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AP RISE 2012-2015

CYTOPATHOLOGY
2012
1) Lung fine needle aspiration; immunoreaction of cytokeratin 20 in colorectal cancer
2) Identification of lung carcinoma on aspirate
3) Acute leukemia; cerebrospinal fluid
4) Warthin's tumor; common bilateral benign tumor of the parotid gland
5) Cervicovaginal specimen; diagnose low grade squamous intraepithelial lesion
6) Identification; squamous cell carcinoma
7) Neck nodule; diagnose epidermal inclusion cyst from Papanicolaou stain
8) Merkel cell carcinoma
9) Deleted
10) Plasma cell neoplasm
11) Tubal metaplasia
12) Recognition of signet ring carcinoma in a body fluid
13) Pancreatic lesion smear; interpret reactive/reparative epithelium
14) Fine needle aspiration technique for a superficial lesion
15) CLIA '88 regulations; review of prior years normal cytology cases
16) Ovarian adenocarcinoma detected on Papanicolaou smear
17) Identification of Cryptococcus
18) Cytology fine needle aspirate; molecular markers of neuroblastoma
19) Bronchioloalveolar carcinoma; identification
20) Cervical smear; identify high grade squamous intraepithelial lesion
21) Fine needle aspiration; parotid mass; interpret pleomorphic adenoma
22) Invasive ductal carcinoma; identification from fine needle aspirate of breast
23) Recognition of malignant rhabdoid tumors
24) High-grade urothelial carcinoma; diagnose in urine
25) Most common chromosome aberrations associated with high grade urothelial carcinoma
26) Ovarian papillary serous carcinoma; identification
27) Large B-cell lymphoma and lymphoglandular body detection
28) Cerebrospinal fluid plasma cells; multiple sclerosis
29) Cervical smear; benign cellular changes/Trichomonas infection
30) Cytomegalovirus; identification
31) Metastatic colon adenocarcinoma; identification from fine needle aspiration
32) Metastatic adenocarcinoma in cerebrospinal fluid
33) Small cell carcinoma; identify cells in bronchial brushing
34) Recognition Hodgkin lymphoma
35) Urine; diagnose polyomavirus
36) Craniopharyngioma; diagnose
37) Esophageal brushing; diagnose adenocarcinoma
38) Fine needle aspirate from liver mass; diagnose hepatocellular carcinoma

39) Cervicovaginal smear; diagnose low grade squamous intraepithelial lesion


40) Amyloid deposition in medullary carcinoma
41) Cystic breast lesion; diagnose apocrine cells
42) Adenoid cystic carcinoma; identification from fine needle aspiration, parotid mass
43) Cytology fluids; immunohistochemical stain to differentiate adenocarcinoma
44) Solid pseudopapillary tumor; identification from pancreatic mass
2013
1)Primitive neuroectodermal tumor; cerebrospinal fluid cytology
2) Complications of a fine needle aspiration in the thorax
3) Etiology of papillary thyroid carcinoma
4) Cytology urines; artifacts
5) Diagnosis of lymphoid origin in large cell lymphoma
6) Neck nodule; diagnose epidermal inclusion cyst from Papanicolaou stain
7) Bethesda reporting; cervical cytology
8) Cerebrospinal fluid with metastatic carcinoma
9) Uterine cervix smear; identify atrophy
10) Cytogenetics of urothelial carcinoma
11) Characteristics of pleomorphic adenoma
12) Cytology of serous cystadenoma
13) Identification of Hrthle cell thyroid lesions
14) Fine needle aspiration of thyroid nodule; diagnose papillary carcinoma
15) Non-small cell carcinoma; diagnose from pleural effusion
16) Ductal carcinoma of the breast
17) Identify hepatocellular carcinoma; fine needle aspirate, liver mass
18) High grade squamous intraepithelial lesion
19) Identify metastatic colonic adenocarcinoma; fine needle aspirate, liver mass
20) Thoracocentesis fluid; diagnose metastatic breast adenocarcinoma
21) Squamous cell carcinoma; identification from bronchial brushing
22) Risk factors for Warthin tumor
23) Myxoid liposarcoma; diagnose from fine needle aspirate
24) Quality control measures established by CLIA 88
25) Cerebrospinal fluid plasma cells; multiple sclerosis
26) Recognition of Echinococcus cyst
27) Burkitt; t(8,14)
28) Identification of anaplastic thyroid cancer
29) Amyloid deposition in multiple myeloma
30) Knowledge of post radiation angiosarcoma
31) Urine; diagnose polyomavirus
32) Pancreatic fine needle aspirate; adenocarcinoma
33) Medullary carcinoma of the thyroid
34) Low grade intraepithelial lesion
35) Association of Actinomyces and intra-uterine devices
36) Most common cause of effusions in adults
37) Cervicovaginal smear; diagnose low grade squamous intraepithelial lesion

38) Recognition of Charcot-Leyden crystal


39) Identification of Candida on a Papanicolaou smear
40) Urine Papanicolaou stain; diagnose high-grade carinoma
41) Normal Papanicolaou smear
42) BRAF mutation in papillary thyroid carcinoma; association with worse prognosis
43) Sputum smear, Papanicolaou stain; interpret pollen
2014
1) Recognize endometrial adenocarcinoma
2) Identification of lymphocytic thyroiditis
3) Etiology and identification of urothelial cancer
4) Neck nodule; diagnose epidermal inclusion cyst from Papanicolaou stain
5) Diagnosis of breast carcinoma in fluids
6) Liver fine needle aspiration; identify hepatocellular carcinoma
7) Identification of the morphologic features of invasive ductal carcinoma of the breast
8) Molecular characterization of urothelial carcinoma
9) Pancreatic head lesion fine needle aspirate; interpret adenocarcinoma
10) Oropharyngeal squamous cell carcinomas; high risk human papillomavirus infection
11) Thyroid, recognize tracheal contamination
12) Oncogenes associated with medullary carcinoma of the thyroid
13) Urine; high grade urothelial cell carcinoma
14) Diagnosis of lobular carcinoma
15) Sialadenosis; characteristics
16) Cytology of pancreatic neuroendocrine tumor
17) Diagnose myeloid sarcoma
18) Cerebrospinal fluid plasma cells; multiple sclerosis
19) HIV +, cervical lymphadenopathy; diagnose Mycobacterium avium
20) Myelolipoma; diagnose from adrenal gland fine needle aspirate
21) Malignant mesothelioma: cellular, large cells, nucleoli, high N/C; differential is adenocarcinoma
22) Squamous cell carcinoma; treatment
23) Morphologic features of conventional renal cell carcinoma
24) Contraindications for fine needle aspiration (FNA)
25) Recognize herpes simplex virus
26) Cervical lymph node; diagnose Cryptococcus neoformans
27) Left parotid mass; identify adenoid cystic carcinoma
28) EGFR and ALK testing; adenocarcinoma therapy
29) Metastatic breast carcinoma to the neck
30) Urine; diagnose polyomavirus
31) Papillary thyroid carcinoma; common genetic lesion
32) Proper fine needle aspiration (FNA) technique
33) Cells of breast origin; pleural effusion
34) Cervicovaginal smear; diagnose low grade squamous intraepithelial lesion
35) Identify small cell carcinoma
36) Bethesda classification
37) Adenocarcinoma; cerebrospinal fluid

