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Endocrinology Paediatrics MD

Part1
1. Primary obesity
a) Reduced bone age
b) Treated with metformin
c) Acanthosis nigricans is a feature
of insulin resistance
d) Can cause metabolic syndrome
e) By definition increase in adipose
tissue with adverse effects
2. Growth hormone secretion
increased by
a)
b)
c)
d)
e)

Exercise
Starvation
Somatostatin
Insulin like growth factor I
Arginine

3. Salt losing 21-OHdeficiency


cause
a) Male ambiguous genitalia at
birth
b) Dexamethazone is given as
treatment in childhood
c) USS shows enlarge suprarenal
shadow
d) Corticosteroids are given to
mothers with a female fetus
4. Hypoglycaemia due to
hyperinsulinaemia occur in
a)
b)
c)
d)
e)
5.

Infant of diabetic mother


Beckwith widerman syndrome
Ketotic hypoglycaemia
Galactosaemia
Septo ceptic dysplasia
Regarding PTH

a) Diurnal variation in secretion


occurs
b) Increases production of 1,25
dihydroxy chilecalceferol in
kidney

c) Inhibits osteoclastic activity


d) Increases renal excretion of
Phosphates
e) Concentration decreases in
hypocalcemia
6. Regarding premature thelarche
a) Commonly occurs in first
2yrs of life
b) GnRH stimulated FSH is
increased
c) Puberty occur early
d) Breast size changing
cyclically
e) Ovarian dysgerminoma
associated
7. Autoimmune hypothyroidism is
associated with
a) Down syndrome
b) Turner syndrome
c) Marfan syndrome
d) Kleinefelter syndrome
e) McCune Albright syndrome
8. At puberty
a) Pubarche occur earlier than
menarche
b) Testicular volume 3ml
c) Maximum height velocity of
life time seen
d) In girls growth spurt
completes before boys
e) Sustained release of GNRH
occur in early mornings
9. Increase PTH seen in
a) Idiopathic severe
hypercalcaemia
b) Pseudohypoparathyrodism
c) Rickets
d) Chronic renal failure
e) MEN syndrome
10.In congenital adrenal hyperplasia
a) 21 hydroxylase deficiency is
found in 95 % cases
b) There is hypertension in 21
hydroxylase deficiency

c) Salt loosing in 11-B


hydroxylase deficiency
d) Increase 17 OH
Progesterone is diagnostic
e) Neonatal screening
programme is available
11.Which of the following are T/F
a) Y chromosome is responsible
for testicular development
b) In female fetuses when
expose to androgens
changes of internal genital
organs
c) Testesterone is responsible
for development of wolfian
duct
d) Testesterone is secreted by
interstitial cells of testis
12.Hypogonadotrophic
Hypogonadism
a) Progeria ?
b) Mccune Albright syndrome
c) Laurance moon belli
syndrome
d) Noonans syndrome
e) Kleinfelter syndrome
13.Regarding management of DKA
a) 0.9 % saline used in the
initial Mx
b) NaHCO3 given at the outset
of Ph < 7.2
c) K+ is given if K+ < 3.5mEq/l
d) Insulin best given I.M
e) Fluid without dextrose is
used until blood sugar
normalize
14.Puberty
a) In boys, it begins with penile
enlargement
b) In girls, growth spurt
preceeds menarche
c) Appearance of Axillary hair
before pubic hair is normal
d) Testicular volume of 5-8ml is
normal in puberty

15.Puberty
a) 85% of girls 1st manifestation
is appearance of breast buds
b) Boys facial hair appearance
is an early feature
c) Girls become fertile as soon
as they reach menarche
d) About 1% of girls do not
menstruate by the age of 16
years
e) Penile enlargement is the 1st
sign in boys
16.Hyperglycaemia of new born is
seen in
a) Neuroblastoma ?
b) Infants of DM mothers
c) Islet cell adenoma
d) LBW babies
e) Beckwiths widemann syndrome
17.Klinefelters
a) Only affects males
b) Increased paternal age is a risk
factor
c) Increased incidence of CA breast
d) ? Infertility
e) ?Dislocation of lens
18.Glycaemic Index
a) When low rapid rise in blood
glucose is seen
b) Is calculated by the amount of
insulin secreted
c) Low glycaemic response
indicates higher insulin secretion
19.A 13 year old girl with Turners
syndrome and a bone age of 12
years,
a) GH is indicated
b) Low levels of oestrogen HRT is
indicated
c) Progesterone and Oestrogen is
indicated
20.A diagnosis of simple obesity is
favoured by

a) A weight for Height . 20%


above median
b) Decreased bone age
c) A height . 97th centile
d) a skinfold thickness 97th centile
e) absence of diurnal variation in
plasma cortisol
21.Following are compatible with a
6yr old child with isolated growth
Hormone deficiency than a
childwho is 3 yr old of same
height
a) Normal random GH level
b) Height velocity for height age is
below 25%
c) Low post exeecise growth
hormone response
d) SkinFold thikness >97%
e) Bone age 1 year
22.Amenorrhea is a clinical feature
of2006
a)
b)
c)
d)

Polycystic ovarian disease


XXX syndrome
Hacmatometrus
Craniopharyngioma

23.Congenital hypothyroidism2006
a) Approximately 90% due to
dyshormonogenesis
b) Prolong jaundice is an early sign
c) Premature closure of anterior
fontanel
24.Hypothyroidism presents at 8yrs
of age due to, 2009
a)
b)
c)
d)
e)

