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6.LiverCancer
(Pleasereferthearticleoneffectofherbotherapytreatmentonlivercanceratthebottom

ofthepage)

LIVERCANCER

(1)Overview

(2)Symptoms
(3)Riskfactors
(4)Metastasis
(5)Diagnosisaspermodernscience
(6)Stagingandgrading
(7)TreatmentasperAyurveda(withayurvedicherbsandayurvedic
preparations)

(1)Overview:
Theliverisaveryimportantorganinthehumanbody.Itisplacedunderrightribs
justundertherightlung.Themostimportantfunctionoftheliveristoconvert
foodintoenergyandfilteringandstoringblood.Theliverplaysapivotalroleinthe
detoxificationofblood,i.e.removaloftoxinsproducedinthebodyduetometabolic
activityofthebody.Theliverreceivesbloodfromtwosources,thehepaticartery
suppliestheliverwithbloodfromtheheartthatisrichinoxygenandtheportal
veincarriesnutrientrichbloodfromthedigestiveorgans.Liveralsoproduces
clottingagentsnecessaryforclottingthebloodwhenthebodyisinjured.Itsecrets
bileintotheintestines,tohelpabsorbnutrients.Theliverismadeupofseveral
differenttypesofcells.Thisiswhythereareseveraltypesofmalignant(cancerous)
andbenign(noncancerous)tumorsthatcanformintheliver.
Benigntumors:
(i)HemangiomaThemostcommontypeofbenigntumoroftheliver,startsin
bloodvessles.Becausemosthemangiomasofthelivercausenosymptoms,theydo
notneedtreatment.Somehowevermayneedtobesurgicallyremoved.
(ii)HepaticadenomasThesearebenigntumorsofhepatocytes(themaintypeof
livercell).Mostcausenosymptomsanddonotneedtreatment.However,some
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eventuallycausesymptoms,suchasabdominalpain,amassintheabdomen,or
bloodloss.Becausethereisariskthatthetumorcouldrupture,andasmallrisk
thatitwouldeventuallydevelopintolivercancer,mostexpertsusuallyrecommend
surgicalremovalifpossible.
(iii)FocalnodularhyperplasiaThisisatumorgrowthofseveralcelltypes.
AlthoughFNHtumorsarebenign,itcanbedifficulttotellthemapartfromtrue
livercancers,andtheysometimesaresurgicallyremovedwhendiagnosisis
unclear.
Malignanttumors:
(i)Hepatocellularcarcinoma:Itisthemostcommonformoflivercancer
occurring.Itisonnumerousoccasionscalledhepatomabecauseitcomesfromthe
hepatocytes.Itaccountsforabout75%ofprimarylivercancers.
(ii)Cholangeocarcinomas:Thisaccountsfor10to20%ofprimarylivercancers.
Thesearealsocalledintrahepatic(startingwiththeliver)Cholangeocarcinomas.
Thesecancerstartsinthesmallbileductswithintheliver.
(iii)Angiosarcomasandhemangiosarcomas:Thesearerarecancersthatbeginin
thebloodvesslesoftheliver.Exposuretovariouschemicalssuchasvinylchlorides
orthoriumoxide,andradioactiveelementslikeradiumorpoisonslikearsenicare
knowntocausethesetypesofcancers.Angiosarcomasgrowrapidly,bythetime
theyaredetectedthegrowthistoolargetobesurgicallyremoved.
(iv)Hepatoblastoma:Thisisaveryrarekindofcancerthatdevelopesinchildren,
usuallyuptofiveyearsofage.Ifdetectedearlythiscancerishighlytreatable.

(2)Symptoms:
Signsandsymptomsinlivercancersarenotpresentuntilthelaststagewhencancer
hasspread.Manysignsandsymptomsarerelativelynonspecific,theycanbe
causedbyothercancersornoncancerousdiseases.Howeverthefollowing
symptomsmayrequireattention.
(i)Unexplained,unintentionalweightloss.
(ii)Anorexiapersistentlackofappetite.
(iii)Liverenlargementoramassthatcanbefeltintheareaofliver.
(iv)Persistentabdominalpain.
(v)Jaundice.
(vi)HyperglycemiaSomeliverhormonesmaycausehyperglycemia(highblood
calciumlevels).Thiscanleadtoweakness.
(vii)HypoglycemiaLowbloodsugarlevels,whichcanleadtofainting.
(viii)GynecomastiaEnlargementofbreastsinmen,andshrinkingoftestis.
(ix)AseitisWaterretentionintheabdominalarea.Manypatientsareseenwith
thesesymptoms.

