Compiled General Pathology Answers (2009-2010) Chapter 1 1. E 2. B 3. C 4. E 5. D: p.13 Robbins 6. D: p.13 PBVD 7. E (PBVD pp 13) 8. B (PBVD pp 35) 9. E (Robbins pp 7) 10. B 11. B 12. A 13.

A- RER contain ribosomes (which contain acid- RNA) which is stained by hematoxylin (stains nucleic acids blue 14. A 15. D 16. D 17. A 18. D 19. E. Correct: Accumulation of lipid breakdown products due to decreased phospholipid synthesis. 20. E 21. E 22. A 23. C 24. D 25. E 26. D 27. B

28. A (Robbins p. 18) 29. E (Robbins p. 19). Cyclosporine targets cyclophilin D, a structural component of the mptp 30. D (Robbins p. 21) 31. C. Robbins 18-19. Ischemia causes reduced cellular glycogen through the increased of anaerobic glycolysis. Calcium increases through the depletion of ATP à reduced Na/K ATPase. 32. E. Robbins 19. ATPases continue to deplete ATP, phospholipases cause membrane damage, proteases break down membrane and cytoskeletal proteins, endonucleases cause chromatin and DNA fragmentation. 33. B. Robbins 25. CCL3 is generated by enzymes, all others are caused by reactive oxygen species. 34. E. Robbins 19. 35. A. Robbins 19. Opening the mitochondrial transition pore causes loss of membrane potential leading to inability to generate ATP and eventually necrosis. Calcium also activates phospholipases, proteases, and endonucleases, and ATPases. Increasing membrane permeability also leads to leakage of cytochrome C and caspases. 36. E. Robbins 24. 37. D. Robbins 24 38. E 39. E 40. D 41. A 42. E (Review) 43. A (Robbins pp 20) 44. B (Robbins pp 20) oxidative enzymes also present in lysosome and cytosol 45. E (Robbins pp 20) Catalase (peroxisomes) and glutathione peroxidase (mitochondrial and cytosol) convert H2O2 to H2O and O2 46. C (Robbins pp 24)

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