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Curriculum vitae

Name
Nationality
Date of Birth
Place of Birth

Dietlind Zohlnhfer-Momm, M.D.


German
June 08, 1969
Freiburg im Breisgau., Germany

Academic Career
1988-1990

Rheinisch-Westflische Technical University of Aachen,


Germany, study of Medicine

1991-1995

Technical University Munich, Germany, study of Medicine

1990-1991

Experimental doctoral work at the Institute of Biochemistry


(Director: Professor Dr. Peter C. Heinrich) at the RheinischWestflische Technical University of Aachen, Germany,
Title: The hepatic interleukin-6 receptor: impact and regulation
of the -subunit

December 1996

Receival of M.D. (summa cum laude) in Medicine from the


Rheinisch- Westflische Technical University of Aachen,
Germany

November 2003

Habilitation in Internal Medicine at the Faculty of Medicine of


Technical University Munich, Germany

October 2008

Professorship for Regenerative and Interventional Cardiology at


Medizinsche Klinik II - Kardiologie und Pulmologie, Campus
Benjamin Franklin, Charit - Universittsmedizin Berlin,
Germany

Professional Training
1/96-6/1997

Residency at the I. Medical Clinic/Deutsches Herzzentrum


(German Heart Center), Technical University Munich, Germany

7/1998-6/1999

Internship at the I. Medical Clinic/Deutsches Herzzentrum,


Technical University Munich, Germany

7/98-12/1998

Scientific work at the Gene Center, Martinsried, Germany, in


the laboratory of Prof. Dr. Michael Meisterernst

1/99-10/2000

Postdoctorate at Micromet AG, Martinsried, Germany, in the


laboratory of Prof. Dr. Patrick A. Baeuerle

10/2000-05/2004

Internship at the I. Medical Clinic/Deutsches Herzzentrum,


Technical University Munich, Germany

Priv.-Doz. Dr. med. Dietlind Zohlnhfer

05/2004-06/2006

Consultant at the I. Medical Clinic/Deutsches Herzzentrum,


Technical University Munich, Germany

07/2006-09/2008

Deputy (Oberrztin) at I. Medical Clinic/Deutsches


Herzzentrum, Technical University Munich, Germany
Deputy (Oberrztin) and Professor for Regenerative and
Interventional Cardiology at Medizinsche Klinik II Kardiologie und Pulmologie, Campus Benjamin Franklin
Charit - Universittsmedizin Berlin, Germany

Since 10/2008

Main Focus in clinical field


Interventional cardiology, intensive care medicine, cell-based therapies after myocardial
infarction, new options for the treatment of coronary atherosclerotic lesions and restenosis
after percutaneous coronary intervention

Stipends and Awards


June 1997

Award of the Borchers-Plakette of Rheinisch-Westflische


Technical University of Aachen, Germany

November 1997

Friedrich-Wilhelm-Award of Rheinisch-Westflischen
Technical University of Aachen, Germany

October 2002

Hermann Rein-Award of Deutsche Gesellschaft fr


Mikrozirkulation und Vaskulre Biologie

Jan. 1999 - Oct. 2000

Postdoctoral stipend from Deutsche Forschungsgemeinschaft,


Bonn, Germany (Zo 104/1-1)

Jan. 2002- Dec. 2005

Research grant by Deutsche Forschungsgemeinschaft, Bonn,


Germany (Zo 104/2-1)

Jan 2005 - Dec. 2006

Research grant by Deutsche Forschungsgemeinschaft, Bonn,


Germany (Zo 104/2-2)

since 2002

Research grant within the Graduiertenkolleg 438 of Deutsche


Forschungsgemeinschaft, Bonn, Germany

since 01/ 2009

Research grant by Deutsche Forschungsgemeinschaft, Bonn,


Germany (Zo 104/4-1)

Patents

Globale Genexpressionsanalyse einzelner Zellen / mRNA


Amplification
Europische Patentanmeldung 3/2000 EP 00106450.0
International 3/2001 PCT/EP01/03311
Identifizierung der pathophysiologischen Relevanz von IFN-
fr die Entwicklung der Restenose im Menschen

