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1: Chui YL, Ma CH, Li W, Xu Z, Yao Y, Lin FK, Chan JY, Lee KK.

Anti-apoptotic protein
BRE/BRCC45 attenuates apoptosis through maintaining the expression of caspase
inhibitor XIAP in mouse Lewis lung carcinoma D122 cells. Apoptosis. 2014
May;19(5):829-40. doi: 10.1007/s10495-013-0963-y. PubMed PMID: 24395041.
2: Chen E, Tang MK, Yao Y, Yau WW, Lo LM, Yang X, Chui YL, Chan J, Lee KK. Silencing
BRE expression in human umbilical cord perivascular (HUCPV) progenitor cells
accelerates osteogenic and chondrogenic differentiation. PLoS One. 2013 Jul
23;8(7):e67896. doi: 10.1371/journal.pone.0067896. Print 2013. PubMed PMID:
23935848; PubMed Central PMCID: PMC3720665.
3: Lin FK, Chui YL. Generation of induced pluripotent stem cells from mouse cancer
10.1089/cbr.2012.1227. Epub 2012 Aug 14. PubMed PMID: 22891678; PubMed
Central PMCID: PMC3516428.
4: Tang MK, Liu G, Hou Z, Chui YL, Chan JY, Lee KK. Livers overexpressing BRE transgene
are under heightened state of stress-response, as revealed by comparative proteomics.
Proteomics Clin Appl. 2009 Dec;3(12):1362-70. doi: 10.1002/prca.200900097. Epub
2009 Oct 13. PubMed PMID: 21136956.
5: Pang JC, Li KK, Lau KM, Ng YL, Wong J, Chung NY, Li HM, Chui YL, Lui VW, Chen ZP,
Chan DT, Poon WS, Wang Y, Mao Y, Zhou L, Ng HK. KIAA0495/PDAM is frequently
downregulated in oligodendroglial tumors and its knockdown by siRNA induces
cisplatin resistance in glioma cells. Brain Pathol. 2010 Nov;20(6):1021-32. doi:
10.1111/j.1750-3639.2010.00405.x. PubMed PMID: 20477830.
6: Chui YL, Ching AK, Chen S, Yip FP, Rowlands DK, James AE, Lee KK, Chan JY. BRE overexpression promotes growth of hepatocellular carcinoma. Biochem Biophys Res
Commun. 2010 Jan 15;391(3):1522-5. doi: 10.1016/j.bbrc.2009.12.111. Epub 2009
Dec 24. PubMed PMID: 20035718.
7: Chan JY, Li L, Miao J, Cai DQ, Lee KK, Chui YL. Differential expression of a novel gene
BRE (TNFRSF1A modulator/BRCC45) in response to stress and biological signals. Mol
Biol Rep. 2010 Jan;37(1):363-8. doi: 10.1007/s11033-009-9796-8. PubMed PMID:
8: Xu W, Zhang X, Chen W, Fok KL, Rowlands DK, Chui YL, Chan HC. Immunization with