38) Pulmonary hamartoma with myxoid stroma


39) Diagnosis of pancreatic adenocarcinoma
40) Primary sclerosing cholangitis; false positive diagnoses in biliary brushings
41) Fungal infections in cerebrospinal fluid
2015
37) Cervical Papanicolaou smear; identify Trichomonas
38) Identification; metastatic conventional (clear cell) renal cell carcinoma
39) Eosinophilic effusion; cause
40) BRAF V600E; papillary thyroid carcinomas
41) Neck nodule; diagnose epidermal inclusion cyst from Papanicolaou stain
42) Causes of false negative diagnosis for fine needle aspiration
43) Clinical associations of thymoma
44) Criteria for high grade squamous intraepithelial lesion
45) Metastatic papillary thyroid carcinoma
46) Benign duodenal contaminant; non-diagnostic
47) Seminoma; immunocytochemical stain profile
48) Breast mass; diagnose lobular carcinoma
49) Cytology of high grade urothelial carcinoma
50) Evaluation of adenocarcinoma
51) Most common cause of malignant pleural effusion in men and women
52) Myelolipoma of the adrenal gland
53) Adenocarcinoma cervical sampling
54) Lung adenocarcinoma; KRAS point mutations
55) Papillary lesions of the breast
56) Hormone therapy for prostatic cancer; cytology of urine
57) Cytomegalovirus; lung transplant patient
58) Transplant patient with malignancy
59) Cytologic description of ciliocytophthoria
60) Identification; branchial cleft cyst
61) Low grade squamous intraepithelial lesion; low risk HPV types
62) Mott cells in a plasma neoplasm
63) Recognition of clinical history and cytology of hamartoma
64) Ductal carcinoma; identification from fine needle aspirate, breast
65) Primarily ultrasound gel; non-diagnostic Bethesda Category I
66) Papanicolaou smear adequacy
67) Cytology of carcinoid tumor
68) Recognize normal Papanicolaou
69) False positive diagnosis for fine needle aspiration of the breast
70) Identify metastatic melanoma
71) Cervical lesion; diagnose high grade squamous intraepithelial lesion
72) Identification of pancreatic neuroendocrine tumor
73) Cervicovaginal smear; diagnose low grade squamous intraepithelial lesion
74) Radiation effect; cytologic features
75) Cerebrospinal fluid plasma cells; multiple sclerosis

76) Pelvic washing Papanicolaou stain, diagnose endosalpingiosis


77) Urine; diagnose polyomavirus
78) Identification of pleomorphic adenoma
79) Glioblastoma multiforme; diagnose in cerebrospinal fluid

AUTOPSY/FORENSIC PATHOLOGY
2012
45) Recognize mummification of hand/fingers
46) Distribution of burns; highly characteristic for inflicted scalding injuries
47) Recognize subacute myocardial infarct microscopically
48) Identification and characterization of pleural plaques
49) Gross myocardial infarct; determine age
50) Recognize cerebellar vermis atrophy related to chronic alcoholism
51) Risk factors for choking
52) Cause of death in automobile collision
53) Recognize a congenital umbilical hernia
54) Stippling around gunshot wound
55) Hypothermia; identification
56) Anthropophagy
57) Identification of hepatic hemangiomas
58) Petechial hemorrhages
59) Recognize livor mortis
60) Recognize seat-belt injuries in driver involved in motor vehicle collision
61) Recognize acid fast bacilli (AFB) stain and mycobacteria
62) Vitreous fluid; hyperglycemia
63) Cocaine; metabolite
64) Identify a suicidal incised wound; hesitation marks
65) Death is due to displacement of oxygen by helium
66) Cardiac valve; mitral valve prolapse
67) Identify epidural hemorrhage
68) Recognize ruptured cerebral artery aneurysm
69) Identify cerebral contusion from fixed brain
70) Recognition of horseshoe kidney
71) Violent deaths, unexpected death; report to Medical Examiner/Coroners Office
72) Commotio cordis; definition
73) Recognize gross and microscopic renal angiomyolipoma
74) Identify gunshot entrance wound; distant range-of-fire
75) Autopsy technique for visualization of esophageal varices
76) Exsanguination; mechanism of death
77) Deleted
78) Define adipocere
79) Recognize bone metastasis in spinal column
80) Recognize peritonitis

2013
44) Hyoid bone fracture
45) Postmortem heat-related epidural hemorrhage
46) Depressed oval skull fracture consistent with a hammer
47) Autosomal dominant (adult) polycystic kidney disease
48) Subepicardial fibrosis of the inferolateral wall; Duchenne muscular dystrophy
49) Electrocution with electrical burns of fingers
50) Identify skin marbling
51) Aortic laceration in motor vehicle collision
52) Air embolism technique
53) Sudden unexplained death in infancy
54) Identify patent ductus arteriosus; 1-month-old child
55) Identification of caf-au-lait spots and neurofibromas inneurofibromatosis
56) Vitreous electrolyte pattern in dehydration
57) Vitreous fluid; hyperglycemia
58) Identification of remote tracheostomy site
59) Postmortem insect bites
60) Identification; incised wounds of the skin
61) Death certification in post-operative pneumonia
62) Anomalous origin of the left coronary artery from the right sinus of Valsalva
63) Organization responsible for providing inspection and accreditation of offices
64) Identify cerebral contusion from fixed brain
65) Recognize dilated cardiomyopathy
66) Caseating apical lesion of secondary pulmonary tuberculosis
67) Recognize carbon monoxide-induced color change in brain
68) Displacement of oxygen by helium gas
69) Recognize prostatic hyperplasia
70) Papaverine; injected into veins prior to postmortem procurement
71) Early post mortem period; urea and creatinine concentrations
72) Definition of mechanism of death
73) Hesitation marks in suicides
74) Recognize fat necrosis grossly
75) Define adipocere
76) Patau syndrome (trisomy 13); identify polydactyly
77) Recognize the importance of scene investigation in infant deaths
78) Approximate the range-of-fire from gunshot wound
79) Cocaethylene; cocaine and ethanol administration
2014
42) Postmortem anal dilatation; pediatric autopsy
43) Identification of patent ductus arteriosus
44) Recognize histologic appearance of a contact gunshot wound
45) Recognize adrenal cortical adenoma
46) Chronic Wernicke's encephalopathy
47) Biochemistry of rigor mortis

