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2010

Inspirations
SUMMER 2010 | VOLUME 17

CO-FOUNDERS

A Newsletter from Gabrielles Angel Foundation for Cancer Research

Denise Rich
Philip Aouad

BOARD OF DIRECTORS
Deborah Dunsire, M.D.
Millennium Pharmaceuticals, Inc.

Leonard & Evelyn Lauder, Honoree Thomas C. Quick & Jennifer Hudson, Angel Ball 2009

Star Jones
Television Personality, Author & Attorney

Patricia Quick
Philanthropist

Angel Ball Slated for October 2010

Thomas C. Quick
First Palm Beach Properties, Inc.

Frank Rella
Trine Corporation

Michle Rella
Director

Daniella Rich Kilstock


Director

Ilona Rich Schachter


Director

Paul Schindler, Esq.


Greenberg Traurig, LLP

Lorraine E. Schwartz
Lorraine E. Schwartz, Inc.

Donald M. Toresco
Toresco Enterprises, Inc.

Erin Zammett Ruddy


Author & Magazine Columnist

MEDICAL ADVISORY BOARD


Chairman Stephen D. Nimer, M.D.
Memorial Sloan-Kettering Cancer Center

Barrie R. Cassileth, Ph.D.

T H E S I G N AT U R E E V E N T of Gabrielle's Angel Foundation, the Angel Ball, has become so


popular it is now a yearly event! Cipriani Wall Street will once again serve as the backdrop for
this black-tie gala, so mark your calendars for Thursday, October 21, 2010! You wont want to
miss this years Angel Ball as the Foundation honors the lead guitarist of one of the worlds
most celebrated rock bands, U2s The Edge and his wife, director, choreographer and dancer,
Morleigh Steinberg; COTY, Inc. Chief Executive Officer, Bernd Beetz for his incredible work
in support of blood cancer research through COTY's DKMS Foundation; and Sean Parker,
Managing Partner of the Founders Fund and creator of online music sharing site Napster and
Facebook Causes. We expect this event to sell out very quickly so, only a limited number of
individual tickets at $1,500.00 will be available. Table levels begin at $15,000.00, so reserve your
seats early this year! Continental Airlines will serve as the Official Angel Ball Airline for the
fourth year in a row with Inez Weinstein Special Events handling all reservations (212-254-6677).
As always, the Angel Ball will showcase A-list celebrities and the best live musical performances
in town! So, save the date: Thursday, October 21st. We look forward to sharing a magical night
with you!

Foundation Announces $2.7M in New Grants

Memorial Sloan-Kettering Cancer Center

Curt I. Civin, M.D.


University of Maryland School of Medicine

James R. Downing, MD
St. Jude Childrens Research Hospital

Carl H. June, M.D.


University of Pennsylvania

Jerome E. Groopman, M.D.


Harvard Institute of Medicine

Janet D. Rowley, M.D., D.Sc.


The University of Chicago

G A B R I E L L E S A N G E L F O U N D AT I O N A N N O U N C E S new grants totaling $2.7 million as it


continues its mission to fund the best junior investigators working in cancer research today.
Twelve of the nations leading young scientists receive $75,000.00 per year to sustain their labs
and further solidify their research careers. Dr. Stephen D. Nimer, Chief of Hematology at
Memorial Sloan-Kettering Cancer Center and Chairman of the Foundations Medical Advisory
Board reaffirmed that only the crme de la crme are chosen for these three-year Medical
Research Awards.

Rainer Storb, M.D.


Fred Hutchinson Cancer Research Center

Jeffrey D. White, M.D.


Bethesda, Maryland

Cheryl L. Willman, M.D.


University of New Mexico Cancer
Research & Treatment Center

FOUNDATION STAFF
Jennifer Ranieri
Director

Due to the overwhelming success of the Angel Ball 2009, ten conventional and two integrative
(complementary) medicine grants were selected from the over 80 applicants. The Shulamit
Benjamini Sandberg Research Grant was established in memory of Foundation sponsor Lorraine
Schwartzs mother. Additional monies partially funded another of these projects in memory of
two ardent Foundation supporters, Jeffrey Steiner and Alan Beeber, as raised by their families.
These twelve promising scientists hail from the nations leading research centers including Fox
Chase Cancer Center, St. Jude Childrens Research Hospital, Dartmouth Medical School and
the University of Texas Southwestern Medical Center.

