MATERIAL SAFETY DATA SHEET

HEXAMINE

PRODUCT CODE NUMBER(S): 3940-5

PRODUCT IDENTIFICATION
Chemical Name and Synonyms: Hexamine;
Hexamethylenetetramine
Chemical Family: Tertiary amine
Chemical Formula: (CH2)6N4
Product Use: Laboratory reagent
Manufacturers Name and Address:
Caledon Laboratories Ltd.
40 Armstrong Avenue
Georgetown, Ontario L7G 4R9
Telephone No: (905) 877-0101
Fax No: (905) 877-6666
Emergency Telephone No: CANUTEC (613) 996-6666

HAZARDOUS INGREDIENTS OF MATERIALS

Ingredients
Hexamine

TLV Units

>98 (TWA) 10 mg/m

CAS No.
3

100-97-0

PHYSICAL DATA
Physical State: Solid
Odour and Appearance: White crystalline solid; odourless
Odour Threshold (ppm): Not applicable
Vapour Pressure (mm Hg): <0.01 mm Hg @ 20C
Vapour Density (Air = 1): Not applicable
Evaporation Rate: Not applicable
Boiling Point (degrees C): Not available
Melting Point (degrees C): 280C (sublimes)
pH: 8.5-9.5 (0.5M, aqueous, 20C)
Specific Gravity: 1.27 @25C
Coefficient of Water/Oil distribution: Log P=-3.68

SHIPPING DESCRIPTION
UN: 1328
T.D.G. Class: 4.1
Pkg. Group: III

REACTIVITY DATA
Chemical Stability: Stable; hygroscopic.
Incompatibility with other substances: May react violently or explosively with strong oxidizing agents.
Hydrolyses in the presence of acids or acid environment.
Reacts violently with Na2O2. Excessive heat will cause decomposition, releasing formaldehye and ammonia, both of
which are toxic and irritating.
Reactivity: Avoid heat, hot surfaces, sparks, open flame,
all other sources of ignition, incompatible materials, generation of dust.

Hazardous Decomposition Products: Formaldehyde,

NOx, CO, CO2, ammonia, hydrogen cyanide, n-nitroso compounds.

FIRE AND EXPLOSION DATA

Flammability: Flammable solid. Accumulation of fine dust
particles can create explosion hazard, if electrostatic or
other high-voltage spark, or other ignition source is present.
Extinguishing Media: Dry chemical, foam, carbon dioxide,
water spray or fog. Water spray or fog can also be used to
disperse dust or vapours and flush spills away from ignition
sources. Fight fire from safe distance and from upwind.
FIrefighters must wear protective equipment (positive-pressure, full face-piece self-contained breathing
apparatus) and clothing (chemical splash suit) sufficient to
prevent inhalation and contact.
Flash Point (Method Used): 250C (CC)
Autoignition Temperature: 410C
Upper Flammable Limit (% by volume): Not available
Lower Flammable Limit (% by volume): Not available
Hazardous Combustion Products: Formaldehyde, NOx,
COx, ammonia, hydrogen cyanide, n-nitroso compounds.
Sensitivity to Impact: None idenitified
Sensitivity to Static discharge: As with most organic powders, mixtures of dust with air may be sensitive under
certain conditions, when ignited by an electrostatic or other
high-voltage spark, or other ignition source.

TOXICOLOGICAL PROPERTIES AND HEALTH DATA

Toxicological Data:
LD50: (oral, mouse) 569 mg/kg; (sc, cat) 200 mg/kg
LC50: Not available
Effects of Acute Exposure to Product:
Inhaled:. Irritating to mucous membranes and upper respiratory tract, causing wheezing, coughing, and shortness of
breath.
In contact with skin: Causes irritation. May be harmful if
absorbed. May cause allergic reaction. May decompose to
formaldehyde in presence of perspiration. Formaldehyde
may be carcinogenic.
In contact with eyes: No information available. May cause
irritation, with redness, tearing, itching.
Ingested: Harmful. Ingestion of 1 to 2 gm may cause gastrointestinal upsets, with vomiting diarrhea and abdominal
pain, and cystitis, inflammatory renal lesions and hematuria.
Effects of Chronic Exposure to Product:
Prolonged or repeated skin contact can cause sensitization
with urticaria or dermatitis. Previously sensitized individuals
can experience asthma-like condition.

