Bossolo A3.

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Endocrinology Division, Internal Medicine Department, School of Medicine, University
Hospital, University of Puerto Rico Medical Sciences Campus, San Juan, PR.
Puerto Rico Clinical and Translational Research Consortium, School of Medicine, University
of Puerto Rico Medical Sciences Campus, San Juan, PR.
Internal Medicine Department, School of Medicine, University Hospital, University of Puerto
Rico Medical Sciences Campus, San Juan, PR.

Vitamin D has been attracting increased attention because of higher prevalences of vitamin D
insufficiency and deficiency than expected in areas with sufficient sun exposure. Even though sunlight
exposure and diet are the main determinants of vitamin D status, other factors, such as age, race, the
use (or not) of sunscreen, medications, and malabsorptive conditions, also affect vitamin D levels.
Recent studies have found high prevalences of vitamin D deficiency and insufficiency in different
populations. However, there are limited data regarding the prevalence of vitamin D deficiency and
insufficiency in Puerto Rico. To shed more light on the subject, we evaluated a sample of 51 internal
medicine residents and research fellows, aged from 25 to 39 years at the University District Hospital in
San Juan, Puerto Rico, doing so by means of a questionnaire that explored basic socio demographic

and lifestyle characteristics and collected anthropometric data; in addition, we obtained blood samples
in order to determine 25-hydroxyvitamin D levels. The median 25-hydroxyvitamin D level was 21
ng/mL (range, 7-38 ng/mL). Forty-five participants (88.2%) had 25-hydroxyvitamin D concentrations of
lower than 30 ng/mL. We found vitamin D deficiencies in 43.1% of the population and insufficiencies in
45.1%. Contributory factors to our findings include limited exposure to sunlight during periods of high
sun intensity, increased body mass index, and a limited area of the body being exposed to sunlight. A
relationship between reduced physical activity levels and hypovitaminosis D was also found. Both
calcium intake and vitamin D intake, which were markedly below recommended daily allowances,
were positively correlated with 25-hydroxy vitamin D levels, but with a weak association.
25-Hydroxyvitamin D/calcium; Dietary/sunlight exposure/physical activity; Dietary/vitamin D

Clinical Trial of Vitamin D2 vs D3 Supplementation in Critically Ill
Pediatric Burn Patients.
Gottschlich MM1, Mayes T2, Khoury J3, Kagan RJ4.

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Department of Research, Shriners Hospitals for Children, Cincinnati, Ohio Department of
Nutrition, Shriners Hospitals for Children, Cincinnati, Ohio Department of Surgery, University
of Cincinnati College of Medicine, Cincinnati, Ohio
Department of Nutrition, Shriners Hospitals for Children, Cincinnati, Ohio Cincinnati Children's
Hospital Medical Center, Cincinnati, Ohio.
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio
Department of Surgery, Shriners Hospitals for Children, Cincinnati, Ohio.

Hypovitaminosis D exists postburn. However, evidence-based guidelines for vitamin D repletion are
unknown. This investigation examined differences between D2 and D3 supplementation on outcome in
children with burn injuries.
Fifty patients with total body surface area burn of 55.7% ± 2.6% and full-thickness injury of 40.8% ±
3.8% were enrolled, ranging in age from 0.7-18.4 years. All participants received multivitamin
supplementation per standardized clinical protocol. In addition, 100 IU/kg D 2, D3, or placebo was
administered daily during hospitalization using a randomized, double-blinded study design. Assay of
total 25-hydroxyvitamin D (D25), 1,25-dihydroxyvitamin D (D1,25), 25-hydroxyvitamin D 2 (25-OH-D2),
25-hydroxyvitamin D3 (25-OH-D3), and parathyroid hormone (PTH) was performed at 4 preplanned
time intervals (baseline, midpoint, discharge, and 1 year postburn). Differences in vitamin D status
were compared over time and at each specific study interval.
There were no significant differences in serum vitamin D levels between groups, but >10% of patients
had low D25 at discharge, and percent deficiency worsened by the 1-year follow up for the placebo
(75%), D2 (56%), and D3 (25%) groups. There were no statistical differences in PTH or clinical

com. regardless of the presence or absence of retinopathy. India. although vitamin D supplementation demonstrated nonsignificant but clinically relevant decreases in exogenous insulin requirements. Seshacharyulu M2. Nephrology. and scar formation. © 2015 American Society for Parenteral and Enteral Nutrition. National Institute of Nutrition. Hyderabad. India. India. National Institute of Nutrition.outcomes between treatment groups. sepsis. Although the mean levels of VD in all three groups were below the normal range. Hyderabad. Abstract OBJECTIVE: Diabetic retinopathy (DR) is a common cause of blindness. However. RESULTS: Although the mean plasma VD levels were significantly lower in the DNR and DR groups compared with the CN group. Sahay M4. KEYWORDS: burn injury. no significant differences were observed between the groups with diabetes. Viswanath K3. Electronic address: Geereddy@yahoo. there were no group differences in the plasma levels of . Continued treatment with vitamin D3 beyond the acute phase postburn is recommended to counteract the trajectory of abnormal serum levels and associated morbidity. vitamin D Plasma vitamin D status in patients with type 2 diabetes with and without retinopathy. suggesting that the prevalence of VDD was higher in individuals with diabetes. Hyderabad. Although an association between hypovitaminosis D and type 1 diabetes is known. Hyderabad. Satyanarayana A2. the clinical profile and the plasma levels of VD and calcium were analyzed. CONCLUSIONS: The high incidence of low serum D25 levels 1 year following serious thermal injury indicates prolonged compromise. Shalini T2. pediatrics. METHODS: A cross-sectional case-control study was conducted with 99 normal control (CN) participants and 164 patients with T2D. Osmania Medical College & Hospital. Reddy GB1. Pushpagiri Vitreo Retina Institute. Biochemistry. India. inclusive of fundus fluorescein angiography. the prevalence of VD deficiency (VDD) was higher in the DNR and DR groups (66% and 63%) than in the CN group (45%). Sivaprasad M2. Balakrishna N2. the association between vitamin D (VD) and type 2 diabetes (T2D) and its complications such as DR has been unclear. The aim of this study was to investigate the status of VD in T2D patients with and without DR. After a complete ophthalmic examination. Author information  1  2  3  4 Biochemistry. of which 82 had retinopathy (DR) and 82 did not (DNR).

Mycobacterium tuberculosis. Galli L.calcium. The aim of this study was to analyze 25hydroxivitamin D levels in children younger than 2 years admitted for acute mild diseases in a tertiary hospital in Valencia and its relationship with factors that can be associated with its deficiency. Tuberculosis.. and other 13 pertinent studies were included. KEYWORDS: Calcium. Hospital Clínico de Valencia. España. Sivó Díaz N2. KEYWORDS: Children. of which 147 studies were initially selected. Blanes Segura S2. Electronic address: togoandrea@yahoo. Villalba Martínez C3. Three hundred ninety-seven articles were initially identified. Further investigations are warranted. Diabetic retinopathy. [Is there vitamin D deficiency in children in a sunny Mediterranean city?] [Article in Spanish] Togo A1. Servicio de Pediatría. Abstract The aim of this study is to critically summarize the available data on the correlation between vitamin D level and tuberculosis (TB) infection. Diabetic complications. Facchini L. Hypovitaminosis D. Martino Md. Immunity. España. España. Valencia. Copyright © 2015 Elsevier Inc. Vitamin D Vitamin D and tuberculosis: a review on a hot topic. Laboratorio de Bioquímica Clínica y Patología Hospital Clínico de Valencia. Espadas Maciá D2. Chiappini E.. VDD did not seem to be related to patient's age or body mass index. Valencia. Author information  1  2  3 Servicio de Pediatría. Type 2 diabetes. Hospital Clínico de Valencia. A literature search covering English language articles published up to 20 October 2014 was conducted in MEDLINE database. A significant association between low vitamin D levels and susceptibility to TB infection has been found. but was related to the duration of diabetes. Valencia. CONCLUSION: Results from this study suggest a possible association between VDD and T2D.. . Abstract INTRODUCTION: Despite the increasing interest in vitamin D functions. Venturini E. All rights reserved. Additionally. Vitamin D. new cases of deficiency have been reported in sunny regions where optimal levels are expected.. but not specifically with DR.