Christa Justus
Development

136 East 57th Street


Suite 1704
New York, NY 10022
tel (646) 861-2033
fax (646) 781-9355
web gabriellesangels.org

With over $13 million distributed to date through the generous support of Gabrielles Angel
Foundation donors and sponsors, these Medical Research Awards give hope to young scientists
and the cancer patients they seek to cure.
For information on our twelve new grantees, please see page 3.

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A Daughters Wish
by Denise Rich
(reprinted from Tonic.com)

Helen Keller noted, Although the world is full of suffering, it is full also of the overcoming of
it. I believe this with all my heart. My life has been an incredible journey from motherhood to a
career in music to my commitment to a cause that means the world to me. In 1996, my daughter,
Gabrielle, a 27-year-old actress and Hodgkins lymphoma survivor, developed acute myelogenous leukemia (AML). In remission for the second time, she needed a bone marrow transplant
and I was the perfect match. AML eventually took my beloved Gabrielles life but not her spirit,
which lives on in the work of the organization her sisters and I created in her memory, Gabrielles
Angel Foundation for Cancer Research. It was Gabrielles last wish to help spare others the
suffering she had endured. We believed the best way to honor her memory was to turn our grief
into a positive force for others.
Gabrielles Angel Foundation funds cutting-edge science in both mainstream research as well as integrative and complementary
medicine which focus on prevention, treatment and quality of life issues of leukemia, lymphoma and related cancers. These are
the countrys most promising young investigators just starting their labs. Our grantees have gone on to obtain federal NIH funding,
published papers, become heads of research institutions, and filed patents on their discoveries. They are Howard Hughes Medical
Institute Early Career Scientists, Leukemia & Lymphoma Special Fellows and on Stand Up 2 Cancers Dream Teamjust a few examples
of the brilliant minds being funded by Gabrielles Angel Foundation! The inspiration is in the numbers and in the many lives this
research touches: over $13 million awarded to 60 of the countrys best and brightest, making Gabrielles Angel Foundation one of the
largest non-governmental sources of grant support to blood cancer researchers in the nation.
Gabrielle believed that life is a quest, something to be lived out loud and celebrated. So, each year we host an incredible party, our
signature gala, The Angel Ball, to celebrate life while raising money for these amazing scientists. I am so thankful to all of my friends
in the entertainment industry who, for one very special autumn night, gather together with a common wishto eradicate cancer in
our lifetime.
I know in my heart Gabrielle would be so proud of all the Foundation has accomplished. We have been approved two years in a row
as one of the Independent Charities of Americas Best in America charities for upholding our commitment to our donors and
sponsors to meet and maintain the highest standards of accountability. 75 cents of every dollar raised by Gabrielles Angel
Foundation directly funds these future leaders of cancer research who continue to push the boundaries of what is possible.
As a songwriter, I understand the healing power of music and its ability to touch the deepest parts of us. I believe that from grief
and tragedy something new can emerge which makes the world a better place and allows us to remember those we have lost. Cancer
has taken my mother, my sister and my daughter from me, but not my resolve to make a difference. As we approach our fifteenth
year, I remain more hopeful than ever for new advancements, a breakthrough, even a cure. I feel strongly that Gabrielles vision and
strength of spirit continue to light the path of Gabrielles Angel Foundation every step of the way. I believe that what we do together
can create miracles.

P U B L I S H E R S N OT E : Gabrielles Angel Foundation President & Co-Founder Denise Rich recently signed on as a Contributing
Columnist at Tonic.com, a digital media company dedicated to promoting the good that happens around the world each day. Tonic.com
shares the stories of people and organizations that are making a difference by inspiring good in themselves and others. Her first article
was published online in March. Visit Tonic.com regularly for future articles.

Our Mission Statement


Gabrielles Angel Foundation, a 501(c)(3) non-profit organization, proudly funds leading junior investigators
whose work represents cutting-edge scientific research in both conventional and integrative disciplines
which focus on prevention, treatment and quality of life issues of leukemia, lymphoma and other related
cancers. To date, the Foundation has awarded over $13 million in Medical Research Awards making it one
of the largest non-governmental sources of grant support to blood cancer researchers in the nation.

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Our 2009 Medical Research Award Grant Recipients


Patrick Brown, M.D.