48) Manner of death in alcohol related collisions


49) Vitreous fluid; hyperglycemia
50) Toxicology specimen collection
51) Decomposition; pattern in blood electrolytes
52) Recognize atrial septal defect-secundum type
53) Progressive massive fibrosis (complicated pneumoconiosis); silicosis
54) Histologic appearance; alcoholic hepatitis
55) 6-monoacetyl morphine; metabolite of heroin
56) Identify; congenital Mongolian spot
57) Authorization of autopsy
58) Recognize normal "brown fat" in infant
59) Identify incised wounds of wrist
60) Identify cerebral contusion from fixed brain
61) Recognize histologic appearance of bile duct hamartoma
62) Inappropriate dress/paradoxical undressing and gastric stress ulcers indicative of
hypothermia
63) Hypoglycemia; cause of death
64) Recognize hemopericardium prior to opening the pericardial sac
65) Know the definition of "strangulation"
66) Identification of hyaline membranes in diffuse alveolar damage
67) Identify; blunt force trauma
68) Suicide; toe to pull the trigger
69) Air embolism; consequence of stab wound
70) Define adipocere
71) Identify scalp laceration
72) Recognize hepatic cavernous hemangioma grossly
73) Recognize empyema
74) Fly eggs; time of death
75) Identify mechanism of intraocular petechiae
76) Identify blunt force injury of aorta
77) Deleted
2015
1) Minocycline exposure; effect on skull table
2) Identify incised wounds
3) Decomposition and liver
4) Gunpowder particles striking the skin; identification
5) Vitreous fluid; hyperglycemia
6) Patau syndrome (trisomy 13); facial effects
7) Identify tram track pattern from cylindrical object
8) Recognize medical conditions that may mimic child abuse
9) Define adipocere
10) Skin cancer; arsenic
11) Identify causes of petechiae
12) Recognizing the "normal" postmortem vitreous pattern

13) Identify cerebral contusion from fixed brain


14) Recognize myocarditis histologically
15) Kaposi sarcoma; autopsy findings
16) Electrical injury; identify
17) Deleted
18) Risk factors for left ventricular hypertrophy
19) Asphyxial deaths; homicide or suicide
20) Deleted
21) Recognize flame hemorrhages seen in cardiopulmonary resuscitation
22) Gastric contents; suicide
23) Embalming; trocar use
24) Autoerotic asphyxial death; manner of death classification
25) Recognize cholesterol gallstones and the associated risk factors
26) Defensive wounds; manner of death homicide
27) Identify smoke and soot inhalation from posterior view of tongue, larynx
28) Identification of postmortem artifact; damage to skin from cockroaches
29) Turner syndrome
30) Identify Mongolian spots
31) Identify medical intervention
32) Post mortem vitreous chemistry decomposition pattern
33) Calcium oxalate crystals; identification in ethylene glycol poisoning
34) Recognition of a gunshot exit wound in skull
35) Mechanism of death; definition
36) Death via arrhythmias; granulomas

SURGICAL PATHOLOGY
2012
81) Recognition of eosinophilic esophagitis
82) Collapsing variant of FSGS; HIV infection
83) Vacuolar interface change; lupus erythematosus, erythema multiforme
84) Nonspecific interstitial pneumonia; characteristics
85) Anaplasia in a nephroblastoma (Wilms tumor); a suboptimal response to chemotherapy
86) Recognition of normal colonic mucosa
87) Identify chondroblastoma
88) Identification of cardiac Quilty lesions
89) Odontogenic keratocyst (keratocystic odontogenic tumor); identification
90) Pseudoepitheliomatous hyperplasia; granular cell tumor in the oral cavity
91) Identification of dysgerminoma
92) Allergic contact dermatitis; recognition of spongiosis
93) Colonoscopy biopsy; ulcerative colitis
94) Metastatic carcinoma, myelophthisic anemia
95) Parathyroid hormone levels; parathyroid adenoma
96) Distinct fibrils; characteristic of amyloidosis
97) Spontaneous primary (idiopathic) pneumothorax; reactive eosinophilic pleuritis

98) Perineum; cytologic atypia in nevi, special site nevi


99) Low-grade fibromyxoid sarcoma; characteristic translocation
100) Cardiac rhabdomyoma
101) Synovial sarcoma; immunohistochemistry
102) Recognition of primary biliary cirrhosis
103) Spitz nevi; location in prepubertal patients
104) Mutations in BRCA1 and BRCA2 genes; autosomal dominant
105) Paraganglioma; features of malignancy
106) Lichen sclerosus; vulvar plaque identification
107) Membranous glomerulopathy; ultrastructure
108) Identify embryologic cause of Meckel's diverticulum
109) Schiller-Duval bodies; yolk sac tumors
110) Steatohepatitis; associated clinical conditions
111) Kernicterus; diagnose
112) Seminoma
113) Recognition of gastrointestinal stromal tumor
114) Juvenile granulosa-cell tumor; clinical characteristics
115) Acetaminophen overdose; hepatotoxicity
116) Parotid gland tumor; salivary duct carcinoma
117) Pancreatic endocrine tumor
118) Pigmented villonodular synovitis; clinical characteristics
119) Pathergy phenomenon; Behet disease
120) Micromedullary carcinoma; identification from thyroid nodule
121) Donor liver transplant criteria of utility
122) Nested variant of urothelial carcinoma; clinical characteristics
123) Alpha-1-antitrypsin deficiency; cirrhosis
124) Outcome of appendiceal mucinous neoplasms
125) Adenosis: benign mimicker of well-differentiated prostate adenocarcinoma
126) Periodic acid-Schiff (PAS) stain; acinic cell carcinoma
127) Recognize fibromatosis with entrapped degenerated skeletal myocytes
128) Prognostic factor for invasive breast carcinoma; axillary lymph node
129) Mutations in thyroid papillary carcinoma
130) Hepatitis C; clinical characteristics
131) Identify esophageal ulcer cells; fibroblasts or myofibroblasts
132) Features of focal nodular hyperplasia
133) Diagnosis high grade ductal carcinoma in situ
134) Meningioma; epithelial membrane antigen immunoreactivity
135) Leprosy; clinical symptoms
136) Endometrial polyps; serous carcinoma, p53 tumor suppressor gene
137) Diagnosis of Zollinger-Ellison syndrome
138) Nephrogenic adenoma; morphologic and immunohistochemical features
139) Spindle cell lipoma; identification
140) HPV 6 and 11; recurrent respiratory papillomatosis
141) V erocay body; characteristics
142) Recognition of pagetoid spread of rectal cancer