Penang. Vitamina D Impact of Vitamin D Replacement on Markers of Glucose Metabolism and Cardio-Metabolic Risk in Women with Former Gestational Diabetes-A Double-Blind. Padova. Randomized Controlled Trial. Department of Medicine. Levels >30ng/mL were associated with vitamin D prophylaxis during the first year. Institute for Medical Research. Kuala Lumpur. even in sunny Mediterranean regions. Malaysia. Khir AS4. Metabolic Unit. Almost one quarter (24. Malaysia. Lactante.65). Author information  1  2  3  4  5  6 Department of Medicine. CONCLUSIONS: In Valencia. Yeow TP1. Malaysia. Toddler. Spain. Denmark.01). Hor CP3. Children were classified into two groups. in children of a Caucasian mother. Department of Medicine. and in children with higher skin phototypes (P<. Italy. Steno Diabetes Centre. Hypovitaminosis. Lim SL2. Cardiovascular. Abstract . Penang. Prophylaxis was given to 47% of the breastfed children younger than one year.3%) of the children had 25-hydroxivitamin D levels <30ng/mL. Malaysia. Sun exposure. Seberang Jaya. Our results emphasize the importance of vitamin D prophylaxis during the first year of life.METHODS: This one year prospective and observational study was conducted on 169 children admitted for acute mild diseases. Clinical Research Centre. and those who did not wear a hijab. S. 25-hydroxivitamin D levels lower than 30ng/mL were found in a quarter of the children younger than two years. Penang Medical College. Malaysia. more frequently in winter/spring. National Research Council.U.3%). 25-hydroxivitamin D levels were analyzed.7%) and youger than one year old (79. being more prevalent Caucasians (75. Vitamin D. No statistical differences were found in diet characteristics (P=. A standardized physical examination and structured interviews to the parents were performed. Malaysia. Prophylaxis. Kepala Batas. Diabetes and Nutrition Research Centre. Published by Elsevier España. Institute of Biomedical Engineering. Seberang Jaya Hospital. KEYWORDS: Exposición solar. Department of Medicine. Malaysia. All rights reserved. Wan Mohamud WN5. with a median age of 9 months. Hipovitaminosis. Kepala Batas Hospital. Profilaxis. Penang General Hospital.L. Copyright © 2015 Asociación Española de Pediatría. RESULTS: A total of 169 children were included. according to 25-hydroxivitamin D levels (cut-off 30ng/mL). Pacini G6. Penang. Penang Medical College. Penang General Hospital. Penang. Penang. Penang. Gentofte.

Abstract BACKGROUND: This study aimed to determine the association of serum 25-hydroxy Vitamin D (25(OH)D) levels with measures of general and abdominal obesity in Iranian adolescents. Ahvaz. Karaj. Tehran. Ahvaz Jundishapur University of Medical Sciences. Iran . Motlagh ME4. Iran. Child Growth and Development Research Center. Department of Epidemiology. In this double blind. Thirty three (76%) women with former GDM screened had vitamin D level of <50 nmol/L at baseline. Chronic Disease Research Center. Qorbani M2. 75g Oral Glucose Tolerance Test (OGTT) and biochemistry profiles were performed at baseline and 6 month visits. Supplementation. Moafi M3. Department of Community Medicine. living in 27 provinces in Iran. Alborz University of Medical Science. Iran. Iran. Endocrinology and Metabolism Population Sciences Institute. Tehran University of Medical Sciences. resulted in increased vitamin D level (+51. 26 participants were randomized to receive either daily 4000 IU vitamin D3 or placebo capsules. There was no clear change in insulin sensitivity or markers of cardio metabolic risk. p = 0.1 nmol/L vs 0. School of Para Veterinary Medicine. School Health Office. aged 10-18 years. Tehran. when compared with placebo. Isfahan University of Medical Sciences. We evaluated the impact of vitamin D supplementation on markers of glucose metabolism and cardio metabolic risk in Asian women with former GDM and hypovitaminosis D.Gestational Diabetes Mellitus (GDM) and vitamin D deficiency are related to insulin resistance and impaired beta cell function.2% (2 mmol/mol) reduction in HbA1c. Research Institute for Primordial Prevention of Non-Communicable Disease. MATERIALS AND METHODS: This nationwide cross-sectional study was conducted among 1090 students. Tehran. Further mechanistic studies exploring the role of vitamin D supplementation on glucose homeostasis among different ethnicities may be needed to better inform future recommendations for these women with former GDM at high risk of both hypovitaminosis D and future diabetes. Serum concentration of 25(OH)D was analyzed quantitatively by direct . p<0. Kelishadi R1. were employed to calculate insulin sensitivity and beta cell function. Mathematical models. There was no effect on markers of cardio metabolic risk. School Health Office. Department of Laboratory Sciences. Iran . using serial glucose. improved basal pancreatic beta-cell function and ameliorated the metabolic state. Iran. Ministry of Health and Medical Education. Association of 25-hydroxy Vitamin D levels with indexes of general and abdominal obesity in Iranian adolescents: The CASPIAN-III study. The vitamin D group also demonstrated a 30% improvement in disposition index and an absolute 0. Ardalan G5. Hamedan. insulin and C peptide measurements from OGTT. Isfahan. Iran. with heightened risk for future development of diabetes. Author information  1  2  3  4  5 Department of Pediatrics. Bu-Ali Sina University. Ministry of Health and Medical Education.001) and increased fasting insulin (+20% vs 18%.2 nmol/L. Keikha M1.034). Jari M1. randomized controlled trial. Department of Pediatrics. Six months supplementation with 4000 IU of vitamin D3 safely restored the vitamin D level. This study highlighted high prevalence of vitamin D deficiency among Asian women with former GDM.

UMR 7211. adolescents.7 (2. Souberbielle JC1. Patrice Cacoub. Lapidus N1.1% urban residents) with mean age. Pol S1. Cacoub P1. respectively. The rate of early virologic response was 0/29 (0%). Overall.competitive immunoassay chemiluminescence method. In modified intention-totreat analysis. and 67. respectively. . Sorbonne Universités.23) cm. obesity Vitamin D in addition to peg-interferon-alpha/ribavirin in chronic hepatitis C virus infection: ANRS-HC25-VITAVIC study. and 39% were Vitamin D insufficient. All patients except one normalized their vitamin D serum levels. This finding may be because of considerably high prevalence of hypovitaminosis D in the study population. UPMC Univ Paris 06. France. Inflammation-Immunopathology-Biotherapy Department (DHU i2B). Ratziu V1. Serfaty L1. 40% of participants were Vitamin D deficient. The primary outcome was the rate of early virological response defined by an HCV RNA < 12 IU/mL after 12 wk PegIFN/RBV treatment. The rate of HCV RNA < 12 IU/mL after 24 wk of PegIFN/RBV was 1/27 (4%). METHODS: Genotype 1 or 4 HCV-infected patients with null response to previous PegIFN/RBV treatment and with hypovitaminosis D (< 30 ng/mL) prospectively received cholecalciferol 100000 IU per week for 4 wk [from week -4 (W-4) to W0].82 (12.6). Asselah T1. 1 Abstract AIM: To investigate if correction of hypovitaminosis D before initiation of Peg-interferon-alpha/ribavirin (PegIFN/RBV) therapy could improve the efficacy of PegIFN/RBV in previously null-responder patients with chronic genotype 1 or 4 hepatitis C virus (HCV) infection. The median serum 25(OH)D was 13. Terrier B1. The safety profile was favorable.0 ng/mL (interquartile range: 20. Body mass index (BMI) and waist-to-height ratio (WHtR) were considered as measures of generalized and abdominal obesity. and waist circumference of 14. RESULTS: Study participants consisted of 1090 adolescents (51.6) years.3 (4.9% boy and 67. respectively. Serum 25(OH)D level was not associated with BMI and WHtR.2) kg/m(2). followed by 100000 IU per month in combination with PegIFN/RBV for 12 mo (from W0 to W48). BMI. F-75005 Paris. 19 (59%) and 13 (41%) patients were HCV genotype 1 and 4. CONCLUSION: We did not document any significant association between serum 25(OH)D level and anthropometric measures in adolescents. The median baseline vitamin D level was 15 ng/mL (range: 7-28). KEYWORDS: 25-Hydroxy Vitamin D. RESULTS: A total of 32 patients were included. Carrat F1. 29 patients who received at least one dose of PegIFN/RBV were included in the analysis. Author information  Benjamin Terrier. Thibault V1. 19.

CONCLUSION: Addition of vitamin D to PegIFN/RBV does not improve the rate of early virologic response in previously null-responders with chronic genotype 1 or 4 HCV infection. infections. Italy . cardiovascular disease. Teta D1. 98125 Messina. 90100 Palermo. Department of Human Pathology. 98125 Messina. Italy. IFC CNR. Ribavirin. Italy. Centre Hospitalier Universitaire Vaudois (CHUV). Vitamin D Vitamin D Deficiency in HIV Infection: Not Only a Bone Disorder. Author information  1  2  3  4 Department of Internal Medicine and Biomedicine. University of Palermo. Abstract Hypovitaminosis D is a worldwide disorder. Hepatitis C virus. Switzerland. Messina Unit. Cascio A4. Italy. Gangemi S2. metabolic syndrome. KEYWORDS: Chronic hepatitis. Mansueto P1. autoimmune diseases like type 1 diabetes mellitus. 98125 Messina. University of Messina. Italy. 98100 Messina. pathogenic mechanisms. high blood pressure. We analysed the extent of the problem. the Risk of Fall. PMID: 26000302 [PubMed . depression. and Frailty. Lausanne. Pegylated interferon. Iaria C3. University of Messina. and potential benefits of vitamin D supplementation in HIV-infected subjects. Seidita A1. In this review. several studies have linked vitamin D status with bone disease. neurocognitive impairment. we focus on the most recent epidemiological and experimental data dealing with the relationship between vitamin D deficiency and HIV infection. 98125 supplied by publisher] PMCID: PMC4426898 Free PMC Article Vitamin D: A Review on Its Effects on Muscle Strength. In HIV patients. clinical implications. with a high prevalence in the general population of both Western and developing countries. Author information  Service of Nephrology. type 2 diabetes mellitus. Department of Medicine. Papardo-Piemonte Hospital. 1 Abstract . AILMI-ONLUS Italian Association for the Control of Infectious Diseases. Italy . Phan O1. Vitale G1. Halfon M1. Department of Human Pathology. and cancer. Infectious Diseases Unit. University of Messina.