Jeffrey C. Rathmell, Ph.D.

Johns Hopkins, Sidney Kimmel Comprehensive Cancer Center

Duke University Medical Center

-----------------------

-----------------------

Investigating promoter hypermethylation in the biology of


MLL-rearranged leukemia, and as a novel target for therapy

Bcl-2 Family Proteins as Metabolic Targets in Leukemia

-----------------------

I chose the field of cancer research because my


patients courage inspires me to look for ways to
make cancer treatment work better.

Cancer impacts everyones lives in one way or


anotherLooking at cancer cell metabolism gives us
a new avenue to potentially treat a wide variety of
cancers. We hope our efforts will make a difference.

Jianjun Chen, Ph.D.

Jennifer Rhodes, Ph.D.

The University of Chicago

Fox Chase Cancer Center

-----------------------

-----------------------

The role and targets of APL-specific miRNAs in leukemogenesis

In Vivo Regulation of Myeloid Cell Development and Leukemia

-----------------------

-----------------------

As a young investigator, I believe that the support


from Gabrielles Angel Foundation should have a
significant influence on my career development.

I find it interesting that the fundamental processes


governing normal cell development are often
deregulated in cancer. What are the key factors? It
is both my curiosity and the importance of this field
that drive me to do cancer research.

-----------------------

Patricia Ernst, Ph.D.


Dartmouth Medical School
-----------------------

Targeting MLL-Cofactor Interaction to Selectively Block Mixed


Lineage Leukemia
-----------------------

I chose the field of cancer research because my


postdoctoral mentor passed away with cancer while
I worked at Dana Farber, making me realize for
how much we know, we still dont know enough to
prevent and treat most cancers.

Ulrich Steidl, M.D., Ph.D.


Albert Einstein College of Medicine
-----------------------

Identification of Functionally Critical Transcriptional Target


Genes in Stem Cells in AML & MDS
-----------------------

There is still no curative treatment options available


for many patients, therefore, I felt that leukemia
research is critically needed for the discovery of
fundamentally novel approaches to ultimately cure
leukemia.

Paul J. Galardy, M.D.


Mayo Clinic Rochester
-----------------------

Exploring the role of UCHL1 in leukemia and lymphoma

Richard T. Williams, M.D., Ph.D.


St. Jude Childrens Research Hospital

-----------------------

The support of Gabrielle's Angel Foundation comes


at a time when it is very difficult to survive as a
physician-scientist. [This] support provides critical
funds that will allow my research to further develop
and for me to explore other avenues of interest in
cancer biology. This award is immensely important
to my career development.

-----------------------

Systematic, High-Throughput Developmental Therapeutics in


High-Risk ALL
-----------------------

My father succumbed to metastatic melanoma


when I was a child and I know that seeded my desire
to make a positive impact as an adult.

Peiying Yang, Ph.D.


Ross L. Levine, M.D.

MD Anderson Cancer Center

Memorial Sloan-Kettering Cancer Center

-----------------------

-----------------------

Fish oil (n-3 fatty acids) and non-Hodgkin lymphoma

Genomic characterizations of myeloproliferative neoplasms

-----------------------

-----------------------

This funding makes it possible to explore the potential


of using dietary interventions for the prevention or
treatment of cancer.

there is a real need to improve our understanding


of leukemia biology so we can improve outcomes
for our patients.

Chengcheng (Alec) Zhang, Ph.D.


Kirsten Ness, P.T., Ph.D.

University of Texas Southwestern Medical Center

St. Jude Childrens Research Hospital

-----------------------

-----------------------

Ex Vivo expansion of hematopoietic stem cells for cord blood


and allogeneic transplantations

Vibration Intervention for Bone Enhancement in Childhood


Cancer Survivors
-----------------------

Cancer survivors face unique challenges (including


potential problems with movement and fitness) as
they age.

-----------------------

This funding gives me confidence in supporting


my own research and offers me the freedom to
pursue new and risky projects.

For more information on these research projects, visit


www.gabriellesangels.org

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Foundation Highlights 2010...


