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UNIVERISTI SAINS MALAYSIA

PUSAT PENGAJIAN SAINS KAJIHAYAT


BO1/116: GENETICS
SEM 1: 2013/2014
Lecturer:
1. Dr. Abdul Hafiz Ab Majid
2. Prof. Dr. Siti Azizah Mohd. Nor
This course presents principles and methods used in the study of genetics. Students will learn
about the difference between Mendelian and non- Mendelian inheritance, predict the outcome
of crosses and understand the extranuclear inheritance. Students also will discover the two
types of cell division and relate that meiosis leads to variation. This course will also discover
how DNA & RNA were proven to be the genetic materials and will explore the composition
and structures of DNA, RNA and chromosome organisation. Students will understand the
concept of central dogma which encompasses replication, gene transcription and RNA
modification and translation. This course will also explicate the processes of gene regulations
(lac & trp operons) and describe the various types of mutation, their causes & effects on life.
Students also will be exposed to the understanding of the basic concept of genetic
engineering and the tools used. Through this course, students will have better understanding
on the concept of relationship and crossing-over and use statistical analysis to verify the
result of crosses. This course will elaborate the application of Hardy-Weinberg Law in
analysing population genetics for gene frequency, sex linkage equilibrium and heterozygote
frequency.
LECTURE SCHEDULES
Week

Date
08/09/1
5

09/09/1
5
11/09/15
15/09/1
5
16/09/1
5
18/09/1
5
22/09/1
5
23/09/1
5
25/09/1
5
29/09/1

Topic

Lecturer

Notes

Overview of genetics
AHAM
Mendelian genetics

16 September (Hari
Malaysia)
Statistical analysis in genetics

Extensions of Mendelian Inheritance


Population genetics

AHAM

AHAM

AHAM

24 September (Hari Raya


Haji)

10

5
30/09/1
3
02/10/1
5
06/10/1
5
07/10/1
5
09/10/1
5
13/10/1
5
14/10/1
5
16/10/1
5
20/10/1
5
21/10/1
5
23/10/1
5
27/10/1
5
28/10/1
5
30/10/1
5
03/11/15
04/11/15
08/11/13
10/11/15
11/11/15
13/11/15

Non-Mendelian Inheritance

AHAM

Sex determination
14 October (Maal Hijrah)

Maal Hijrah
AHAM
Linkage, crossing over & mapping of
genes on chromosomes

Variations in chromosome structure &


number

Chromosome transmission - Mitosis &


Meiosis

AHAM

TEST 1
Molecular structure of DNA & RNA

SAMN

Mid Semester Break

17/11/15
11

18/11/15

Organization & molecular structure of


chromosome

SAMN

20/11/15
12
13

24/11/15
DNA replication.
25/11/15
27/11/15
01/12/1 Synthesis of protein (gene transcription
5
& RNA modification, translation of
02/12/1

SAMN
SAMN

TEST 1

5
04/12/1
5
08/12/1
5
14

15

09/12/1
5
11/12/15
15/12/1
5
16/12/1
5
18/12/1
5
16/12/1
5
18/12/1
5

mRNA
Gene regulation (in bacteria &
bacteriophages, eukaryotes)

Gene mutations & repair.

SAMN

SAMN

TEST 2
Introduction to genetic engineering
(recombination recombinant DNA
technology)

SAMN

References
1. Concept of Genetics. W. S. Klug, M. R. Cummings, C. A. Spencer & M. A. Palladino.
Pearson International Edition. (latest edition)
2. Genetics, Analysis & Principles.Robert, J. Brooker, McGraw-Hill Book Company.
(latest edition)
3. Principles of Genetics. D. Peter Snustad & Michael J. Simmons, John Wiley & Sons.
(latest edition)
4. Cell and Molecular Biology. Concepts and Principles. Gerald Karp, John Wiley &
Sons. (latest edition)