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International Congress

of Scientific Iridology




Monday 21 September 2015 - IFSH - 65 Rue dAmiral Mouchez - 75013 Paris

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Overview of Modern Iridology Findings

PNEI & Modern Iridology
John Andrews (UK)
The scientic integration of mind/body medicine for the hormonal, immune, limbic &
nervous systems with how the patient has acquired or inherited stress-related mechanisms,
basically; how stress & emotions impact these systems and vice versa

The Future
of Iridology...

Modern Iridology & PNEI

Each iris is perfect for that individual - it
shows how the individual can retain or nd
Remember that Iridology should be not be a
judgement on the patient (Px)
It should be a positive & empowering
experience (PNEI pathways inuence).
Remember the impact words can have on
a person & PNEI pathways in both negative
& positive terms - the emotional connects
with the physical
Many signs are genetic in the iris, so may not
relate to the individual - iris shows inherent
talents & abilities for the Px - many signs
relate to our grandparents (recent genetic

Modern Iridology
Modern Iridology helps us to direct the
right clinical questions for the patient
& practitioner
When we are faced with thousands of
iris and associated signs in other tissues
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Modern Iridology helps the iridologist to

prioritize the many signs, so we have a both
a genetic & individual priority
Look for co-signs or an amalgamation of
evidence in the iris - utilize the different
systems. This work on both the physical &
emotional/psychological levels
Modern Iridology uses the Collarette
Structure & Diameter to determine the
dominant iris to help with prioritizing

PNEI Approaches - Mind Body Medicine

PNEI is an abbreviation for Psycho-neuro-endocrino-immunology. PNEI is a scientic approach
that recognizes the interaction and interdependence for homeostasis of the organism
depends on the correct biological communication between and within the immune, hormonal,
neurological, limbic an other systems of the body
It is the scientic validation of mind-body medicine and demonstrates that the emotional or
psychological states inuence the physical and vice versa

The Microbiota-gut Interplay Serves many Functions

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Psycho-neuro-endocrino- immunology - PNEI

Developing science
Clinical & experimental psychoneuroimmunology studies to date conrm the long-standing
belief that the immune system does not function completely autonomouslyfrom Basic Clinical
Immunology, 7th Edition, USA, 1991 by Stiles
The immune & endocrine systems can be referred to as a brain or brains in a uid state
Scientic validation of the mind-body approach
Recognizes the diverse & profound inuence stress has on the individual
Recognizes the emotional epigenetic impact & inheritance from previous generations (exactly
what we see with modern Iridology
Shows the central importance to all function of the limbic system (emotional centres of the
brain) & the PNEI via the hypothalamus

PAX6 gene can be inuenced by emotions & stress

Symptoms are the tip of
the iceberg - the end result
of various pathways or
triggers. The iris shows
the foundation - the body
of the iceberg hidden
under the surface - which
contributes to the formation
of the tip.
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Modern Iridology Summary

Based on new research & ndings in relation
to the iris, inner pupillary border, the cells,
genetics & the human body
New systems of analysis involving:
New interpretation of many established iris
signs due to advances in ocular embryology,
development of iris signs, human physiology,
genetics & technological developments over
the last 10-15 years
The identication of new signs, iris topographies
(maps/charts) & new iris with inner pupillary
border combinations combinations
Indentication of the Maternal/Paternal DNA
Flexible systems with an emphasis on the
collarette, Pupillary Zone & Inner Pupillary
The future of iridology... now
It is an extension & enhancement of classical
approaches - Modern Iridology does not replace
classical approaches, but is an signicant
& profound addition

For example in my own practice I use 1% to 5%

of the material from classical approaches, on
average 2 %, such is the wealth of resources
in modern iridology
Modern Iridology is expanding because
iridology is compelled to develop & progress
Modern Iridology provides exible systems of
analysis. These are interchangeable, depending
on what is required at the time which validate
& enhance each other
With Modern Iridology & PNEI the Limbic
system (the emotional regions of the brain) with
the Amygdala, Hippocampus & Hypothalamus
are fundamental in this approach and how they
impact the gastrointestinal system, nutritional
& metabolics, endocrine balance, immune
function, cellular potential & neurotransmitters.
Modern Iridology can be related to all of these

It is robust & valid

It is a combination of science & intuition
Modern Iridology provides many other
possibilities and can improve the condence
& professional competence for the Iridologist
If we face any limitations or a silent iris - you
can look towards Modern Iridology
Modern Iridology enables the practitioner to
prioritize the thousands of potential signs &
combination of signs in the iris & IPB

Non-invasive & inexpensive

The foundation of Modern Iridology is the
understanding & extrapolation of the psychoneuro-endocrino-immunology pathways or
PNEI Network pathways in combination with
iris & IPB markers
The beauty of Modern Iridology is that it can
be applied to all forms of clinical & therapeutic

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Modern Iridology utilising new technologies has identied

many new PNEI & related Signs/Co-Signs Examples
New Dysglycemia (Blood sugar tendency) Systems with 1830 Px
462 Chronic Fatigue Syndrome Px
368 Citric acid cycle imbalance Px (Cellular Topography)
New autoimmune proles with 1214 autoimmune Px
701Progesterone Ratio Px
162 Hyperprolactinemia (HPRL - elevated prolactin)
107 Px with reduced zinc (shadow ring (iris) & Tubes (IPB)