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Co-Founder Hosts Fashion Fete


With Americana Manhasset
Americana Manhasset, Long Islands premiere luxury shopping
destination, brought their exquisite merchandise to Denise
Richs Manhattan residence for a preview of the summers
newest fashions. Fortunately for guests, the rainy April afternoon gave way to sunshine that filled that apartment. The
break in the weather coupled with an amazing 25% of all proceeds going to the Foundation afforded attendees the perfect
incentives to spend. Guests were encouraged to sip, shop and
splurge and through their generosity, the Foundation received
over $72,000 for cancer research. Haute couture stalwarts Dior,
Etro, Fendi, Frette, Hirshleifers, Louis Vuitton, Prada, and
Spring Flowers beautifully displayed their wares while a select
list of supporters nabbed the latest high-end items for their
summer jaunts. The Director of Americanas VIP Personal
Shopping Services, Danielle Merollo and Marketing Director,
Rebecca Hollander organized the festive afternoon with catering provided by Mary Giuliani Catering & Events and parting
gifts by Zegna, Herms and others. Americana Manhasset has
long supported Gabrielles Angel Foundation through their
Champions for Charity event. Last years holiday promotion
netted the Foundation over $15,000. With the ongoing and very
generous support from Americana Manhasset President
Deirdre Costa Major and its Owner, Frank Castagna, Gabrielles
Angel Foundation looks forward to future events with an
organization whose philanthropic reach knows no bounds.
For more information, please visit:
www.championsforcharity.org & ww.americanamanhasset.com
Photos: Amber De Vos/PatrickMcMullan.com
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1. Happy shoppers, Allison Lutnick & Marcy Lehrman


2. Americana Manhassets Danielle Merollo with hostess Denise Rich & Erica Reid
3. Long Island vintner, Cynthia Rosicki
4. Queen of the New York comedy scene, Caroline Hirsch
5. Gabby DeMatteis & her mom, Lynn DeMatteis love their new Vuitton!
6. Supporters Jennifer Fischer & Michele Herbert
7. Etros colorful wares on display
8. Americana Manhasset President, Deirdre Costa Major with Denise Rich
9. Foundation Board member Lorraine E. Schwartz & her sister, Ofira Sandberg
10. Fendi President of North America, Stacy Sharp Van Praagh came by for a visit
11. The Louis Vuitton leather goods section was a hit!
12. Natalie Cole tries on a beautiful scarf with the help of an Americana employee

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...Since being diagnosed with CD20+


Hodgkins Lymphoma and joining this
elite club that no one asks to belong to...
I quickly found, once youre in, its like a
family that doesnt judge, a community
that welcomes you with open arms,
a village that renews itself through the
strength of numbers.
ETHAN ZOHN, Angel Ball 2009

Foundation Announces Angel Ambassador


Survivor: Africa winner, Ethan Zohn,
knows the true meaning of adventure.
So, its no surprise that after being
diagnosed with a rare form of cancer,
CD 20+ Hodgkins Lymphoma, and living
to tell the tale, that he continues his
crusade to help make a difference in the
lives of others. A self-proclaimed soccer
crazy, cancer crusher and big dreamer,
Ethan has agreed to speak out on behalf of
Gabrielles Angel Foundation as an Angel
Ambassador. As an Angel Ambassador,
Ethan will share the latest Foundation
news through his vast reach in the media
and speak from his experience as a cancer
survivor. He will also attend various
Foundation functions throughout the
year to impress upon a wider audience the
urgent need for funding cancer research.
His charitable work speaks for itself. After winning Survivor: Africa in
2001, Ethan Co-Founded Grassroots Soccer, a nonprofit organization
that trains professional soccer players to teach African children, through a
tailor-made curriculum, about HIV/AIDS prevention. His desire to change
the world extends to other charities, as well, including America Scores and
the Elizabeth Glazer Pediatric AIDS Foundation. Ethan has been recognized
for his philanthropic efforts by the International Association of Physicians
in AIDS Care, received the Heroes Among Us Award from the Boston
Celtics and many others. He works with the Alliance for Global Conservation to raise awareness of the links between international conservation
and treatments for deadly diseases and, like Co-Founder Denise Rich,
Ethan pens a column for Tonic.com.
Gabrielle Rich Aouad believed that Life is an adventure, a quest Ethan
Zohn lives his life with the passion and drive befitting a true survivor. His
many accomplishments speak to the limitless possibilities one committed
individual can attain. Gabrielles Angel Foundation is very grateful to have
this inspired philanthropist on its team!

