Professional Documents
Culture Documents
Disorders in Immunity
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 1. Remember
Learning Outcome: 16.01 Define immunopathology, and describe the two major categories of immune dysfunction.
Learning Outcome: 16.02 Identify the four major categories of hypersensitivity, or overreaction to antigens.
Section Number: 16.01
Topic: Hypersensitivities
2. Which is mismatched?
A. food allergy - type I hypersensitivity
B. poison ivy dermatitis - type IV hypersensitivity
C. serum sickness - type III hypersensitivity
D. transfusion reaction - type II hypersensitivity
E. hay fever - type IV hypersensitivity
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.02 Identify the four major categories of hypersensitivity, or overreaction to antigens.
Section Number: 16.01
Topic: Hypersensitivities
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 1. Remember
Learning Outcome: 16.02 Identify the four major categories of hypersensitivity, or overreaction to antigens.
Section Number: 16.01
Topic: Hypersensitivities
4. The study of diseases associated with excesses and deficiencies of the immune system is
A. humoralpathology.
B. hemopathology.
C. epidemiology.
D. immunopathology.
E. histopathology.
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 1. Remember
Learning Outcome: 16.01 Define immunopathology, and describe the two major categories of immune dysfunction.
Section Number: 16.01
Topic: Autoimmunity
Topic: Hypersensitivities
Topic: Immunodeficiency
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 1. Remember
Learning Outcome: 16.02 Identify the four major categories of hypersensitivity, or overreaction to antigens.
Section Number: 16.02
Topic: Hypersensitivities
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 1. Remember
Blooms Level: 2. Understand
Learning Outcome: 16.03 Summarize genetic and environmental factors that influence allergy development.
Section Number: 16.02
Topic: Hypersensitivities
7. Fungal spores and animal dander are considered to be which type of allergen?
A. ingestant
B. inhalant
C. injectant
D. contactant
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 1. Remember
Learning Outcome: 16.03 Summarize genetic and environmental factors that influence allergy development.
Section Number: 16.02
Topic: Hypersensitivities
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.04 Outline the steps of a type I allergic response, and discuss the effects on target organs and tissue.
Section Number: 16.02
Topic: Hypersensitivities
9. A second encounter with an allergen that causes a response is called the _____ dose.
A. sensitizing
B. provocative
C. allergic
D. hypersensitivity
E. desensitizing
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 1. Remember
Learning Outcome: 16.04 Outline the steps of a type I allergic response, and discuss the effects on target organs and tissue.
Section Number: 16.02
Topic: Hypersensitivities
10. What will be the immediate action of an allergen when it enters the body for a second
time?
A. degranulation
B. bonding of allergen to adjacent IgE binding sites on mast cells and basophils
C. binding of IgE by the Fc region to mast cells and basophils
D. histamine acts on smooth muscle
E. prostaglandins cause vasodilation and increased vascular permeability
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.04 Outline the steps of a type I allergic response, and discuss the effects on target organs and tissue.
Section Number: 16.02
Topic: Hypersensitivities
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.04 Outline the steps of a type I allergic response, and discuss the effects on target organs and tissue.
Section Number: 16.02
Topic: Hypersensitivities
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.04 Outline the steps of a type I allergic response, and discuss the effects on target organs and tissue.
Section Number: 16.02
Topic: Hypersensitivities
13. Which of the following is not a possible outcome of a type I hypersensitivity reaction?
A. rhinitis
B. rashes
C. sneezing
D. diarrhea
E. contact dermatitis
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 1. Remember
Learning Outcome: 16.02 Identify the four major categories of hypersensitivity, or overreaction to antigens.
Section Number: 16.02
Topic: Hypersensitivities
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.04 Outline the steps of a type I allergic response, and discuss the effects on target organs and tissue.
Section Number: 16.02
Topic: Hypersensitivities
15. The chemical mediator that causes prolonged bronchospasm, vascular permeability, and
mucus secretion of asthmatic patients is
A. prostaglandin.
B. histamine.
C. leukotriene.
D. serotonin.
E. platelet-activating factor.
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.04 Outline the steps of a type I allergic response, and discuss the effects on target organs and tissue.
Section Number: 16.02
Topic: Hypersensitivities
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.12 Identify commonalities and differences between type II and type III hypersensitivities.
Section Number: 16.03
Section Number: 16.04
Topic: Hypersensitivities
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.05 Identify three conditions caused by IgE-mediated allergic reactions.
Section Number: 16.02
Topic: Hypersensitivities
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.03 Summarize genetic and environmental factors that influence allergy development.