143) Diabetic nephropathy; common renal disease in tumor nephrectomy specimens


144) Fibrolamellar variant of hepatocellular carcinoma; chronic infection with Hepatitis B risk factor
145) Features of prostatic duct adenocarcinoma
146) Oligodendroglioma; identification
147) Leydig cell tumor; diagnose
148) Thyroid medullary carcinoma; calcitonin stain
149) Brenner tumors; mucinous cystadenomas
150) Nephrotic syndrome in children; minimal change disease
151) Radiology/pathology correlation in breast biopsy
152) Immunohistochemistry of high-grade urothelial carcinoma and collecting duct carcinoma
153) Parotid gland mass; epithelial-myoepithelial carcinoma
154) Mitral valve; identify Aschoff nodule
2013
80) Viral inclusions
81) Humoral rejection in kidney grafts; association with vasculitis
82) Oncocytomas; characteristics
83) Polyoma virus; primary neuroendocrine carcinoma (Merkel cell carcinoma)
84) Vacuolar interface change; lupus erythematosus, erythema multiforme
85) Phospholipase A2 receptor; antigenic target in idiopathic membranous nephropathy
86) Retrieving antigens and/or inducing epitopes; steam
87) Identification of hemochromatosis
88) Nonspecific interstitial pneumonia; characteristics
89) Recognition of normal colonic mucosa
90) Knowledge of rhabdomyoma
91) Recognition of Schwannoma
92) Anaplastic oligoastrocytoma; FISH presentation
93) Diagnose intraepidermal apocrine carcinoma with invasion
94) Characteristics of pancreatic endocrine neoplasms
95) Mucinous fibroplasia, glomerulations and perineural invasion; prostate cancer
96) Polyoma virus nephropathy occurs in any immunosuppressed patients
97) Differential diagnosis of papillary lesions
98) Immunohistochemical stain displaying nuclear staining; S100 protein
99) Warthin tumor
100) Mediastinal mass, germinoma; clinical characteristics
101) High-grade papillary urothelial carcinoma; significance and morphology
102) Metastatic carcinoma, myelophthisic anemia
103) Recognition of colorectal medullary carcinoma
104) Desmoid tumor; FAP association
105) Scalp lesion; lymphoepithelioma-like carcinoma
106) Characteristics of hyperparathyroidism
107) Identification of lobular carcinoma in situ
108) Focal segmental glomerulosclerosis; podocin
109) Malakoplakia; identification
110) Deleted

111) Corticosteroid therapy; avascular necrosis


112) Deleted
113) Fabry disease; electron microscopy renal
114) Colon resected; cancer of the ampulla
115) Stromal lesion of the breast and CD34 staining
116) V ery early complete hydatidiform mole; identification
117) Uterine serous carcinoma; p53
118) Recognition of autoimmune pancreatitis
119) Thyroid; papillary carcinoma, tall cell variant
120) Liver biopsy; recognition of hepatitis B
121) Identify olfactory neuroblastoma
122) Molecular characterization of synovial sarcoma
123) Juvenile granulosa-cell tumor; prognostic factors
124) Inherited syndromes associated with breast cancer
125) Glomus tumor; identification, immunohistochemical stains
126) Pancreas mucinous cystic neoplasm
127) Tubular adenosis of the breast and differential diagnosis
128) Squamous differentiation; endometrioid histotype
129) Grade 1 chondrosarcoma; clinical characteristics
130) Radiation-associated angiosarcoma; identification in breast tissue
131) Primary biliary cirrhosis; high titer anti-mitochondrial autoantibody
132) Amyloid angiopathy; spontaneous cerebral hemorrhage in the elderly
133) V on Hippel-Lindau syndrome; endolymphatic sac tumor
134) Prognostic factor for invasive breast carcinoma; axillary lymph node
135) Angiomyofibroblastoma; diagnose from vaginal mass
136) Intraductal carcinoma of prostate; aggressive lesion associated with high-grade prostate cancer
137) Goodpasture syndrome; immunofluorescence pattern
138) Pulmonary Langerhans' cell histiocytosis; immunohistochemical stains
139) Gross identification of colorectal cancer
140) Meningioma; epithelial membrane antigen immunoreactivity
141) Identification of partial atrophy
142) Knowledge of characteristic translocations and fusion products in sarcomas
143) Diagnose cryptosporidiosis; colon biopsy
144) Neural tube defects risk factors
145) Pulmonary large cell neuroendocine carcinomas; immunohistochemical marker
146) Cylindroma; diagnose from scalp lesion
147) Leydig cell tumor; characteristics
148) Heart mass; atrial myxoma
149) Diagnosis of Barrett esophagus
150) Organ transplant; medication-gastrointestinal tract changes, mimic graft-versus-host disease
151) Recognize Wilms tumor and distinguish it from other primitive pediatric neoplasms
152) Liver mass; identification of focal nodular hyperplasia
153) Neurofibromatosis 1 and 2; autosomal dominant conditions
154) Medullary carcinoma of thyroid; mutations

2014
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Vacuolar interface change; lupus erythematosus, erythema multiforme


Identification of Helicobacter heilmannii
Nonspecific interstitial pneumonia; characteristics
Differentiating high-grade urothelial and prostate carcinoma; immunohistochemistry
Recognition of normal colonic mucosa
Peutz-Jeghers polyposis; pancreatic ductal carcinoma
Hyalinizing trabecular tumor; diagnose
Xanthogranulomatous pyelonephritis; identify
Clinical features of cerebellopontine angle (CPA) meningioma
Gastric carcinoid tumors; enterochromaffin-like cells
Survey stain in neuropathology; hematoxylin and eosin
Identification of rhabdoid tumor
Clear cell and endometrioid carcinoma; endometriosis
Morphology of clear cell papillary renal cell carcinoma
Metastatic carcinoma, myelophthisic anemia
Benign notochordal tumor
Vulvar intraepithelial neoplasia, simplex type; immunoreactivity
Recognition of granuloma annulare
Carcinoma of the male breast
Transplant kidney biopsy; identification of polyomavirus infection
Myxoid liposarcoma; characteristics
Cancer staging
Immunohistochemical features of ependymoma
Recognizing giant cell tumor of bone
Positive immunostaining for S100 protein; distinguishing neoplasms
Intestinal adenocarcinoma
Identification and characteristics of mucoepidermoid carcinoma
Cytomegalovirus; cells infected
Morphology of inflammatory myofibroblastic tumor
Identification of radiation change in squamous mucosa
Adrenal cortical carcinoma; melan-A and calretinin antibodies
Fabry disease
Identification of pancreatic serous cystadenoma
Prognostic factor invasive breast cancer; T classification
Identification of dividing membranes; twin gestation placenta
Soft tissue mass; identify alveolar soft part sarcoma
Alveolar proteinosis; clinical characteristics
Mucinous cystic neoplasm with ovarian like stroma
BRAF mutation; in tall cell carcinoma
Microsatellite unstable colorectal carcinoma
Medullary thyroid carcinoma; diagnose from thyroidectomy specimen
Recognition of cell mediated hypersensitivity
Chemical/reactive gastropathy
Recognize the gross appearance of breast angiosarcoma

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Collagenous colitis with subepithelial collagen deposition


Identify endometrioma
Adrenal nodule; adrenal cortical adenoma
Glomerular diseases; diabetic glomerulopathy
Diagnosis of malignant phyllodes tumor
Genetics of basal cell carcinoma
Diagnose endodermal choristoma; upper interventricular septum
HER2 by immunohistochemical staining
Prognostic factor for invasive breast carcinoma; axillary lymph node
Duodenum, neuroendocrine neoplasm with calcospherites; somatostatin
Cortical thymoma with starry sky stained for TDT
Heterotopic gastric mucosa; Meckel diverticulum
Meningioma; epithelial membrane antigen immunoreactivity
Asbestos and lung cancer
Eosinophilic neuronal degeneration
Subtotal villous atrophy, celiac sprue and dermatitis herpetiformis
Fibrous dysplasia
Liver biopsy; Mallory bodies
Diagnose leiomyosarcoma
Staining C4d in kidney peritubular capillaries; acute humoral rejection
Classic seminoma cells; C-kit, SALL4, CD 30
Identification of toxoplasma
Ependymoma; identification
Recognition of classic silicotic nodule
Testicular germ cell tumor; common chromosomal abnormality
Chondromyxoid fibroma
Variant of focal segmental glomerulosclerosis; clinical outcome
Chromophobe renal cell carcinomas; CK 7, vimentin
Common site of occurrence of polymorphous low grade adenocarcinoma
Lesions positive immunohistochemistry; alpha-methylacyl-CoA racemase (P504S)
Molecular translocations of bone and soft tissue tumors