Is vitamin d deficiency related to accumulation of advanced glycation end products. and degree of renal impairment. A putative transmembrane receptor may be responsible for nongenomic effects leading to rapid influx of calcium within muscle cells. which has led to new research exploring the effects of vitamin D on a variety of tissues. N (ε) -(carboxymethyl)lysine (CML). vitamin D supplementation has been shown to improve muscle strength and gait in different settings. Author information  1  2  3  4  5 Comenius University Medical Faculty. Hamburg. Stäb F4. 97080 Würzburg. Ranchal I2. In 276 diabetics (160  M/116  F. Villela-Nogueira CA3. This is why many authorities recommend vitamin D supplementation in the frail patient.T1DM. Germany. Methods. the ubiquitary nature of vitamin D receptor (VDR) suggests potential for widespread effects. KfH Nierenzentrum Würzburg. a reduced risk of falls has been attributed to vitamin D supplementation due to direct effects on muscle cells. skin autofluorescence (SAF). and renal function (eGFR) were determined. Lewis-Ximenez LL1. 97080 Würzburg. 811 07 Bratislava. Bahner U3. 43 type 1. de P Scalioni L1. Fazeli G2. Germany . Conclusion.5 years) routine biochemistry. duration of diabetes. acts in myocytes through genomic effects involving VDR activation in the cell nucleus to drive cellular differentiation and proliferation. We asked whether a hypovitaminosis D associates with an increased formation and toxicity of AGEs in diabetes. Germany.6 ± 15. soluble vascular adhesion protein-1 (sVAP-1). and 233 type 2 patients. However. Hypovitaminosis D is consistently associated with decrease in muscle function and performance and increase in disability. Finally. Miguel JC1. Heidland A5. In T2DM patients but not in T1DM the age-dependent rise of SAF directly correlated with hs-CRP and sVAP-1. University of Würzburg. Lampe E1. KfH Nierenzentrum Würzburg. Del Campo JA2. University of Würzburg. Results. especially in elderly patients.5 ng/mL. age: 65. Slovakia. Despite some controversies in the interpretation of meta-analysis. Abstract Objectives. In diabetics hypovitaminosis D does not augment accumulation of AGEs and studied markers of microinflammation and oxidative stress except for sVAP-1. high sensitive C-reactive protein (hs-CRP). 97080 Würzburg. In the diabetics SAF and AGE-Fl were higher than those of the controls and correlated with age. On the contrary. soluble receptor for AGEs (sRAGE).Vitamin D is the main hormone of bone metabolism. and oxidative stress in diabetic subjects? Šebeková K1. Germany. calcitriol.4. especially in the skeletal muscle. . Germany. T2DM) and 121 nondiabetic controls (60  M/61   F. In vitro studies have shown that the active form of vitamin D. plasma AGE-associated fluorescence (AGE-FL). No relationship between 25-(OH)D and studied markers except for sVAP-1 was observed in the diabetics. markers of inflammation. Melo-Villar L1. Stürmer M2. Beiersdorf AG. Hypovitaminosis D and its relation to demographic and laboratory data among hepatitis C patients. a low vitamin D status is consistently associated with the frail phenotype. In diabetes accumulated advanced glycation end products (AGEs) are involved in the striking cardiovascular morbidity/mortality. 25-(OH)D levels in diabetics and nondiabetics were lowered to a similar degree averaging 22. levels of 25-hydroxyvitamin D3 (25-(OH)D). 97080 Würzburg.0 ± 13. age: 58. Romero-Gomez M2. de Almeida AJ1.

RESULTS: Mean serum values of 25(OH)D was 26. Advanced age (> 55 years). Penang.7 ± 11. high mean values of ALT. Kepala Batas Hospital. Correlations between serum 25(OH)D levels. however baseline 25(OH)D level is not independently associa Impact of Vitamin D Replacement on Markers of Glucose Metabolism and Cardio-Metabolic Risk in Women with Former Gestational Diabetes-A Double-Blind. Malaysia. Rio de Janeiro. Randomized Controlled Trial.9%). SVR was associated to low mean values of LDL. Hospital Universitario de Valme. Hepatology Unit. Malaysia. and laboratory data. Penang General Hospital. Penang Medical College. Kepala Batas. Antiviral treatment was underwent by 133 HCV patients and 44. Penang. Rio de Janeiro. high mean values of LDL. Medical Clinic Department. Penang. Yeow TP1. total cholesterol and platelets.2 years) using chemiluminescence immunoassay. Khir AS4. The aim of this study was to determine pre-treatment 25(OH)D serum level among HCV infected individuals and to evaluate the association between vitamin D status. . Clementino Fraga Filho University Hospital. CONCLUSIONS: In conclusion. Pacini G6. virological and laboratory data regarding HCV infection as well as sustained virological response (SVR) to antiviral therapy were evaluated. Hor CP3. Abstract BACKGROUND: The relationship between 25-hydroxyvitamin D [25(OH)D] serum levels and response to antiviral therapy and laboratory data in HCV infection remains unclear. Denmark. Brazil. FIOCRUZ. AST and low fibrosis grade. virological response. Sevilla. Spain. Author information  1  2  3 Department of Medicine. MATERIAL AND METHODS: Baseline serum 25(OH)D levels were measured in 237 chronic HCV infected patients (139 female. Malaysia. Brazil.Author information  1  2  3 Laboratory of Viral Hepatitis. HDL and low mean values of alkaline phosphatase and hemoglobin were statistically associated to vitamin D deficiency. Unit for the Clinical Management of Digestive Diseases and CIBERehd. Malaysia. Lim SL2. Oswaldo Cruz Institute.3% of them achieved SVR. low vitamin D levels were observed among HCV infected patients and was associated to laboratory findings. Seberang Jaya. Clinical Research Centre. Gentofte. Penang. Wan Mohamud WN5. Steno Diabetes Centre.2%. total cholesterol. age 53. UFRJ. Seberang Jaya Hospital.2 ± 12 ng/mL and prevalence of vitamin D deficiency (< 30 ng/mL) was 66. Most of individuals that presented SVR also presented 25(OH)D level higher than 30ng/mL (55. Department of Medicine.

Malaysia. Author information  Internal Medicine IV . Thirty three (76%) women with former GDM screened had vitamin D level of <50 nmol/L at baseline. RECENT FINDINGS: Experimental studies suggest that hyperphosphatemia. randomized controlled trial. We evaluated the impact of vitamin D supplementation on markers of glucose metabolism and cardio metabolic risk in Asian women with former GDM and hypovitaminosis D. Penang. 75g Oral Glucose Tolerance Test (OGTT) and biochemistry profiles were performed at baseline and 6 month visits.034). 4  5  6 Department of Medicine. p = 0. Institute of Biomedical Engineering. Italy. Homburg. recent evidence suggests that cardiovascular disease may not only follow but also induce mineral metabolism disorders: severe derangements in mineral metabolism were observed in patients with acute heart failure. individuals with high plasma levels of phosphate.parathyroid hormone and fibroblast growth factor-23 (FGF-23) . p<0. Malaysia. Further mechanistic studies exploring the role of vitamin D supplementation on glucose homeostasis among different ethnicities may be needed to better inform future recommendations for these women with former GDM at high risk of both hypovitaminosis D and future diabetes. in longitudinal clinical cohort studies.2% (2 mmol/mol) reduction in HbA1c. There was no effect on markers of cardio metabolic risk. face worst cardiovascular prognosis. Vice versa.001) and increased fasting insulin (+20% vs 18%. Six months supplementation with 4000 IU of vitamin D3 safely restored the vitamin D level. Department of Medicine. There was no clear change in insulin sensitivity or markers of cardio metabolic risk. parathyroid hormone and FGF-23. Abstract Gestational Diabetes Mellitus (GDM) and vitamin D deficiency are related to insulin resistance and impaired beta cell function. Supplementation. Saarland University Medical Center. Penang Medical College. insulin and C peptide measurements from OGTT. Mineral metabolism in heart disease. Germany. Padova. Metabolic Unit. Penang.Nephrology and Hypertension. improved basal pancreatic beta-cell function and ameliorated the metabolic state. resulted in increased vitamin D level (+51. recent work suggests that cardiovascular disease may also cause mineral metabolism alterations. This study highlighted high prevalence of vitamin D deficiency among Asian women with former GDM. when compared with placebo.2 nmol/L. Diabetes and Nutrition Research Centre.and hypovitaminosis D exert detrimental effects on vascular tissue and on the myocardium.Notably. 1 Abstract PURPOSE OF REVIEW: Strong experimental and clinical evidence points towards a substantial contribution of mineral metabolism disorders to the initiation and progression of cardiovascular disease. Heine GH1. were employed to calculate insulin sensitivity and beta cell function. In this double blind. few prospective studies have been completed . using serial glucose. elevated plasma levels of phosphaturic hormones . 26 participants were randomized to receive either daily 4000 IU vitamin D3 or placebo capsules. with heightened risk for future development of diabetes. Unfortunately. Institute for Medical Research. Mathematical models. Kuala Lumpur. Accordingly. Cardiovascular.1 nmol/L vs 0. and with low vitamin D levels. Malaysia. who face a tremendous increase in plasma FGF-23. Penang General Hospital. National Research Council. The vitamin D group also demonstrated a 30% improvement in disposition index and an absolute 0.