(3)Riskfactors
(i)GenderHepatocellularcarcinomaispredominantlymorecommoninmales
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thaninfemales.
(ii)ChronicviralhepatitisChronic(longterm)infectionwithhepatitisBvirusor
HepatitisCvirusisanimportantlivercancerriskfactor.Theseinfectionsare
responsibleformakinglivercancerthemostcommontypeofcancerintheworld.
(iii)CirrhosisCirrhosisistheresultofscartissueformationintheliver.Thiscan
oftenleadtocancer.Mostlivercirrhosisoccursinpeoplewhoabusealcohol.But,
HepatitisBandCarealsomajorcausesoflivercirrhosis.Anothercauseis
excessiveironinliver.
(iv)TobaccouseAlinkhasbeenestablishedbetweentobaccouseandlivercancer.
Combinedwithalcoholtobaccoisverypotentincausingcancer.
(v)InheritedmetabolicdiseasesCertainmetabolicdiseasescanalsoleadto
cirrhosis.Peoplewithhemochromatosis,absorbtoomuchironfromtheirfood.
Theyaremorelikelytodevelopcirrhosisbecauseofthehighlevelsofironintheir
liver.
(vi)AflatoxinsThesecancercausingsubstancesareproducedbyafungusthat
contaminatescrops.LongtermexposuremaycauseHepatocellularcarcinoma.
(vii)ArsenicChronicexposuretodrinkingwatercontaminatedwithnaturally
occurringarsenicsuchasthatfromwells,increasestheriskoflivercancer.

(4)Metastasis:
Mostlywhencancerisfoundintheliver,itdidnotstarttherebutspread,or
metastasizedfromacancerthatdevelopedintheotherorgansofthebodysuchas
pancreas,colon,stomach,breast,orlung,andmetastasizedtotheliver.These
tumorsarenamedaftertheirprimarysiteofoccurrencesandarefurtherknownas
metastasis.Forexample,cancerthatstartedinthelungandspreadtotheliveris
calledmetastaticlungcancerwithspreadtotheliver.

(5)Diagnosis:
Thefollowingmethodsareusedbymodernscienceinthediagnsisoflivercancer.
(i)Ultrasound
(ii)Computedtomography(CT)
(iii)Magneticresonanceimaging(MRI)
(iv)Angiography
(v)Leproscopy
(vi)Biopsy
(vii)Alphafetoproteinbloodtest.

(6)Staging:
(i)Stage1Thetumormaybesmallorlargebuthasnotaffectedbloodvessles.
(ii)Stage2Theremaybemanytumorsoflargesizebutbloodvesslesarenotyet
affected.
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(iii)Stage3aThereareseveraltumors,andatleastoneislargerthan5cms.And
atumorinvadesabranchofmajorliverbloodvessles.(PortalveinorHepaticvein)
(iv)Stage3bAtumorinvadesanearbyorganoratumorhaspenetratedthe
liningoftheliver.
(v)Stage3cThecancerhasinvadednearbylymphnodes.
(vi)Stage4Thecancerhasspreadtootherpartsofthebody.