Modern Iridology Developments

New research & clarication with the Pure
Brown Iris - vast expansion of knowledge.
With the pure brown iris the importance of the
pupillary zone, collarette & IPB are amplied.
Previous iridology texts have small % brown
iris, yet 80% of global population have pure
brown irises
Neurotransmitters, Immune Cells & hormonal
interaction tendencies identication via the
IPB & iris
The potential of the Cell for the Px
Nutritional markers including with tyrosine,
zinc, selenium, manganese, chromium,
magnesium & others
The profound signicance of the pupillary
zone hypothalamus sign

Pure Brown Iris - Achromia = Dysglycemia & <

Chromium Tendency + Hypertrophy IPB = ImmunoMetabolic Network Pro-Inammatory cascades

Modern Iridology ndings - Rectangular melanin pigment equates

to a spleen PNEI Network Tendency. Px requires further spleen
support - with both Physical & emotional Levels. 62/83 Px had
spleen dysfunction or genetic spleen-related conditions. Topolabile
- Signicant for what it is - independent of location
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Iris melanocytes

Modern Iridology
New Topographies developed Andrews 1993 - 2015
Modern Iridology Chart
Immune Cell Collarette Chart
Cellular Iridology
(Citric Acid Cycle Iris Chart)
Emotional Dynamics of the Collarette
Pupillary Zone Topography

Immune System Pupillary Zone Chart

Endocrine System Pupillary Zone Chart
Emotional Anatomy Chart
Individual Chronobiology Iris Chart
PNEI Collarette Chart, Neurotransmitter
& New IPB Charts to be published 2016

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Pupillary Zone Endocrine Hypothalamus Topography. If the sign is located or reaches to zone 4 = hypothalamus.
Zone 5 = hypothalamus & hippocampus. Zone 6 = hypothalamus & amygdalaindependent of location

New PZ Hypothalamus Sign 360
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The Hypothalamus
Chronobiological clock resides in the suprachiasmatic nucleus of the hypothalamus
The Hypothalamus has central importance for all approaches in medicine, health &
It regulates the varied interactions of Psychoneuroendocrinoimmunology (PNEI) - this
veries the mind-body connection in medicine
By the 5th week of gestation the hypothalamus has formed and the limbic system
(emotional responses) is in place. The hypothalamus is helping to control the endocrine
system from this time, including the anterior pituitary
The hypothalamus is directly connected to the iris, pupil & IPB through micro neural
pathways to and from the lateral geniculate bodies in the thalami
Blood sugar, blood pressure, body temperature, pain, inammation, immune function,
hormonal balance, stress, intestinal peristalsis, etc are all regulated by the hypothalamus.
Endocrine glands act on instruction from the hypothalamus

The hypothalamus is of vital importance
in general, health, homeostasis,
psychoneuroendocrinoimmunology (PNEI)
& modern iridology

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Hypothalamus - Radial Sign

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Amygdala - Rx (Dx)

Base section of the of pupillary

zone Hypothalamus Sign
(Number 6 in this diagram) - Rx

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EFAs & Mg required for healthy cell membrane - also in blood sugar balance, detox and nerve functions

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Linear Pigment on the Collarette < Malic acid = hypothyroidism tendency

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Linear Pigment on Collarette - catalogue the colour & topography metabolic accumulation & < EFAs tendency

Irregular Pigment
Immune dysfunction consequence of CAC disruption

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La Cronobiologie
24.2 Hour Individual Chronobiology Iris Map

Adrenal Pigment/Indent
PNEI Network

SCN & La Chronobiologie

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This iris collarette topography

is applicable to both
the Dx/Rx & Gx/Lx

Pure Brown Iris

Immune Cell Chart
(Neutropenia < Neutrophils)

M Sign IPB
Signicant blood sugar sign. Dysglycemia with
extreme symptoms & rapid development
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Globular IPB Serotonin Sign

(white arrow)
Claws Sign Progesterone
(black arrow)

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Sections of DNA at the tip of chromosomes
They shorten every time cell replicates
Cells can maintain the length of their telomeres
with an enzyme telomerase - this adds genetic
material to the end of the DNA strand, thus
lengthening the number of times it can replicate
and prolong the cell life
Linked to IPB & pupillary zone topographies
Telomeres very prone to oxidative stress
Nutritional deciencies - vits C, D & E

Every disease is a result of

reduced cell-to-cell & intracellular
communication - Modern Iridology
can show this foundation
Immune cells, cytokines, hormones, peptides &
neurotransmitters all speak with each other in an
attempt to maintain homeostasis
Research has found in many tumours you need
to stimulate Somatostatin. This can be considered
a new fundamental platform for any therapies.
Many tumours have increased Growth Hormone
(GH) in the cells. Increased somatostatin (mainly
produced from the hypothalamus) down-regulates
GH. Melatonin dow-regulates GH