The prevalence of hypovitaminosis D [defined as 25(OH)D3 <9. The goal of this study was to determine the prevalence of vitamin D deficiency (hypovitaminosis D) and its association with serum calcium.05).09 pmol/L were more likely to die (OR=3. College of Veterinary Medicine. The Ohio State University. Author information  1  2  3  4  5 College of Veterinary Medicine. disease severity.037). and PTH concentrations. the pathogenesis of equine neonatal hypocalcemia is poorly understood. METHODS AND RESULTS: One hundred newborn foals ≤72 hours old divided into hospitalized (n = 83. Sadat City. 59 septic. Dembek KA2. Serum 25(OH)D3 and 1. Kamr AM1. Septic foals with 25(OH)D3 <9. Vitamin D Metabolites and Their Association with Calcium.25(OH) 2D3].25(OH) 2D3 concentrations were significantly lower in septic and SNS compared to healthy foals (P<0. Hypovitaminosis D in critically ill people has been linked to hypocalcemia and mortality. Toribio RE2. 64% for septic. Reed SM3. OR = 5.51 ng/mL and 1. Septic foals had significantly lower calcium and higher phosphorus and PTH concentrations than healthy and SNS foals (P<0.52. However. and mortality in hospitalized newborn foals. United States of America.25-dihydroxyvitamin D3 [1. 1. and 63% for SNS foals.1-12. Rood and Riddle Equine Hospital. Faculty of Veterinary Medicine. and parathyroid hormone (PTH) concentrations. respectively). clinical evidence for a cardiovascular benefit of therapeutic interventions into mineral metabolism is outstanding. In hospitalized and septic foals. University of Sadat City.62. University of Sadat City. 95% CI = 1.hitherto that specifically target components of the mineral metabolism for cardiovascular disease prevention or treatment. Ohio. Lexington. Rosol TJ2. phosphorus. Phosphorus. The Ohio State University. However. Columbus. 95% CI = 1. Egypt. Abstract BACKGROUND: Hypocalcemia is a frequent abnormality that has been associated with disease severity and outcome in hospitalized foals. Kentucky. Zaghawa AA5. Faculty of Veterinary Medicine. low 1. Sadat City. Egypt. Kentucky.0001. United States of America. Ohio. and Mortality in Hospitalized Equine Neonates. United States of America. and PTH Concentrations.41. Data were analyzed by nonparametric methods and univariate logistic regression.25(OH)2D3 concentrations were associated with increased PTH but not with calcium or phosphorus concentrations.51 ng/mL] was 63% for hospitalized. SUMMARY: A bidirectional interaction exists between mineral metabolism disorders and cardiovascular disease.19-24.25(OH) 2D3 <7. . however. P = 0.40. Slovis NM4. Columbus. Lexington. United States of America. Blood samples were collected on admission to measure serum 25-hydroxyvitamin D3 [25(OH)D3]. 24 sick nonseptic [SNS]) and healthy (n = 17) groups were included. Severity of Illness. Hagyard Equine Medical Institute. information on vitamin D metabolites and their association with clinical findings and outcome in critically ill foals is lacking.

Boyer L2. GHU Mondor.CONCLUSIONS: Low 25(OH)D3 and 1. Marseille. GHU Mondor. Aix Marseille Université. Belzeaux R1. We report a young premenopausal female with osteomalacia secondary to vitamin D deficiency and spontaneous bilateral femur neck fractures. CRN2M UMR 7286. CNRS. Assistance Publique . Créteil. Otero-López A. Osteomalacia secondary to low serum levels of vitamin D may lead to stress and fragility fractures. France. France. Atraumatic bilateral femoral neck fractures in a premenopausal female with hypovitaminosis D. Fondation FondaMental. France. Marseille. University Paris Est-Créteil. Créteil. EA 3279 Research Unit. Fondation FondaMental. Paraliticci G. Mood disorders are associated with a more severe hypovitaminosis D than schizophrenia. Sainte-Marguerite University Hospital. INSERM U955. Marseille. Marseille. 82 individuals with mood disorders or schizophrenia/schizoaffective disorders were included. La Timone University Hospital.Hôpitaux de Marseille. France. UMR7259. Hypovitaminosis D was significantly lower in patients with mood disorders than patients . NICN. Assistance Publique . Author information  1  2  3  4  5  6 Department of Psychiatry. Créteil. Ibrahim EC3. Identification and treatment of at risk patients may decrease the incidence of stress fractures and its possible complications. La Conception University Hospital. DHU Pe-Psy. Féron F4. Abstract Patients with psychiatric disorders display high levels of hypovitaminosis D (<50nmol/L). Dávila A. Créteil. CNRS. Leboyer M5. Créteil. DHU Pe-Psy. Patients had no reported risk factors for osteomalacia but hypovitaminosis D was noted on laboratory evaluation. Abstract Bilateral femur neck fractures in young adult patients are very rare in atraumatic circumstances. Fondation FondaMental. France. INSERM U955. Fondation de coopération scientifique en santé mentale. France. France. CNRS. 13344. Aix Marseille Université. Créteil.25(OH)2D3 concentrations are associated with disease severity and mortality in hospitalized foals. Hypocalcemia and hyperphosphatemia together with decreased 1. Eq 15.fond@gmail.25(OH)2D3 but increased PTH concentrations in septic foals indicates that PTH resistance may be associated with the development of these France. Fondation de coopération scientifique en santé mentale. France.Hôpitaux de Marseille. France. Fond G6. Fondation de coopération scientifique en santé mentale. Department of Public Health. David Rodríguez-Quintana R. It remains unclear whether it is associated with specific diagnoses. To further explore vitamin D status in psychiatric inpatients. Fondation FondaMental. University Paris Est-Créteil. CRN2M UMR 7286. Vitamin D deficiency may contribute to a pro-inflammatory state in equine perinatal diseases. Fondation de coopération scientifique en santé mentale. France. Eq 15. Electronic address: guillaume. Aix Marseille Université.

1 Abstract OBJECTIVES: The aim of this study was to investigate the 25-hydroxyvitamin D [25(OH)D] status of children with growing pains and to evaluate the efficacy of vitamin D treatment on the resolution of pain symptoms. Author information  Department of Pediatrics.with schizophrenia (standardized β coefficient=0. KEYWORDS: Bipolar disorders.9 to 2. Dysthymia.4 ng/ml. Vitamin D Are Growing Pains Related to Vitamin D Deficiency? Efficacy of Vitamin D Therapy for Resolution of Symptoms. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved. Karger AG.6%). Vehapoglu A1. The 25(OH)D levels and VAS scores before and after oral vitamin D administration were compared by means of a paired Student's t test. © 2015 S. Ersoy M. Laurent Boyer . the pain intensity was remeasured by means of the VAS at 3 months. p < 0. Further studies are warranted to determine specific causes of hypovitaminosis D and the interest of supplementation. Schizophrenia. Turel O.001) and the difference was statistically significant. Basel. Following vitamin D supplementation. Istanbul. Aksoy T.9 ± 2.007). Turkey.5 ± 16.385. Bezmialem Vakıf University School of Medicine. Inal BB.1.8 ± 1. After a single oral dose of vitamin D. Serum 25(OH)D and bone mineral levels were measured in all subjects at the time of enrollment. SUBJECTS AND METHODS: One hundred and twenty children with growing pains were included in a prospective cohort study. RESULTS: In the 120 children with growing pains. p=0.5 cm (a mean reduction of -3. Turkmen S. vitamin D insufficiency was noted in 104 (86. El Chérif Ibrahim .8 ± 2. Major depression. the mean pain VAS score decreased from 6.2 to 44. the mean 25(OH)D levels increased from 13. CONCLUSION: Supplementation with oral vitamin D resulted in a significant reduction in pain intensity among these children with growing pains who had hypovitaminosis D. Article in Press Switch to Standard View Switch to Enhanced View Mood disorders are associated with a more severe hypovitaminosis D than schizophrenia Raoul Belzeaux .4 ± 7. Ozgurhan G. The pain intensity of those with vitamin D deficiency was measured using a pain visual analog scale (VAS).

Mikkilä V. Determinants of serum 25(OH)D concentration in young and middleaged adults. Radermacher L. Kaji BC. Männistö S. Turku . [Article in French] Pirotte B. Marniemi J. Vijverman A. Raitakari OT. in predisposed individuals it may lead to hypervitaminosis D. Lehtimäki T. 2015. Whilst this approach is generally safe. Jula A. Here we present a case where empirical use of high dose vitamin D supplementation had serious consequences highlighting the need to use vitamin D therapy judiciously and to remain vigilant for side-effects in high-risk individuals. Abstract Vitamin D deficiency is highly prevalent in India. University of Turku . Marion Leboyer . Received in revised form: March 6. Magnussen CG. and whether achievement of recommended dietary vitamin D intake (10 μg/d) is associated with absence of hypovitaminosis D in adults. 2015. We report the case of a 20 year old patient with abdominal pain in the setting of hypercalcemia due to intoxication by VTD. Juonala M.. Stifkens F. Abstract Vitamin D (VTD) deficiency has become a topical issue leading to screening with frequent supplementation. 1 Abstract INTRODUCTION: We studied prevalence of hypovitaminosis D. This has set off a trend among medical practitioners to prescribe vitamin D supplements empirically. Hutri-Kähönen N. Accepted: April 20. Published Online: May 19. Pahkala KA. Kaye O. Author information  The Research Centre of Applied and Preventive Cardiovascular Medicine. The Cardiovascular Risk in Young Finns Study. an uncommon reality! Mansuri ZH. Deflandre J. Kähönen M. its determinants. Voipio AJ1. The latter can be dangerous and exceptionally causes overdoses. Buch HN. Loo BM. This case offers the opportunity to describe the differential diagnosis of hypercalcemia and to brownse through the literature in search of clinical practice recommendations for VTD supplementation Hypervitaminosis-D. 2015 Publication stage: In Press Corrected Proof [Hypercalcemia and acute renal failure: a case report of vitamin D intoxication]. Finland. Guillaume Fond Received: June 4. Dumra S. Putzeys V. Viikari JS. . 2014. François Féron .