Priv.-Doz. Dr. med. Dietlind Zohlnhfer

Europische Patentanmeldung 3/2000 EP 00106468.2


International 3/2001 PCT/EP01/03312

Research Training
1990-1991

Experimental doctoral work at the Institute of Biochemistry


(Director: Professor Dr. Peter C. Heinrich) at the RheinischWestflische Technical University of Aachen, Germany,
Title: The hepatic interleukin-6 receptor: impact and regulation
of the -subunit(Grade: 1.0; summa cum laude)

01/96-06/1997

Experimental research work in the group of Prof. Dr. F.-J.


Neumann investigating the molecular mechanisms of the
interaction between vascular cells governing an inflammatory
response
I. Medizinische Klinik/Deutsches Herzzentrum, Technische
Universitt Mnchen, Germany

7/98-12/1998

Scientific work at the Gene Center, Martinsried, Germany, in


the laboratory of Prof. Dr. Michael Meisterernst

1/99-10/2000

Postdoctorate at Micromet AG, Martinsried, Germany, in the


laboratory of Prof. Dr. Patrick A. Baeuerle

Since 10/2001

Group leader within the department of Experimental Cardiology


at the German Heart Centre Munich

Topics of previous research focuses


1.
2.
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Identification of cardiovascular candidate genes by cDNA array technology


Role of the TH1 immune response (IFNsignal cascade CXCR3 chemokine axis)
in cardiovascular diseases
Identification of novel therapeutic option for restenosis after percutaneous coronary
interventions by gene expression analysis
Effect of sirolimus and Imatinib on molecular mechanisms of vasoproliferative
disease, in particular on mechanisms of progenitor cell recruitment
Effect of the tyrosine kinase inhibitor imatinib or of an oral sirolimus therapy
regimen on restenosis prevention in patients
Effect of stem cell mobilization by Granulocyte-Colony Stimulating Factor (GCSF) in patients with acute myocardial infarction

Topics current research focuses


1.

Meaning of the mTOR kinase in mitochondrial dysfunction in cardiovascular


disease such as atherosclerosis and myocardial infarction

Priv.-Doz. Dr. med. Dietlind Zohlnhfer

2.
3.
4.
5.
6.

Meaning of the CXCR3 chemokine axis on progenitor cell recruitment, in


particular on mechanisms of the recruitment of endothelial progenitor cells in
cardiovascular disease
Clarification of the role of bone marrow-derived stem cells for cardiovascular
disease
Effect of bone marrow transplantation from mice with a genetically determined low
risk for neointima formation into mice with a genetically determined high risk for
neointima formation and vice versa
Effect of stem cell mobilization by Erythropoietin in patients with acute myocardial
infarction
Role of CCR10 in cardiovascular disease (in cooperation with Professor Dr. H
Pavenstdt, Director of the Medizinische Klinik D, University of Mnster)

International connections and cooperations


1.

2.

Cooperation with Matthias A. Clauss, MD, Indiana Center for Vascular Biology &
Medicine, Indianapolis, USA regarding the role of the CXCR3 chemokine EMAPII in cardiovascular disease, particular in the recruitment and differentiation of
endothelial progenitor cells
Multiple cooperation within the WP7 of the Cardiogenics Proposal FP6-2005th
LIFESCIHEALTH-6 (LSH-2005-2.1.1-1)(No. 037593) of the 6 Framework
Programme on Research, Technological Development and Demostration of the
European Commision

Major Achievements
First transcriptome analyses in human restenosis, hibernating myocardium and
ruptured plaques
Identification of interferon and the TH1 immune response as culprit in restenosis
Identification of new therapeutic options for the treatment of restenosis (sirolimus)
First proof that stem cell mobilization with G-CSF does not have any benefit in
patients with acute myocardial infarction

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Publications
1.

Zohlnhfer,D., Graeve,L., Rose-John,S., Schooltink,H., Dittrich,E., Heinrich,P.C. (1992). The hepatic


interleukin-6 receptor: down-regulation of the interleukin-6 binding subunit (gp80) by its ligand. FEBS
306, 219-222.

