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RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES,

KARNATAKA,BANGALORE
COMPLETED PROFORMA FOR REGISTRATION OF
SUBJECT FOR DISSERTATION

AN EXPERIMENTAL EVALUATION OF ROLE OF ANUPANA IN THE


PURGATIVE ACTION OF ICCHABHEDI RASA

BY
Dr. SWETHA S.
M.D. (Ayu) Scholar
Dept. of Post Graduate Studies in Rasashastra
S.D.M College of Ayurveda, Udupi.
GUIDE
Dr. SUJATHA K.
M.D. (Ayu)
Assistant Professor
Dept. Of PG Studies in Rasashastra and Bhaishajya kalpana
S.D.M College Of Ayurveda, Udupi.
Co- Guide
Dr. SUDHEENDRA.V.HONAWAD
M.D. (Ayu)
Lecturer
Dept. Of PG studies in Rasa shastra and Bhaishajya kalpana
S.D.M College of Ayurveda, Udupi.
2010-2011
S.D.M College of Ayurveda
Kuthpady, Udupi.

From,
Dr. SWETHA S.
M.D. Scholar,
Dept. of Post Graduate Studies in Rasashastra,
S.D.M College of Ayurveda ,
Kuthpady, Udupi-574118.
To,
THE REGISTRAR,
Rajiv Gandhi University of Health Sciences,
Karnataka, Bangalore.
Through,
The Principal and H.O.D of Rasashatra Dept.
S.D.M College of Ayurveda,
Kuthpady, Udupi.
Respected Sir,
Sub: Submission of completed Proforma for registration of subject Of
dissertation
I request you kindly register the below mentioned subject which has been
reviewed and clarified, against my name for the submission of the
dissertation to the Rajiv Gandhi university of Health Sciences, Bangalore,
for the partial fulfillment of M.D. (Ayu) in Rasashastra.

TITLE OF DISSERTATION
AN EXPERIMENTAL EVALUATION OF ROLE OF ANUPANA IN THE
PURGATIVE ACTION OF ICCHABHEDI RASA.
Here with, I am enclosing the completed Performa for the registration of Subject
of dissertation.
Thanking you,

Place: Udupi

Yours faithfully

Date:
[Dr. SWETHA S.]

1) Name of the candidate

Dr. SWETHA S.
M.D. (AYU) SCHOLAR
DEPT. OF P.G. STUDIES IN
RASASHASTRA
S.D.M. COLLEGE OF AYURVEDA

2) Permanent Address

D/O R. SRINIVASA
PULIOBAREDDIHALLI
G.MARANDAHALLI POST, VIA
NANGALI, MULBAGAL TALUK
KOLAR DISTRICT-563131
KARNATAKA

3) Name of Institution

S.D.M. COLLEGE OF AYURVEDA


KUTHPADY, LAXMINARAYANA
NAGARA, UDUPI-574118
KARNATAKA

4) Course of study & Subject

M.D. (Ayu) IN RASASHASTRA

5) Date of admission of course

11th OCTOBER 2010

6) Title of the topic

AN EXPERIMENTAL EVALUATION OF ANUPANA IN THE


PURGATIVE ACTION OF ICCHABHEDI RASA.

6) Brief Resume of Intended Work:

6.1) Need for the study:


Anupana is the drug which is administered along with or after
the intake of the main active drug. Just as the oil spreads quickly
when put into water, similarly the quick absorption and assimilation
of the medicine in the body is facilitated due to the addition of
anupana1.
Anupana also helps in increasing the palatability, in changing the
physical form, in disintegration, dissolution, absorption and
reduction of gastric irritation of the main drug. As the same drug is
indicated in different diseases by changing the Anupana
accordingly, this indicate the site specific drug delivery2.
Purgative is a drug which promotes defecation and is used in the
treatment of constipation. Icchabedi rasa is a drastic purgative
indicated in diseases like Jalodara, Gulma, Ajeerna etc., for the
purpose of Kaya shodhana in the form of Virechana. It is specified
to administer with Sheethajala as Anupana and is also said that
intake of Ushnajala stops the purgative action of the drug3.
Considering the above factors, the study is planned in order to
evaluate the role of Anupana in the purgative action of Icchabhedi
rasa.

6.2) Review of literature


1. Anupana is the drug which is administered along with the main
active drug to
obtain better therapeutic efficacy is mentioned in Rasatarangini 2
.
2. Anupana facilitates quick absorption and assimilation of the
main active drug
similar to quick spread of water in oil is mentioned in
Sharangadara Samhitha1.
3. Icchabhedi rasa is a drastic purgative indicated in diseases like
Jalodara, Gulma,
Ajeerna etc., with Sheetajala as Anupana is mentioned in
Bhaishajya Ratnavali3.
4. Intake of Ushnajala stops the purgative action of the Icchabhedi
rasa is mentioned
in Bhaishajya Ratnavali3.

6.3) Previous works done:


1. Dr. Rana Sushil(1998), National Institute of Ayurveda, Rajasthan
University,
Jaipur, has worked on the topic Gridhrasi roga mein rasnadi
guggulu ka anupana
bheda se chikitsatmaka adhyayana6.
2. Dr. Vijaya Vargeeya. A.M(1999), Institute for Post Graduate
Teaching and
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Research in Ayurveda, Gujarath Ayurveda University, Jamnagar,


has worked on
the topic Anupana evam Sahapana ka Saiddhantika aur
Prayogika Adhyayana6.
3. Dr. Sandhya D S (2003), S D M College of Ayurveda, Rajiv Gandhi
University,Karnataka, has worked on the topic A comprehensive
clinical study of
Anupana in the management of Shukra Dushti vis--vis
Oligozoospermia6.
4. Dr. Rajiv (2008), JSS Ayurvedic medical college, Mysore, Rajiv
Gandhi
University, Karnataka, has worked on the topic Pharmaco
analytical study on
Icchabhedi rasa.

