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FBGVZ

C"FZBC \GBKZCF \MZTPC FDBE

N M N E K P T Y E K K I N [ Q G [ BZ F Z Y P
F Y K J G K CK J R B F K D G S

\GGFN NGNT ,FKRCNKSRVP F[KB NXB OGFKHN OZD[ E Coli DGSP NTF-YEKKI &
& O KNGI K\CC J[V\K[ FZYPC ZGPI OGKB

OKBVGZF ONGB ,FYCER EXKM TGEK BN FH CN[C
FEKPC ,ZGPI OGKBC ZCGEP KM OKMKZTP
.OKNGI K\CC \GZKFPC J[V\K YEKKIFG
FEGDBF N[ \TF C\MC OSZGV[ ZYIPC
YEKKIF KM BXPR ,FKDGNGKCGZYKPN \KBYKZPBF
mcr-1 QDN OZGDF B"RE TJYP B[GR EKPTF
.QKJSKNGY KRVC EKPT \GKFN

ET[ ,QKJSKNGY ,Z\GKC FYHIF FYKJGKCKJRBF
OKPKNBF OKYEKKIF \B NGJYN FIKNXF FM
BN ONGB IGYKV \I\ \BXPR FNGIF .Z\GKC
.\TM FCXP FP IGGE
KRVP TKZ\F CDC -F NFRP QPEKZV SPG\
EKPTF NT-YEKKI \GJ[V\F N[ OGZKI CXP
\G[[IF .\GPKKYF \GYKJGKCKJRBF NMN
FBXK BN FNGIF KM ZZCGF[ ZIBN GPXT\F
.OKRGZIBF OK[EGIF \[PIC FRKEPF KPGI\P

QEKT KZIB[ ONGTF" KRVP C"FZBC \G[[I
\ZYCN HMZPF ,CDC -F :"FYKJGKCKJRBF
N[ QG[BZ FZYP NT IGGEP ,FJRNJBC \GNIP
KDGS NMN EKPTF YEKKIC FYCER[ FNGI
.OGKM OKPKKYF FYKJGKCKJRBF
F\YN[ FKRCNKSRVP 49 \C F[KB ,FNGIF
LB FHV[GB ,OK[EGI ZVSP KRVN OGFKHC
.OGFKHF NT JN\[FN GIKNXF BN OKBVGZF
EDRM OD \GEKPT I\VN IKNXF YEKKIF

\B Z[KB \GBKZCF EZ[P OEC OGYPC FTKH SKSZC ZMGS \YKEC
"JRBGNBZV" FVGZ\F
NGZJSNGM \EZGFN LZE \XZGV FVGZ\ ,"JRBGNBZV"
KEK NT FZ[GB ,OKKTGC[N \IB \KZGT \\ FYKZHC \R\KRF
.NBZ[KC \GBKZCF EZ[P
QGRDRPC \NTGV "QGZR’DZ"G "KVGRBS" N[ JRBGNBZV
\GNKTK FIKMGF BKFG ,\GPKKYF OKRKJJSF \GVGZ\P ZIB
NGZJSNGM \GPZC 60% ET N[ F\IVFC OKEY\ \ZSI
,FR[M KRVN FDA -F ZG[KB \B FNCKY[ FVGZ\F .LDL
BKF JRBGNBZV .PCSK9 KCMTP N[ [EI ZGEN \MKK[
BKFG ,OKRG[ NGVKJ KRGRKP KR[C FRKPH[ GH FXGCYP FEKIKF
FRKPH FVGZ\F .\GZIB \GVGZ\C NVGJP[ KPN OD FPKB\P
KIGJKC \ZDSPCG \KNNM N[ OKN[PF IGJKCF KIJGCPN
.2017 \GVGZ\F NSN [DG\G ,OKKJZV \GBKZC

\G[KDZF \PZG KJVGB CKS NT TPJGP
IVRC YV\SFN \Z[VBP GN[ FFGCDF
ZJPGRR 1 N[ OKNHGR N[ EGBP QJY
.HGYGNDF \EKEP LZGXN

HGYGNDF \YKEC OBF
LZGX BNN TXC\\ \KEK\TF
HMZPC OKZYGI ?OE \VKJC
-SZCKRGBC YKRGJGV ZYIPF
GI\KV DRGY DRGF \JK
-KI N[ \KR[EI FKDGNGRMJ
\GFHN NDGSPF KRGJGV Q[K
SKSZC HGYGNDF \GPZ \B
-GCPF ,Q[KKIF .ZKTH FTKH
OKNYKPKM KGFKH NT SS
KJPZE QVGBC ZXYP ,ZGBF \GTXPBC
70 = FYKECF N[ FCGD\F QPH \B
.\GYE 6 OGYPC ECNC \GKR[
microfluidic chip-F CC[