Please refer to the following book >

and the chapter from page 135 on Classical Topographical
Questions in Modern Iridology
Modern Iridology approaches do not replace
existing methods, but enhances the iridology
experience for both Px and Pr - due to the abundance
of new and reliable information resources
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Striated/String Pigment 107/138 Px = Initial: Cortisol

Reversal - Topolabile
Secondary: Intestinal Immune
Dysfunction & Dysbiosis

The Solitary sign - either

lacuna or pigment - on the
collarette is highlighted
in the modern iridology

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In Modern iridology this

type of iris is not a Weak
constitution, etc. This is a
exible & absorbant person
that can endure a lot of
stress. with a distended
collarette there is a
dominance of the paternal

Restricted/Contracted Collarette

Vital immune indications

with ENT, HPA Axis, MALT,
zinc, vitamin C &maternal
DNA predominance

Main Iris Signs & Progesterone Tendency

Progesterone integral to the gastrointestinal mucosa
Elevated & Multibridged collarette structure - Progesterone Collarette - Andrews,
Sao Paulo 2004
New Hypothalamus Sign - Pupillary Zone topography - Andrews, Padova, 2004
Claws morphologies on the Inner Pupillary Border - Andrews, Charlotte, 2006
Partial atrophy on the IPB - Andrews, San Diego 2002

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The Central Role of the Collarette in Iris

Analysis -The Progesterone Collarette

Claws IPB - Lower Progesterone Ratio

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The Hypothalamus is involved in the following:

for the brain, blood & nervous system
the fulcrum for mind-body medicine approach
central to the limbic system
PNEI dynamics
direct connections to the iris & IPB tissues
blood sugar regulation

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blood pressure control

serotonin & other neurotransmitter
sleep pattern regulation
pain responses


This iris collarette topography

is applicable to both the Rx & Lx

B Cells & Natural Killer Cells - reduced

potential Rx

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Nerve ending

Iris melanocytes
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Linear Pigment on Collarette

catalogue the colour & topography
metabolic accumulation & < EFAs tendency

Shadow Ring< Reduced Zinc

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Another Shadow Ring sign

(see arrow)
Zinco & natural killer cells link established Andrews 1994 - 2015.

Gx Clinical Case: Autoimmunity - Female Px

Note: Erratic/Missphapen Collarette Structure- AI Typical.
Autoimmune Systemic Lupus (SLE). < Reduced selenium tendency

Dx - Hypertrophy IPB
(protective/reactive immune system when in balance. Over/
hyperactive when Px imbalanced. Note Erratic Collarette
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Iris Co-signs

Pigment Indent

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New in 2008 - 270 page comprehensive iridology text book for

the practitioner, tutor, student or researcher
All information has been extensively revised &
updated from previous editions and over ten new
chapters have been produced. The book comes
complewte with 270 slide iris image gallery

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GI System Therapeutics
For Children/Teenagers & Adults:
Plantago lanceolata folia
Nux vomica Homaccord drops (liver & GI)
Licorice root
Emblica ofcinalis fruc (Amla Berry)
Nervoheel (IBS & stress-related)
Progesterone D6 (Mucosa support)
Melatonin 4CH (Gastric mucosa)
Mucosa Compositum
(GI immune support)
Gastricumeel (Gastric balance)
Spascupreel (Spasmodic conditions/IBS)
Aletris farinosa
(progesterone up-regulation/adrenal

Magnolia cortex


Artemisia vulgaris folia

GI System Therapeutics
Ziziphus spinosa/Z.jujube fruc
(IBS & stress-induced GI conditions,
excessive BMs)
Magnolia cortex (IBS, anxiety, etc)
Mucuna pruriens (Velvet bean) GI/NTs support
Arctium lappa radix GI & hepatic support
Guacatonga - Caesaria sylvestris
(Gastric ulcers)
Artemisia vulgaris folia
(CFS, GI immune support, IBS)


Achylia gastrica
Nux vomica

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EFAs & Mg required for healthy cell membrane

- also in blood sugar balance, detox and nerve

in the pure brown iris
blood sugar/metabolic

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Ex - Peppercorn pigments distributed through

ciliary iris - modern ndings correlate with
chromium tendency. German iridology
1950/1960s linked to iron, but ten year study
only found 3 cases of anemia from 61 Px with
peppercorn pigments. However 48/63 had
lower chromium. 10 other Px had Diabetes in
genetics. 2 Px no links.