2.

Pietzko,D., Zohlnhfer,D., Graeve,L., Fleischer,D., Stoyan,T., Schooltink,H., Rose-John,S.,


Heinrich,P.C. (1993). The hepatic interleukin-6 receptor: studies on structure and regulation by phorbol
12-myristate 13-acetate and dexamethasone. J. Biol. Chem. 268, 4250-4258.

3.

Marx,N., Neumann,F.-J., Zohlnhfer,D., Dickfeld,T., Fischer,A., Heimerl,S., Schmig,A. (1998).


Enhancement of monocyte procoagulant activity by adhesion on vascular smooth muscle cells and
ICAM-1 transfected CHO-cells. Circulation 98, 906-911

Priv.-Doz. Dr. med. Dietlind Zohlnhfer


4.

Gawaz,M., Ruf,A., Neumann,F.-J., Pogatsa-Murray,G., Dickfeld,T., Zohlnhfer,D., Schomig,A. (1998).


Effect of glycoprotein IIb-IIIa receptor antagonism on platelet membrane glycoproteins after coronary
stent placement. Thromb Haemost 80, 994-1001.

5.

Neumann,F.-J., Zohlnhfer,D., Fakhoury,L., Ott,I., Gawaz,M., Schomig,A.(1999). Effect of


glycoprotein IIb/IIIa receptor blockade on platelet-leukocyte interaction and surface expression of the
leukocyte integrin Mac-1 in acute myocardial infarction. J Am Coll Cardiol. 34, 1420-1426.

6.

Zohlnhfer,D., Brand,K., Schipek,K., Pogatsa-Murray,G., Schmig,A., and Neumann,F.J. (2000).


Adhesion of monocyte very late antigen-4 to endothelial vascular cell adhesion molecule-1 induces
interleukin-1beta-dependent expression of interleukin-6 in endothelial cells. Arterioscler. Thromb.
Vasc. Biol. 20, 353-359.

7.

Zohlnhfer,D., Klein,C.A., Richter,T., Brandl,R., Murr,A., Nhrenberg,T., Schmig,A., Baeuerle,P.A.,


and Neumann,F.J. (2001a). Gene expression profiling of human stent-induced neointima by cDNA
array analysis of microscopic specimens retrieved by helix cutter atherectomy: Detection of FK506binding protein 12 upregulation. Circulation 103, 1396-1402.

8.

Zohlnhfer,D., Richter,T., Neumann,F.J., Nhrenberg,T., Wessely,R., Brandl,R., Murr,A., Klein,C.A.,


and Baeuerle,P.A. (2001b). Transcriptome Analysis Reveals a Role of Interferon- in Human Neointima
Formation. Mol. Cell 1059-1069.

9.

Massberg S, Gawaz M, Gruner S, Schulte V, Konrad I, Zohlnhfer D, Heinzmann U, Nieswandt B


(2003). A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo. J
Exp Med 197(1):41-9.