2015
80) Dissecting aortic aneurysm; characteristics
81) Hepatic mass, CD 34 stain; epithelioid hemangioendothelioma
82) Inhalation rabies infection from bat infested caves
83) Dermatopathology, inflammatory
84) Knowledge of main type of cell participating in cardiac transplant rejection
85) Nested variant of urothelial carcinoma infiltrating muscularis propria
86) Classification of smooth muscle tumors of the uterus
87) Serous cystadenoma; characteristics
88) Gardner syndrome; identify osteoma
89) Palate mass; chordoma
90) Small cell carcinoma
91) Characteristics of uterine serous carcinomas

92) Elastofibroma; clinical characteristics


93) Liver disease; toxin overexposure
94) Intravascular lesion; papillary endothelial hyperplasia
95) Invasive micropapillary carcinoma
96) Relationships between enzyme histochemical stain and muscle fiber type
97) Pericecal lymph node; Yersinia
98) Prognostic factor for invasive breast carcinoma; axillary lymph node
99) Guidelines for testing for EGFR and ALK in non-small cell lung carcinoma
100) Mucinous adenocarcinoma; genetic alterations
101) Giant cell tumor of bone; classic locations
102) Viral culture; diagnosing disseminated neonatal herpesvirus infection
103) Identification of pancreatoblastoma
104) Recognition of germ cell neoplasm in children; yolk sac tumor
105) Nonspecific interstitial pneumonia; characteristics
106) Human papillomavirus (HPV) associated driven squamous cell carcinomas of head and neck
107) Identify lobular carcinoma in situ
108) Immunoprofile of rare prostate carcinomas with aberrant diffuse p63 expression
109) Arid1a; clear cell carcinoma
110) Metastatic carcinoma, myelophthisic anemia
111) Vacuolar interface change; lupus erythematosus, erythema multiforme
112) Steatosis, lack of atypia and L-FABP loss; HNF1a-inactivated hepatocellular adenomas
113) Neck lesion; spindle cell lipoma
114) MLH1 loss; sporadic microsatellite instability
115) Lung biopsy; Langerhans cell histiocytosis
116) Diagnose ependymoma
117) Recognition of adenomatoid tumor
118) Ovarian sex cord tumor with annular tubules; Peutz-Jeghers syndrome
119) Identification of juvenile nasopharyngeal angiofibroma
120) Triple negative breast carcinoma
121) Neurofibromatosis; increased risks
122) Cutaneous adnexal tumors, hidradenoma papilliferum
123) Thyroidectomy; diagnose diffuse toxic goiter (Graves disease)
124) Morphologic and immunohistochemical criteria for partial atrophy
125) Diagnosis of follicular lymphoma
126) Morphology and risk for persistent gestational trophoblastic disease associated with a complete mole
127) Whipple disease; small bowel mucosal biopsy
128) Pheochromocytoma; identification
129) Diabetic mastopathy
130) Ulcerative colitis; superinfection with cytomegalovirus
131) Recognition of normal colonic mucosa
132) Distribution of sarcoidosis
133) Gastrointestinal stromal tumor, mutation in exon 11; prognosis
134) Identify chemical/reactive gastropathy
135) Differential diagnosis for nodular glomerulosclerosis
136) Meningioma; epithelial membrane antigen immunoreactivity

137) Indications for p16 immunohistochemistry in cervical neoplasia


138) Gross pathology of focal brain lesions
139) Epidermal nevus; characteristics
140) Larynx lesion; presence of human papillomavirus; laryngeal papillomatosis
141) Identification of angiofibroma
142) Staging; TNM system anal carcinomas
143) Polyoma virus infection; characteristics
144) Embryonal rhabdomyosarcoma; diagnose from bladder biopsy
145) Xp11.2 translocation associated renal cell carcinoma (RCC), TFE3 by FISH
146) Identify synovial osteochondromatosis
147) High grade salivary gland tumor; salivary duct adenocarcinoma
148) Identify florid papillomatosis of the nipple
149) Prognosis of thymoma subtypes
150) Intra-abdominal tumor; translocation in desmoplastic small round cell tumor
151) Tubulocystic carcinoma

CP RISE 2012-2015
CLINICAL CHEMISTRY
2012
155) Methanol ingestion; serum osmole gap
156) Acute rhabdomyolysis; diagnostic chemistry tests
157) Hereditary angioedema; C4
158) Turnaround time
159) Heroin and codeine; morphine metabolite
160) Receiver operating characteristic (ROC) curves
161) Acute intermittent porphyria
162) Toxic metabolite of cocaine and alcohol co-use
163) Lead poisoning in children; venous whole blood
164) Mixed cryoglobulins
165) Methanol ingestion; formate formation
166) X-linked agammaglobulinemia; immune deficiency
167) Transthyretin; nutritional status
168) Sulfonylurea; type II diabetes therapy; insulin testing
169) Major intracellular cation; potassium
170) Drug monitoring for oxycodone
171) Sensitive and specific test for celiac disease; serum IgA anti-tissue transglutaminase
172) Desirable lipid concentrations; outcomes and consensus opinion; e.g., NCEP-ATPIII
173) Allergic bronchopulmonary mycosis; total IgE and IgE against Aspergillus
174) Delta checks; identify mislabels and major isolated instrument errors
175) Plasma free metanephrines; pheochromocytoma
176) Functional sensitivity of an assay; interpretation of results
177) Friedewald calculation
178) Rheumatoid arthritis; antibodies to cyclic citrullinated peptides
179) Knowledge of abnormal laboratory values in acid-base and electrolyte disorders
180) Protein content in lipid fractions
181) Antimitochondrial antibodies; primary biliary cirrhosis
182) Multi-drug resistance gene (MDR1) and cytochrome P450 3A; tacrolimus
183) Repeated fist clenching during the tourniquet phase of hlebotomy; affect potassium level
184) Clinical test sensitivity; calculate
185) Comparison of methods; systematic error
186) Negative fetal fibronectin result; associated with delivering within a week
187) Antigen excess
188) Glomerular filtration rate; age, sex, race, serum creatinine
189) Calcium homeostasis disorders and nutritional deficiencies
190) Cushing syndrome; ACTH-secreting pituitary adenoma
191) Hair; drug abuse detection
192) Bence Jones proteinuria

