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Control Mechanism:

a) Negative Feedback- observed in the body wherein certain conditions in the


body is above or below normal and the feedback tries to bring back the body
back to normal. (eg. high BP, it will bring it back to normal); counteract
existing mechanism and bring the condition back to normal; term used for
neuronial activity
If it involves the activity of the endocrine system (hormonal control)endocrine axis driven feedback (eg. Hormone in blood decreases, the
effect will be greater than normal, it will decrease the hormone back to
normal) CHANGE IN THE LEVEL OF HORMONE IN THE BLOOD WHICH
AFFECTS THE ACTIVITY OF THE ENDOCRINE SYSTEM BRINGING
THE CONDITION BACK TO NORMAL
b) Modified Negative Feedback (Physiologic Response Driven Feedback)
change in the level of a certain non-hormonal agent in blood and
alter activity of the endocrine system bringing it to normal. NOT LEVEL OF
HORMONE (eg. Level of blood glucose produced by beta cell of islets of
langerhans changing endocrine cell)
*take note: whatever is that agent that affects activity of the endocrine cell,
level of that agent in the blood is controlled by the affected endocrine cell.
eg. Level of blood glucose is affected by the secretory product of the beta
cell of islets of langerhans; level of calcium in the blood produced by
parathyroid hormone
c) Positive Feedback control-compared to negative feedback, (-) feedback,
you oppose the condition, in (+) feedback, it allows existing condition to
continue or even exaggerate the condition. (eg. pregnancy- progressive
release of hormone to make the baby grow until labor. hormone oxytocin); for
neural: bleeding conditions during injury. Body will respond by lessening the
blood loss. Progressions is vasoconstrictionactivate platelets- activate
clotting factor) ALLOW THE ACTIVITY TO PROGRESS.
d) Feed Forward- observed anticipatory responses of body to a certain
condition once exposed to a certain condition (eg. Response of digestive
system when person smells/ sees food; beginning of exercise, there is initial
hyperventilation and increase in heart rate)
e) Up Regulation (Supersensitization) changes in level of certain
structures present in the cell affected by hormones and even the agents.
(eg. growth hormones, DM type I and II)
Whether it is a neurotransmitter or a hormone, what is needed for them to
effectively exert their effects on the cell? - Receptors
Condition wherein there is decreased level of neurotransmitters or hormones
in the blood, lesser effect of the agent in the body or targeted cell. The cell
affected or target cell will try to increase the number of receptors
responding to the hormone or the neurotransmitter to maintain normal
condition. To maintain normal effect of the transmitter or hormone
f) Down Regulation (Desensitization) observed in excess level of the
hormone or neurotransmitter. If sumobra, the effect of the cell will be more
than normal. The affected cell will decrease the number of receptors to
lessen the effect of the agent of the cell.