New Publications Pending 2015-16

Imunologia & Iridologia (em Portuguese)
Chronobiology in Natural Medicine
New Inner Pupillary Border Findings 2008 - 2015
Pure Brown Iris in Modern Iridology Vol.2 2008-15
Chronic Fatigue Syndrome & Natural Medicine
Modern Iridology Introduction
Cellular Iridology
& the New Citric Acid Cycle Topography
For 2016/17 PNEI & Modern Iridology
1200 pages approx

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Irregular Pigment
Immune dysfunction consequence
of CAC disruption

The crypt is a genetic or embryological sign
Interestingly, despite the crypts reputation in classical iridology for deep-seated chronic
cases, this cellular CAC research found that the conditions with the crypt sign attached saw
greater levels of resolution of the condition - replicating what we see with the crypt within the
modern iridology PNEI & emotional approaches

Grey Arrow - Crypts

Globular IPB

* Crypt formation like this suggests genetic

< vitamin D tendency - emphasis blood group A
Note white arrow: HPA/Stress Axis

Serotonin Sign (white arrow)Claws Sign Progesterone (black arrow)


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Striated/String Pigment
107/138 Px = Cortisol Reversal - Topolabile
Intestinal Immune Dysfunction & Dysbiosis

Mucuna pruriens

Pigmento Porquinho da India

Linear Pigment on the Collarette

metabolic accumulation/<EFAs
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New Publications Pending 2015-16

Imunologia & Iridologia (em Portuguese)
Chronobiology in Natural Medicine
New Inner Pupillary Border Findings 2008 - 2015
Pure Brown Iris in Modern Iridology Vol.2 2008-15
Chronic Fatigue Syndrome & Natural Medicine
Modern Iridology Introduction
Cellular Iridology & the New Citric Acid Cycle Topography
For 2016/17 PNEI & Modern Iridology 1200 pages approx

Peak Mental Peformance 3 PM

take Rhodiola, Eleuthero, Centella, Gingko, GunaAwareness, Cerebrum Compositum, Zincum, etc
between 1 & 3 PM

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Lycium barbarum - Goji Berry WolfBerry

Rich in vitamin C, selenio, zinco,
polysaccharides, avanoids
Requires average soil, good drainage
in full sun
Modulates inammation, superfood
nutritional adaptogen, chemoprotective,
hepatoprotective, balances blood sugar

Lycium - Wolfberry

Regular use helps to promote intestinal

Can strengthen capillaries in the eyes as
well as veins & arteries through the system
Can help with testosterone & sperm
counts & sperm motility
Contraindications: Nightshade family
allergy & may cause diarrhea with
excessive use

Manganese -The forgotten mineral

Manganese (Mn) should be routinely
tested but is not in the UK & many other
Mn important for neurological functions
(deciency linked to shizophrenia & anxiety
for example) & blood sugar level balance.
Mn helps convert phenylalanine into
tirosina & tirosina into dopamina
26 Px with Mn deciency (established via
blood test between 2002 & 2014) 24 has
multiple frontal radial furrows

Manganese (Mn) & Frontal Radial


64 Px with radial furrows - 24 had < Mn.

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Superfood adaptogens

Pupil Ellipse - Bilateral

note Pupillary zone Hypothalamus & orange pigment.
Overactive hypothalamic pathways

Inammation Regulation
Anger or resentment (Staphisagria?)
Chronobiology (Timing of the therapies)
Th 1/Th 2 (Which pathway is rigid?)
Metabolic elements (Pancreas & Hepatic)
Endocrine (Optimal HPA Axis function)
Ex - Intestinal Transversal & Solitary
Pigment (baco/spleen) - amplify the TH2
immune rigidity in Ulcerative colitis

Solitary Pigment on collarette

Vascular Transversal -

is signicant for all systems classical &/or modern

very important ciliary iris sign.

Potential active inammation & immune
compromise (with pigment) - Note IPB &
Pupil too. HPA & adaptogen support

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Shadow Ring sign around pupil- >

New Square Collarette

Zinco, < natural killer cells - tendency to <

immunity. Also note Distended Collarette 90%+ cance of paternal DNA dominance

tendency to Therapy Resistance involving

PNEI Network, requires extra detoxication
& there is a blood sugar tendency with
Insulin Resistance too

Another Shadow Ring sign

Restricted Collarette

(see arrow). Zinco & natural killer cells link

established Andrews 1994 - 2015. * Note
also the pupillary zone pigments. Important
in classical iridology with GI tract (Russian,
South Korean & German authors), but also
in modern iridologia with previously released
cellular iridology, pupillary zone topography
(embryology) & pending neurotransmitters

maternal DNA dominance.Tendency to <

Zinco. In modern iridology smaller pigments
will be very signicant

Autoimmune diabetes

Erratic collarette structure

autoimmune tendency with lower selenium

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Hyperactive hypothalamus

Shadow Ring Sign

vertical ellipse pupil

Endocrine Axis

Progesterone Collarette
refer to Progesterona PDF in your folder

Adrenal Pigment/Indent PNEI Network

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Pure Brown Iris

One or two signs on the external collarette are v.important. Observe PZ topographies
too & IPB, including cellular iridology. The collarette structure reveals a lot here: <
progesterone, Th 2 inammation (AI), < selenio & dyslycemia

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Hostility & Inammation - IL-6

Psychological hostility proles have been linked to depression, cardiovascular disease,
metabolic syndrome, increased stress, autoimmunity, lower EFAS & inammation
Niaru, et al (2000) found 1,081 had metabolic syndrome and hostility has inammatory
metabolic effects. Hostility and the metabolic syndrome in older males: The normative aging
study, Psychosomatic Medicine 62, 7-16
Raikkonen et al, 2003, looked at 134 teens in a 3 year follow-up & found hostility increased
the risk of metabolic syndrome in adolescents. Hostility predicts metabolic risk factors in children and
adolescents, Health Psych, 22, 279-286