Board of Directors
Expands to Include
Prominent Philanthropists
Gabrielles Angel Foundation is thrilled
to announce the expansion of its Board of
Directors to include three individuals
committed to helping further the reach and
the mission of the Foundation. The newest
members of Gabrielles Angel Foundations
Board of Directors include (left to right)
celebrity jeweler and longtime sponsor of
the Angel Ball, Lorraine E. Schwartz; 2009
Angel Ball honoree, Thomas C. Quick of
First Palm Beach Properties, Inc.; and his
sister, also a 2009 honoree, philanthropist
Patricia Quick. All three of these outstanding
humanitarians have demonstrated unwavering
loyalty and generosity to Gabrielles Angel
Foundation, and each of them remains
committed to making a difference in the
lives of others through their considerable
charitable endeavors. In its ongoing quest
to increase the awareness for the need
for cancer research, Gabrielles Angel
Foundation gratefully welcomes Lorraine,
Tom and Tricia to the Board!

If we did
all that we
were truly
capable of,
we would
astound
ourselves.

Follow Ethan on Twitter @EthanZohn or visit him online: www.ezohn.com


THOMAS EDISON

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More 2010 Highlights ...


GABRIELLES ANGEL FOUNDATION
WOULD LIKE TO THANK THE FOLLOWING
FOR THEIR GENEROUS SUPPORT:

Teens Raise $70,000 for Foundation!


York Prep Junior, Andrew Warren, and a committee of his high-school friends rallied
the troops for the second Teens Making a Difference on Friday, May 7th raising an
incredible $70,000.00 for Gabrielles Angel Foundation. Sponsored by Rocawear and
espace, the event drew over 300 New York-area high school students dressed to the
nines and ready for a good time.
The excitement began on the red carpet where the teens mingled with celebrities such
as Tinsley Mortimer and Jules Kirby (High Society), Mark Indelicato (Ugly Betty),
Broadway star Orfeh (Legally Blonde) and Sports Illustrated model Esti Ginsberg.
They munched on delicious donated treats from Pop Burger, Sant Ambroeus, and
Serafina and desserts by TLCs The Cake Boss and Crumbs while Serendipity 3 served
up their signature frozen hot chocolate. Student DJ Mac Petrycki opened for DJ PS1
who then handed over the spinning duties to DJ Enferno. The DJs kept the dance floor
packed and the crowd went wild when Cash Money/Universal Artist Jay Sean got up
and rocked the house with three of his hit singles.

Food and Beverage underwritten by: Aquaforte


Water, Carlos Bake Shop, Crumbs, Pop Burger,
Sant Ambroeus, Serafina, Serendipity 3
Giftbags Courtesy of: The Shiboleth Family
Contents Courtesy of: Elizabeth Grant
Cosmetics, i[2]y Foundation, KLS Cosmetics,
Neutrogena, Pop Chips, Rocawear, Sephora,
Tommy Hilfiger
Transportation Courtesy of: The Schwartz Family
Security donated by: Mike Zimmet LLC
Fashion Show by: Jan Planit, Planit Management,
LLC, One Model Management, Q Models,
DNA Men, Alice + Olivia, Anlo, Calvin Klein,
Cynthia Rowley, Elizabeth & James, Jill Stuart,
Maglia, Michael Kors, Shoshanna, Unk & Will
Stylist: Nikki Diamond
Fashion Assistant: Remy

Andrews proud parents, longtime Foundation supporters Marcy & Michael, pitched in
with party preparations to help make the event a success. Other parents whose help
was invaluable in the planning and execution were Michael Cohen of the Trump
Organization and Jan Planit who, with student committee member Danielle Brizel, put
on an amazing fashion show. Professional models, including Calvin Klein newbie
Grayson Vaughn, strutted the runway in clothes by Michael Kors, Jill Stuart, Anlo,
Shoshanna, Elizabeth and James, Unk and Will, Calvin Klein, Cynthia Rowley and
more. Foundation Board member, Daniella Rich Kilstock and her husband, Richard
stopped by in support of the event to thank everyone for their efforts. At nights end,
guests went home with gift bags, underwritten by the Shiboleth family, which included
products from KLS Cosmetics, Neutrogena, Tommy Hilfiger, Pop Chips, Rocawear and
more. The teens enthusiasm inspired everyone involved to create another memorable
night for cancer research. Gabrielles Angel Foundation has faith that this next generation
of philanthropists will carry on the tradition of giving back as they truly showed what
it means to make a difference in the lives of others.