10. Klein CA, Zohlnhfer D, Petat-Dutter K, Wendler N (2003). Gene expression analysis of a single or
few cells. Curr Protoc Mol Biol. 2003 Feb ;Chapter 25:Unit 25B.8.
11. Zohlnhfer D, Nhrenberg TG, Neumann FJ, Richter T, May AE, Schmidt R, Denker K, Clauss MA,
Schomig A, Baeuerle PA (2004). Rapamycin effects transcriptional programs in smooth muscle cells
controlling proliferative and inflammatory properties. Mol Pharm 65(4):880-9.
12. Hausleiter J, Kastrati A, Mehilli J, Vogeser M, Zohlnhfer D, Schuhlen H, Goos C, Pache J, Dotzer F,
Pogatsa-Murray G, Dirschinger J, Heemann U, Schmig A (2004). Randomized, double-blind, placebocontrolled trial of oral sirolimus for restenosis prevention in patients with in-stent restenosis: the Oral
Sirolimus to Inhibit Recurrent In-stent Stenosis (OSIRIS) trial. Circulation 17;110(7):790-5
13. Nhrenberg TG, Voisard R, Fahlisch F, Rudelius M, Braun J, Gschwend J, Kountides M, Herter T,
Baur R, Hombach V, Baeuerle PA, Zohlnhfer D (2005). Rapamycin Attenuates Vascular Wall
Inflammation and Progenitor Cell Promoters after Angioplasty. FASEB J. 19(2):246-8
14. Gick M, Jander N, Bestehorn H-P, Kienzle R-P, Ferenc M, Werner K, Comberg T, Peitz K, Zohlnhfer
D, Bassignana V, Buettner HJ, Neumann F-J (2005). A Randomized Evaluation of the Effects of FilterBased Distal Protection on Myocardial Perfusion and Infarct Size After Primary Percutaneous Catheter
Intervention in Myocardial Infarction With and Without ST-Elevation. Circulation 6;112(10):1462-9.
15. Ott I, Michaelis C, Schuermann M, Steppich B, Seitz I, Dewerchin M, Zohlnhfer D, Wessely R,
Rudelius M, Schmig A, Carmeliet P. (2005). Vascular remodeling in mice lacking the cytoplasmic
domain of tissue factor. Circ Res. 5;97(3):293-8.
16. Zohlnhfer D, Hausleiter J, Kastrati A, Mehilli J, Goos C, Schhlen H, Pache J, Pogatsa-Murray G,
Dirschinger J, Schmig A (2005). A Randomized, Double-blind, Placebo-controlled Trial on Restenosis
Prevention by the Receptor Tyrosine Kinase Inhibitor Imatinib. J Am Coll Cardiol. 46(11):1999-2003.
17. Klein CA, Zohlnhfer D, Petat-Dutter K, Wendler N.(2005). Gene expression analysis of a single or
few cells.Curr Protoc Hum Genet;Chapter 11:Unit 11.8.

Priv.-Doz. Dr. med. Dietlind Zohlnhfer


18. Zohlnhfer D, Ott I, Mehilli J, Schmig K, Michalk F, Ibrahim T, Meisetschlger G, von Wedel J,
Bollwein H, Seyfarth M, Dirschinger J, Schmitt C, Schwaiger M, Kastrati A, Schmig A for the
REVIVAL-2 Study Investigators (2006). A Randomized Clinical Trial of Stem Cell Mobilization by
Granulocyte-Colony Stimulating Factor in Patients With Acute Myocardial Infarction, JAMA
295(9):1003-10.
19. Massberg S, Konrad I, Schurzinger K, Lorenz M, Schneider S, Zohlnhfer D, Hoppe K, Schiemann M,
Kennerknecht E, Sauer S, Schulz C, Kerstan S, Rudelius M, Seidl S, Sorge F, Langer H, Peluso M,
Goyal P, Vestweber D, Emambokus NR, Busch DH, Frampton J, Gawaz M (2006). Platelets secrete
stromal cell-derived factor 1alpha and recruit bone marrow-derived progenitor cells to arterial thrombi
in vivo, J Exp Med. 5;203(5):1221-33.
20. Nhrenberg TG, Langwieser N, Schwarz JKB, Hou Y, Frank P, Sorge F, Matschurat S, Seidl S,
Schmig A, Kastrati A, Clauss MA, Zohlnhfer D (2008). EMAP-II downregulation contributes to the
beneficial effects of Rapamycin after vascular injury. Cardiovasc Res. 1;77(3):580-9.
21. Zohlnhfer D, Dibra A, Koppara T, de Waha A, Ripa RS, Kastrup J, Valgimigli M, Schmig A,
Kastrati A (2008). Stem Cell Mobilization by G-CSF for Myocardial Recovery after Acute Myocardial
Infarction: - A Meta-Analysis - J Am Coll Cardiol.15;51(15):1429-37.
22. Zohlnhfer D, Nhrenberg TG, Haas F, Bengel F, Schmig A, Baeuerle PA, Schwaiger M. (2008).
Myocardial gene expression of matched hibernating and control tissue from patients with ischemic left
ventricular dysfunction. Heart Vessels. 23(4):230-42.
23. Zohlnhfer D (2008). G-CSF for Left Ventricular Recovery after Myocardial Infarction: Is it Time to
Face Reality? Cardiovasc Drugs Ther. 2008 Oct;22(5):343-5.
24. Schwarz JBK, Langwieser N, Langwieser NN, Bek MJ, Seidl S, Eckstein HH, Lu B, Schmig A,
Pavenstdt H, Zohlnhfer D. Novel Role of the CXC Chemokine Receptor 3 in Inflammatory Response
to Arterial Injury Involvement of mTORC1. Circ Res. 2009 Jan 30;104(2):189-200