A study of 6,814 healthy men & women found that individuals with higher levels of distrust,
cynicism, chronic stress or depression has increased inammation (Ranjit et al, 2007 Psychosocial
factors & inammation, Archives of Internal Medicine, 167, 174-181). Inammation included > CRP ,
brinogen & IL-6. Suarez et al, 2004, found hostility associated with > IL-1 alpha & beta,
IL-8 in 44 healthy, non-smoking, premenopausal women. More severe depression & hostility
= .cytokine production. There was a link established between > IL-6 & hostility. Suarez et al
Enhanced expression of cytokines Pyschoneuroendocrinology, 29, 1119-1128

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Th2 Conditions
Asthma - Th2 dominance

Chronic allergies, hay fever

Chronic Fatigue Syndrome

Systemic Lupus (SLE)

Chronic fungal infection


Ulcerative colitis

Inammatory Bowel disease


Multiple chemical sensitivity


Antiphospholipid syndrome

Chronic sinusitis/rhinitis

Graves disease (hyperthyroid)

Some forms of tumours

Parasite infection

Th1 Conditions

Primary Biliary Cirrhosis (PBC)

Pain syndromes
(including chronic tendonitis)

Ankylosing spondylitis

Crohns disease

Granuloma annulare

Multiple sclerosis


Type Autoimmune Diabetes

Sjogrens syndrome

Some researchers suggest

Parkinsons & Alzheimers are Th1

Hashimotos disease (AI


Recurrent spontaneous

Lichen planus


Chronic viral infection

Cytokines in Th cell Responses- Therapeutically be aware of Th

pathway dominance chronobiology
Interferon-gamma (IFN)
suppresses IL-4
IL-1 & IL-2
Main partner cell: Macrophage,
CD8+ T cell
IL-9, IL-10 & IL-13

Main partner cell: B cell, eosinophil (due

to IL-4), mast cells
Peak production of the pro-inammatory
cytokines IL-1, IL-2, IFN-gamma, TNFbeta all occurs during the night and early
hours when cortisol production is at
lowest level
The time of the Th1 responses explains
why gastric pain, RA are-ups, Crohns
disease, colds, dental pain are all worse
in the early morning
Ref: Int Rev Immunol. 1998;16(5-6):635-49.The
chronobiology of human cytokine production.
Petrovsky, Harrison

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Alcohol & recreational drugs can

cause TH2 rigidity
Immune T cell receptors can alter
their messaging and status in the
immune system depending on
The normal oscillation between
Th1, Th2 & Th3 balance happens
every few hours as an integral
part of a healthy immune system.
Like the endocrine system there
is an innate chronobiology of the
immune system. which we can
harness & hone our therapeutic
approach with optimal windows of
immune opportunity, depending
on the condition involved

The chronobiology of the immune

system is regulated via the
suprachiasmatic nuclei in the
Healthy (or unbalanced) sleep pattern
have a direct impact on the success of
this immuno-chronobiology, for example
research has found this with natural killer
cells, cancer cell production and the Th1
& Th2 harmony

Porozov S, Cahalon L Weiser M, Branski D, Lider O, Oberbaum M., Inhibition of IL-1 and TNF alpha Secretion from
Resting and Activated Human Immunocytes by Homeopathic Medication Traumeel S. Clinical & Developmental
Immunology. 2004 ;11(2): 143-149.

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Hormones & Immunomodulation

Pregnenolone and subsequently DHEA are called the mother of hormones by researchers
because it is used by the body to manufacture many other hormones, including our sex
hormones that are necessary for many body functions (e.g. estrogen, testosterone,
progesterone, cortisol,...) They are responsible for the maintenance of many body functions
such as fat and mineral metabolism, controlling stress, maintaining male and female
characteristics and others. The body produces DHEA and then converts it on demand to
these other hormone
DHEA stimulates cellular immunity or skewing of TH-1 mediated reaction in the balance where
as cortisol inhibits TH-1 reactions but will stimulate on long term TH-2 mediated reactions.
We can state that a long term secretion of cortisol (e.g. stress) will induce a skewing at the
TH-2 side of the balance inducing allergies, some auto-immune diseases and even cancer.
Some auto-immune diseases are TH-1 driven (e.g. Crohns disease)
As TH-3 regulator cells, over the release of TGF-, inhibit both sides of the balance (down
regulation) it does not directly intervene in the dysbalance but in the intensity of both the
TH-1 or TH-2 expression
We know from research1 that Traumeel S inhibits the sectretion of IL-1 and TNF-. These
two mediators inhibit cortisol production. That is why Traumeel S has such an infammation
down regulating effect, amongst others
1. Porozov S, Cahalon L Weiser M, Branski D, Lider O, Oberbaum M., Inhibition of IL-1 and TNF alpha
Secretion from Resting and Activated Human Immunocytes by Homeopathic Medication Traumeel S. Clinical &
Developmental Immunology. 2004 ;11(2): 143-149.