(7)Ayurvedictreatmentoflivercancer(AyurvedicherbsandAyurvedic
preparations)
Resultsof770patientsofvarioustypesofcancertreatedatDARFduringJan.2004
toDec.2004.
(1)Totalno.ofPrimarycancer504.Inall504patientswithprimarycancerof
varioustypesweretreatedatDARF.
13%patientswererendereddiseasefree
20.63%patientsweremarkedlyimproved
65.27%patientswereimproved
0.9%patientswereuncured
(2)Totalno.ofSecondary(metastases)cancer266.Inall266patientswith
metastasesofdifferenttypesweretreatedatDARF.
12.03%patientswererendereddiseasefree
18.04%patientsweremarkedlyimproved
68.79%patientswereimproved
1.12%patientswereuncured
TheaboveresultsshowthehigheffectivenessofDARFanticancertherapy.
(3)AyurvedaHerbsUsedinthecureoflivercancer:
EffectofherbotherapytreatmentofLivercancer
ShreeShreeMaaAnantanandTirthji
DivyajyotAyurvedicResearchFoundation,`Anantdham',
PaldiCharRasta,Ahmcdabad380007,GujaratINDIA
Keywords:Herbotherapy.LFT,primaryandmetastaticcancer
Abstract:Cancerisoneofthemostdangerousdiseases:Livercancer
(Malignancies)isaterminaleventinmanycancers.Herbotherapyisa
veryeffectivetreatmentwithnosideeffects.Citrusmedica(Bijoru)isa
fruitusedsinceancienttimesbytheAyurvedapractitioners.Juiceofa
singlebijorufruitisgiventothepatientsofprimaryaswellas
metastaticcancerregisteredat'DivyajyotAyurvedicresearch
Foundation'.Itimprovespatient'slivermetabolism,gradually
normalizesLFT,preventsrecurrence,stopsfurtherspreadofdisease,
decreasestumorgrowth.Attheendof4to6months,patientbecomes
freefromthediseasesymptomsandleadsanormallife.
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INTRODUCTION:
Liveristhelargestglandinthebodyandperformsmorethan500
differentfunctions.PrimaryliverCancerisrelativelyrarebut
metastaticlivercancer(spreadfromadistantcancerousorgan)isat
least20timesmorethanprimarylivercancer.Livermetastasisisa
terminaleventinmanycancers.Advancedlivermetastaticcancerisa
significantproblemwithlimitedtreatmentoptionsandhasverylittle
chancesofsurvival.Chronicliverdiseasesincludesviralhepatitis,
Jaundice,,Alcoholiccirrhosisorprimarybilliarycirrhosis,hepatitisB,
alltheseareriskfactorsofhepatocellularcarcinoma.Maleshavehigher
riskforHCCthanfemales.Themetastasiscanbeeithersolitaryor
multiple.Incaseofmultiplemetastasis,liverfunctioncanbecome
altered,leadingtofurtherdeteriorationinapatient'scondition.The
treatmentoptionsinsuchascenarioarelimitedwithausualfatal
outcome.Commonsymptomsfoundinthesepatientsarehepatomegaly,
weightloss,abnormalelevationofliverenzymes,elevationofAFP,
Anemia,massormultipleliverlesions,obstructivejaundice...etc.For
thedetectionoflivercarcinoma,elevationofAFP,USGAbdomen,CT
scanorMRIofabdomen,needlebiopsyorlaproscopicliverbiopsyis
helpful.
100patientsareselectedtobescreenedfor"Citrusmedica"juice
effectsontheirdisease,registeredat`DivyajyotAyurvedicResearch
Foundation'.Thechiefoftheinvestigatingteamandheadofthe
institute"VaidyaShreeShreeMaaAnantanandTirthaji"andother
researchcommitteemembers,alongwiththeirassistantresearch,
doctorsandscientistconductedthewholeproject.
AIMSANDOBJECTIVES:
1.Theaimistostudytheeffectsofthejuiceofthe"Citrusmedica'",
popularlyknownas"Bijora",inthetreatmentofpatientshaving
primaryormetastaticlivercancerswithimprovingliverfunctions.
2.Oneofthemost"ancient"medicalsciencesoftheworldis
"Ayurveda".Ayurvedicmedicinehasnosideeffects.Since1978Vaidya
ShreeShreeMaaAnantanandTirdhjitreatsalltypesofadvanced
cancerswithdifferenttypesofanticancertreatments,somrofthemare
panchkarmatherapyandherbaljuicetherapy.Thesetreatmentsfind
excellentresults.Theinstituteisworkingtowardsprovidingthepatients
withacureforthisterribledisease.
3.Todocumentthedataandpublishittoenrichthegeneralquantumof
medicalknowledge.
CRITERIAFORSELECTION:
Allthepatientsregisteredat`DivyajyotAyurvedicResearch
Foundation'hospitalwereassessedandselectedirrespectiveofsex,cast
creedandagefortheirpresentsymptomsofabdominalpain,jaundice,
hardnessofliversideinabdomen,weightloss,lossofappetite.etc...
Theirclinicalinvestigationsatthetimeofregistrationprovetheirsite
withrespecttocancer.
MATERIALANDMETHOD:
Material:Scientificname:CitrusmedicaL.Commonname:Bijoru
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Family:RutaceaeUsefulParts:Fruit.
Uses:Itisusedinallkindsofliverdiseases,likelivercirrhosis,
jaundice,damagedliver.function,viralhepatitisBandC,primaryand
secondarylivermalignancies.
Methods:Allpatientsregisteredat`DivyajyotAyurvedicResearch
Foundation'weregivenspeciallypreparedtreatment.
Theirrespectivefindingswereanalyzedforstatisticalsignificance.
Patientswithliverdiseasesunderwentbaselineinvestigationsinthe
formofliverfunctiontest,tumormarkerstudies,Ultrasound
examinationofliveranddetaileddocumentationofclinicalstatus.The
patientareadministeredaglassofsingleBijorafruitjuiceintheearly
morningwithemptystomachfollowedaftertwohours.Thismustbe
continuedregularlyatleastforaminimumperiodof3months.
FortheothersymptomspatientswereadvisedtotakeAyurvedic
medicinesasperrequirementaftertheirprakrutiexaminationandnadi
pariksha.Thefollowingherbswereadministeredalongwiththe
treatment.
(1)Lindipiper(2)Morepinchhbhasma(3)Kapurkachalichurna(4)
TapvadilohKanchnar(5)Bhoamli(6)Vikalo(7)Vayavarno(8)
Garmalo(9)Kunvarpathu.
Thesepatientswerealsoadvisedstrictdietrestrictionlike
(1)Tostopgheeandoilpreparationscompletely.(2)Toavoidspicyfood.
(3)Totakeboiledvegetables.(4)Totakegoatmilk.(5)Totakepapaya
andallkindsofcitrusfruit.
Theirclinicalstatusandbiochemicalparameterswerestudiedatthe
intervalof4to6weeks.Thecoursewascarriedoutforatleast3
months.Ifthejuicegivesgivespositiveresponseitcanbeincreasedup
to6months.After6months,radiologicalinvestigationswerealso
carriedout.
CRITERIAOFASSESMENT:
(1)Allsymptomsoflivercancerwerereportedatthetimeofpatient's
registration.Thesymptomswhenreassessedandifimprovedorscored
assymptomaticallyreliefandLFT(LiverFunctionTest)is
encouraging,isconsideredtobeas`Improved'.
(2)Patientwhoisobservedtobesymptomaticallynormalfromdisease
andLFTisnormalandradiologicalfindingsarealsonearabout
normal,isconsideredtobe'MarkedlyImproved'.
(3)Thosepatientswithallinvestigationslikeradiologicaland
hematologicalreportsnormal,areconsideredDiseaseFree.
(4)Patientswithsymptomsinstatusquoorincreasedareconsideredto
be`Uncured'.
RESULTS:
Totalnumbersofselectedprimarycancerpatientswere30.Total
numbersofselectedmetastasescancerpatientswere70.
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Table:1Resultsofprimaryandmetastaticlivercancerpatients
Status

