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DISSEMINATED INTRAVASCULAR COAGULOPATHY

Predisposing Factor Precipitating Factors


- Infections
- None- - Obstetric
Complications
- Trauma or Surgery
- Vascular Disorder
- Shock

Stimulus

Tissue Destruction Endothelial Injury

Tissue Factor Endotoxin


Extrinsic Pathway

Thrombin Generation Factor XII Activation


(Intrinsic Pathway)

Intravascular Fibrin Plasminogen


Deposition
Platelet Consumption
Plasmin Generation

Decreased Amount
of Platelet

Thrombosis Fibrinolysis Clotting Factor


Degradation

Hemolyti Tissue Fibrin Degradation


c Anemia Ischemia (Inhibit Thrombin and BLEEDING
Platelet Aggregation)

If Treated: If Not Treated:


- Anti-coagulants
- Blood Components
- Antifibrinolytics
POOR PROGNOSIS

GOOD PROGNOSIS
Hypovolemic Shock

Coma

DEATH