Vitamin B6 - Washed out/thin collarette

potential inammatory sign. Also, see l ighter spots achromia - Dysglycemia tendency

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Plasma vitamin B6 level - marker for inammation

Inammatory Bowel Disease (IBD) = < B6 - Podophyllum Compositum, Nux vomica
Homaccord, Traumeel S, Mucosa Compositum, Dopamina D4 granules
< B6 = > CRP levels (Zeel, Traumeel S, Galium-Heel)
< B6 could be due to < EFAs
< B6 can reduce GABA & dopamine
Elevated urinary GABA could reect poor conversion from B6 to succinic acid (Coenzyme
Vitamin B6 undervalued inammatory & immune element - Coenzyme Compositum & Ubichinon
Compositum can assist with absorption and CAC utilizilation & efciency
B6 requirements increase during pregnancy
Urinary B6 loss caused by diarrhea (Diarrheel, Mucosa Compositum or Veratrum Homaccord)
B6 can be reduced by oral contraceptives, alcohol or yellow dyes such as tartrazine
Vitamin B6 requires zinc for correct absorption
Zinc tends to be lower in plasma for up to 2 hours after eating - the heavier the meal the lower

Inammation Regulation
Anger or resentment (Staphisagria?)
Chronobiology (Timing of the therapies)
Th 1/Th 2 (Which pathway is rigid?)
Metabolic elements (Pancreas & Hepatic)
Endocrine (Optimal HPA Axis function)

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Hypertrophy IPB
(protective/reactive immune system when in balance.
Over/hyperactive when Px imbalanced

Relationship between hormones & cytokines

Hormones inuence cytokine levels (prolactin, melatonin, progeterone, cortisol, etc)
Endocrine & immune systems - brains in a uid state
Female sex hormones, such as estrogen inhibit Th2 reaction & up-regulate Th1 cytokines
Cortisol inhibits the Th1 reaction & in particular IL-2
> Stress > Cortisol = < Th1 x IGF < = Herpes simplex virus

Estudos de Caso

> Flexibility/Adaptability

Estudos de Caso

IPB - Partial atrophy Endocrine

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Estudos de Caso

Estudos de Caso

Estudos de Caso

Smooth Isolated orange pigment

> severity of extreme dysglycemia symptoms.
Chomium. & modern iridology

Resentment (usually towards a parent)lacuna, crypt or pigment in classical knee

topography. Could be a genetic sign. Pigment
harder to resolve in this topographyWillow Bach
ower remedy (massage into knee).

Estudos de Caso

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Renal rarefaction

Therapy Resistance

Kidney dysfunction. Inherent creativity. With small

pigments creative thought

Musical/Artistic Ability

Estudos de Caso

Deep transformation potenital. Flexibility in life as

long as connected with the creativity

Estudos de Caso

Estudos de Caso

Dyscratic Iris

Estudos de Caso

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Estudos de Caso

(remember pupillary hippus)

Multiple pigments in inferior

section of the iris = hormonal imbalance.
Males & Females.

Pigments in this upper

low section = thyroid & metabolic

Pigments in the lower iris & of

this size
female hormone imbalance. Remember to
support the liver & HPA Axis. Agoniada, Vitex
agnus castus, Paeonia, Siberian ginseng, etc


imbalances. Ipotiroidismo. Iodine<,


- 54 -

Claws com Partial Atrophy IPB

Lens Distortion

- endocrine & < progesterone ratio

Clinical Case

AI- Hashimotos

Autoimmunity - Female Px, Systemic Lupus

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Stress & Neurohormonal Production

Embryology & Iridology - collarette & IPB formation
Stress = > maternal neurohormonal production
Thus > childs biological susceptibility to emotional distress (Nervoheel, Pulsatilla Compositum)
Results in physical & psychological consequences of anxiety & stress (Tonico-injeel)
Prenatal experience hormonally inuences our positive & negative tendencies during life
(Ginseng Compositum)

Immunity & Endocrine Function in PTSD

Kronfol & Remick, 2000, Cytokines & the brain, American Journal of Clin Psychiatry, 157
NKCs reduce during examination, Kiecolt-Glasser, et al 1984, Psychosocial modiers of
immunocompetence in medical students. Psychosomatic Medicine, 46, 7-14
Schneiderman et al, 2005 found that Px with autoimmune disease, in comparison with
healthy individuals, exhibited an overactive proinammatory cytokine production, caused by
constant acute stress response. Stress & Health, Annual Review of Clinical Psychology, 1,

Amygdala-Hippocampus-Hypothalamus Connection in PNEI &

Amygdala-Hippocampus-Hypothalamus (AHH Axis) = Limbic Foundation to PNEI, ECM
terrain & homotoxicology applications
Embryological development link -observe germinal layers
Iris tissue correlation with in utero experience and PNEI & HPA Axis pathways during life - in
essence how we respond to stress & trauma and why
The AHH Axis can have a genetic basis based on our grandparents stress & nutritional
experience - epigenetic PNI correlation according to geneticists


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Ginseng Compositum
Homotoxicology Adaptogenic - supports the HPA Axis
PNEI Network Interactions supported
Supports physiology in times of stress and to function normally
Counters fatigue

