AUC

t (jam)

c (ppm)
0
2
4
6
8
10
12
14
16
18
20
22
24
26
28

0
15
35.4
48.5
39.6
27.94
20.29
15.19
11.25
9.68
8.17
7.39
6.89
6.35
6.23

A FASE ELIMINASI
slope (b)
interesep Ln B
B
Persamaan B. E-bt

ln C

b*t

CI
e^(b*t)

B*e^(b*t) C-Ci
ci

2.70805
3.566712
3.881564
3.678829 -0.20139 0.817594 10.2004 29.3996
3.330059 -0.251737 0.777449 9.699553 18.24045
3.010128 -0.302084 0.739276 9.223295 11.0667
2.720637
2.420368
2.270062
2.100469
2.000128
1.930071
1.848455
1.829376

-0.025174
2.523817
12.47612
Cp (1)= 12,5 . e 0,025t

B FASE DISTRIBUSI
slope (y)
-0.24426
interesep C 5.338788
C
208.2601
Cp (2)= 208,26.e 0,244t

cii
y*t

Ln (C-Ci)

e^(y*t)

C*e^(y*t) C-Cii

Ln (C-Ci)

AUC

-0.48852 0.613534 127.7746 112.7746 4.725391

-0.97704 0.376424 78.39403 42.99403 3.761061
-1.46556 0.230949 48.09739 0.402614 -0.909776
3.380981
2.903642
2.403941

,26.e 0,244t

C FASE ABSORBSI
Slope (ka) -0.482165
interesep ( 5.689721
A
295.8111
Cp (3)= 295,811.e 0,482t

Cp= 12,5 . e 0,025t + 208,26.e 0,244t - 295,811.e 0,482t

MRT=
AUMC Tot
AUC total
4.5
4
3.5

f(x) = - 0.0750619249x + 3.7898509207

R = 0.7574522354

3
2.5
2
1.5
1
0.5
0
0

10

15

20

8,26.e 0,244t - 295,811.e 0,482t

0.0750619249x + 3.7898509207
7574522354
Column D
Linear (Column D)
Linear (Column D)

10

15

20

25

30

t (jam)
c (ug/ml)
ln c
c exp= 46 e. (exp-0.Cexp- C
0.25
2.85
1.0473
0.5
5.43
1.6919
0.75
7.75
2.0477
1
9.85
2.2875
2
16.2
2.7850
4
22.15
3.0978
6
23.01
3.1359
10
19.09
2.9492
14
13.9
2.6319
20
7.97
2.0757

A FASE ELIMINASI
slope (b)
-0.088
interesep Ln B
3.8395481
B
46.504453
B. E-bt
Cp (1)= 46,5 . e 0,088t

ln(

B FASE DISTRIBUSI
slope (y)
2.001
interesep C
0.5953
C
1.8135
Cp (2)= 34,32.e 0,063t

3.5000
3.0000
R ==0.0668747073
f(x)
0.0258050012x + 2.2240345468
R = 0.0668747073

2.5000
2.0000

Col

Line

1.5000

Line

1.0000
0.5000
0.0000
0

C FASE ABSORBSI
Slope (ka)
#REF!
interesep (
#REF!
A
#REF!
Cp (3)= 295,811.e 0,482t

10

15

20

25

Cp= 12,5 . e 0,025t + 208,26.e 0,244t - 295,81

MRT=
AUMC Tot
AUC total

468
Column D
Linear (Column D)
Linear (Column D)

20

25

208,26.e 0,244t - 295,811.e 0,482t