METHODS: The study is part of the Cardiovascular Risk in Young Finns Study. 1. being a smoker (1.97-1. fortification. investigation month (December versus other) (1. Dietary vitamin D intake (OR 0. 1 Abstract BACKGROUND: Patients who undergo bariatric surgery are at risk for micronutrient deficiencies. Hypovitaminosis was defined as vitamin D concentration ≤ 50 nmol/L. 1959 NE Pacific Street. 0. 0.210 women aged 30-45 years). neander@u. Hypovitaminosis D was common also when recommended dietary intake was obtained (men 29%. women 24%). 1.55.06. We collected serum samples of 25hydroxyvitamin D as part of the 27-year follow-up (994 men and 1. and oral contraceptive use in women (0. . The condition was common even when recommended vitamin D intake was reported. CONCLUSION: Several factors were associated with hypovitaminosis D. 95% CI 0.36. Kirk EA. Vitamin D sufficiency was achieved in 62.75). Neilson CH.5 % of those patients with baseline vitamin D insufficiency. Chan LN1.410. RESULTS: Data from 134 recipients of RYGB were analyzed. KEYWORDS: 25(OH)D. Young Finns Study. and was significantly affected by seasonal change and the number of comorbidities. University of Washington. Javelli DR.93). 98195.31. USA. Hypovitaminosis D was identified in 86 patients (64 %). Khandelwal S. use of vitamin-mineral supplements (0.03-1. and to evaluate the effectiveness of a daily maintenance dose of vitamin D 2000 IU in preventing hypovitaminosis D within 1 year after bariatric surgery. 1.61). Increase in body mass index (1.90.86-0.45. hypovitaminosis D.09).85).51-0. Seattle. 1. and risk alleles in genotypes rs12785878 (1. with the most significant increase in 25(OH)D associated with daily vitamin D intakes  ≥  2000 IU. RESULTS: Hypovitaminosis D was found in 38% of men and 34% of women.75) were independently associated with reduced odds of 0. Longitudinal changes in serum vitamin D concentrations and clinical parameters were measured and collected. Box 357630. The aims of this study were to determine the prevalence and predictors of vitamin D deficiency in obese patients residing in the northern climate.12-1. single nucleotide polymorphism.00-1.27-0.washington. sunny holiday (0. WA. The results support the importance of vitamin D fortification and nutrient supplement use.70) and rs2282679 (2. vitamin D Optimization of Vitamin D Status After Roux-en-Y Gastric Bypass Surgery in Obese Patients Living in Northern Climate.08.35. Colovos TF.60) increased odds of hypovitaminosis.66-2. School of Pharmacy. A dose-response relationship of vitamin D intake was observed. 0. METHODS: A cohort study involving adult patients undergoing RYGB was conducted. Follow-up data were available in 60 patients.92). Author information  Department of Pharmacy.

Ansari Nagar.03. Tandon N1. insulinogenic index. India rajeshkhadgawat@hotmail. New Delhi. New Delhi. Gupta N1. Kachhawa G1. Abstract To assess the effect of vitamin D supplementation on parameters of insulin sensitivity/resistance (IS/IR) and insulin secretion in subjects with polycystic ovarian syndrome (PCOS).e19.8% of all subjects with mean serum 25 hydroxy vitamin D level of 7. Kabeshova A2. Ramot R1. IS (by whole-body IS index or Matsuda index). Author information  1  2 Departments of EndocrinologyObstetrics and GynecologyBiostaticsAll India Institute of Medical Sciences. Beauchet O2. Annweiler C1. disposition index (DI). were included in this study. Ansari Nagar. Effect of vitamin D supplementation on insulin kinetics and cardiovascular risk factors in polycystic ovarian syndrome: a pilot study.e8-536. lipid profile. and cardiovascular risk factors between the two groups. insulin:glucose ratio. HOMA-IR.16(6):536.45ng/ml. and DI). Epub 2015 Apr 24. II30. Daily vitamin D intake meeting at least 2000 IU is associated with greater improvement in serum vitamin D concentration. there was no significant difference in any of the parameters of IS/IR (area under curve (AUC)-glucose. Fantino B2. 1 J Am Med Dir Assoc. 110029. at a dose of 4000IU/day   for 6 months.jamda. Author information . Secondary outcome included blood pressure (BP). India.   After 6 months of vitamin D supplementation. Khadgawat R2. Out of 36 subjects who consented. © 2015 The authors. Hypovitaminosis D was observed in 93.008. AUC-insulin. doi: 10. and insulin secretion (by insulinogenic index. 110029. Kriplani A1. Garg G1. IR (by homeostasis model assessment IR (HOMA-IR)). Matsuda index. Departments of EndocrinologyObstetrics and GynecologyBiostaticsAll India Institute of Medical Sciences. Oral glucose tolerance tests with 75g   glucose were carried out at baseline and 6 months after supplementation. metformin and vitamin D 4000IU/day)   or group B (n=17.1016/j. Sreenivas V1.2015. Derivation and validation of a clinical diagnostic tool for the identification of older community-dwellers with hypovitaminosis d. Legeay M3. The trial was conducted in a tertiary care research hospital. II30) were the main outcome measures. 32 completed the study. A total of 36 subjects with PCOS. metformin and placebo). A prospective double-blind randomized control trial was conducted to assess the effect of vitamin D on insulin kinetics in women with PCOS. Vitamin D3 4000IU/day   versus placebo was given once a month for 6 months and both groups received metformin.30±4. 2015 Jun 1. did not have any significant effect on parameters of IS/IR and insulin secretion in subjects with PCOS. and vascular Supplementation of vitamin D. aged 18-35 years. Subjects were randomized into two groups: group A (n=15.CONCLUSIONS: The prevalence of hypovitaminosis D before RYGB was comparable to patients living in the nonnorthern climate.

fr. polymorbidity. MEASUREMENTS: Hypovitaminosis D defined as serum 25-hydroxyvitamin (25OHD) concentration ≤ 75 nmol/L.5. . Robarts Research Institute. UPRES EA 4638. France. and 525 (27. were tested consecutively. Angers University Hospital. psychoactive drugs. universal vitamin D supplementation is not desirable either. and validation in randomized testing subgroup. UPRES EA 4638.0 (moderate agreement). It was also able to diagnose hypovitaminosis D ≤ 50 nmol/L with accuracy = 81.867. vertebral fractures. Although evidence is insufficient to recommend routine vitamin D screening in seniors.2%) had 25OHD ≤25 nmol/L. A set of clinical variables (age. London. Electronic address: CeAnnweiler@chu-angers. living alone. Angers. University of Angers. Lyon. SETTING: Health Examination Centers of health insurance. France. Department of Neuroscience. MLP using 16 clinical variables was able to diagnose hypovitaminosis D ≤ 75 nmol/L with accuracy = 96. ≤50 nmol/L. The University of Western Ontario. Timed Up and Go. RESULTS: A total of 1729 participants (89. and κ = 79. Abstract OBJECTIVES: Hypovitaminosis D is highly prevalent among seniors. 1  2  3 Division of Geriatric Medicine and Memory Clinic. visual acuity. Réseau 4' cohort. our objective was to elaborate and test a clinical diagnostic tool for the identification of seniors with hypovitaminosis D without using a blood test. Published by Elsevier Inc. calcium supplements. wearing glasses. All rights reserved. gender. lower-limb proprioception. CONCLUSIONS: We elaborated an algorithm able to identify. sad mood) were recorded. 1288 (66. body mass index. handgrip strength. number of drugs used daily. walking aids. Several MLPs.5. MLP) in randomized training subgroup of Prévention des Chutes. falls. and hypovitaminosis D ≤ 25 nmol/L with accuracy = 82. biphosphonates. PARTICIPANTS: A total of 1924 community-dwellers aged ≥65 years without vitamin D supplements. UNAM. To rationalize vitamin D determination. Department of Neuroscience. cognitive disorders. individual deprivation.9%) had 25OHD ≤50 nmol/L.9%) had 25OHD ≤75 nmol/L. undernutrition. Ontario. France.385. AUC = 0. from 16 clinical variables. and κ = 57. Department of Medical Biophysics. Copyright © 2015 AMDA – The Society for Post-Acute and Long-Term Care Medicine. area under curve (AUC) = 0.3%. Division of Geriatric Medicine and Memory Clinic. Schulich School of Medicine and Dentistry. seniors with hypovitaminosis D.3 indicating almost perfect agreement.8 (moderate agreement). DESIGN: Derivation of a clinical diagnostic tool using artificial neural networks (multilayer perceptron. Canada. Angers. and κ = 55. or ≤25 nmol/L. Angers. Angers University Hospital. School of Medicine. fear of falling. UNAM.938. strontium. France. based on varying amounts of variables according to their relative importance. consecutively recruited between 2009 and 2012. AUC = 0.