PNEI & Homotoxicology

Involvement of multiple systems - ECM, RES
Multiple symptom presentations
Quantum layers of triggers and consequences
Offers syngergistic solutions
Disease is a consequence of impaired cellular communication across the PNEI matrix
Cells use cytokines, hormones & neurotransmitters to interact & communicate across the
PNEI network
In the blood/lymph/ECM - cytokines are concentrated in picograms & nanograms

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Modern Iridology
New Systems & Topographies
New Signs and reclassication of existing signs
Focus on the collarette, pupillary zone & IPB tissues & structures
PNEI Axis Integration

Immune system
Endocrine system
Gastrointestinal system
Limbic system
The Cell - Citric acid cycle

B Cells & Natural Killer Cells

reduced potential Rx

Please refer to the following book >

and the chapter from page 135 on Classical Topographical
Questions in Modern Iridology
Modern Iridology approaches do not replace
existing methods, but enhances the iridology
experience for both Px and Pr - due to the abundance
of new and reliable information resources
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The Collarette

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The Collarette is a prominent

and major landmark in the iris - in eavery sense

In some territories, especially in the USA & Germany

the Collarette is referred to as the Autonomic Nerve Wreath.
In some countries it is know an as the ruff.
However, the correct medical & anatomical terminology is the Collarette

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John Andrews is internationally recognised for research and

exploration with the Collarette on the following levels:
The Endocrine System (Glands for the Hormonal System are placed topographically on the
external border of the collarette)
Emotional Dynamics of the Collarette
Embryology with Daniele Lo Rito
Limbic System

A combination of new research & technology have provided exciting

new applications in iridology - the analysis of the collarette provides
the ability to ask the right type of questions to decide
on any short or long term treatments

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Iridology validates Epigenetics

The emerging science of epigenetics also
helps to validate iridology
Within this eld geneticists have concluded
that the emotional & psychological traumas
an individual has inherited from their parents
or grandparents can have a profound
inuence on the genetic development of
physical disease for that person - without
altering the DNA structure
This is exactly what we can identify with the
many layers of transparent maps of the iris
What we assess with the iris & IPB is an
expression of epigenetic aspects

The IPB & the collarette demonstrates the genetic & epigenetics links

Every Iris is Individual

The iris, and particularly

the Collarette, is individual to us
to an even greater degree than

just like the person it belongs to

This is why the collarette is being

utilised in biometric security scanning

The Integrity of the Collarette

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Px = Patient
CR = Circadian rhythm
HPA = Hypothalamic-pituitary-adrenal axis
PNEI = Psycho-neuro-endocrino-immunology
ECM = Extracellular matrix
Pr = Practitioner
IPB = Inner Pupillary Border

Rx = right eye/iris
Lx = left eye/iris
CNS = central nervous system
CAC = citric acid cycle or Krebs cycle
PRL = Prolactin
GH = Growth hormone

24.2 Hour Individual Chronobiology Iris Map

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Individual Chronobiology Map

Utilizes the Collarette with a 24.2 chronobiology timeframe for humans - collarette divided
into 14.8 sections
Connects with all topographies/systems in modern iridology - pupillary zone, IPB, emotional,
PNEI, cellular - citric acid & modern iridology chart - Graco de iridologia moderna
Correlations with classical iridology as well
We can identify our personal biological body clock, regulated by the hypothalamic
suprachiasmatic nucleus (SCN), using the collarette and connect with important signs on
the IPB and the other topographies or we can connect with signicant topolabile iris signs these are markings signicant for what they are; not where they are
In the future we can check our individualised gene maps with our chronobiology map and
the IPB
So for example we have a M sign on the IPB - se next image - we know this is important, but
the meaning is further enhanced if we have a sign on the collarette for 08.30 AM, 13.30 PM,
15.30 PM & 19.30 PM - we can prescribe for these times for the Px - diet, zinc, chromium,
spirulina, Gymnema, Myrtillo fruc, Bauhinia (Pata de Vaca), etc

M Sign IPB- Signicant blood sugar sign

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Chronobiology Denition
The term chronobiology come from the Greek
word for time chronos meaning time and the
study of life biology, basically time-biology of
plants, animals & humans
Chronobiology is the science that studies how
living organisms adapt to the cycles of the
sun &moon to establish biological rhythms
In the 1970s this began looking at the sleep/
wake cycle, but has since extended to
look at all systems/organs in the body and

The Iridologist needs to observe for uniformity

in the collarette

Collarette Summary
One of the main landmarks of the iris
Scientic studies throughout the world have demonstrated its signicance in disease tendency
Recent research has examined its embryological origin & developmental completion at 6
months gestation, except in rare cases (complete collarette atrophy)
vOngoing research has explored the emotional & PNEI interpretation of the collarettes
The collarette has several levels of information pertaining to physical and emotional tendencies
including that of the neuroendocrine & immune systems
The collarette does not change its structure, unless due to trauma or surgery to the iris or
pupillary deformation - in reality transient dynamics of the pupil or even the iris tonus give the
basis for such claims
Analysis & interpretation of the Collarette is suitable for iris types, indeed it is the most
accessible iris structure available and will provide multiple levels of information, when other
signs may prove to be non-existent or unclear