:OKTKZ\P \SNG FV KIPGP
\IEY KZYP FTCZB
NBZ[KC GND\F SGNKRF FTKDP FVF NNI QJZSP F\GP\F
\GBKZCF EZ[P
\GNKTV KRVP ZKFHP
\IEY UKDR N[
.NBZ[KC SGNKRF
-RGZIBF OK[EGIC
FTCZB NT IGGE OK
UKDR KEK NT \PZDRF ,FNIPC \GYCEKF N[ OKZYP
.SGNKRF CZTP \IEY
-TGP (West Nile Fever) SGNKRF CZTP \IEY
,[G\K \XKYT KEK NT OKKI KNTCNG OEB KRCN \ZC
ZYKTC \ZCTGP FNIPF WZBC .OKTGDR \GVGTP QGHKR[
NT \GBKZCF EZ[PN IGGE 2015 -C .OK[G\K KEK NT
.SGNKRF CZTP \IEY N[ OKZYP 149
\VNGIG FNY CGZNG ,\TV[ \KKGPE FNIPF
,F[NGI ,[BZ KCBM ,OGI OF FNIPF KRPKS .FKNBP
FIKZV ,QKTF \KPINC \YNE OKZKZ[G OKYZV KCBM
.OKNG[N[G \GNKIC OK\KTNG
OKRPKS OT ,F[Y FNIPF OKNGIFP 1%-MC
IP \YNE GB FCXT \YNEN OKPKB\PF OKKDGNGZKGR
LB ,OKPK 14 ET 7 NNM LZEC BKF FZKDEF \VGY\ .FEI
.OKPK 21-N OKPK 3 QKC LGZBN FKG[T
\TKRP BKF FNIPF N[ Z\GKC FNKTKF FTKRPF
EZ[P .\GXKYT KRVC \GRRGD\FG OK[G\KF KTDVP
GPM \GRRGD\F KTXPB JGYRN ZGCKXN WKNPP \GBKZCF
\GRGNIN \G\[Z ,OK[G\K KIGE OKZK[M\C [GPK[
\GT[ QF[ FMK[IF \GT[C ZYKTC ,OKB\P [GCNG
\G[ZN IGGEN WNPGP .OK[G\KF N[ \GNKTVF
OEYFC OKP KZDBPG OK[G\K KEZJP NT \KPGYPF
.KZ[VBF

HGIB OK[KPIN

EGDKB ZKMHP ,QFM ZKEB Z"E &
-[ \GZPN" : \SNG FV \KKDZGZKM
FVF NNI QJZSC OKNGIFP 50%
ZSGI ZGCKXC OKKY ,OKR[TP OF
& FNIPN \GTEGP
GYKHIK BN OKNGIF OK[RBFP 43% .FR[C
FNIPFP G\GPK OKR[ [PI LG\G EPTP
FR[C ZCM G\GPK [KB 8,000 EGTC
."FRG[BZF
BZGY \SNG FV \KKDZGZKM EGDKB
CZYC FNIPN \GTEGPF \ZCDFN NGTVN
KG[T FVF NNI QJZS .CIZF ZGCKXF
,OKKMKRIC ,QG[NC ,OKK\V[C TKVGFN
. LIFG KINF \KZKZC ,FVF \VXZC
TKVGFN OKNGMK OKZKBPP OGZJ OKTDR
NNI \GKZKZC OKPGEB GB OKRCN OKP\MM
KCKM TXVM Z\GK OEY\P CN[CG FVF
GKGNKD NT F[YP[ ,FNKI\C CBM ZSI
OKCZ OKTGZKBC OKNY\R GRB" .OEYGPF
,ZIGBP CN[C OKRGICB N[ EGBP
ZETFP FRG[BZCG [BZC OKTCGR[
FZCSFF N[ F\GCK[I .FNIPN \GTEGP
N[ OFKKI NT FZKP[N \KJKZY BKF
."OKNGIF

-KZF QJZSP ZYKTC OK[[GI OKR[TP
QJZSN OKTEGP \GIV FCZF LB = \GB
FV \KKDZGZKM KBVGZ EGDKB .FVF NNI
50% -[ \GZPN" :TKZ\P NBZ[KC \SNG
,OKR[TP OF FVF NNI QJZSC OKNGIFP
-P\F KHGIB[ FNIPC ZCGEP[ \GZPNG
= 50%-N CGZY ET OKTKDP FC F\G
-RKPS\NG FNIPN \GTEGP ZSI ZGCKXF
."FK
KM QKKXP ,EGDKBF ZKMHP QFM ZKEB Z"E
\KSIK FNY FNIP BGF FVF NNI QJZS
OKPTV QM[ QGICBN F[Y LB ,KGVKZN
FKCN[C CBM NM [I BN FNGIF \GCZ
-GD FNIPF[ BKF FBXG\F .OKRG[BZF
NNMP 50%-N CGZY N[ \GGPN \PZ
FRGKNT \GCK[I FR[K" .FC OKNGIF
,FVF NNI QJZS N[ OEYGP QGICBN
BGF OKK\NI\FF OKCN[C NGVKJ[ ZIBP
OGKFN QGMR .OKFGCD FINXF KHGIB NTC
OK[EI OKZYP 35,000 OKND\P C"FZBC