Hashimotos disease
Turners syndrome
Spironolactone treatment
Thalassemia
Dyshormogenesis

25.Recognised causes of
hypercalcaemia, 2009

a)
b)
c)
d)
e)

Hyperparathyroidism
Malignancy
Malnutrition
Low alkaline phosphatase
Hypophophatasia

26.Six years old boy, previously


normal. He has pubic hair, penile
length is 6cm, testes 3ml. What
are the features and
investigations? 2009
a)
b)
c)
d)
e)

Pigmentation
SE
midnight gonadotrophins
17-OH progesterone
Dexamethazone suppression test

27.Insulin2009
a) Fastest action when given over
the abdomen
b) Effect is changed by rubbing
c) Nasal spray can be given several
times a day
d) Subcutaneous injections can be
given together with nasal insulin
28.Type I IDDM
a) Acanthosisnigrican is a
commonly recognized feature
b) Need to increase insulin dose
before major surgery
c) When taken a food with high
glycaemic index it causes
increase in blood sugar
d) Associated with autoimmune
thyroditis
29.Renal glycosuria
a) Seen with ketone bodies
b) Failure to thrive
c) Associated with autosomal
dominant disorders
d) Associated with mixed RTA
e) Associated with amino acid uria
30.Ketone bodies(2010)

a) Increased with
hyperinsulinaemia
b) Tested by fouchest test
c) Heart uses it as fuel
d) Produced in skeletal muscles
when exercise
31.Regarding puberty(2010)
a) Females achieve peak growth
velocity at Tanner stage II
b) LH secretion is increased in boys
before than girls
c) Active male child gets delayed
puberty
d) The bone age is correlated with
puberty than chronological age
32.True, False regarding
Gynaecomastia (2005)
a) Normal pubersent boys having
mild degree of gynaecomastia
b) Klienfelters have
prepubertalGynaecomastia
c) In Adrenal tumours it is seen
d) As as side effect of Digoxin it is
seen
e) Due to Neonatal mastitis need
further intervention
33.Regarding hypoglycaemia(2005)
a) In those with hyperinsulinaemia,
Ketone bodies are seen in the
urine
b) Islet cell hyperplasia is sen in the
rhesus hemolytic newborn
c) Is a manifestation of growth
hormone deficiency
d) Associated with IV quinine
e) Persistanthypoglycaemia treated
with Diazoxide
34.Congenital adrenal hyperplasia
of the salt loosing variety(2005)
a) Normal saline is used in initial
management
b) Fludricortizone needs in the
neonatal period is more than in
childhood

c) Hydrocortizone over replacement


can cause short stature
d) Serum rennin level is used to
asses the minerlocorticoid
adequacy
e) Increase K + occurs in day 2 of
life
35.Obesity(2005)
a) Has a retarded bone age
b) If associated with
acanthosisnigricans it is
associated with androgen excess
c) Is associated with metabolic
syndrome with insulin resistance
d) Is associated with non
alcoholicsteatohepatitis
e) BMI is the best way to measure
36.Following conditions can cause
delayed bone age(2005)
a) Malnutrition
b) Coeliac disease
c) Familial short stature
d) Untreated congenital adrenal
hyperplasia
e) Silver russels syndrome
37.21 (OH) deficiency with
ambiguous genitalia(2004)
a) XY Karyotype
b) Advanced bone age
c) Abdominal testis
d) Associated with decrease Na
e) Increase 17 (OH) in blood
38.Hyperinsulinaemia in the
fetus(2004)
a) Macrosomia
b) Surfactant deficiency
c) LBW
d) Hypertrophy of heart chambers
e) Catracts
39.Disproportionate short stature
seen in (2004)
a) Achondroplasia
b) Downs syndrome

c) Hypochondroplasia
d) Emotional deprivation
e) GH deficiency
40.Bone studies are needed to
investigate following(2004)
a) Rickets
b) Achondroplasia
c) Partial insensitivity to Androgen
d) Obesity
e) Delayed puberty
41.Juvenile onset Diabetese
Mellitus(2004)
a) Acanthosisnigricans common
b) Prednisolon prevents islet
antibodies formation in siblings
c) Increase insulin prior to a
surgery
d) Diets with Increase glycaemic
index will cause Increase glucose
in blood
e) Spontaneous recovery by adult
life
42.In puberty(2004)
a) Axillary hair appears before pubic
hair
b) Growth velocity is more than in
infancy
c) In females growth spurt proceeds
menarche
d) In males LH not needed for
spermatogenesis
e) GnRH pulsatile secretion initiates
menarche
43.True, False regarding calcium
metabolism

a) In
HypoparathyrodismintracerebralCa
occurs
b) In hypocalcaemia polyuria is a
feature
c) Ca compete with H+ to bind to
proteins
d) PTH inhibits osteoclastic activities
e) PTH stimulates 1 alpha
hydroxylation of 25(OH) D3 in the
Kidney
44.True ,False(2004)
a) GH causes hypogycaemia
b) Asprin poisoning causes
hypoglycaemia
c) Neonatal cholestatic jaundice will
cause Increase ALP
d) Captopril causes Decrease K+
e) Sterodis can be used for
refactoryhypogycaemia
45.W.O.T.F are true regarding simple
obesity (1999)
a) Associated with hypogonadism
b) Unlikely to lead to adulthood
obesity
c) Common in social class I than in V
d) Before puberty height is greter
than their peers
e) .? Calculation of I.V. fluids
46.Insulin resistance associated
with(1999)
a) Obesity
b) Stein Leventhel syndrome
c) Acanthosisnigricans