Bin1b decreases sperm motility with compromised fertility in rats. Fertil Steril. 2010
Feb;93(3):952-958.e1. doi: 10.1016/j.fertnstert.2008.10.066. Epub 2009 Jan 8.
PubMed PMID: 19135192.
9: Chen HB, Pan K, Tang MK, Chui YL, Chen L, Su ZJ, Shen ZY, Li EM, Xie W, Lee KK.
Comparative proteomic analysis reveals differentially expressed proteins regulated by
a potential tumor promoter, BRE, in human esophageal carcinoma cells. Biochem Cell
Biol. 2008 Aug;86(4):302-11. doi: 10.1139/o08-069. PubMed PMID: 18756325.
10: Leung WK, Wu KC, Wong CY, Cheng AS, Ching AK, Chan AW, Chong WW, Go MY, Yu
J, To KF, Wang X, Chui YL, Fan DM, Sung JJ. Transgenic cyclooxygenase-2 expression and
high salt enhanced susceptibility to chemical-induced gastric cancer development in
mice. Carcinogenesis. 2008 Aug;29(8):1648-54. doi: 10.1093/carcin/bgn156. Epub
2008 Jul 7. PubMed PMID: 18611916.
11: Yu J, Wu CW, Chu ES, Hui AY, Cheng AS, Go MY, Ching AK, Chui YL, Chan HL, Sung JJ.
Elucidation of the role of COX-2 in liver fibrogenesis using transgenic mice. Biochem
Biophys Res Commun. 2008 Aug 8;372(4):571-7. doi: 10.1016/j.bbrc.2008.05.069.
Epub 2008 May 27. PubMed PMID: 18503750.
12: Chan BC, Ching AK, To KF, Leung JC, Chen S, Li Q, Lai PB, Tang NL, Shaw PC, Chan JY,
James AE, Lai KN, Lim PL, Lee KK, Chui YL. BRE is an antiapoptotic protein in vivo and
overexpressed in human hepatocellular carcinoma. Oncogene. 2008 Feb
21;27(9):1208-17. Epub 2007 Aug 20. PubMed PMID: 17704801.
13: Yu J, Hui AY, Chu ES, Cheng AS, Go MY, Chan HL, Leung WK, Cheung KF, Ching AK,
Chui YL, Chan KK, Sung JJ. Expression of a cyclo-oxygenase-2 transgene in murine liver
causes hepatitis. Gut. 2007 Jul;56(7):991-9. Epub 2006 Dec 5. PubMed PMID:
17148503; PubMed Central PMCID: PMC1994375.
14: Lo AK, Lo KW, Tsao SW, Wong HL, Hui JW, To KF, Hayward DS, Chui YL, Lau YL, Takada
K, Huang DP. Epstein-Barr virus infection alters cellular signal cascades in human
nasopharyngeal epithelial cells. Neoplasia. 2006 Mar;8(3):173-80. PubMed PMID:
16611410; PubMed Central PMCID: PMC1578522.
15: Tang MK, Wang CM, Shan SW, Chui YL, Ching AK, Chow PH, Grotewold L, Chan JY,
Lee KK. Comparative proteomic analysis reveals a function of the novel death receptorassociated protein BRE in the regulation of prohibitin and p53 expression and

proliferation. Proteomics. 2006 Apr;6(8):2376-85. PubMed PMID: 16518872.