Photos: Eugene Mim/PatrickMcMullan.com


1

1. Jay Sean rocks the house


2. Andrew Warren & friends
3. Cupcakes courtesy of Crumbs Bake Shop
4. DJ PS1
5. Runway fashion show

Hair: Jemma Muradiam & Arte Salon at


Rona Represents
Makeup: Hope Choman
Music Courtesy of: DJ Enferno, DJ PS1, Mac Petrycki
Event Head: Andrew Warren
Co-Chair Committee: Danielle Brizel, Olivia Davis,
Katie Fraguela, Chloe Greisman, Natalie Jackson,
Gaia Matisse, Katie Resnick, Annabel Schwartz,
Karen Shiboleth
Committee Members: Alexa Eshaghian, Allegra
Bliken, Anna Novogratz, Ariella Haase, Avery
Singer, Bella Chartuni, Blayne Planit, Carolina
Bouzan, Chloe Goutal, Elizabeth Hilfiger, Gabe
Iello, Gaby Novogratz, Gaetano Guarducci, Hayley
Helene, Isabella Trent, Jen Alper, Julian Taffel,
Juliana Hatkoff, Kate Yellin, Kerri Arfa, Leah
Bardwill, Lucille Agapova, Madison Brill, Maggie
Sachs, Makenzie Moon, Molly Brill, Nell Blagg,
Nicole Butler, Nicole Slaine, Rebecca Cher,
Samantha Cohen, Sammy Zaits, Serena Liegey,
Sophie Curtis, Stephanie Rosenfeld, Yael Ginzburg
Special Thanks to: Seth Greenberg, Marcy &
Michael Warren, Jan Planit, Michael Cohen,
Lynne Patton, Larry Goldfarb, Barry Rosenthal,
Amanda Lens and the entire staff at espace.

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Grantee Shaves Head in Support of Pediatric Cancer Patients


Dr. Alex Huang has a missionto find a cure for childhood cancer. Thats why, for the second year in a
row, this 2007 Foundation grantee showed solidarity with his young patients by shaving his head and all
for a very good cause. In conjunction with Team UH Rainbow Babies & Childrens Hospital, Dr. Huang
& his colleagues at Case Western Reserve joined the thousands of volunteers participating in the St.
Baldricks Foundation St. Patricks Day shave to show compassion for these children who typically lose
their hair during treatments. The Rainbow Babies & Children's Hospital Team, with seventeen participants,
raised nearly $19,000 earning them the honor of #1 Team in the City of Cleveland. Dr. Huang led them
in fundraising by bringing in over $4000. His lab will continue to accept donations through the end of
June with all proceeds directly benefiting their research. As of press time, St. Baldricks Foundation
experienced a record-breaking year raising over $19.3 million for childhood cancer research. In the
United States, more children die of childhood cancer than any other disease. As a physician, Dr. Huang
works tirelessly so that there will come a day when he can follow the sentence Your child has cancer
with the words We have a cure. As a parent, Dr. Huang prays for the success of this mission every day.
To make a donation to Dr. Huangs team or for more information on his research, visit www.huanglab.com

