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Generic Name: Gliclazide

Brand Name: Diamicron


Classification: Anti-diabetes
Action: Lowers blood glucose by stimulating the release of insulin from the pancreas and
increasing sensitivity to insulin at receptor sites.
Indication: This medication is an oral hypoglycemic, prescribed for type 2 diabetes. It stimulates
the pancreas, which helps in more insulin secretion.
Contraindication: This medication must not be used in the following cases:
-if you are allergic to gliclazide
-if you have diabetes requiring treatment with insulin,
-in case of diabetes complicated by ketosis and acidosis, diabetic precoma
-if you suffer from severe liver or kidney disease.
- Pregnancy and lactation
Dosage: oral route: the standard dosage is 2 tablets per day (30mg), in 2 daily doses.
Side Effects: headache, nausea, vomiting, slow reaction time, sweating, clammy skin, anxiety,
faster heart rate, chest pain, raised blood pressure, palpitations, hunger, a lack of interest or
energy, drowsiness, sleeping problems, feeling agitated or aggressive
Adverse Effects: heart rhythm changes, depression, confusion, speech problems, aphasia,
tremors, paresis, sensory problems, dizziness, feelings of powerlessness, loss of self-control,
delirium, convulsions, shallow breathing
Drug-drug interaction:
-medications which risk increasing hypoglycemia:

Miconazole
Phenylbutazone
beta-blockers
fluconazole
angiotension converting enzyme inhibitors
Alcohol.

-medications which risk producing hyperglycemia by reducing the efficacy of the antidiabetic
agent:

danazol
chlorpromazine
glucocorticoids
salbutamol
terbutaline
ritodrine

Nursing Intervention:
1. Instruct patient to take diamicron directed at the same time every day.
2. Take medication with meals
3. Explain to patient that this medication does not cure diabetes and must be used in
conjunction with a prescribed diet, exercise regimen, to prevent hypoglycemic and
hyperglycemic events.
4. Review signs of hypoglycemia and hyperglycemia with patient. If hypoglycemia occurs,
advice patient to drink a glass of orange juice or ingest 23 tsp of sugar, honey, or corn
syrup dissolved in water or an appropriate number of glucose tablets and notify health
care professional.
5. Concurrent use of alcohol may cause a disulfiram-like reaction (abdominal cramps,
nausea, flushing, headaches, and hypoglycemia).
6. Caution patient to avoid other medications, especially aspirin and alcohol, while on this
therapy without consulting health care professional.
7. Advise patient to notify health care professional promptly if unusual weight gain,
swelling of ankles, drowsiness, shortness of breath, muscle cramps, weakness, sore
throat, rash, or unusual bleeding or bruising occurs.
8. Encourage patient to follow prescribed diet, medication, and exercise regimen to prevent
hypoglycemic or hyperglycemic episodes.
9. Advise patient to carry sugar packets or candy, and identification describing diabetes
diagnosis and medication regimen.
10. Monitor the drug efficacy.