Section Number: 16.02
Topic: Hypersensitivities
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 1. Remember
Learning Outcome: 16.03 Summarize genetic and environmental factors that influence allergy development.
Section Number: 16.02
Topic: Hypersensitivities
20. A systemic, sometimes fatal, reaction with airway obstruction and circulatory collapse is
A. delayed.
B. T-cell-mediated.
C. atopic.
D. antibody-mediated.
E. systemic anaphylaxis.
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 1. Remember
Learning Outcome: 16.05 Identify three conditions caused by IgE-mediated allergic reactions.
Section Number: 16.02
Topic: Hypersensitivities
22. All of the following are associated with IgE and mast-cell-mediated allergy except
A. drug allergy.
B. eczema.
C. anaphylaxis.
D. allergic asthma.
E. systemic lupus erythematosus.
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.05 Identify three conditions caused by IgE-mediated allergic reactions.
Section Number: 16.02
Topic: Hypersensitivities
23. Epinephrine
A. is an antihistamine.
B. reverses constriction of airways.
C. causes desensitization.
D. inhibits the activity of lymphocytes.
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 1. Remember
Learning Outcome: 16.06 Describe the symptoms of anaphylaxis and link these to physiological events.
Section Number: 16.02
Topic: Hypersensitivities
24. Allergic patients receiving small, controlled injections of specific allergens are
undergoing
A. desensitization.
B. sensitization.
C. tissue matching.
D. degranulation.
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.08 Explain the mode of action of two strategies for treating and preventing type I allergic reactions.
Section Number: 16.02
Topic: Hypersensitivities
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.06 Describe the symptoms of anaphylaxis and link these to physiological events.
Section Number: 16.02
Topic: Hypersensitivities
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.08 Explain the mode of action of two strategies for treating and preventing type I allergic reactions.
Section Number: 16.02
Topic: Hypersensitivities
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 1. Remember
Learning Outcome: 16.08 Explain the mode of action of two strategies for treating and preventing type I allergic reactions.
Learning Outcome: 16.12 Identify commonalities and differences between type II and type III hypersensitivities.
Section Number: 16.03
Topic: Hypersensitivities
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 1. Remember
Learning Outcome: 16.09 List the three immune components causing cell lysis in type II hypersensitivity reactions.
Learning Outcome: 16.10 Explain the molecular basis for the ABO blood groups, and identify the blood type of a "universal donor" and the
blood type of a "universal recipient."
Section Number: 16.03
Topic: Hypersensitivities
29. The serum of a person with blood type A and Rh- will have the ability to make which of
the following antibodies?
A. anti-A and anti-Rh
B. anti-B and anti-Rh
C. anti-A
D. anti-B
E. anti-A, anti-B, and anti-Rh
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.10 Explain the molecular basis for the ABO blood groups, and identify the blood type of a "universal donor" and the
blood type of a "universal recipient."
Section Number: 16.03
Topic: Hypersensitivities
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.09 List the three immune components causing cell lysis in type II hypersensitivity reactions.
Learning Outcome: 16.10 Explain the molecular basis for the ABO blood groups, and identify the blood type of a "universal donor" and the
blood type of a "universal recipient."
Section Number: 16.03
Topic: Hypersensitivities
31. A person who produces anti-A and anti-B serum antibodies will have blood type
A. A.
B. B.
C. AB.
D. O.
E. Rh.
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 3. Apply
Learning Outcome: 16.10 Explain the molecular basis for the ABO blood groups, and identify the blood type of a "universal donor" and the
blood type of a "universal recipient."
Section Number: 16.03
Topic: Hypersensitivities
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.09 List the three immune components causing cell lysis in type II hypersensitivity reactions.
Learning Outcome: 16.10 Explain the molecular basis for the ABO blood groups, and identify the blood type of a "universal donor" and the
blood type of a "universal recipient."
Section Number: 16.03
Topic: Hypersensitivities
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 3. Apply
Learning Outcome: 16.11 Explain the role of Rh factor in hemolytic disease development and how the disease is prevented in newborns.
Section Number: 16.03
Topic: Hypersensitivities
34. The potential for hemolytic disease of the newborn occurs when
A. maternal Rh+ cells enter an Rh- fetus.
B. fetal Rh+ cells enter an Rh- mother.
C. maternal Rh- cells enter an Rh+ fetus.
D. fetal Rh- cells enter an Rh+ mother.
E. fetal Rh+ cells enter an Rh+ mother.
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.11 Explain the role of Rh factor in hemolytic disease development and how the disease is prevented in newborns.
Section Number: 16.03
Topic: Hypersensitivities
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.11 Explain the role of Rh factor in hemolytic disease development and how the disease is prevented in newborns.