16: Wan J, Zhang W, Wu L, Bai T, Zhang M, Lo KW, Chui YL, Cui Y, Tao Q, Yamamoto M,
Akira S, Wu Z. BS69, a specific adaptor in the latent membrane protein 1-mediated cJun N-terminal kinase pathway. Mol Cell Biol. 2006 Jan;26(2):448-56. PubMed PMID:
16382137; PubMed Central PMCID: PMC1346911.
17: Wong SL, Chen Y, Chan CM, Chan CS, Chan PK, Chui YL, Fung KP, Waye MM, Tsui
SK, Chan HY. In vivo functional characterization of the SARS-Coronavirus 3a protein in
Drosophila. Biochem Biophys Res Commun. 2005 Nov 18;337(2):720-9. Epub 2005 Sep
26. PubMed PMID: 16212942.
18: Shan SW, Tang MK, Cai DQ, Chui YL, Chow PH, Grotewold L, Lee KK. Comparative
proteomic analysis identifies protein disulfide isomerase and peroxiredoxin 1 as new
players involved in embryonic interdigital cell death. Dev Dyn. 2005 Jun;233(2):266-81.
PubMed PMID: 15858817.
19: Chan BC, Li Q, Chow SK, Ching AK, Liew CT, Lim PL, Lee KK, Chan JY, Chui YL. BRE
enhances in vivo growth of tumor cells. Biochem Biophys Res Commun. 2005 Jan
14;326(2):268-73. PubMed PMID: 15582573.
20: Li Q, Ching AK, Chan BC, Chow SK, Lim PL, Ho TC, Ip WK, Wong CK, Lam CW, Lee KK,
Chan JY, Chui YL. A death receptor-associated anti-apoptotic protein, BRE, inhibits
mitochondrial apoptotic pathway. J Biol Chem. 2004 Dec 10;279(50):52106-16. Epub
2004 Oct 1. PubMed PMID: 15465831.
21: Ma CH, Hui J, Tang JT, Leung DT, Chui YL, Fok TF, Lim PL. Antibodies to guanosine
triphosphate misidentified as anti-double-stranded DNA antibodies in a patient with
antinuclear antibody-negative lupus, due to buckling of insolubilized assay DNA.
Arthritis Rheum. 2004 May;50(5):1533-8. PubMed PMID: 15146423.
22: Lo AK, Huang DP, Lo KW, Chui YL, Li HM, Pang JC, Tsao SW. Phenotypic alterations
induced by the Hong Kong-prevalent Epstein-Barr virus-encoded LMP1 variant (2117LMP1) in nasopharyngeal epithelial cells. Int J Cancer. 2004 May 10;109(6):919-25.
PubMed PMID: 15027126.
23: Wan J, Sun L, Mendoza JW, Chui YL, Huang DP, Chen ZJ, Suzuki N, Suzuki S, Yeh WC,
Akira S, Matsumoto K, Liu ZG, Wu Z. Elucidation of the c-Jun N-terminal kinase pathway

mediated by Estein-Barr virus-encoded latent membrane protein 1. Mol Cell Biol. 2004
Jan;24(1):192-9. PubMed PMID: 14673155; PubMed Central PMCID: PMC303354.
24: Ching AK, Li Q, Lim PL, Chan JY, Chui YL. Expression of a conserved mouse stressmodulating gene, Bre: comparison with the human ortholog. DNA Cell Biol. 2003
Aug;22(8):497-504. PubMed PMID: 14565866.
25: Chan BC, To KF, Pang JC, Chung YF, Lo KW, Tong JH, Huang DW, Lim PL, Chui YL.
Generation of monoclonal antibodies against Hong Kong nasopharyngeal carcinomaassociated Epstein-Barr virus latent membrane protein 1 (LMP1). Int J Cancer. 2002
Dec 10;102(5):492-8. PubMed PMID: 12432552.
26: Poon KM, Tam FC, Chui YL, Lim PL. Single-chain Fv fragment lacks carrier specificity
of the native antibody. Mol Immunol. 2002 Sep;39(1-2):19-24. PubMed PMID:
27: Ching AK, Li PS, Li Q, Chan BC, Chan JY, Lim PL, Pang JC, Chui YL. Expression of
human BRE in multiple isoforms. Biochem Biophys Res Commun. 2001 Nov
2;288(3):535-45. PubMed PMID: 11676476.
28: Wun HL, Leung DT, Wong KC, Chui YL, Lim PL. Molecular mimicry: anti-DNA
antibodies may arise inadvertently as a response to antibodies generated to
microorganisms. Int Immunol. 2001 Sep;13(9):1099-107. PubMed PMID: 11526090.
29: Leung DT, Yam NW, Chui YL, Wong KC, Lim PL. A human and a mouse anti-idiotypic
antibody specific for human T14(+) anti-DNA antibodies reconstructed by phage
display. Gene. 2000 Sep 19;255(2):373-80. PubMed PMID: 11024298.
30: Ching AK, Li PS, Chan WY, Ma CH, Lee SS, Lim PL, Chui YL. Strand bias in Ig somatic
hypermutation is determined by signal sequence within the variable region. Int
Immunol. 2000 Sep;12(9):1245-53. PubMed PMID: 10967019.
31: Lim PL, Tam FC, Chui YL, Ng LW. Identification of a surrogate TSL-1 antigen of
Trichinella spiralis from a phage library of random peptides. Parasite Immunol. 1997
Jun;19(6):281-6. PubMed PMID: 9364558.
32: Poon VK, Chui YL, Lim PL. Phage-displayed La/SS-B antigen as a diagnostic reagent.
Immunotechnology. 1997 Jun;3(2):155-9. PubMed PMID: 9237100.