- 70 -

Even though the collarette can be

described as a boundary wall, it
transcends all iris boundaries - well in
99.8% of cases - it is easily identied
& assessed in all iris types leading to
multiple levels of information

Elephants - IPB - One of the most

important IPB signs - yet discovered
- as it highlights the importance of
HPA Axis balance. usually in a frontal
location. Emotional epigenetics & the
limbic system

IPB Elephants Review

Genetic history of HPA compromise & susceptibility - especially with inammation compounds the Stress Axis - Adpatogens & other forms of suitable cellular support
Thus often seen in Autoimmunity, polyarthritis, poor ECM drainage, dysmetabolic
mesenchymia, chronic fatigue syndrome (CFS), etc
Good emotional memory, will learn from negative emotional experience & stress - emotional
Tendency to Anxiety
Elevated cortisol Tendency(the A in the HPA axis)
Dysglycaemic Tendency - Elephants emphasize any blood sugar dysregulation
Leptin disturbances leading to poor hypothalamic control of fat metabolism

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HPA Axis

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- 75 -

Avaliao profunda dos nveis fsicos e emocional

Emotional Anatomy Correlations
Each organ or gland carries an emotional, psychological & energetic memory & interaction
Hormones, neurotransmitters, immune cells & cytokines have these correlations - PNEI!
Psycho-emotional iris topography (applicable to any of the iris maps)

Iris melanocytes
- 76 -

Amygdala - Rx
- 77 -


Hypothalamus - Radial Sign

& Limbic System
- 78 -

New in 2008 - 270 page comprehensive iridology text book for

the practitioner, tutor, student or researcher
All information has been extensively revised &
updated from previous editions and over ten new
chapters have been produced. The book comes
complete with 270 slide iris image gallery

Geographical Tongue

The solitary sign

In Modern iridology

this type of iris is not a

Weak constitution, etc. This is a exible & absorbant
person that can endure a lot of stress. with a distended
collarette there is a dominance of the paternal DNA

Either lacuna or pigment - on the collarette is highlighted

in the modern iridology approach

- 79 -

Also in this case the pupillary mydriasis (page 35) that

could indicate adrenal hypofunction/fatigue - check if not
a child or adolescent

Erratic/misshapen Collaretteselenium tendency

Modern iridology does not overlook the pure brown iris.

80% approx of global population has brown iris

(check autoimmunity, thyroid, immune status, blood

group 0, etc)

When we are faced a lot of a certain iris sign then it

is usually less signicant to them individually. More =
Less. Less = More. Look for what stands out against the
iris background. By the way, many iris pigments in the
lower section show an endocrine tendency

With the brown iris the focus is usually the collarette,

Pupillary zone, Pupil & IPB - all the signs associated in
these areas. The potential importance for new modern
iridology maps becomes apparent

- 80 -

In modern iridology there is no need to overdiagnose/

analyse when faced with many signs. Focus on
the smaller signs - pigments. Also the iridomelanin
pigments suggest tyrosine conversion compromise in
the liver

Linear Collarete, orange pigment in the Limbic/cerebral

areas. Also note Magnesium (whitened) & Zinc (restricted
collarette) - all suggest a dysglycemia tendency with
neurological symptoms if the Px is out of balance

Main Iris Signs & Progesterone Tendency

Elevated & multibridged collarette structure - progesterone collarette - Andrews
New Hypothalamus Sign - Pupillary Zone topography
Claws morphologies on the Inner Pupillary Border
Partial atrophy on the IPB

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The Central Role of the Collarette in Iris Analysis

Collarette Bridge

The Central Role of the Collarette in Iris Analysis

Progesterone Collarette - highlighting previous progesterone ratio imbalance
leading to endocrine, immune, metabolic (blood sugar) & inammatory
conditions - full research to be published 2010. The Collarette becomes
elevated, thickened & is genetically multibridged. Claws on the IPB clarify &
enhance the analysis

- 82 -

Pupillary membrane

Claws IPB - Progesterone

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- 85 -

The Pigment Triangle (Pigment Triad)

The pigment triangle links three pigments of similar type
& size as means of immune system tendencies from the
pigment type and/or topography - PNEI & ECM dynamics
are involved

Pigment Triangle
Andrews Modern Iris research - to be published 2011

Pigment Triangle
Links 3 pigments of similar type & size as means of
immune system tendencies from the pigment type and/or
topography - PNEI & ECM compromise

Pigment Triangle
Pigment Triangles with one or more of the pigments on
the Collarette have > signicance for the Px
- 86 -

Pigment Triangle
They can appear in any iris type & the immune system &
ECM indications are the same

Modern Iridology Summary

Improved accuracy & competence
Flexibility for the practitioner & patient (Px)
Multifaceted approach with the integration of different and varied methods & systems
Priority of signs
Improved condence
Positive Px Empowerment

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The noblest joy is in the understanding

Leonardo Di Vinci

Thanks for your attention & participation

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