193) Trisomy 21; clinical laboratory results


194) Method of tandem mass spectrometry
2013
155) Anion gap metabolic acidosis
156) Analytical error; specimen collection in K2EDTA tube
157) Screening and monitoring of vitamin D
158) Methanol ingestion; serum osmole gap
159) X-linked agammaglobulinemia; clinical history
160) Iron status studies in anemia of chronic disease
161) Tacrolimus; therapeutic drug level in whole blood
162) Preterm delivery
163) Opiate immunoassay; cross-reactivity
164) Lamellar body counts can be done on platelet channel of a hematology analyzer
165) Method comparison and proportional bias
166) Licorice; inhibition of 11-beta hydroxysteroid dehydrogenase
167) Type II cryoglobulinemia; hepatitis C
168) Additive to preserve blood specimens; glucose measurement
169) Diagnostic criteria for diabetes mellitus; fasting blood glucose level
170) Diagnosis of corticosteroid excess
171) PO2; room air
172) Transthyretin; nutritional status
173) Pharmacogenomic testing of warfarin dosing; CYP 2C9 and vitamin K reductase
174) Clinical significance of homovanillic acid; oat-cell carcinoma
175) Major intracellular cation; potassium
176) Extrahepatic biliary atresia; clinical characteristics
177) Gas chromatography/mass spectrometry derivatization; molecule volatile
178) Allergic bronchopulmonary mycosis; total IgE and IgE against Aspergillus
179) Hypertension; 11-beta hydroxylase deficiency
180) Test sensitivity; calculate percent
181) Free thyroxine; thyroid stimulating hormone
182) Laboratory error; preanalytic phase
183) Protein content in lipid fractions
184) Positive predictive value; definition
185) Promoter repeat polymorphism; Gilbert syndrome, pharmacogenetics
186) Diagnosis of celiac disease; anti-tissue transglutaminase and antiendomysial antibodies
187) Myocarditis; troponin values
188) Proficiency testing
189) Pregnancy; effect on albumin
190) DNA topoisomerase I
191) Brain natriuretic peptide; differentiating dyspnea due to cardiac (versus non-cardiac) causes
192) Diagnosis of diabetic ketoacidosis
193) Pseudohypoparathyroidism; parathyroid hormone, calcium, and phosphorus levels
194) Calculated LDL

2014
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CLIA 88 and quality control


Biliary obstruction; elevations in serum conjugated bilirubin
Carbohydrate-deficient transferrin and alcohol abuse marker
Glomerular filtration rate; equation to estimate
Monoclonal gammopathy
Methanol ingestion; serum osmole gap
Tumor marker; prostate specific antigen
Heroin metabolites
Ketones; creatinine measurement
Alpha-1-antitrypsin deficiency
Anti-smooth muscle antibodies; auto-immune hepatitis
Cholesterols; fasting and nonfasting changes
Dopamine metabolites
Acute porphyria; diagnostic testing
Skin biopsy; scleroderma
Immunosuppressive drug, 6-mercaptopurine (6-MP); metabolism
Transthyretin; nutritional status
Major intracellular cation; potassium
Pheochromocytoma; diagnostic tests; plasma free metanephrines
Magnesium deficiency; hypocalcemia
Arsenic and mercury; toxic forms
Westgard Rules
Hepatitis C infection; cryoglobulin
Interpretation of laboratory values in acid-base and electrolyte disorders
Allergic bronchopulmonary mycosis; total IgE and IgE against Aspergillus
Cushing syndrome; urinary free cortisol
Protein content in lipid fractions
Avidin in egg whites; decrease absorption of dietary biotin
Diagnosis of syndrome of inappropriate antidiuretic hormone (SIADH)
Pseudohyponatremia due to hypertriglyceridemia
Assay calibration
Accuracy versus precision
Refeeding syndrome after malnutrition
Diagnosis of diabetes
Celiac disease diagnosis; test most sensitive and specific
Cerebrospinal fluid; asialotransferrin
2C9; metabolism of warfarin
History of hemoptysis and hematuria; anti-glomerular basement membrane antibody; Goodpasture
syndrome
Phase1 classification; drug metabolizing reactions
Functional assay used to determine thiamine deficiency

2015
152) Lamellar body counts; fetal lung maturity

153) Serum neuron-specific enolase concentrations; small cell lung cancer


154) SAMHSA; five drugs
155) Diagnosis of multiple sclerosis
156) Neural tube defect; quadruple screen
157) Chemistry tests; delta checks
158) Allergic bronchopulmonary mycosis; total IgE and IgE against Aspergillus
159) Chemical reaction; nonenzymatic glycation of proteins
160) Protein content in lipid fractions
161) Vitamin D; test selection to assess status
162) Major intracellular cation
163) Churg-Strauss syndrome; clinical characteristics
164) Transferrin receptor; iron deficiency
165) Dexamethasone suppression test; interpretation
166) Macrocytosis, methylmalonic acid; diagnosis vitamin B12 deficiency
167) Ion selective electrodes and electrolyte exclusion effect
168) Utility of free PSA in screening for prostate cancer
169) Alcoholic hepatitis; interpretation of chemistry results
170) Neonatal hyperbilirubinemia; glucuronyl transferase activity
171) Conjugated bilirubin; Dubin-Johnson syndrome
172) Likelihood ratio advantage; independent of test prevalence
173) Statistical definition; precision
174) Steady state; minimum effective concentration
175) Nephelometry instrument diagram
176) Arterial blood gas interpretation-acid-base disorders
177) Transthyretin; nutritional status
178) Deleted
179) Direct LDL; clinical usefulness with triglycerides
180) Ethanol consumption marker; ethyl glucuronide
181) Sweat testing in cystic fibrosis
182) Diagnosis of diabetes using HbA1c
183) Methanol ingestion; serum osmole gap
184) Familial dysbetalipoproteinemia
185) Thyroid function testing; Graves disease
186) Receiver-operator characteristic (ROC) curve
187) Suspected false positive serum pregnancy tests due to HAMA
188) C-peptide; glyburide abuse
189) Biochemical testing for pheochromocytoma
190) Acute porphyria; spot urine porphobilinogen
191) Serum compared to plasma; chemistry results