33: Lim PL, Leung DT, Ng LW, Wong KC, Song SY, Chui YL, Leung JC, Lai KN, Lui SF. An
anti-idiotypic (T14) antibody found commonly in patients with systemic lupus
erythematosus that may be pathogenic. Ann N Y Acad Sci. 1997 Apr 5;815:462-4.
PubMed PMID: 9186697.
34: Lo AK, Ching AK, Lim PL, Chui YL. Strand breaks in immunoglobulin gene
hypermutation. Ann N Y Acad Sci. 1997 Apr 5;815:432-5. PubMed PMID: 9186690.
35: Lim PL, Ng LW, Leung DT, Wong KC, Song SY, Chui YL, Leung JC, Lai KN, Lui SF.
Common occurrence of an antiidiotypic antibody that recognizes T14+ anti-DNA
antibodies in patients with systemic lupus erythematosus. Arthritis Rheum. 1996
Dec;39(12):1980-9. PubMed PMID: 8961902.
36: Yeung VT, Mak AS, Chui YL, Ho SK, Lai KN, Nicholls MG, Cockram CS. Identification
of C-type natriuretic peptide gene transcripts in glial cells. Neuroreport. 1996 Jul
29;7(11):1709-12. PubMed PMID: 8905648.
37: Ylamos J, Klix N, Goyenechea B, Lozano F, Chui YL, Gonzlez Fernndez A, Pannell
R, Neuberger MS, Milstein C. Targeting of non-Ig sequences in place of the V segment
by somatic hypermutation. Nature. 1995 Jul 20;376(6537):225-9. PubMed PMID:
38: Chui YL, Lozano F, Jarvis JM, Pannell R, Milstein C. A reporter gene to analyse the
hypermutation of immunoglobulin genes. J Mol Biol. 1995 Jun 9;249(3):555-63.
PubMed PMID: 7783211.
39: Lim PL, Leung DT, Chui YL, Ma CH. Structural analysis of a phosphorylcholinebinding antibody which exhibits a unique carrier specificity for Trichinella spiralis. Mol
Immunol. 1994 Oct;31(14):1109-16. PubMed PMID: 7935500.
40: Lai KN, Ho RT, Leung JC, Chui YL, Lim PL, Lui SF, Li PK. CD4-positive cells from
patients with IgA nephropathy demonstrate increased mRNA of cytokines that induce
the IgA switch and differentiation. J Pathol. 1994 Sep;174(1):13-22. PubMed PMID:
41: Lai KN, Wong KC, Li PK, Lai CK, Chan CH, Lui SF, Chui YL, Haskard DO. Circulating







1994;68(3):294-300. PubMed PMID: 7530811.

42: Leung JC, Lai CK, Chui YL, Ho RT, Chan CH, Lai KN. Characterization of cytokine gene
expression in CD4+ and CD8+ T cells after activation with phorbol myristate acetate
and phytohaemagglutinin. Clin Exp Immunol. 1992 Oct;90(1):147-53. PubMed PMID:
1356669; PubMed Central PMCID: PMC1554547.
43: Chui YL, Batchelor JR. Mechanisms underlying continued survival of rat kidney
allografts after a short period of chemical immunosuppression. Transplantation. 1985
Aug;40(2):150-3. PubMed PMID: 3895620.
44: Lancaster F, Chui YL, Batchelor JR. Anti-idiotypic T cells suppress rejection of renal
allografts in rats. Nature. 1985 May 23-29;315(6017):336-7. PubMed PMID: 3158822.