MSDS

HEXAMINE

CODE: 3940-5
Carcinogenicity: No evidence of caracinogenicity in humans or animals, but formaldehyde, a decomposition
product, is a known carcinogen.
Teratogenicity: No information available
Reproductive Effects: No information available
Mutagenicity: Has been to shown to alter genetic material
in drosophila.
Synergistic Products: None known

PREVENTIVE MEASURES
Engineering Controls: Local exhaust ventilation required.
Use grounded, non-sparking ventilation system and electrical equipment that does not provide a source of ignition.
Respiratory Protection: Dust mask. Use only in a fume
hood. NIOSH/MSHA approved respirator for concentrations
above TLV. For higher or unknown concentrations, as in fire
or spill conditions, full face-piece, positive-pressure
self-contained breathing apparatus.
Eye Protection: Chemical safety goggles.
Skin Protection: Rubber gloves. Other protective clothing,
apron, sleeves, boots sufficient to prevent contact.
Other Personal Protective Equipment: Safety shower
and eye-wash fountain in work area.
Leak and Spill Procedure: Restrict access to area of spill.
Eliminate all sources of ignition and combustible materials.
Cleanup personnel must be thoroughly trained in the hazards of this chemical and its safe use, and must wear
protective equipment and clothing sufficient to prevent inhalation of dust or fumes, and contact with skin and eyes.
Wet if necessary to avoid generating dust. Prevent from entering sewers and waterways. Contain spill with inert
material (earth, sand, inert absorbent). Use non-sparking
tools to collect material, in suitable, labelled, covered containers for disposal. Contaminated absorbent may pose the
same hazards as the chemical; treat with caution. Flush
area of spill with large amounts of running water.
Waste Disposal: Follow all federal, provincial and local
regulations for disposal.
Handling Procedures and Equipment: FLAMMABLE,
TOXIC SOLID. Eliminate all sources of ignition and have all
engineering controls operating before handling. Personnel
working with this chemical must be thoroughly trained regarding its hazards, and its safe use, and must wear
appropriate protective equipment and clothing. Ground and
bond all equipment to prevent static charge accumulation.
Use non-sparking tools. Post No Smoking signs. Use
smallest amount possible for the purpose in an area with appropriate ventilation. Avoid all contact with eyes, skin or
clothing. Avoid generating dust; use good-housekeeping
procedures to prevent accumulation of dust. Keep containers closed when not in use. Wash thoroughly after working
with this product.
Storage Requirements: Store in a cool, well-ventilated
area out of sun and away from all ignition sources. Keep
storage area free of combustible materials and incompatible
materials such as strong oxidizers. Storage facilities should
be made of fire-resistant materials, and have raised sills and
be trenched to safe location. Keep containers tightly closed.
Protect from damage and inspect frequently for signs of
damage or leaking.

FIRST AID MEASURES

Specific Measures:
Eyes: Flush eyes thoroughly with gently running water,
holding eyelids open while flushing, for five to ten (5-10)
minutes, or until no trace of chemical remains. Wear gloves
to avoid contact during first aid procedures. Get medical attention.
Skin: Remove contaminated clothing, including watches,
rings, belts and shoes. Flush skin with plenty of running water and non-abrasive soap until no trace of chemical
remains. Wear gloves to avoid contact during first aid procedures. Get medical attention.
Inhalation: Remove to fresh air. Give oxygen and get
medical attention for any breathing difficulty.
Ingestion: If victim is alert and NOT convulsing, rinse
mouth thoroughly with water, give 2 to 4 glasses of water to
drink and induce vomiting under medical supervision. When
vomiting occurs, have casualty lean forward to avoid breathing in of emesis. Rinse mouth and administer more water.
Get medical attention.

REFERENCES USED
CCINFO disc: MSDSs, May 2007
Budavari: The Merck Index, 12th ed., 1997
Sax, Lewis: Hawleys Condensed Chemical Dictionary, 11th
ed., 1987
Sax: Dangerous Properties of Industiral Materials, 5th ed.,
1979
Suppliers Material Safety Data Sheets

ADDITIONAL INFORMATION
Date Issued: June 11, 1991
Revision: May 2010
MSDS: 3940-5
Proposed WHMIS Designation: B4; D2A; D2B
Prepared by: Caledon Laboratories Ltd. (905) 877-0101
Caledon Laboratories Ltd. believes the information contained
herein is reliable and accurate. Caledon makes no warranty
with respect thereto and expressly disclaims all liability for reliance thereon. Such information is solely for your consideration, investigation, and verification.