6.4) Objective of the study:


1.

To do comprehensive literary review of Anupana and Icchabhedi


rasa.

2. To prepare Icchabhedi rasa as explained in Bhaishajya Ratnavali.


3. To do physico-chemical analysis of Icchabhedi rasa.
4. To evaluate the role of Sheethajala and Ushnajala as Anupana in the
purgative action of Icchabhedi rasa.

7) Materials & Method


7.1) Source of Data:
[A] Literary source:
Literary source will be collected from Ayurvedic classical textbooks,
relevant
modern texts and research literature.
[B] Medicinal source:
1. Raw drug for the preparation of Icchabhedi rasa will be collected from
S.D.M
Pharmacy, Udupi.
2. Preparation of Icchabhedi rasa will be carried out in S.D.M Pharmacy,
Udupi.

[C] Analytical source:


The samples of Icchabhedi rasa will be subjected to Organoleptic
characters, PhysicoChemical parameters, Chromatography in SDM Centre for Research
in Ayurveda and
Allied Sciences, Udupi.
[D] Sample source for experimental Study:
Albino rats will be taken randomly from SDMCA Animal house for the
study and
grouped into 4, each group consisting of 6 rats.

7.2) Experimental Study


1

Sample

24 albino rats of either sex will be selected


randomly.

Inclusion Criteria

Exclusion Criteria

(1) Healthy albino rats of either sex will be


considered
(2) Weighing about 150-200gms
1. Less than 150gms-more than 200gms.
2. Pregnant and diseased rats
3. Rats which are under trial of other
experiments
Each group having 6 rats and will be kept in
separate cages.
Group(1)-Control Group(without any medicine)
Group(2)Icchabhedi
rasa
with
suitable
suspension.
Group(3)- Icchabhedi rasa with Sheetha jala as
Anupana.
Group(4)- Icchabhedi rasa with Ushna jala as
Anupana.

Grouping

Intervention

6
7
8

Mode
Administration
Duration
Method

Materials used

Comparison

Rat dose will be calculated on the basis of


Human dose by using Standard Conversion
Method.
of Oral
Single dose study
Standard protocol for assessment of Laxatives
and Purgatives.
Metabolic cages, filter paper, biochemical
microscope.
All Groups are compared
6

0
1
1
1
2

Assessment
Criteria
Statistical Analysis

Consistency and Frequency of stools, Weight of


stools in 24 hour collection, Intestinal motility
test, Diarrhoea free period
ANOVA-one way

7.3) Does the study require any investigation or any intervention to be conducted
On Patient or other humans or animals:
Yes-Since this is an experimental study on Albino rats of either sex
that are
maintained on Standard Laboratory, Foods and Water.

7.4) Has ethical clearance been obtained from your institution?


Yes-Concurrence has been obtained from the Ethical Committee of
S.D.M.C.A, Udupi.

8) List OF REFERENCES:1. Sharangadara, Sharangadara Samhitha: with Deepika and Gudartha


Deepika
Commentary, 5th edition, Varanasi: Chaukambha Orientalia; 2002
Pp 398 P-178.
2. Sharma Sadanand, Rasatarangini: with Prasadini Samskrita Commentary
and Rasa Vijnana Hindi Commentary, 11th edition, Delhi: Motilal
Banarsidasa ; 1979
Pp 772 P-143.
3. Govindadasa, Bhaishajya Ratnavali: with Vidyotini Hindi Commentary,
Varanasi:
Choukambha Samskritha Samstana; 2002 Pp 891 P-472.
4. Sharma Sadanand, Rasatarangini : Prasadini Samskrita Commentary and
Rasa Vijnana Hindi
Commentary, 11th edition, Delhi: Motilal Banarasidas ; 1979 Pp 772 P-78,
318, 176,704.
5. Dr. Lohar and Ravindra Singh: Quality control manual for Ayurvedic, Siddha
and Unani medicine, Ghaziabad: Department of Ayush, Ministry of Health
and Family
welfare Pharmacopeial laboratory for Indian Medicine; 2008 Pp-71 P-11.
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6. Bhagel M S, Research in Ayurveda: 2nd edition, Jamnagar: Mridu Ayurvedic


publication and
Sales; 2005 Pp 381 P-119, 22, 202.

9.0) Signature of the candidate

10.0) Remarks of the guide

11.0) Name and Designation

11.1) Guide

Dr. SUJATHA K.
M.D. (AYU)
ASSISTANT PROFESSOR
DEPT. OF PG STUDIES
RASASHASTRA
S.D.M.C.A., UDUPI.

11.2) Signature
11.3) Co-Guide

:
:

Dr. SUDHEENDRA.V.HONAWAD
M.D. (AYU)
LECTURER
DEPT. OF PG STUDIES
RASASHASTRA
S.D.M.C.A., UDUPI.

11.4) Signature

11.5) Head of the Department

Dr. PRABHAKARA UPADHYAYA


RENJAL
M.D. (AYU)
PROFESSOR & H.O.D
DEPT. OF PG STUDIES
RASASHASTRA
S.D.M.C.A., UDUPI.

11.6) Signature

:
8

11.7) Remarks of the Chairman


and Principal

11.8) Signature