1 . was lower to that of previous studies with HIV-infected patients. WI 53726 USA. Paiva AM2. PB. AL. Portuguese] Canuto JM1. version 17. Iglar PJ1. University of Wisconsin School of Medicine and Public Health. Brazil. older adults. The level of significance was set at 5% across tests.01). Hogan KJ2.01). Brazil. mean vitamin D concentrations were analyzed using Kolmogorov-Smirnov. Diniz ET3. overweight and obesity (p < 0. Vitamin D status and surgical outcomes: a systematic review. review of medical records. Maceió. Instituto Federal de Alagoas.05). Brazil. and obesity. Maceió. The association between hypovitaminosis D and the independent variables was assessed using the Chi-square or the Fisher's exact tests. with a significant association with higher household income (p < process] Risk factors associated with hypovitaminosis D in HIV/aids-infected adults. Mann-Whitney. The data were analyzed using the SPSS® software. Morais TM1. considering values > 20 ng/mL or > 30 ng/mL as vitamin D sufficiency. [Article in English. Author information  1  2  3  4 Centro Universitário Cesmac. Canuto VM1. Conclusion Lower vitamin D concentrations were significantly associated with well-known risk factors for hypovitaminosis D: use of sunscreen. Universidade Federal de Alagoas. Higher vitamin D levels were associated with female gender (p < 0. the prevalence of hypovitaminosis D and mean levels of vitamin D were determined.05). Campina Grande. Madison. Brazil.0. Author information  Department of Population Health Sciences.05). physical examination.001). Omena AL1. vitamin D. 707 WARF Building.KEYWORDS: Screening. vitamin D deficiency PMID: 25922119 [PubMed . Results The prevalence of hypovitaminosis D was 24%. Ferreira SM1. Abstract Objective To investigate risk factors associated with hypovitaminosis D in adult patients infected with HIV/aids. AL. overweight. Subjects and methods This cross-sectional study involved 125 patients evaluated from April to September 2013 by means of interviews. Brazil. at a referral hospital in Maceió. Almeida DJ4. antiretroviral medication. The prevalence of hypovitaminosis D in this study. AL. 610 North Walnut Street. Lima MH1. a fact that might be related to the low latitude and high intensity of solar radiation of the location of the present study. and Kruskal-Wallis tests. and previous opportunistic infections (p < 0. Maceió. and laboratory tests. Universidade Federal de Campina Grande. Lower values were associated with the use of antiretroviral medication (p < 0. no use of sunscreen (p < 0.

and PROSPERO were searched through December. Future studies should focus on additional surgeries and outcomes. Although it has been possible for many decades to quantify serum markers of vitamin D deficiency. Postoperative outcome. Ovid MEDLINE. The initial search yielded 90 manuscripts. we conducted a systematic review to assess the association between perioperative vitamin D status and outcomes after surgery.0% had insufficient levels of 25(OH)D. 25(OH)D (calcifediol) level. After applying exclusion criteria. Mellati AA. Fifteen studies employed prospective observational designs. Sharifi F. Faghihzade S. B/6 319 Clinical Sciences Center. Vitamin D deficiency was higher in girls (χ2=13. this review supports the hypothesis that hypovitaminosis D is associated with adverse outcomes after diverse surgical procedures. 1. diastolic blood pressure (DBP). 25(OH)D (calcifediol). these data have not been the subject matter of formal review. and awareness of significant extra-skeletal effects in health and disease is rapidly emerging. and on the role of vitamin D supplementation in the improvement of patient safety in participants with low vitamin D status at the time of surgery. anthropometric indices [body mass index and waist circumference (WC)]. The databases of PubMed. The Cochrane Databases of Systematic Review. WI 53792-3272 USA. Five of 31 studies (16%) found no association. To the present. the influence of vitamin D status on post-surgical outcomes has only recently been identified as a research topic of interest. systolic blood pressure (SBP). 31.25-dihydroxyvitamin D3 (calcitriol) level. Accordingly. p=0. Department of Anesthesiology. 31 studies were eligible for inclusion. C-reactive protein. The aim of this cross-sectional study was to determine the prevalence and association of vitamin D status with components of metabolic syndrome.00). METHODS: Lipid profile indices. CINAHL (EBSCOHost).12±8. AMED. KEYWORDS: 1. Chiti H. Surgery complication. The main finding of the present review is that 26 of 31 studies (84%) report at least one statistically significant worse outcome in patients with low vitamin D status. EMBASE. University of Wisconsin School of Medicine and Public Health.25-dihydroxyvitamin D3 (calcitriol). and 13 report retrospective database interrogations. 600 Highland Avenue. 25(OH)D level was negatively associated . In conclusion. Vitamin D Vitamin D status and its associations with components of metabolic syndrome in healthy children. intact parathyroid hormone (iPTH). and serum 25-hydroxyvitamin D [25(OH)D] concentration were evaluated in 297 healthy schoolchildren aged 7-11 years. 2014 for studies relating to vitamin D and surgery. Madison.66. and to correct deficiency at low cost and with high safety. Surgery outcome. Mousaviviri SA. Multivariate linear regression was used to determine independent predictors associated with low serum 25(OH)D concentrations.20 ng/mL (35. RESULTS: The mean serum 25(OH)D concentration was 14. Abstract AIM: High prevalence of vitamin D insufficiency/deficiency has been reported in populations of different countries. insulin resistance index (HOMA-IR).5 nmol/L).0% were deficient. 3 used prospective randomized protocols.3±20. and 65. Kazemi SA. Postoperative complication. 96% of children had low serum 25(OH)D levels. 2 Abstract The importance of vitamin D for musculoskeletal health has long been recognized.

Lower levels of 25-hydroxyvitamin D3 are associated with a higher prevalence of microvascular complications in patients with type 2 diabetes.01). via S. and HOMA-IR were significant independent predictor of low 25(OH)D concentrations. the aim of our study was to investigate the association of 25(OH)D levels with coronary heart disease (CHD) in 698 consecutive type 2 diabetic outpatients.024) were the most powerful predictors of CHD. 1 Abstract Vitamin D (25(OH)D) levels have been associated with cardiovascular disease. The prevalence of hypovitaminosis D was higher in diabetic patients than in control subjects (90 vs. Hypovitaminosis D: a novel risk factor for coronary heart disease in type 2 diabetes? Muscogiuri G1. Verona .01).01).01). and iPTH. Outdoor activity for optimum sun exposure and additional studies are needed to evaluate the underlying metabolic syndrome components and hypovitaminosis D complications. SBP. BMI (p < 0.01). and sex. Savastano S.01). CONCLUSION: The prevalence of low vitamin D level in the studied healthy children was high and it is correlated with some components of metabolic syndrome. Stoico and total (p < 0. and glycemia (p < 0. A1C (p < 0. while BMI (p < 0.01). 25(OH)D assay and the main cardiovascular risk factors were explored. The current study demonstrates that 25(OH)D does not have a direct effect on CHD but may have an indirect effect mediated by cardiovascular risk factors such as diabetes duration. Thus. Zoppini G1. Cacciatori V1. Azienda Ospedaliera Universitaria Integrata. Trombetta M1. diabetes duration (p = 0.muscogiuri@gmail.01) and LDL cholesterol (p < 0. 698 consecutive type 2 diabetic outpatients (25. fibrinogen (p < 0. Pansini 5. Italy. WC.026). 83 %. the association of vitamin D with CHD was lost.023).01).2 % men.01). glycemia (p < 0. Section of Endocrinology. Bonora E1.with WC. Zuccoli A. Nuzzo V. 80131. In the multivariate model. 25(OH)D and HDL cholesterol were lower (p < 0. Negri C1. age (p < 0. DBP. 25(OH)D concentration was 22 ± 10 ng/ml in control subjects and 18. Galletti A1. De Santi F1. DBP. p < 0. systolic (p < 0. age 66 ± 9 years) and 100 (90 % men. triglycerides (p < 0. giovanna. Gatti A. 1 Abstract . University of Verona . Pivonello R. Diabetic subjects with hypovitaminosis D had higher prevalence of high values of A1C (p < 0.01). Author information  Department of Medicine. Pichiri I1. Brangani C1. Colao A. At the logistic regression analysis.01). age. Università di Napoli "Federico II". Orio F. while sex (p = 0. triglycerides (p < 0. LDL cholesterol (p < 0. Naples.01). Di Somma C.01). Author information  Dipartimento di Medicina Clinica e Chirurgia. Targher G1. Italy. age 65 ± 13 years) age-matched non-diabetic volunteers were enrolled. HOMA-IR. and age (p = 0.01).01) and diastolic blood pressure (p < 0.01) were higher in diabetic subjects with CHD than diabetic subjects without CHD. Diabetes and Metabolism . diabetes duration (p < 0.01) than their vitamin D-sufficient counterparts.23 ± 10 ng/ml in diabetic patients (p < 0.01).

