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PathoInflammationQuizChronicInflammation

Prolongedduration
Howlongdoeschronicinflammationlast
3thingsassociatedwithchronicinflammation
ChronicInflammationsignificanttissue____,altered
____,andchangesto____
____abnormaltissueinfiltrationbycellsofimmune
systemsuchasmacrophagesandneutrophils
Continuousreleaseandactivitiesofgrowthfactors
andcytokinesfromdamagedtissuesandimmune
systemcells
Collagendepositsthatmakeupscartissuesand
fibrosis
Hypertrophy/plasiaareexamplesofwhatpartof
tissueremodeling
Chronicinflammationfollowsanepisodeofwhat
Chronicinflammationcanbegin____
TorF.Chronicinflammationbeginswith
manifestationofacutereactions.
Growthsignalforkeratinocytesandfibroblasts,
woundhealing
Signalforhepatocytesandepithelialcellreplication
Signalforonlyangiogenisisandwoundhealing

weeksormonths
prolongedduration
inflammation,tissueinjury,attemptsatrepair
remodeling,physiology,homeostasis
persistent
Tissueremodeling

fibroblasts
celladaptations
prolongedacuteinflammation
insidiously
Canbewithout,soF
EpidermalGrowthFactorAlpha(EGFa)
Transforminggrowthfactoraandb(TGFaandTGFb)
VEGF

Signalforchemotaxisforimmunesystemcells

Plateletderivedgrowthfactor(PDGF)

Signalforactivatingcellreplicationprocesses

Plateletderivedgrowthfactor

Signalforregulationofimmunefunctionsand
inflammation

TNF

Immunesystemmediators
MediatorsforWoundHealing
Mediatorsforangiogenesis
Scarringaka
4outcomesofchronicinflammation

outcomeofchronicinflammationthatcanleadto
emergenceofotherdisorders/diseases
Nearlyallchronicdiseasehassome
components/contributionsfromwhat
Proliferationoforiginalcellsandtissuestoreplace
lostones
Tissueregenerationoccurswhere
exof2selectedtissueswheretissueregeneration
occurs
Tissueregenerationdependentofavailabilityofwhat

Interleukins
EGFa,TGFa/b,VEGF,PDGF,TNF
VEGFandPDGF
fibrosis
Excessiveinflammation,Resolutionofinjury/cure,
Scarring/fibrosis,insufficient/defectiveremovalof
injuriousagents
excessiveinflammation
chronicinflammation
tissueregeneration
onlyinveryselectedtissues
bonemarrow,liver
adulttissuestemcells

Tissue____restoresfullfunctionoforiginaltissues

regeneration

Tissue____isideal,butrarelyoccurs

regeneration

Whatoccurswhentissueregenerationisnotpossible
Tissueregenerationcanoccurintheextracellular
matrix.TorF?
Wherecantissuerepairoccur?
Intissuerepair,whatisnecrotictissuereplacedwith?

repair
F
everywhereinbody
collagenthatresultsinscartissueformation

Tissue____doesNOTrestorefullfunctionoforiginal
tissues
Injuriousdamageremovedearly/promptly
persistenttissuedamage
Tissue____isnotideal,butcommonlyoccurs

repair
scarformation
fibrosis
repair

Atough,densemassofcollagen

Scartissue

Bridgeorcoveracrossdamagedarea

scartissue

Scartissueavascularorvascular
Scarringresultsinlossofwhat

avascular
normalphysiologicfunction

ECMremodelingalways____thetissuestructure
andnever____it

modifies,improves

Dotissueregenerationandtissuerepairinfluence
eachother?

theycan

Anattemptbytheimmunesystemtoisolateforeign
invadersbywallingorsealingthemoff
Purulentcollectionoffluid/pus
Granulomatousinflammationhaveinvolvementof
what
Whataremacrophagestransformedintoin
granulomatousinflammation
Whendogranulomatousinflammationsinclude
fibroblastsandconnectivetissue
Whatcellsinvolvedingranulomatousinflammation
(notoldones)
Restrictivelungdiseasecausedbyoccupational
exposure

abscessandgranuloma
abscess
Macrophages
epitheliumlikecells
oldergranuloma
macrophages,lymphocytes,plasmacells
Pneumoconiosis

Pneumoconiosisinvolveswhattypeofexposureto
offendingagent

chronic

Pneumoconiosisinvolveswhatkindofinflammation

chronic

Pneumoconiosiscauseswhattohappentolungs
Lossoflungtissueelasticityresultsinwhat
3examplesofaccumulations
Fattyliverisabnormalretentionofwhatwithinliver
cell
Isfattyliverreversible?
Wilson'sdiseaseisaccumulationofwhatwhere
Alzheimer'sdiseaseisaccumulationofwhatwhere
Inflammationoccursonwhichday

lossoflungtissueelasticity
chronicimpairmentofbreathing/oxygenchange
Fattyliver,Wilson'sdisease,Alzheimer's
lipids
yes
copperinliver
betaamyloidproteinsandpossiblyaluminuminbrain
0

Proliferationoccursonwhatday

34

Granulomatoustissuesoccuronwhichday

34

3stepsofwoundhealinginorder
4systemicfactorsthatcanhinderhealing
Exofnutritionalhinderance

inflammation,proliferation,remodeling
nutrition,metabolicstatus,impairedcirculatorystatus,
hormones/drugs
VitaminCorproteindeficiency

Exofmetabolicstatushinderance

Diabetes

Exofimpairedcirculatorystatushinderance

ischemia

3exofhormones/drugs
Glucocorticoidfrom
Exofsteroid
4localfactorsthatcanhinderhealing

glucocorticoid,steroids,sirolimus
adrenalhormone
prednisoneandsirolimus
infection,mechanicalfactors,presenceofforeign
bodies,size/type/locationofwounds

Worseoutcomesinsmallorlargewound
Moreorlessvascularizedleadtoworseoutcomes
andwhy
localizedexcavationattributedtoinflammation
generallydevelopafterthermal/traumaticinjurythat
involvesdeeplayersofdermis
Scartissuethatgrowsbeyondboundariesoforiginal
woundanddoesn'tregress
Keloidmorecommoninwhichrace
Woundhealinginexcesscancausewhattohappen
tomusclesandtendons

large
less,lessbloodsupply
ulcer
hypertrophicscars
keloid
AfricanAmerican
contraction