QKXY .R :\MKZTC

n

KRVP QDFN \NGMK KNTC OKIPX
NKDC \GZG[YF \GNIP
NBKXRJGV BXPR FEGFK ZGHBC OKNEDF OKIPXC
.NKDN \GZG[YF \GNIPG \GRYEHF \TKRPC
\JKSZCKRGBC OKKY\F[ QGZPG[G FEGFK KZYIP SRMC
KR[EI ZYIP KBXPP KYSCGEGC FKZB Z"E DKXF ,NBKZB
Z\BN FZJPC OKKPGYP OKIPX \GZ[TP OKKGXKP YEC[
FRDF ,OKTXV KGVKZ \PEYPF \GNKTV GPM FRDF \GRGM\
-KJRB \GNKTVG \K\YNE-KJRB \GNKTV ,OKB\F NT
OKRKKVBP KNTC OF ZGHBC OKNEDF OKIPXF .\KRJZS
OKEKBGZJS N[ \KSIK \GFGCD \GPZ KNTCG OKEGIKK
\GKXP\F KM BXPR ZYIPC .(OKEKBGZJS-GJKV) OKKIPX
UBG \K\YNE \GNKTV \G\KIVP ,OKB\F NT \GRKDP
.OKKRJZS OKB\ SZFN \GPZG\
}}}}}}}} }}}}}}}}}}}}}}}}

KTP \GNIPC NGVKJN FBVZP
\GK\YNE
QFGZY \GK\YNE KTP \GNIPC NGVKJN FBVZP
HMZPC GZJSDF QGMPC FI\VR (IBD) \KCKM SKJKNGYG
\NFRP SKRKZ FCGJ Z"E .FVKIC QGKX KRC KBGVZF
KM FZKCSP ,\KEGTKKF FBVZPFG GZJSDF QGMP
NT \MN \GYKIZP \GMN[F [K \GKRGZM \GYNEN"
OKMZX [K FNB OKNGIN Z[BM ,OKKIF \GMKB
QGGDP FMKP\ K\GZK[ NS \YRTF OKCKKIPF OKEIGKP
."K\YGST\FG K[DZF ,K\ZCIF JCKFC Z\KF QKC
NBZ[KC \GK\YNE KTPF \GNIPC OKNGIF ZVSP
\GNIP .OKENK 2,000 -M OMG\P ,30,000 -MC EPBR
FNGED \GIKM[C \GRGZIBF OKR[C \GKGXP FNB
.\M[P\P FKKNT \PDPCG
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CN \YKVS KB B[GRC QGKT OGK
\PHGKC OKKY\F "CN \YKVS KB" B[GRC QGKT OGK
TGC[F \ZDSPC ,GEBKRNC CNF OGYK[N QGMPF
OGK \ZDSPC .CN \YKVS KBN [EYGPF KPGBNRKCF
,CN \YKVS KB B[GRC OKZKMC OKBVGZ GXZF QGKTF
-NGVKJF ,NGVKJF \IRHFP OZDKFN OKNGNTF OKMGCKSF
\KRVGDF \GNKTVF \GCK[I ,OKNGIN OGKF OKTXGPF OK
KPTR .\XNPGPF FRGH\FG CN \YKVS KBP OKNCGSN
KM \ZPGB GEBKRNC CN OGYK[N QGMPF \NFRP FKCGJ
\GXGVRF CNF \GNIPP \IB BKF CN \YKVS KB"
GRIRB GEBKRNC CNF OGYK[N QGMPC .ONGTCG NBZ[KC
\NNGMF \KJSKNGF \KPGYK[ \KRM\ OKNVGJPN OKTKXP
OT EIKC \KJSKVZ\GKHKVG \KRJBKE ,BVGZ N[ CYTP
BGF OKNVGJPF OKGGI[ ZGVK[F .FTGCY \KRVGD \GNKTV
."K\GTP[P
} } } } } } } } } }} } } } } } } } } } } } }

HGJYNN OK[KDZN QKHJYN \GSGPM
ZGCT FDKXP QPJNB \ZCI :\GTGC[ \BZYN
NGMKTN QKHJYN \GSGPM ,HBJYNN \G[KDZP OKNCGSF
NGMKT \GKTCN \PZGD HGJYNN \GNKCS KB .CNI KZXGP
GNB \GTVG\ TGRPN Q\KR ,CNI KZXGP \NKMBP FBXG\M
HGJYNF \B YZVPF HBJYN OKHRBF \NKJR KEK NT
QKHJYN .OKKCNI \GRGHP \NKMB QPHC (CNIF ZMGS)
N[ DIGEST NGMKTF \ZESP YNI GRKF \GSGPMC
FPZC OKHRBF N[ HGMKZ FNKMP FSGPM NM .QPJNB
87.90 :ZKIPF .\TXGPP \KCNI FIGZBN FPKB\PF
.I"[ 

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