Reviews
1. Zohlnhfer D, Kastrati A, Schmig A (2007). Stem cell mobilization by granulocyte-colony-stimulating
factor in acute myocardial infarction: Lessons from the REVIVAL-2 trial. Nature Clinical PracticeCardiovascular Medicine. Vol 4 Suppl 1

Books
1. Klein CA, Zohlnhfer D, Petat-Dutter K, Wendler N (2003). Gene expression analysis of a single or
few cells.Curr Protoc Mol Biol.;Chapter 25:Unit 25B.8.
2.

Klein CA, Zohlnhfer D, Petat-Dutter K, Wendler N (2005).Gene expression analysis of a single or few
cells.Curr Protoc Hum Genet. Chapter 11:Unit 11.8.

3.

Zohlnhfer D und Kastrati A. Molekular-genetische Aspekte in Roskamm, H.; Neumann, F.-J.;


Kalusche, D.; Bestehorn, H.-P.: Herzkrankheiten - Pathophysiologie, Diagnostik, Therapie; Springer, 5.
Aufl. 2004

4.

Zohlnhfer D, Neumann FJ (2007). Gene Expression Profiling and Restenosis in: Essentials of
Restenosis: For the Interventional Cardiologist. Edited by H-J- Duckers, P.W. Serruys, and E.G. Nabel.
Humana Press, ISBN 1588294919, 9781588294913

5.

Zohlnhfer D (2008) in Kapitel Elektrokardiographie in Klinikleitfaden Psychiatrie und Psychotherapie


herausgegeben von M. Rentrop, R. Mller, J. Buml, Elsevier, ISBN 978-3-437-23146-9

Priv.-Doz. Dr. med. Dietlind Zohlnhfer

External funding
1.
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Research grant by Deutsche Forschungsgemeinschaft, Bonn, Germany (Zo 104/21); Jan. 2002- Dec. 2005
Research grant by Deutsche Forschungsgemeinschaft, Bonn, Germany (Zo 104/22); Jan 2005 - Dec. 2006
Research
grant
within
the
Graduiertenkolleg
438
of
Deutsche
Forschungsgemeinschaft, Bonn, Germany; Jan 2002-Dec 2007
Project in Working Package 7 des Cardiogenics-Antrags FP6-2005LIFESCIHEALTH-6 (LSH-2005-2.1.1-1)
Ongoing funding within the Klinische Kommission fr Forschung (KKF) of the
Technische Universitt Mnchen since 2001 (KKF 8732194, KKF 8732151, KKF
7-05)
Rolle des CXCR-3-Systems fr die Rekrutierung und Differenzierung
zirkulierender Vorluferzellen im Rahmen der Th-1-Antwort nach
Gefwandverletzung: DFG Zo 104/4-1

Teaching
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Teaching experience within the scope of lectures, weekly bedside teaching, weekly
seminars, conferences, practical training of the students since 1997.
Participation in innovative teaching approaches such as supervision of students for
a week at the beginning of the term and mentorship for students for the duration of
their studies.
Annual lecture within the Intensivkurs Innere Medizin (subject: heart failure) at
Munich since 2004.
Supervision of doctoral candidates (n= 9) partly within the Graduiertenkolleg 438
of the DFG (n=2).

Memberships
1.
Deutsche Gesellschaft fr Kardiologie (DGK)
2.
Europische Gesellschaft fr Kardiologie (ESC)
3.
Gesellschaft fr Mikrozirkulation und Vaskulre Biologie