King AbdulAziz University. Marzouki ZM1. Microvascular Complications. KEYWORDS: Microangiopathy.015). Saudi Arabia. is caused by excessive immune responses to environmental antigens. . fundus examination. Jeddah 21483.OBJECTIVE: Low levels of serum 25-hydroxyvitamin D [25(OH)D] are commonly found in type 2 diabetes. this association remained significant even after excluding those with an estimated glomerular filtration rate <60 mL/min/1. lower 25(OH)D levels were independently associated with the presence of microvascular complications (considered as a composite end point. p=0. Abstract BACKGROUND: Asthma.6% of these patients. In multivariate logistic regression analysis. Aldubi HM1. Saudi Arabia. a 25(OH)D level <20 ng/mL) was found in 36. OBJECTIVE: Given the immuno-modulatory properties of vitamin D. King AbdulAziz University. Kamfar HZ2. 95% CI 0. Notably.607 to 0.4%. We examined whether there is an association between circulating 25(OH)D concentrations and the presence of microvascular complications in people with type 2 diabetes. Participants were evaluated for the presence of microvascular complications (namely retinopathy and/or nephropathy) by clinical evaluation. while deficiency (ie. RESEARCH DESIGN AND METHODS: We studied 715 outpatients with type 2 diabetes who regularly attended our clinic. CONCLUSIONS: We found an inverse and independent relationship between circulating 25(OH)D levels and the prevalence of microvascular complications in patients with type 2 diabetes. Department of Paediatrics. a serum 25(OH)D level <30 ng/mL) was found in 75. RESULTS: Hypovitaminosis D (ie. Jeddah 21483. Serum 25(OH)D levels were also measured for each participant.73 m(2). Gaber O1. Vitamin D Bronchial asthma and hypovitaminosis D in Saudi children.947. a common lung disease in children. Faculty of Medicine. Author information  1  2 Department of Clinical Biochemistry.758. urine examination and biochemical tests. Alissa EM1. Whether vitamin D supplementation in patients with type 2 diabetes may have beneficial effects on the risk of microvascular complications remains to be investigated. the aim of the current study was to investigate the relationship between vitamin D levels and markers of asthma severity. However. Serum 25(OH)D levels decreased significantly in relation to the severity of either retinopathy or nephropathy or both. vitamin D may be simply a marker and causality cannot be implied from our cross-sectional study. OR 0.

Diabetes. and the Concept of a Desirable Range. MRC Lifecourse Epidemiology Unit. Child. USA. Jeddah. Oregon Osteoporosis Center. Southampton. Portland. American University of Beirut. Division of Endocrinology. Rochester. Saudi Arabia. Singh RJ3. Bouillon R2. Significant correlations between several inflammatory and immunological markers and vitamin D levels were also found. and lack of government regulation account for up to 50% in variations in serum 25OHD levels. Latitude. OR. Vitamin D Serum 25-Hydroxyvitamin D Levels: Variability. and atopy markers (IgE and eosinophil count). Katholieke Universiteit Leuven. Leuven. Pulmonary function test was performed by recording changes in the peak expiratory flow. McClung M5. Cooper C4. Abstract Hypovitaminosis D is prevalent worldwide but proportions vary widely between regions. University of Southampton. over the period of 11 months (May 2011-April 2012). whereas genetic polymorphisms in the vitamin D pathway account for less than 5%. cytokines profile (interleukin-10. the threshold to define deficiency. Metabolism. gender. Calcium Metabolism and Osteoporosis Program. Lebanon. Department of Endocrinology and Laboratory Medicine. Clarke B3. KEYWORDS: Asthma. RESULTS: Hypovitaminosis D is highly prevalent among asthmatic children with highly significant increase in several markers of allergy and asthma severity as compared with healthy control children. Hypersensitivity.METHODS: This was investigated in a 70 Saudi children with and without asthma and were recruited from the King Abdul Aziz University Hospital. tumor necrosis factor-alpha. dietary habits. MN. USA. and Nutrition. pollution. Author information  1  2  3  4  5 Department of Internal Medicine. Childhood asthma control test instrument was employed to assess the level of asthma control among asthmatic patients. Belgium. and accuracy of 25-hydroxyvitamin D (25OHD) assays used. Anthropometric measurements were taken and interviewer-administrated questionnaire was completed for all study participants. Mayo Clinic Foundation. platelets derived growth factor). Knowledge Gaps. Chakhtoura M1. CONCLUSION: Our study showed that hypovitaminosis D is highly prevalent in the whole population in addition to a highly significant increase in several markers of allergy and asthma severity among asthmatic children as compared with healthy control children. El-Hajj Fuleihan G1. Venous blood samples were withdrawn for measurements of vitamin D. sun exposure. UK. Organizations/societies have developed guidelines for recommended desirable 25OHD levels and . lower 25-hydroxyvitamin D levels were associated with a higher asthma prevalence in multivariable analysis. bone profile. concealing clothing. depending on genetic and lifestyle factors. Beirut. Saudi Arabia. Finally.

and the use of 25OHD assays calibrated against the recommended international standards. lucianacangussu@gmail. A total daily allowance of vitamin D of up to 1000  IU in the pediatric age groups. defined by disease or lifestyle. 40 to 60  ng/mL. higher levels. INTRODUCTION: We aimed to evaluate the effect of supplementation of vitamin D (VITD) alone on muscle function in younger postmenopausal women. Additional data are needed to validate the proposed range and vitamin D doses. lifestyle. and Tukey's test.vitamin D doses to reach them. while keeping efficacy and safety data as the dominant factors when defining a desirable range for 25OHD levels. uncertainties and knowledge gaps. The intervention time was 9 months. using ANOVA. © 2015 American Society for Bone and Mineral Research. especially in children. with assessments at two points. 15 to 20  ng/mL. may be sufficient for some infants and adults. but their applicability across age groups and populations are still debated. Bueloni-Dias FN. Author information  Department of Obstetrics and Gynecology. placebo-controlled clinical trial. We propose a desirable range of 20 to 40  ng/mL (50 to 100  nmol/L).com. tailored to an individual patient risk profile. Statistical analysis was by intention to treat (ITT). and non-white populations. This desirable range allows physicians to tailor treatment while taking season. Nahas-Neto J. vitamin D intake. with a history of falls (previous 12 months). Sao Paulo. This article and the accompanying online Supporting Information highlight sources of variations in circulating 25OHD levels. . Women with amenorrhea for more than 12 months and age 5065 years. and other sources of variation into account. Effect of vitamin D supplementation alone on muscle function in postmenopausal women: a randomized. Nahas EA. with significant increases in muscle strength and control of progressive loss of lean mass. Lean mass was estimated by total-body dual-energy X-ray absorptiometry (DXA) and muscle strength by handgrip strength and chair rising test. Although slightly lower levels. Sao Paulo State University-UNESP. were included. is probably safe over long durations. Brazil. Most target groups reach desirable target levels by a daily intake of 400 to 600  IU for children and 800 IU for adults. pregnant women. It has been shown that vitamin D supplementation in postmenopausal women with hypovitaminosis D provides significant protective factor against sarcopenia. Cangussu LM1. placebocontrolled clinical trial. provided precise and accurate assays are used. METHODS: In this double-blind. Student's t test. We reserve 25OHD measurements for at-risk patients. Botucatu Medical School. Orsatti CL. and analytical problems facing 25OHD assays. 1 Abstract The present study investigates the effects of vitamin D on muscle function in postmenopausal women. 160 Brazilian postmenopausal women were randomized into two groups: VITD group consisting of patients receiving vitamin D3 1000 IU/day orally (n = 80) or placebo group (n = 80). may still be safe. and up to 2000 IU in adults. The plasma concentrations of 25-hydroxyvitamin D [25(OH)D] were measured by highperformance liquid chromatography (HPLC). start and end. double-blind.

5  ±  10. Serum 25-hydroxyvitamin D (25-OHD) levels were measured.2 (21.3-19.5) vs. Vitamin D deficiency and adrenal function in critically ill children.7 to 13.4 ng/ml (+45. PRISM III score. Patients with serum 25-OHD of less than 12 ng/mL had higher median (IQR) PRISM III score (14 (6-20) vs. outcome and adrenal function assessed by 1microgram adrenocorticotropic hormone test were collected. p = 0. In women in the placebo group.  •Further studies are warranted to determine the potential interest of vitamin D supplementation. Mahachoklertwattana P. In the VITD group. Chailurkit LO. there was significant increase in muscle strength (+25.6 (13. CONCLUSION: The supplementation of vitamin D alone in postmenopausal women provided significant protective factor against the occurrence of sarcopenia.9 ± 6. and adrenal function were not different between patients with and without VDD. with significant increases in muscle strength and control of progressive loss of lean mass.0  ±  7. average values of 25(OH)D increased from 15.001).RESULTS: After 9 months. length of intensive care unit stay and ventilator used. 5 (2-10). RESULTS: Median (IQR) serum 25-OHD of thepatients was less than that of the controls (16. p < 0. OBJECTIVE: To determine vitamin D status in critically ill children and its relationship with adrenal function. CONCLUSION: A greater proportion of VDD in critically ill children as compared with that of the controls was demonstrated. Pediatric Risk of Mortality (PRISM) III score. MATERIAL AND METHOD: Thirty-two patients and 36 controls were included.3 %) of the lower limbs by chair rising test (p = 0.001). Abstract BACKGROUND: Data on interrelationship between vitamin D deficiency (VDD) and adrenal insufficiency in critically ill children are limited. Poomthavorn P. 24. Twenty-five (78%) patients and seven (19%) controls had VDD. Serum 25-OHD was not associated with adrenal function. Highlights  •Patients with psychiatric disorders display high levels of hypovitaminosis D. proportions of patients with shock and vasopressive drug used. . Korwutthikulrangsri M.033) and higher proportion of mortality than those with serum 25OHD of 12 ng/mL or greater.9) ng/mnL.0 ng/ml (-18.036).5 %) in the placebo group (p <  0.4 %) in the VITD group and decreased from 16.030).  •Patients with mood disorder had lower vitamin D levels than patient with schizophrenia. Lertbunrian R.8 %) in the lean mass (p = 0.0-27.5 to 27. there was considerable loss (6.8  ±  6.