HEMATOLOGY
2012
195) Identification; Babesia microti

196) Heterozygosity for hemoglobin D


197) Diagnostic criteria for acute myeloid leukemia (AML)
198) Flow cytometry; lymphocyte light scatter techniques
199) Morphology and genetics of acute myeloid leukemia (AML) with inv(16)
200) Venous thromboembolism; D-dimer, quantitative
201) Chediak Higashi syndrome
202) Hypersegmented neutrophils
203) Chronic myelomonocytic leukemia; absolute monocytosis, dysplasia, blasts
204) Myeloperoxidase deficiency
205) Factor XII deficiency not associated with bleeding
206) Giemsa stained thin and thick smear; means for identifying malaria
207) Hypercoagulable; antiphospholipid antibody syndrome
208) APTT; antiphospholipid syndrome
209) B-lymphoblastic leukemia; immunophenotype and morphology
210) Primary central nervous system lymphoma
211) Evans syndrome; autoimmune hemolytic anemia and thrombocytopenia
212) Cytogenetic findings; prognosis
213) Staghorn megakaryocytes nuclei; association with essential thrombocythemia
214) Disseminated intravascular coagulation (DIC); clot formation and clotting factors
215) Acquired factor VIII inhibitors; autoantibodies to coagulation factors leading to bleeding
216) Peripheral blood smear with microangiopathic anemia; associated with valve replacement
217) Anemia of chronic disease; clinical laboratory findings
218) Red blood cell agglutination; effect on automated cell count
219) Acute monoblastic leukemia; t(9;11)(p22;q23)
220) Morphologic appearance of circulating cells in follicular lymphoma
221) Metastatic tumor cells in bone marrow aspirate
222) Platelet aggregation; von Willebrand disease
223) Clinical symptoms for factor XIII
224) Cerebrospinal fluid sample with peripheral blood contamination ("traumatic tap")
225) Pelger-Huet anomaly; identification
226) Anemia; caused by a decrease in alpha chains of hemoglobin
227) Heterozygosity for hemoglobin C; high performance liquid chromatography method
228) Automated cell counters; falsely low platelet count
229) Flow cytometry study showing loss of CD59 expression in paroxysmal nocturnal hemoglobinuria
230) Glucose-6-phosphate dehydrogenase deficiency
231) Routine coagulation testing; specimen collection
232) Myelodysplastic syndrome; dysplastic megakaryotypes
233) Acute promyelocytic leukemia
234) Pseudothrombocytopenia due to ethylenediaminetetraacetic acid (EDTA)
2013
195) Testing; chronic granulomatous disease
196) Flow cytometric immunophenotyping; leukemia interpretation
197) Flow cytometry; lymphocyte light scatter techniques
198) Type IIB von Willebrand disease; diagnostic tests

199) Chronic myelomonocytic leukemia; absolute monocytosis, dysplasia, blasts


200) Laboratory findings; hemolytic anemia
201) Mean cell volume; factors affecting
202) Prothrombin and partial thromboplastin times and Factor VIII levels
203) Diagnostic translocation of acute myeloid leukemia with inv16
204) Factor XII deficiency; association with bleeding
205) Acute promyelocytic leukemia, microgranular variant; clinical characteristics
206) B-lymphoblastic leukemia; immunophenotype and morphology
207) Cause for truly elevated mean cell hemoglobin concentration
208) Gaucher disease; enzyme deficiency
209) Etiology of heparin resistance
210) Vitamin K depletion; heparin-induced thrombocytopenia contraindicates warfarin
211) Newborn; most abundant hemoglobin
212) Method to overcome spurious hematology results associated with cold agglutinins
213) Lupus anticoagulant; prothrombin time
214) Favorable prognostic factors in B lymphoblastic leukemia
215) Deleted
216) Expected reticulocyte counts for anemia due to different causes
217) Bacterial meningitis on cerebrospinal fluid cytospin
218) Citrate dose carefully balanced for amount of blood drawn
219) Diagnostic laboratory and morphologic features; congenital dyserythropoietic anemia
220) Metastatic adenocarcinoma; bone marrow
221) Autosomal recessive V deficiency; variable symptoms
222) Dysplastic megakaryocytes; identification
223) Morphologic and immunophenotypic features; Szary Syndrome
224) Beta-thalassemia; beta-globin production
225) Distinction between iron deficiency anemia and anemia of chronic disease
226) Intron 22 inversions predict hemophilia A inhibitors
227) Diagnostic testing for hemolytic disorders
228) Paroxysmal nocturnal hemoglobinuria; symptoms of hypercoagulability
229) Fluid cytology and flow cytometric studies in T-lymphoblastic lymphoma
230) Deleted
231) Automated cell counters; falsely low platelet count
232) Mastocytosis; morphology
233) Pencil cells; iron deficiency anemia
234) Agglutination of red blood cells; autoimmune hemolytic anemia, cold type with IgM
235) Leukocyte adhesion deficiency; functional abnormalities and morphology
2014
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Protein C and S results in patients on anticoagulants


Factor XIII deficiency; prothrombin time, partial thromboplastin time, thrombin time
Flow cytometry; lymphocyte light scatter techniques
Deleted
Chronic myelomonocytic leukemia; absolute monocytosis, dysplasia, blasts
Expansion of benign B cell precursors (hematogones) as shown by CD10 vs CD20 maturation pattern

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Bone marrow aspirate morphology of Gaucher disease


Diagnosis of antiphospholipid syndrome; antiphospholipid antibodies over time
Acquired hemophilia; clinical findings
Acquired sideroblastic anemia
Factor XII deficiency; association with bleeding
B-lymphoblastic leukemia; immunophenotype and morphology
Common cause of heparin resistance when monitoring with activated partial thromboplastin time
Defective NADPH oxidase; in chronic granulomatous disease
Red blood cell inclusions; associated precipitated substance
Cerebrospinal fluid findings in multiple sclerosis
Type 2B von Willebrand disease; association with thrombocytopenia
Myeloproliferative disorder of Down syndrome; megakaryoblast identification
Morphology of hemoglobin H disease on Wright and brilliant cresyl blue stains
Dhle bodies; May Hegglin anomaly
Effect of pregnancy/post-partum state on protein S levels
Laboratory findings that help distinguish secondary erythrocytosis from polycythemia vera
Dysplastic megakaryocytes; identification
Acute myeloid leukemia with inv 16
Myeloperoxidase deficiency prevalence and clinical features
WHO recommendations; blasts in a diagnosis of myelodysplastic syndrome
Hereditary elliptocytosis clinical features and pathophysiology
Squamous cell with bacteria; contamination of bronchioalveolar lavage specimen
Ethylenediamine tetraacetic acid (EDTA) induced pseudothrombocytopenia
Plasma cell leukemia; atypical plasma cells in peripheral blood
Factor deficiency; primary amyloidosis
Beta-thalassemia minor; diagnose
Major target of antiphospholipid syndrome antibodies
Hepcidin
Interpretation of red blood cell histogram
Automated cell counters; falsely low platelet count
Cold agglutinins; technique to obtain valid red blood cell parameters
Ringed sideroblasts; drug-induced
Diagnosis of glucose-6-phosphate deficiency
Prognosis of precursor B-cell acute lymphoblastic leukemia (ALL) with hyperdiploidy
Flow cytometry; precursor B-cell acute lymphoblastic leukemia

2015
192) Flow cytometry; lymphocyte light scatter techniques
193) Neuroblastoma: bone marrow aspirate smear morphology and MYCN amplification as a prognostic
marker
194) Antimalarial drug therapy; adverse effect
195) Prothrombin complex concentrates; reverse anticoagulant effect
196) Hemoglobin S/+-thalassemia
197) Drying artifact and effect on red blood cell morphology
198) Increased sensitivity to low dose (0.5 mg/mL) ristocetin in type 2B von Willebrand Disease