Improved

Primary
Metastatic

7
31

Markedly
Improved
12
20

Disease
Free
5
12

Uncured

Total

6
7

30
70

Table:2Nadidisturbancesinprimaryandmetastaticcancerpatients
Status
Primary
Metastatic

DwidoshPrakriti TridoshPrakriti
20
10
25
45

Total
30
70

Table:3ResultsofBijorajuicetherapyinprimaryandmetastaticliver
cancer
Patientswithrespecttotheirliverfunction
LiverFunctionTest
StatusQuo/Increased
Improvesupto30%
Improvesmorethan
50%
Normal

Primary
20%
23%
40%

Metastatic
10%
44%
29%

17%

17%

Conclusions:
1AsingleBijorajuiceearlyinthemorningwithemptystomachupto3
monthsdailygivesverypositiveresults.
2Itimprovesmetabolism,liverfunctionandappetiteofthepatient.
3Itgraduallyminimizesthesymptomslikenadidosha,imbalanceof
prakritianddisturbancesintheconstitutionofpatient.
4Itdissolvesthetumorgradually.
5Thisjuicetherapygivesrapidresultsinmetastaticcancerthan
primarycancer.
6DwidoshPrakritiiscommoninprimarycancerpatients.Metastatic
cancerpatientshavemoreoftenatridoshprakriti.
7ItmaintainsHemoglobinlevelindirectlybygraduallyimprovingliver
functions.
8Fewpatientshavingadvancenatureofdiseasemaynotbecured.

(PreparedbyDivyajyotAyurvedicResearchfoundationIndia.Weareconductingresearchand
treatmentinAyurvedicherbalcureofcancersincelast25years.Thedataandinformation
containedonthissiteisbasedonAyurvedicherbalwisdomandourresearch.)

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