Section Number: 16.03
Topic: Hypersensitivities
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.12 Identify commonalities and differences between type II and type III hypersensitivities.
Learning Outcome: 16.13 Describe the ways in which the Arthus reaction differs from serum sickness.
Section Number: 16.04
Topic: Hypersensitivities
37. Which of the following is not a target for immune complex deposition?
A. blood vessels and skin
B. heart and lungs
C. brain
D. joints
E. kidneys
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 1. Remember
Learning Outcome: 16.12 Identify commonalities and differences between type II and type III hypersensitivities.
Section Number: 16.04
Topic: Hypersensitivities
38. Large quantities of antibodies that react to the second entry of antigen and lead to
formation of antigen-antibody complexes occurs in
A. serum sickness.
B. delayed hypersensitivity.
C. anaphylaxis.
D. hemolytic disease of the newborn.
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.12 Identify commonalities and differences between type II and type III hypersensitivities.
Learning Outcome: 16.13 Describe the ways in which the Arthus reaction differs from serum sickness.
Section Number: 16.04
Topic: Hypersensitivities
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.14 Identify one type IV delayed hypersensitivity reaction, and describe the role of T cells in the pathogenesis of this
condition.
Section Number: 16.05
Topic: Hypersensitivities
40. What could result when grafted tissue such as bone marrow contains passenger
lymphocytes?
A. host rejection of graft
B. graft versus host disease
C. formation of autoantibodies
D. hypogammaglobulinemia
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.15 List four classes of grafts, and explain how host versus graft and graft versus host diseases develop.
Section Number: 16.05
Topic: Hypersensitivities
41. Tissue transplanted from one body site on a patient to a different body site on that patient
is called a/an
A. isograft.
B. autograft.
C. allograft.
D. xenograft.
E. hypograft.
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 1. Remember
Learning Outcome: 16.15 List four classes of grafts, and explain how host versus graft and graft versus host diseases develop.
Section Number: 16.05
Topic: Hypersensitivities
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.16 Outline at least three different explanations for the origin of autoimmunity.
Section Number: 16.06
Topic: Autoimmunity
43. Autoantibodies cause tissue injury in all of the following diseases except
A. rheumatoid arthritis.
B. myasthenia gravis.
C. Graves' disease.
D. tuberculin reaction.
E. multiple sclerosis.
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 1. Remember
Learning Outcome: 16.17 List three autoimmune diseases, and immunologic features common to all.
Section Number: 16.06
Topic: Autoimmunity
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 1. Remember
Learning Outcome: 16.16 Outline at least three different explanations for the origin of autoimmunity.
Learning Outcome: 16.17 List three autoimmune diseases, and immunologic features common to all.
Section Number: 16.06
Topic: Autoimmunity
45. Myasthenia gravis disease arises from the production of autoantibodies against
A. myelin sheath cells of the nervous system.
B. acetylcholine receptors on smooth muscle.
C. acetylcholine receptors on skeletal muscle.
D. sodium pump proteins in the cell membrane.
E. cells in thyroid follicles.
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.17 List three autoimmune diseases, and immunologic features common to all.
Section Number: 16.06
Topic: Autoimmunity
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.17 List three autoimmune diseases, and immunologic features common to all.
Section Number: 16.06
Topic: Autoimmunity
47. Which of the following is not a theory to explain the origin of autoimmune diseases?
A. sequestered antigen theory
B. forbidden clone theory
C. molecular mimicry theory
D. theory of bystander effect
E. All the choices are currently being investigated as possible explanations.
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.16 Outline at least three different explanations for the origin of autoimmunity.
Section Number: 16.06
Topic: Autoimmunity
48. What can be a consequence of a genetic deficiency in B-cell survival and maturity?
A. host rejection of graft
B. graft versus host disease
C. formation of autoantibodies
D. hypogammaglobulinemia
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.18 Distinguish between primary and secondary immunodeficiencies, explaining how each develops.
Section Number: 16.07
Topic: Immunodeficiency
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 1. Remember
Learning Outcome: 16.18 Distinguish between primary and secondary immunodeficiencies, explaining how each develops.
Section Number: 16.07
Topic: Immunodeficiency
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
Blooms Level: 2. Understand
Learning Outcome: 16.18 Distinguish between primary and secondary immunodeficiencies, explaining how each develops.
Learning Outcome: 16.19 Define severe combined immunodeficiency, and discuss current therapeutic approaches to this type of disease.
Section Number: 16.07
Topic: Immunodeficiency
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 1. Remember
Learning Outcome: 16.18 Distinguish between primary and secondary immunodeficiencies, explaining how each develops.
