Drug Thorazine

Mechanism of Action The precise mechanism whereby the therapeutic effects of thorazine are produced is not known. The principal pharmacological actions are psychotropic. It also exerts sedative and antiemetic activity. thorazine has actions at all levels of the central nervous system— primarily at subcortical levels— as well as on multiple organ systems. it has strong antiadrenergic and weaker peripheral anticholinergic activity; ganglionic blocking action is relatively slight. It also possesses slight antihistaminic and antiserotonin activity.

Indication Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods).

Contraindication You should use Thorazine cautiously if you have ever had: asthma; a brain tumor; breast cancer; intestinal blockage; emphysema; the eye condition known as glaucoma; heart, kidney, or liver disease; respiratory infections; seizures; or an abnormal bone marrow or blood condition; or if you are exposed to pesticides or extreme heat. Be aware that Thorazine can mask symptoms of brain tumor, intestinal blockage, and the neurological condition called Reye's syndrome. Stomach inflammation, dizziness, nausea, vomiting, and tremors may result if you suddenly stop taking Thorazine. Follow your doctor's instructions closely when discontinuing Thorazine. Thorazine can suppress the cough reflex; you may have trouble vomiting. This drug may impair your ability to drive a car or

Adverse Effects • feeling like you might pass out; • jaundice (yellowing of the skin or eyes); • fever, sore throat, flu symptoms; • stiff muscles, confusion, sweating, fast or uneven heartbeats, rapid breathing; • restless muscle movements in your eyes, tongue, jaw, or neck; • drooling, trouble swallowing, problems with balance or walking; • unusual thoughts or behavior; • blurred vision or other eye problems; • skin rash, bruising, severe tingling, numbness, pain,

Nursing responsibility > Give the right medication to the right patient > Give the right dose > Give medication using the right route > Give medication with right frequency > Observe proper documentation > Assess for hypersensitivity to hydralazine, tartrazine; CAD valvular rheumatic heart disease > Assess for CVAs, increased intracranial pressure, lactation, pregnancy, pulmonary hypertension

operate potentially dangerous machinery. Do not participate in any activities that require full alertness if you are unsure about your ability. This drug can increase your sensitivity to light. Avoid being out in the sun too long. Thorazine can cause a group of symptoms called Neuroleptic Malignant Syndrome, which can be fatal. Some symptoms are extremely high body temperature, rigid muscles, mental changes, irregular pulse or blood pressure, rapid heartbeat, sweating, and changes in heart rhythm. If you are on Thorazine for prolonged therapy, you should see your doctor for regular evaluations, since side effects can get worse over time.

muscle weakness; • pale skin, easy bruising or bleeding; • urinating less than usual or not at all; • seizure (black-out or convulsions); • severe blistering, peeling, and red skin rash; or • slow heart rate, weak pulse, fainting, slow breathing (breathing may stop). • drowsiness; • feeling jittery or agitated; • sleep problems (insomnia); • breast swelling or discharge; • changes in menstrual periods; • dry mouth or stuffy nose • nausea, constipation; • darkened skin color;


It blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.

PROLIXIN is indicated in the management of manifestations of psychotic disorders.


The precise mechanism of action has not been clearly established.

HALDOL (haloperidol) is indicated for use in the treatment of schizophrenia.

Phenothiazines are contraindicated in patients with suspected or established subcortical brain damage, in patients receiving large doses of hypnotics, and in comatose or severely depressed states. The presence of blood dyscrasia or liver damage precludes the use of fluphenazine hydrochloride. PROLIXIN (fluphenazine hydrochloride) is contraindicated in patients who have shown hypersensitivity to fluphenazine; crosssensitivity to phenothiazine derivatives may occur. HALDOL (haloperidol) is contraindicated in severe toxic central nervous system depression or comatose states from any cause and in individuals who are hypersensitive to this drug or have Parkinson's disease. Navane is contraindicated in patients with circulatory collapse, comatose states, central nervous system

Drowsiness, lethargy, dizziness, nausea, loss of appetite, sweating, dry mouth, blurred vision, headache, or constipation may occur

Breast development in men, breathing problems, cataracts, constipation, drowsiness, dry mouth, insomnia, involuntary muscle contractions, skin reactions, tardive dyskinesia, tightening of the throat muscles, weight loss


Navane is an antipsychotic of the thioxanthene series. Navane possesses

Navane is effective in the management of schizophrenia. Navane has not been evaluated in the

certain chemical and pharmacological similarities to the piperazine phenothiazines and differences from the aliphatic group of phenothiazines.

management of behavioral complications in patients with mental retardation.


Trilafon acts with all levels of the central nervous system, particularly the hypothalamus. Its therapeutic mechanism of action is unknown.

For the management of schizophrenia.

depression due to any cause, and blood dyscrasias. Navane is contraindicated in individuals who have shown hypersensitivity to the drug. It is not known whether there is a cross sensitivity between the thioxanthenes and the phenothiazine derivatives, but this possibility should be considered. In comatose or greatly A few common side obtunded patients and in effects of Trilafon patients receiving large include doses of CNS depressants drowsiness, a loss (barbiturates, alcohol, of appetite, and analgesics or blurred vision. antihistamines); in the While side effects presence of blood of this medication dyscrasias, bone marrow are usually minor, depression or liver damage; certain side and in patients who have effects are more shown hypersensitivity to serious and the components of the should be injection or related reported to your compounds. healthcare It is also contraindicated in provider right patients with suspected or away. Some of established subcortical brain these more damage, with or without serious Trilafon hypothalamic damage. side effects include unusual body movements, an irregular heart

rhythm, and psychotic symptoms that are becoming worse.

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