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UNIVERSITAS SANATA DHARMA

Fakultas
Program Studi

: Farmasi
: Farmasi

RENCANA PEMBELAJARAN SEMESTER (RPS)


A. Identitas Mata Kuliah

Kode/Mata Kuliah
Sks/JP/Sifat Mata Kuliah
Prasyarat
Semester
Tahun Akademik
Dosen
B.
Deskripsi Mata Kuliah

: SMF 517 /Farmakokimia (Medicinal Chemistry)


: 4 sks/4 jp/Wajib
: Farmakologi Toksikologi (SMF 310)
: V (lima)
: 2014/2015
: Enade Perdana Istyastono, Ph.D., Apt. dan Agustina Setiawati, M.Sc., Apt.

Understanding the important interactions of drugs and their targets, i.e., DNA, RNA and proteins. The course discusses the physicochemical properties
of drugs and how this determines the interactions of small molecules (drugs) with biological macromolecules (proteins and nucleic acids) as the
targets. The course covers also the fundamental mechanisms of the regulation of targets, as well as fundamental molecular interactions important for
both detection and diagnostic applications for drugs and metabolites. The following are the selected contextual topics in medicinal chemistry to be
discussed in this course as examples: (i) Cholinergics, anticholinergics, and anticholinesterases; (ii) The adrenergic nervous system; (iii) The opium
analgesic; (iv) Antiulcer agents; (v) Antibacterial agents; (vi) Antiviral agents; and (vii) Anticancer agents.

C.

Capaian Akhir Pembelajaran


Able to identify and explain the important interactions of drugs and their targets. Therefore, he/she is able to rationally design novel drugs for particular
targets.

D. Uraian Rencana Pembelajaran

Bobot
Nilai
(%)
(6)
10

Lecture, small group Accuracy


discussion

30

Cholinergics,
anticholinergics, and
anticholinesterases | The
adrenergic nervous system.

Lecture, discussion, Accuracy


contextual learning

The opium analgesic | Anti


ulcer agents.

Lecture, discussion, Accuracy


contextual learning

Bentuk
Pembelajaran

Pertemuan Ke-

Kemampuan Akhir yang Diharapkan

Materi Pembelajaran

(1)
1

(2)
Able to define and classify drugs, distinguish
between drugs and medicines, explain basic
concept of drug targets and how drugs bind to
them.

(3)
(4)
Classification of Drugs | Discovery learning,
Drugs and the Medicinal small group
Chemist | The why and the discoussion
wherefore: Drug targets

2-5

Able to explain the role, the structure and the


mechanism of proteins as receptors (including
enzymes/catalytic reseptors).

Protein as drug targets |


Enzymes | Reseptors |
Receptor structure and
signal tranduction

Able to explain the medicinal chemistry aspects of


cholinergics, anticholinergics, and
anticholinesterases, and the medicinal chemistry
aspects of the adrenergic nervous system

Able to explain the medicinal chemistry aspects of


the opium analgesic, and the medicinal chemistry
aspects of antiulcer agents

MASA UJIAN TENGAH SEMESTER

Kriteria
(Indikator)
Penilaian
(5)
Accuracy

Referensi
(7)

Pertemuan Ke8-11

Kemampuan Akhir yang Diharapkan

Materi Pembelajaran
as

drug

Bobot
Nilai
(%)
20

Lecture, small group Accuracy


discussion

10

Referensi

Able to explain the role, the structure and the


nucleic acids as drug targets.

Nucleic
targets

Able to employ the understanding of


pharmacokinetics related topics in understanding
medicinal chemistry.

Pharmacokinetics
related topics

12

Able to explain the medicinal chemistry aspects


antibacterial agents

Antibacterial agents

Lecture, discussion, Accuracy


contextual learning

13

Able to explain the medicinal chemistry aspects of


antiviral agents

Antiviral agents

Lecture, discussion, Accuracy


contextual learning

Able to explain the medicinal chemistry aspects of


anticancer agents

Anticancer agents

Lecture, discussion, Accuracy


contextual learning

10

14

acids

Kriteria
(Indikator)
Penilaian
Lecture, small group Accuracy
discussion
Bentuk
Pembelajaran

and

MASA UJIAN AKHIR SEMESTER

E. Penilaian/evaluasi

Pada bagian ini diuraikan alat penilaian/evaluasi untuk mengukur ketercapaian standar pembelajar

No

Jenis Evaluasi (UTS, UAS, kuis, tugas, praktikum, dll)

Bentuk (tertulis, lisan,


perbuatan, dll)

Bobot (%)

1.

Individual Project: Create index cards to study amino acids properties

Action

2.

Group Projects: Create and play board games to study drug-protein interactions

Action

15

3.

UTS I - 1st Mid test: Course materials on weeks 1-7

Written

30

4.

UTS II - 2nd Mid test: Summary on medicinal chemistry aspects of a particular drug in the market
(Individual Project/Take Home Exam)

Written

10

5.

UAS - Final Exam: All course materials

Written

40

Total

F. Referensi

1. Patrick, G.L., 2005, An Introduction to Medicinal Chemistry, 3rd edition, Oxford University Press.

100%

UNIVERSITAS SANATA DHARMA

Fakultas
Program Studi

:
:

Farmasi
Farmasi

RANCANGAN TUGAS PERKULIAHAN

A. Identitas Mata Kuliah

Kode/Mata Kuliah
Sks/JP/Sifat Mata Kuliah
Prasyarat
Semester
Tahun Akademik
Dosen

: SMF 517 /Farmakokimia (Medicinal Chemistry)


: 4 sks/4 jp/Wajib
: Farmakologi Toksikologi (SMF 310)
: V (lima)
: 2014/2015
: Enade Perdana Istyastono, Ph.D., Apt. dan Agustina Setiawati, M.Sc., Apt.

