Pathophysiology

Brain

DEFICIENCIES IN NEUROTRANSMITTER htrauma

Acetylcholine

somatostatin

Nor epinephrine

Repeated head trauma

Genetic

Degeneration of brain cells

amyloid plaques(neurotic/senil e plaques

neurofibrillatory tangles

ganuvacuolar degeneration

Linked to areas of cerebral cortex assoc. with cognition

Temporal & parietal cortices

Degeneration of neurons in hippocampus

Interferes w/ nutrient exchange & disrupts blood: brain barrier

Memory, learning, fear aggression & thinking

Vacuoles enlarge the cell body

Marked reduction in acetyltransferase

Abnormally phosphorylated NFT’s

Neuron malfunction or DEATH

Decreased Ach

Instability of all structures

Disturbance of the normal functioning of the brain