Department of Internal Medicine. Debrecen. Szegedi A3. University of Debrecen.5 ± 11. Our study intended to explore possible correlations between vitamin D status and BMD.385. Gaál J1. as well as between the former and the severity of skin involvement. © 2015 Japanese Dermatological Association. Author information  1  2  3  4  5 Department of Rheumatology. Varga J4. Furthermore. Kincse G1. Department of Nuclear Medicine. Division of Dermatological Allergology. in particular. Hungary. Hungary. It remains unclear whether it is associated with specifc diagnoses. Herédi E3. mean duration of follow up. disease activity. measured the serum vitamin 25(OH)D 3 levels of the patients. Further studies are warranted to determine specifc causes of hypovitaminosis D and the interest of supplementation. Faculty of Medicine. We found an inverse correlation between the serum level of vitamin 25(OH)D 3 and body mass index. the activity of psoriatic arthritis was significantly higher in patients with inadequate vitamin D 3 status. Hungary. 58.7 ± 147. Hungary. Seventy-two patients with psoriasis/or psoriatic arthritis (female : male ratio. The proportion of patients with a low BMD value did not exceed that seen in the general population. bone mineral density. 142. as well as among these parameters and the features of the underlying disorder. University of Debrecen. Department of Dermatology. Bhattoa PH2. BMD significantly exceeded the values measured in patients suffering from psoriatic skin lesions only. To further explore vitamin D status in psychiatric inpatients. mean age. Faculty of Medicine.5. Our findings suggest the importance of evaluating the vitamin D 3 status and screening for comorbid conditions in patients with psoriasis or psoriatic arthritis.6 years. due to the possible role of hypovitaminosis D3 in provoking the development of skin lesions and joint symptoms. Kéri J5. and undertook the statistical analysis of the relationships between the clinical and the laboratory parameters. 40:32.Abstract Patients with psychiatric disorders display high levels of hypovitaminosis D (<50  nmol/L).007). Faculty of Medicine. performed bone densitometry of the lumbar spine and the hip region.7 months) participated in the study. This appears justified. . Debrecen. In patients with psoriatic arthritis. 82 individuals with mood disorders or schizophrenia/schizoaffective disorders were included. University of Debrecen. Department of Laboratory Medicine. Debrecen. Division of Clinical Immunology. Debrecen. psoriasis Performance characteristics of the ARCHITECT Active-B12 (Holotranscobalamin) assay. "Kenézy Gyula" Hospital. Faculty of Medicine. Hungary. Debrecen. p=0. Vitamin D3 levels and bone mineral density in patients with psoriasis and/or psoriatic arthritis. University of Debrecen. We evaluated the characteristic clinical features of the underlying disease. Hypovitaminosis D was signifcantly lower in patients with mood disorders than patients with schizophrenia (standardized β coefficient=0. KEYWORDS: D vitamin level. Abstract Limited data are available on the vitamin D3 status and bone mineral density (BMD) of patients with psoriasis or with psoriatic arthritis.

UK). Italy. This study determined that the ARCHITECT HoloTC assay is suitable for routine clinical use. Pinchera B2. automated holoTC assay (ARCHITECT i2000(SR) Active-B12 (Holotranscobalamin)) and compare it to other available methods. Naples. Italy. CONCLUSIONS: This assay performed acceptably for LoB. imprecision. r = 0.0. Author information  1  2  3  4 Department of Clinical Medicine and Surgery . METHODS: Manufacturer-specified limits of blank (LoB). Pascale". Scarpato N4. Italy. Low Vitamin D Levels Are Associated with the Presence of Serum Cryoglobulins in Patients with Chronic HCV Infection.Section of Infectious Diseases. Ten to thirty percent of circulating cobalamin is bound to transcobalamin (holotranscobalamin. r = 0. and linearity were evaluated for the ARCHITECT HoloTC assay. University of Naples. Italy ivan.2 pmol/L.950 (n = 221). Studies estimate the deficiency prevalence as high as 30% in the elderly population. LoQ. Department of Molecular Medicine and Medical Biotechnology. holoTC) which can readily enter cells and is therefore considered the bioactive form. Celotti A2. Piccirillo M3. National Tumor Institute "Fondazione G. Abstract BACKGROUND: Vitamin B12 (cobalamin) is a necessary cofactor in methionine and succinyl-CoA metabolism. interference. . RESULTS: Manufacturer's claims of LoB. interference.8 pmol/L. Cavalcanti E3. Izzo F3. DE Iuliis E3. The objective of our study was to evaluate the analytical performance of a high-throughput. linearity and method comparison to the predicate device (AxSYM). which provides a high-throughput alternative for automated testing of this emerging marker of cobalamin deficiency. S(y/x) = 11. S(y/x) = 6. Naples. and quantitation (LoQ). and linearity to the highest point tested (113. Granata V3. Meola M4. LoD. Gentile I1. Method comparison of the ARCHITECT HoloTC to the AxSYM HoloTC produced the following Deming regression statistics: (ARCHITECT(HoloTc)) = 0. D'Ambra A4. Scarano R3. DI Paola F3. Comparison to the Active-B12 EIA produced: (ARCHITECT(HoloTC)) = 1. Department of Clinical Medicine and Surgery . Straseski JA. Borgia G2. An additional comparison to a manual Active-B12 EIA method performed similarly. Federico II. University of Naples. Naples.Merrigan SD. LoD. University of Naples. Scotland.105 (EIA(Active-B12)) .941 (AxSYM(HoloTC)) + 1.947 (n = 98). Naples. detection (LoD). imprecision.Section of Infectious Diseases. Federico II. Residual de-identified serum samples were used to compare the ARCHITECT HoloTC assay with the automated AxSYM Active-B12 (Holotranscobalamin) assay (Abbott Diagnostics) and the manual Active-B12 (Holotranscobalamin) Enzyme Immunoassay (EIA) (Axis-Shield Diagnostics.4 pmol/L) were verified for the ARCHITECT HoloTC assay. Dundee.6. Federico II. imprecision.gentile@unina. Owen WE. with minor exceptions. LoQ. Scarano F2.4.

low-antigen diet.029). RESULTS: Thirty patients (28.e. Kolkata.65 ng/ml. p=0. Its pathogenic mechanisms involve HCV-induced chronic stimulation of B-lymphocytes. the median serum 25(OH)vitamin D level was 10. Dept. immune regulation. India. Copyright © 2015 International Institute of Anticancer Research (Dr. India.108). Resident. Delinassios). For the cohort overall. extrahepatic manifestation. of Medicine. metabolism PMID: 25977388 [PubMed . We aimed to investigate the relationship between serum levels of vitamin D (a regulator of immune response) and the presence of serum cryoglobulins in the setting of HCV infection. Medical College. IPGMER and SSKM supplied by publisher]  Share on Facebook  Share on Twitter  Share on Google+ A study of the prevalence of osteoporosis and hypovitaminosis D in patients with primary knee osteoarthritis. Patients with serum cryoglobulins had significantly lower levels of 25(OH)vitamin D (5. Kolkata. PATIENTS AND METHODS: We evaluated the serum concentration of 25(OH)vitamin D and cryoglobulins in 106 patients with chronic HCV infection. severe hypovitaminosis [i. Ganguly S3.Abstract BACKGROUND/AIM: Mixed Cryoglobulinemia (MC) represents the most frequent extrahepatic manifestation of chronic Hepatitis C Virus (HCV) infection. Pal T2. Dept. John G. KEYWORDS: Hepatitis C. 25(OH)vitamin D <13 ng/ml] was the only independent predictor of cryoglobulinemia (odds ratio=3.3%) showed the presence of serum cryoglobulins. lymphoma. At multivariate analysis. CONCLUSION: Severe deficiency of vitamin D was independently associated with mixed cryoglobulinemia in patients with HCV infection. Ghosh B1. All rights reserved. Ghosh A4. Author information  1  2 Associate Professor. of Rheumatology.61 ng/ml) than those without (13. .95 ng/ml.

of Medicine. India. The matter is complicated by the fact hypovitaminosis D is also prevalent in the population and positively correlated with both Osteoporosis and osteoarthrosis. 3  4 Professor. Dept. Knee osteoarthitis. RESULTS: Total number of participants in this study was 206. For each patient age and sex matched friend or relative of same locality was taken in the study as controls. Dept. Out of which there were 98 cases and 108 controls. Osteoporosis . We also compared the prevalence of oseotoporosis between general population and patients of primary osteoarthritis. METHODS: Patients suffering from primary knee OA were taken from Rheumatology OPD of Medical College Hospital and SSKM Hospital Kolkata. Serum Vitamin D3 status correlates significantly with Osteoarthritis. We tried to find out prevalence of osteoporosis and hypovitaminosis D in patients suffering from primary knee Osteoarthritis. Abstract INTRODUCTION: Osteoarthritis and Osteoporosis are highly prevalent disease. India. Kolkata. India. of Rheumatology. Kolkata. Medical College. The control population was the representative of general population. KEYWORDS: Hypovitaminosis D. Professor. though we cannot comment on further pathogenesis because of cross sectional design of the study. CONCLUSION: Osteoporosis is prevalent both in general population and patients suffering from Knee Osteoarthritis and may increase the disability. BMD status correlates significantly with Primary OA. Hospital staffs that come from different part of state was taken in the study as controls. so is hypovitaminosis D. There were significant correlation between the Serum Vitamin D3 status and BMD of the subjects. Age of the patients correlated significantly with both BMD Status and Knee OA but not with the vVitamin D level. IPGMER and SSKM Hospital.