ASTHMA Extrinsic (Allergy) Inhaled allergens: Pollen, dander, etc.

(Antigens) Sensitization of bronchial mucosa by tissue specific antibodies (Immunoglobulin of the IgE type 1 class) IgE mediators are affixed To the most cells of the tracheobronchial tree Reflex stimulation of parasympathetic nervous system receptors in bronchial mucosa Most cell stabilizers Chemical mediators -Histamines (Antihistamines) -Leukotrines (Leukotrine modifiers) -Prostaglandins -Bradykinin (Antiinflammatory) Increase vascular permeability Smooth muscle relaxation causing leakage of proteins and fluid into tissue produce early and late-phase bronchoconstriction Increase stimulus level of the irritant receptors in the trancheobronchial tree Hyperactivity nonspecific stimuli triggers activation of most cells Reflex stimulation of tracheobronchial receptors Vagal stimulation of bronchial smooth muscle contraction (Bronchial wall response) (Methylxanthine derivatives) (B-adrenergic) (Anticholinergic) Increase mucous secretion -Mucolytics -Expectorants -Eosinophilia -Non productive cough (steroids) Stimulate the beta receptors within smooth muscle of the tracheobronchial tree Opening airway passages to greater volumes of air Regulate fat and carbohydrate metabolism Intrinsic (Idiosyncrotic) Viral infection, physical exertion, aspirin, smoke fumes, psychologic stress

Tissue changes Increase in serum

Vasodilators with mucosal edema

Smooth muscle contraction Prolonged expiration




Submitted by: BSN3O1 Argente, Maria Angelica Bercasio, Kristine Castañeda, Ma. Angelica Estepa, Ana Marie Labrada, Maydean Libao, Riola Mendoza, Angeli Mendoza, Ma. Allyza Tuazon, Rachel Ann Barangan, Victor Emmanuel Barreda, Michael Seña, Christopher Jello Submitted to: Dr. Jahnen I. Calugan-Tanamal, R.N., M.D. (NCM-102 Lecturer)

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