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7782 Federal Register / Vol. 71, No.

30 / Tuesday, February 14, 2006 / Notices

compounds is a billion dollar industry. WO 2003/008627, PCT filed July 19, Agenda: To review and evaluate personal
The diversity of compounds that elicit 2002 and global IP, and HHS Ref. No qualifications and performance, and
bitter-taste sensations is very large and 099–2005/0: Human Sweet and Umami competence of individual investigators.
Place: National Institutes of Health,
more than two dozen members of the Taste Receptor Genes, U.S. Provisional National Cancer Institute, 9000 Rockville
T2R bitter taste receptor family have Patent Application No. 60/671,173 filed Pike, Building 31, Conference Room 6,
been identified. Individuals are now April 2005]. Bethesda, MD 20892.
known to be genetically predisposed to In addition to licensing, the Contact Person: Florence E. Farber, PhD,
respond or not to respond to the bitter technology is available for further Executive Secretary, Office of the Director,
taste of a number of substances. For development through collaborative National Cancer Institute, National Institutes
example, large individual differences in research opportunities with the of Health, 6116 Executive Boulevard, Room
the perception of bitterness have been inventors. 2115, Bethesda, MD 20892. 301–496–7628.
ff6p@nih.gov.
well documented in compounds as Dated: February 2, 2006. Any interested person may file written
different as nicotine, thiocyanates such Steven M. Ferguson, comments with the committee by forwarding
as those found in cruciferous vegetables, the statement to the Contact Person listed on
Director, Division of Technology Development
and many bitter beta-glucopyranosides. and Transfer, Office of Technology Transfer, this notice. The statement should include the
This may have broad implications for National Institutes of Health. name, address, telephone number and when
nutritional status and tobacco use and applicable, the business or professional
[FR Doc. E6–2015 Filed 2–13–06; 8:45 am] affiliation of the interested person.
common allelic variants of a member of
the T2R bitter taste receptor gene family BILLING CODE 4140–01–P In the interest of security, NIH has
instituted stringent procedures for entrance
have been shown to underlie variation into the building by non-government
in the ability to taste DEPARTMENT OF HEALTH AND employees. Persons without a government
phenylthiocarbamide (PTC) [Science HUMAN SERVICES I.D. will need to show a photo I.D. and sign-
(2003) 299, 1221–1225; HHS Ref No: E– in at the security desk upon entering the
169–2001/0]. National Institutes of Health building.
Scientists at the NIDCD have (Catalogue of Federal Domestic
extended these results to other bitter National Cancer Institute; Notice of Assistance Program Nos. 93.392, Cancer
taste receptors and have sequenced 22 Meeting Construction; 93.393, Cancer Cause and
of the 24 known T2R genes in a series Prevention Research; 93.394, Cancer
of populations worldwide, including Pursuant to section 10(d) of the
Federal Advisory Committee Act, as Detection and Diagnosis Research;
Northern Europeans, Hungarians, 93.395, Cancer Treatment Research;
Japanese, Cameroonians, Pygmies and amended (5 U.S.C. Appendix 2), notice
is hereby give of a meeting of the Board 93.396, Cancer Biology Research;
South American Indians and the present 93.397, Cancer Centers Support; 93.398,
invention includes these isolated of Scientific Counselors for Basic
Sciences National Cancer Institute. Cancer Research Manpower; 93.399,
sequences and their variants. This Cancer Control, National Institutes of
includes a total of 127 SNPs and 103 The meeting will be open to the
public as indicated below, with Health, HHS)
different protein coding haplotypes,
including those defined for the PTC attendance limited to space available. Dated: February 1, 2006.
Receptor (T2R38) [E–169–2001/0]. The Individuals who plan to attend and Anna Snouffer,
inventors showed that 77% of the SNPs need special assistance, such as sign Acting Director, Office of Federal Advisory
identified caused an amino acid language interpretation or other Committee Policy.
substitution in the encoded receptor reasonable accommodations, should [FR Doc. 06–1323 Filed 2–13–06; 8:45 am]
protein, giving rise to a very high degree notify the Contact Person listed below BILLING CODE 4140–01–M
of receptor protein variation in the in advance of the meeting. The meeting
population (Kim et al. (2005) Human will be closed to the public as indicated
Mutation 26, 199–204). The frequencies below in accordance with the provisions DEPARTMENT OF HEALTH AND
of these different haplotypes have been set forth in section 552b(c)(6), Title 5 HUMAN SERVICES
shown to differ in different populations U.S.C., as amended for the review,
which will aid in population-specific discussion, and evaluation of individual National Institutes of Health
studies, such as those targeting intramural programs and projects
conducted by the National Cancer National Cancer Institute; Notice of
differences in taste perception between Meeting
Europeans and Asians, for example. Institute, including consideration of
The invention available for licensing personnel qualifications and Pursuant to section 10(d) of the
includes these novel SNPs and performance, and the competence of Federal Advisory Committee Act, as
haplotypes and methods of use, which individual investigators, the disclosure amended (5 U.S.C. Appendix 2), notice
can be used to better identify and of which would constitute a clearly is hereby given of a meeting of the
characterize different groups of unwarranted invasion of personal Board of Scientific Counselors for
individuals within and between privacy. Clinical Sciences and Epidemiology
populations that vary in their bitter taste Name of Committee: Board of Scientific National Cancer Institute.
abilities. This is important to the food Counselors for Basic Sciences National The meeting will be open to the
and flavoring industry, for example, Cancer Institute. public as indicated below, with
where these variants can be used to aid Date: March 13, 2006. attendance limited to space available.
in the development of a variety of taste Open: 8 a.m. to 10:30 a.m. Individuals who plan to attend and
improvements in foods and orally Agenda: Joint Session of NCI, Board of need special assistance, such as sign
administered medications. [Also Scientific Advisors and Boards of Scientific
language interpretation or other
rmajette on PROD1PC67 with NOTICES

Counselors.
available for licensing in the Human Place: National Institutes of Health, reasonable accommodations, should
Taste Receptor Haplotype patent National Cancer Institute, 9000 Rockville notify the Contact Person listed below
portfolio is HHS Ref No. E–169–2001/0- Pike, Building 31, Conference Room 10, in advance of the meeting.
PCT–02: Phenylthiocarbamide Taste Bethesda, MD 20892. The meeting will be closed to the
Receptor, International Publication No. Closed: 11 a.m. to 7:30 p.m. public as indicated below in accordance

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