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ANNA UNIVERSITY

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CHENNAI 600025
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BONAFIDE CERTIFICATE
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Certified that this project titled DEVELOPMENT OF ELETROSPUN


MATRIX FOR MEDICAL APPLICATION is a bonafide work of TARUN K
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(2009411009) who carried out the project work under my supervision. Certified

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further that to the best of my knowledge the work reported herein does not form
part of any other project work/thesis or dissertation on the basis of which a degree
or award was conferred on an earlier occasion on this or any other candidate.

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Dr. SELVAKUMAR N

Dr. GOBI N

PROFESSOR AND HEAD

SUPERVISOR

Department of Textile Technology

Assistant Professor

Anna University

Department of Textile Technology

Chennai 600025

Anna University
Chennai 600025
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ABSTRACT
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Ultrafine electrospun fibres have a great potential for the manufacture


of long fibre composite materials. Application is limited by difficulties in making
sufficient quantities of fibre to make substantial large scale articles in a reasonable
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time scale. For this reason, medical application which requires small amount of
fibres is chosen. Electrospinning was investigated as a source of cost-effective,
easy to manufacture wound dressings, medical implants, and scaffolds for the
production of artificial human tissues.
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Until now, many common natural and biodegradable biopolymers, such


as cellulose, collagen, gelatin, hyaluronic acid, chitin, and chitosan, have been
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successfully electrospun into nanofibers. To our knowledge, pure alginate has not
yet been successfully electrospun into nanofibers due to their high molecular
weight. Hence, an attempt was made to blend calcium alginate and polyvinyl
alcohol by electrospinning. The experimental trial was carried out by preparing
calcium alginate and poly vinyl alcohol separately at different concentration and it
was blended with ratios which had maximum miscibility.
Scanning electron microscopy and Fourier transform infrared
spectroscopy was used to characterize the produced web. The physical and
functional properties such as water vapour permeability, anti microbial activity
etc., were studied which helped to assess the wound healing property.

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ACKNOWLEDGEMENT

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3 Dr. Gobi N, Assistant Professor,
I express my sincere thanks

Department of Textile Technology, Anna University, Chennai for his valuable


guidance, constant encouragement and timely suggestions rendered for the
successful completion of the second phase of the project.
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I wish to thank Dr. Selvakumar N, Professor and Head, Department


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of Textile Technology, Anna University, Chennai for his support during the

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period of project.
I wish to thank Dr. Giri Dev V R, Assistant Professor, Department of
Textile Technology, Anna University, Chennai for his initiation in the project.
Grateful acknowledgements are made to all the staff members in the
department and I would particularly express my gratitude to all the faculty
members and technicians of the Department of Textile Technology.

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TARUN K

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TABLE OF CONTENTS
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CHAPTER NO.

TITLE

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1
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Title case

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CHAPTER NO.

ABSTRACT
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ACKNOWLEDGEMENT
LIST OF TABLES
LIST OF FIGURES
LIST OF ABBREVIATIONS
INTRODUCTION
LITERATURE REVIEW
2.1 INTRODUCTION
2.2 WOUND
2.3 TYPES OF WOUNDS
2.3.1 Open Wounds
2.3.2 Avulsions
2.3.3 Contusions
2.3.4 Crush Wounds
2.3.5 Cuts
2.3.6 Fish Hook
Wounds
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2.3.7 Incised Wound
2.3.8 Lacerations
2.3.9 Open Wound
2.3.10 Penetrating Wound

TITLE

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2.4.1 Normal Wound- healing


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Phases

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2.4.1.1 Hameostasis and

inflammation
2.4.1.2 Growth of cells on

the wound bed


2.4.1.3 Proliferation
2.4.1.4 Maturation phase of

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the wound
2.5 DRESSINGS
2.5.1 Traditional Dressings

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Covered with Primary


Dressings
2.5.4 Alginate Dressings on the

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Wound Bed
2.5.5 Hydrogel Dressings
2.5.6 Semi-permeable Adhesive

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Film
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2.5.7 Foam Dressings

CHAPTER NO.

3.5 TESTING METHODS


3.5.1 Water Vapour Permeability
3.5.2 Tensile Tests
3.5.3 Antimicrobial Test

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TITLE

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APPENDIX / APPENDIX I
APPENDIX II
APPENDIX II
REFERENCES
LIST OF PUBLICATIONS

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LIST OF TABLES
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TABLE NO.

TITLE

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2.1

Wounds used in study of calcium alginate

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FIGURE NO.
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2.1
2.2
2.3

LIST OF FIGURES
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TITLE

Structure of alginate
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Structure of polyvinyl alcohol
Schematic diagram to show polymer nano

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fibers by electrospinning

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LIST OF SYMBOLS AND ABBREVIATIONS


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AATCC

2 tabs

1 tab

American Association of Textile Chemists and


Colorists

ASTM

American Standard for Testing and Materials

CA

Calcium Alginate

CMC

Carboxy Methyl Cellulose

DC

Direct Current

DW

Distilled Water

eV

Electron Volt

FHC

Fluid Handling Capacity

FTIR

Fourier Transform Infrared Spectroscopy

Tab width = 0.5 (12.7 mm)