Foundation Grantee Awarded Million Dollar


Grant from NIH
2007 Foundation Grantee, James C. Mulloy, Ph.D.
of Cincinnati Childrens Hospital Medical Center
and his colleague Yi Zheng, Ph.D. recently received a
five-year award totaling $1.04 million from NIHs
National Cancer Institute for their grant entitled
Targeting CDC42 in Leukemia Stem Cells. The
scientists are part of the Cancer and Blood Diseases
Institute at Cincinnati Childrens and its division of
Experimental Hematology/Cancer Biology.
Dr. Mulloys research has shown that human blood stem cells can be induced to
make leukemia upon introduction of a leukemia oncogene into these cells. His
laboratory developed a novel mouse model of acute myeloid leukemia (or
AML), one of the first models that use human cells rather than mouse cells to
produce leukemia. Dr. Mulloy's discovery heralded a significant advance for the
field of leukemia biology, since the signals that are important in mouse cancer
can be different from the signals needed for human cancer. With funding from
Gabrielle's Angel Foundation, his laboratory has used this model system to test
novel therapeutic approaches targeted to the key events that occur during the
development of leukemia.
According to the press release from Cincinnati Childrens, the focus of Dr.
Mulloys NIH-NCI studies (research into CDC42) involves a protein that
normally is crucial to cell adhesion, survival and migration. Scientists have
learned that under certain conditions CDC42 stimulates development of disease
initiating cells in bone marrow and leukemia stem cells, which they believe can
fuel prolonged disease, relapse and mortality. Ultimately, the goal of Dr.
Mulloys newly funded research is to develop a new therapeutic strategy for
targeting CDC42 to eliminate leukemia stem cells in bone marrow for leukemias
that are resistant to conventional chemotherapies.
Were really excited about this novel approach to cancer therapy, remarked
Mulloy on this five-year grant. We expect that inhibition of CDC42 will promote the release of leukemia stem cells from the bone marrow and make them
more susceptible to chemotherapy. He emphasized the important role his 2007
grant from the Foundation played in these discoveries stating, The funding
from Gabrielles Angel Foundation gave me the flexibility to put some resources
into these other studies. I want to thank you again for investing in me and my
work. It really does make a difference. Gabrielles Angel Foundation wishes Dr.
Mulloy and his team continued success in their efforts to find better treatments
for those living with AML.

New Addition to
Medical Advisory Board
Gabrielles Angel
Foundation for
Cancer Research
proudly welcomes
Carl H. June, M.D.
to its Medical
Advisory Board.
June, the Director
of Translational
Research at the Abramson Cancer Center
at the University of Pennsylvania and an
investigator with the Abramson Family
Cancer Research Institute, joins the
Foundations team of nine of the nations
top scientific researchers. Dr. June
maintains a research laboratory that studies
various mechanisms of lymphocyte
activation as they relate to immune
tolerance and adoptive immuno-therapy.
He has co-authored more than 250 peerreviewed publications and is the recipient
of numerous awards, including the Frank
Brown Berry Prize in Federal Medicine
(1997), the William Osler Award (2002),
and the Bristol-Myers Squibb Freedom to
Discover Award (20052009). Dr. June
currently serves as President of the Clinical
Immunology Society. After graduating
from the Naval Academy in Annapolis,
Maryland, and Baylor College of Medicine
in Houston, Texas, Dr. June completed his
graduate training in immunology at the
World Health Organization in Geneva,
Switzerland. He then went on to pursue
postdoctoral training in transplantation
biology and medical oncology at the Fred
Hutchinson Cancer Research Center in
Seattle, Washington. Gabrielles Angel
Foundation considers Dr. June a valuable
and exceptional addition to its team.

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News in Brief

ANGEL BRACELETS SPECIAL!

EVERY NOTE COUNTS!


In conjunction with the Memorial Sloan-Kettering Cancer Centers Integrative
Medicine Department, Gabrielles Angels Music Therapy team brings the
healing power of music to oncology patients and their families (Inspirations
Volume 16, Winter 2009). This amazing group of trained therapists brings
hope and comfort to patients at their bedside and in pre-surgical settings. The
buttons worn in this photo use the Foundations purple and red colors and read,
Brought to you by Gabrielles Angels and the MSKCC Music Therapy Program.
The Foundation proudly supports this vital service. (Left to right) Taryn Thomas
(piano keyboard), Holly Mentzer (harp), Karen Popkin (guitar), Alessandro
Ricciarelli (guitar), Candia Bouzioti (djembe), Kate Beever (barred percussion).

Catherine M. Zadeh wants to help change the


world one bracelet at a time. Luckily for
Foundation supporters, her unique creation
made expressly for Gabrielles Angel
Foundation is available for purchase now at
half the price! Gabrielles Angel Bracelet,
part of her Live and Let Live campaign, is
a beautiful sterling silver wing design set
elegantly on a simple black cord. Normally
retailing for $100.00, the Foundation is
making available limited quantities for $50.00.
All proceeds help to fund the cutting-edge
research projects for which Gabrielles
Angel Foundation is known. To order you
or your loved one this exquisite expression
of hope, please call the Foundation
directly at (646) 861-2033.

Find us, Follow us, Become a Fan


Gabrielles Angel Foundation has a
Facebook Fan Page and a
Twitter feed @CureCancerNow!
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Did you know


10 of our Foundation grantees were previously awarded
American Society of Hematology Young Scholar Awards?

Somewhere, something incredible is waiting to be known.


CARL SAGAN