Learning Outcome: 16.20 List three conditions that can lead to the development of secondary immunodeficiency diseases.
Section Number: 16.05
Topic: Hypersensitivities
52. All of the following can result in acquired immune deficiency except
A. malnutrition.
B. stress.
C. pregnancy.
D. bacterial infection.
E. radiation treatment.
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.20 List three conditions that can lead to the development of secondary immunodeficiency diseases.
Section Number: 16.07
Topic: Immunodeficiency
53. In the theory for allergic desensitization, which immunoglobulin blocks the allergen from
binding with IgE?
A. IgE
B. IgG
C. IgA
D. IgD
E. IgM
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.08 Explain the mode of action of two strategies for treating and preventing type I allergic reactions.
Section Number: 16.01
Topic: Hypersensitivities
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.04 Outline the steps of a type I allergic response, and discuss the effects on target organs and tissue.
Section Number: 16.03
Topic: Hypersensitivities
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 1. Remember
Learning Outcome: 16.06 Describe the symptoms of anaphylaxis and link these to physiological events.
Section Number: 16.03
Topic: Hypersensitivities
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 1. Remember
Learning Outcome: 16.04 Outline the steps of a type I allergic response, and discuss the effects on target organs and tissue.
Learning Outcome: 16.05 Identify three conditions caused by IgE-mediated allergic reactions.
Section Number: 16.03
Topic: Hypersensitivities
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 1. Remember
Learning Outcome: 16.05 Identify three conditions caused by IgE-mediated allergic reactions.
Section Number: 16.03
Topic: Hypersensitivities
58. A person who is Rh- will have anti-Rh antibodies in his/her serum from early infancy.
FALSE
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.11 Explain the role of Rh factor in hemolytic disease development and how the disease is prevented in newborns.
Section Number: 16.04
Topic: Hypersensitivities
59. The tuberculin reaction develops within 30 minutes of the skin test in people with prior
sensitization due to tuberculosis infection.
FALSE
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 1. Remember
Learning Outcome: 16.03 Summarize genetic and environmental factors that influence allergy development.
Learning Outcome: 16.14 Identify one type IV delayed hypersensitivity reaction, and describe the role of T cells in the pathogenesis of this
condition.
Section Number: 16.05
Topic: Hypersensitivities
60. During graft rejection, cytotoxic T cells of the recipient recognize and respond to foreign
class I MHC receptors on the grafted cells.
TRUE
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.15 List four classes of grafts, and explain how host versus graft and graft versus host diseases develop.
Section Number: 16.06
Topic: Hypersensitivities
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 1. Remember
Learning Outcome: 16.03 Summarize genetic and environmental factors that influence allergy development.
Section Number: 16.03
Topic: Hypersensitivities
62. A xenograft is graft tissue from a donor of one species transplanted to a recipient of
another species.
TRUE
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 1. Remember
Learning Outcome: 16.15 List four classes of grafts, and explain how host versus graft and graft versus host diseases develop.
Section Number: 16.05
Topic: Hypersensitivities
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 1. Remember
Learning Outcome: 16.17 List three autoimmune diseases, and immunologic features common to all.
Section Number: 16.06
Topic: Autoimmunity
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 1. Remember
Learning Outcome: 16.17 List three autoimmune diseases, and immunologic features common to all.
Section Number: 16.06
Topic: Autoimmunity
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 1. Remember
Learning Outcome: 16.18 Distinguish between primary and secondary immunodeficiencies, explaining how each develops.
Section Number: 16.07
Topic: Immunodeficiency
66. AIDS is a secondary immunodeficiency disease that affects several types of immune
cells.
TRUE
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 1. Remember
Learning Outcome: 16.20 List three conditions that can lead to the development of secondary immunodeficiency diseases.
Section Number: 16.07
Topic: Immunodeficiency
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 3. Apply
Learning Outcome: 16.06 Describe the symptoms of anaphylaxis and link these to physiological events.
Section Number: 16.03
Topic: Hypersensitivities
68. John, a Peace Corps worker in the country of Mali in Africa, was in a car accident while
traveling through a rural area. He was treated at a tiny rural hospital, and due to his loss of
blood required a transfusion. John is B- blood type and has never received a transfusion
before. Which statement is correct regarding this scenario?
A. He can safely receive O- blood even though he makes anti-A antibodies.
B. He can be give types O or B, no matter whether Rh- or Rh+. At this point in time, he does
not have anti-Rh antibody. O has no antigens on the blood cells, so he is also safe to receive
that type in addition to his own B type.
C. He can be given A+ blood type, in addition to B+. Rh- means that he makes no antibody
to Rh.