B. Rancangan Tugas

Project 1: Individual Project: Create index cards to study amino acids properties
Tujuan Tugas
Uraian Tugas
a Objek Garapan
b

Hal yang harus dikerjakan


dan batasan-batasannya:

Able to identify and explain the nomenclature of amino acids and their properties
Summary of amino acids nomenclature and their properties. It can be accessed in http://molmod.org/enade/medchem_1st_2013-2014/
(password: farmasiusd)
The index cards should be shown in the 2nd lecture (week 2). The studentss knowledge about amino acids nomenclature and their
properties will also be tested in the 2nd lecture (week 2).

Metode atau Cara Pengerjaan


Tugas:

1)
2)
3)
4)

Download the raw materials from http://molmod.org/enade/medchem_1st_2013-2014/ (password: farmasiusd)


Create index cards
Learn from the index cards
Show/submit the index cards to be graded

Deskripsi Luaran Tugas yang


Dihasilkan:
Kriteria Penilaian

Able to identify and explain the nomenclature of amino acids and their properties by learning from the index cards.

Hal yang harus dikerjakan


dan batasan-batasannya:

Group of 6-8 students create and play a board game to study drug-protein interactions. The game should be shown and played in front
of lecturer in the 5nd lecture (week 5). The studentss knowledge about drug-protein interactions will also be tested in the 5nd lecture
(week 5).

Metode atau Cara Pengerjaan


Tugas:

1) Create a board game


2) Learn from the board game
3) Show/play the board game to be graded
Able to identify and explain the interactions between ligands and proteins based on their properties by playing the board game.

1) Discipline (on time submission).


2) Accuracy
Project 2: Group Projects: Create and play board games to study drug-protein interactions
Able to identify and explain the interactions between ligands and proteins based on their properties
Tujuan Tugas
Uraian Tugas
Index cards from the 1st project and strutures of some popular drugs.
a Objek Garapan

Deskripsi Luaran Tugas yang


Dihasilkan:
Kriteria Penilaian

1) Discipline (on time submission).


2) Accuracy
UTS II - 2nd Mid test: Summary on medicinal chemistry aspects of a particular drug in the market (Individual Project/Take Home Exam)
Tujuan
Uraian
a Objek Garapan

Evaluate the understanding medicinal chemistry aspects on a particular marketed drug.

1)
2)
3)
4)
5)

Hal yang harus dikerjakan


dan batasan-batasannya:

A particular marketed drug. The list of drugs will be announced in the lecture 3rd (week 3).
Download the example and the template from http://molmod.org/enade/medchem_1st_2013-2014/ (password: farmasiusd)
Write the summary on (an) A4 paper(s) (maximum 2 pages) on the selected drug following the template.
Submit the printed version of the summary to the class chairperson.
The chairperson submit all papers sequenced by the students number to the lecturer (via lecturers locker)
Deadline of the submission to the lectuter is November 10th, 2014 12.30 WIB

Metode atau Cara


Pengerjaan:

Deskripsi Luaran yang


Dihasilkan:
Kriteria Penilaian

1)
2)
3)

Download the example and the template from http://molmod.org/enade/medchem_1st_2013-2014/ (password: farmasiusd)
Write the summary on (an) A4 paper(s) (maximum 2 pages) on the selected drug following the template.
Submit the printed version of the summary to the class chairperson.

Summary on maximum 2 A4 papers


1) Discipline (on time submission).
2) Accuracy

UNIVERSITAS SANATA DHARMA

Fakultas
Program Studi

:
:

Farmasi
Farmasi

RUBRIK PENILAIAN
=========================================================================================================================
A. Identitas Mata Kuliah

Kode/Mata Kuliah
Sks/JP/Sifat Mata Kuliah
Prasyarat
Semester
Tahun Akademik
Dosen

: SMF 517 /Farmakokimia (Medicinal Chemistry)


: 4 sks/4 jp/Wajib
: Farmakologi Toksikologi (SMF 310)
: V (lima)
: 2014/2015
: Enade Perdana Istyastono, Ph.D., Apt. dan Agustina Setiawati, M.Sc., Apt.

B. Rubrik Penilaian

Komponen
Penilaian

Discipline (on time


submission) and
Accuracy

Sangat Baik

Baik

Batas

Dibawah Standar

Project 1: Individual Project: Create index cards to study amino acids properties (5%)
Correct Index Cards.
Correct Index Cards.
Correct Index Cards.
Incorrect index
Correctly identify some
Incorrectly identify some cards/Could not show the
(70-85)
examples.
examples.
index cards on time.
( 85)
(56-69)
( < 56)

Skor

Komponen
Penilaian

Sangat Baik

Baik

Batas

Dibawah Standar

Skor

Project 2: Group Projects: Create and play board games to study drug-protein interactions (15%)
Acceptable/understandable
Acceptable/understandable
Acceptable/understandable Could not show the board
board game.
board game.
board game..
game on time.
Correctly explain some
Incorrectly identify some
(70-85)
( < 56)
examples.
examples.
( 85)
(56-69)
UTS II - 2nd Mid test: Summary on medicinal chemistry aspects of a particular drug in the market (Individual Project/Take Home Exam) (10%)
Discipline (on time Correct format, complete aspects
Correct format, complete
Acceptable format,
Unacceptable format or
submission) and
covered in the paper.
aspects covered in the paper
complete aspects covered could not submit on time.
Accuracy
( 85)
with minor mistakes.
in the paper with major
( < 56)
mistakes.
(70-85)
(56-69)
Discipline (on time
submission) and
Accuracy

Nilai Total (%)

85,00

Nilai Huruf

Konversi Nilai Total


70,00 - 84,99
56,00 - 69,99
B

20,00 - 55,99

< 20,00