D. The preferred blood type to give John, in addition to his own B type blood, would be AB.
Both types of blood have the B antigen on the cells, so they would correspond to his own
antigens. As for Rh, he can receive only Rh- blood since he would have a reaction against Rh
+.
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 4. Analyze
Learning Outcome: 16.10 Explain the molecular basis for the ABO blood groups, and identify the blood type of a "universal donor" and the
blood type of a "universal recipient."
Section Number: 16.03
Topic: Hypersensitivities
69. You have a dermatitis related to a particular material in your socks. Your feet are covered
with a really itchy rash, which has developed blisters over the last day or so. You had first
worn them 2 to 3 days ago, and you did not launder them after buying them at the store.
Finding some anti-histamine medication in your bathroom cabinet, you decide to take it to
relieve the itching rash believing:
A. The rash will go away because the anti-histamine neutralizes the histamine chemicals
coming from mast cells in your skin.
B. The anti-histamine will make the rash worse. The anti-histamine chemical in the
medication reacts with chemicals release by the lymphocytes in your skin, creating a much
worse reaction.
C. The anti-histamine will have no effect on the rash because histamine is not the chemical
mediator in this hypersensitivity.
D. The anti-histamine will have no effect because once a type I hypersensitivity kicks in, it
will last for a few days.
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 3. Apply
Learning Outcome: 16.14 Identify one type IV delayed hypersensitivity reaction, and describe the role of T cells in the pathogenesis of this
condition.
Section Number: 16.05
Topic: Hypersensitivities
Ranking Questions
70. Place these events in the pathogenesis of contact dermatitis in order, with 1 being the first step.
1 chemical absorbed through skin
2 antigen identified by dendritic cell
4 cytokine chemicals attract macrophages, dendritic cells, and cytotoxic T lymphocytes to site of antigen
3 sensitized T lymphocytes recognize antigen and make cytokine chemicals
5 chemicals released from phagocytic cells and cytotoxic T cells, resulting in host tissue damage
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 2. Understand
Learning Outcome: 16.14 Identify one type IV delayed hypersensitivity reaction, and describe the role of T cells in the pathogenesis of this
condition.
Section Number: 16.05
Topic: Immunodeficiency
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 3. Apply
Learning Outcome: 16.13 Describe the ways in which the Arthus reaction differs from serum sickness.
Section Number: 16.04
Topic: Hypersensitivities
72. In the situation of systemic lupus erythematosis (called lupus), complexes of antibody and
antigen form and these immune complexes insert themselves into small blood vessels, joints,
heart, and kidney, causing damage to the organ tissue. The course of the disease is
unpredictable, with periods of illness alternating with remissions. How is lupus, a type III
hypersensitivity, similar to infectious allergy, a type IV hypersensitivity reaction?
A. The mechanism of both lupus and infectious allergy involve large amounts of
inflammatory chemicals released into tissue.
B. Both lupus and infectious allergy involve large amounts of antibody production.
C. Both lupus and infectious allergy are immediate-type hypersensitivities, occurring within a
few hours.
D. Both lupus and infectious allergy have IgE in their mechanisms.
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 4. Analyze
Learning Outcome: 16.12 Identify commonalities and differences between type II and type III hypersensitivities.
Learning Outcome: 16.14 Identify one type IV delayed hypersensitivity reaction, and describe the role of T cells in the pathogenesis of this
condition.
Section Number: 16.04
Section Number: 16.05
Topic: Hypersensitivities
73. Many men make antibodies to sperm, resulting in destruction of sperm to the point of
sterility. What would be the likely origin of this autoimmune disease?
A. Since sperm are not made until after puberty, the immune system cannot scan the antigens
on the sperm for immune tolerance. After sperm are made and the immune system sees them,
they are recognized as foreign.
B. Antigens on sperm cells are similar to antigens on a variety of bacteria, like Streptococcus.
After a strep throat, caused by Streptococcus, the immune system produces antibodies to
streptococcal antigens, which then cross react with sperm antigens, destroying them.
C. T helper cells erroneously identify sperm cells as foreign invaders, triggering the T
cytotoxic cells to start killing sperm.
D. These antibodies are produced as a result of mutations in T lymphocytes, causing them to
make large amounts of antibody.
ASM Objective: 05.04 Microorganisms, cellular and viral, can interact with both human and nonhuman hosts in beneficial, neutral or
detrimental ways.
ASM Topic: Module 05 Systems
Blooms Level: 4. Analyze
Learning Outcome: 16.17 List three autoimmune diseases, and immunologic features common to all.
Section Number: 16.06
Topic: Autoimmunity