199) Calculated hematocrit


200) Pyropoikilocytosis; hereditary elliptocytosis family of diseases
201) Clinical indications; heterophil antibody test
202) Gaucher disease; morphology
203) Principle of automated reticulocyte analysis
204) Automated cell counters; falsely low platelet count
205) Normal range serum ferritin associated with iron deficiency and inflammation
206) Features of transient erythroblastopenia of childhood
207) Bone marrow manifestations of cystinosis
208) Automated cell red blood cell count; electrical impedance
209) Prolonged umbilical cord attachment in leukocyte adhesion deficiency type I
210) Ciliated bronchial epithelial cells in wet preparations
211) Partial thromboplastic time and mixing studies; Factor VIII inhibitor
212) Common hereditary risk factors for thrombosis
213) Diagnostic criteria and clinical features of plasma cell leukemia
214) Chronic myelomonocytic leukemia; absolute monocytosis, dysplasia, blasts
215) Blood smear interpretation; anemia, hereditary elliptocytosis
216) Heparin-induced thrombocytopenia; heparin platelet factor 4 complex
217) Dihydrorhodamine 123 assay for chronic granulomatous disease
218) Calculation of INR
219) B-lymphoblastic leukemia; immunophenotype and morphology
220) Dysplastic megakaryocytes; identification
221) Iron deficiency anemia; TIBC, zinc protoporphyrin, soluble transferrin receptor, MCV/RBC, and Hb A2
222) Acute promyelocytic leukemia; bone marrow flow cytometric immunophenotyping
223) Effect of argatroban on clotting times
224) Sickle trait; anemia
225) Detection of disseminated histoplasmosis
226) AML with inv 16; morphology
227) Megaloblastic anemia and laboratory testing
228) Effect of lupus anticoagulant on clot-based factor assays
229) Pleural fluid; metastatic adenocarcinoma
230) Cresyl blue staining; hemoglobin H
231) Factor XII deficiency; association with bleeding

MICROBIOLOGY
2012
235) Penicillium marneffei; etiology and identification
236) Cryptococcus neoformans, cornmeal agar
237) D test; inducible resistance to clindamycin
238) Microscopic morphology of Plasmodium falciparum gametocytes
239) Detection of Clostridium difficile
240) Virus detection; rapid shell vial culture
241) Streptococcus pyogenes cellulitis and soft tissue infection; clinical characteristics
242) Modified Hodge test for Klebsiella pneumoniae carbapenemase

243) Rhizopus lactophenol cotton blue morphology


244) Campylobacter jejuni; identification in methylene blue wet mount
245) Optimal specimen to isolate Schistosoma hematobium
246) Exophiala causing mycetoma; colony morphology and microscopic appearance
247) Coccidioidomycosis; valley fever
248) Extended spectrum beta lactamase confirmatory testing
249) Beaded appearance of mycobacteria on Gram stain; Kinyoun acid fast stain
250) Blastomyces dermatitidis macroscopic and microscopic identification
251) Dermacentor variabilis; identification
252) Agar disk diffusion; inoculum requirement
253) Colony appearance and microscopic identification of Fusarium
254) Gram stain; reagent effects
255) Guidelines for discontinuing isolation of patients with pulmonary tuberculosis
256) M. marinum; cutaneous lesions and growth at lower temperatures
257) Antibody to hepatitis C virus; HCV RNA test
258) Adenovirus; identification
259) Serological diagnosis of past Epstein-Barr virus infection
260) Association of the mecA gene with resistance to methicillin in Staphylococcus aureus
261) Strongyloides larva; clinical symptoms and identification
262) Serological diagnosis of chronic hepatitis B infection
263) Mycobacterium abscessus; identification
264) Babesia microti; identification from peripheral blood smear
265) Histoplasmosis identification
266) Identification of nutritionally variant gram-positive cocci
267) Identify Proteus mirabilis; swarming on agar plate
268) Gram stain morphology and hemolysis on culture for Streptococcus pneumoniae
269) Candida krusei; therapy
270) Fusobacterium nucleatum; clinical and laboratory presentation
271) Aspergillus niger; hyaline mold, cause of otomycosis
272) Methods of mycobacterial culture
273) Hemadsorbing viruses
274) Appearance of Taenia saginata proglottid
275) Gram stain morphology of Actinomyces spp.
2013
237) Mycobacterium marinum culture, incubation temperature
238) Cutaneous myiasis with human botfly larva; identification
239) Fusobacterium brain abscess
240) Extended spectrum beta-lactamase; E. coli and Klebsiella pneumoniae
241) Schistosoma mansoni ovum; identification
242) Diagnosis of Legionella infection
243) Carbapenem resistant Enterobacteriaceae
244) Dermatophyte infection; identification from potassium hydroxide wet mount
245) Bacille Calmette-Gurin vaccination; interferon-gamma release assays; tuberculin skin testing
246) Streptococcus agalactiae (Group B); clinical presentation

247) Mycobacterium fortuitum; clinical and laboratory findings


248) Diagnosis of parasites; peripheral blood smear
249) Maxillary sinus infection; Rhizopus
250) Diagnosis of Parvovirus infection from bone marrow
251) Utility of influenza A subtyping
252) Serological diagnosis of primary Epstein-Barr virus infection
253) Identify; Ascaris lumbricoides
254) Microscopic identification of Pneumocystis
255) Gram stain; reagent effects
256) Reduction of normal oropharyngeal bacteria; mycobacterial culture
257) Identify; Pediculus capitis
258) Coagulase negative Staphylococci contaminating blood cultures
259) Strongyloides larva; clinical symptoms and identification
260) Coccidioides; culture identification
261) Haemophilus influenzae culture conditions
262) Neisseria meningitidis sepsis
263) Antibiotic resistance; Staphylococcus aureus
264) Adenovirus as cause of conjunctivitis
265) Differentiation of low and high risk genotypes of human papillomavirus (HPV)
266) Categorical agents of bioterrorism; categorized by the CDC as serious threats to national security
267) Pseudomonas aeruginosa; identification from Gram stain and clinical history
268) Blood media for M. haemophilum
269) Identify Proteus mirabilis; swarming on agar plate
270) Gram stain appearance of Listeria
271) Vancomycin resistance; bacteria
272) Serological diagnosis of acute hepatitis B infection
273) Growth conditions for Malassezia furfur
274) Primary isolation medium for Nocardia
275) Salmonella characteristics on Hektoen enteric agar
2014
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Dematiaceous mould (Bipolaris) allergic sinusitis


Epstein-Barr virus infection; heterophile antibodies
Culture characteristics of Arcanobacterium haemolyticum
Western blot; confirmation test, HIV
Green pyoverdin pigment of Pseudomonas aeruginosa
Escherichia coli identification; basic tests
Adenovirus disease association
Laboratory diagnosis of influenza
Urinary tract infection (UTI) diagnosis
Diagnosis of West Nile virus infection in symptomatic patients
Satellite colonies of Abiotrophia species around S. aureus
Lactose fermentation on MacConkey agar by Enterobacter aerogenes
Mycobacterium fortuitum; clinical characteristics
Deleted

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Diagnosis of herpes-simplex virus meningoencephalitis by polymerase chain reaction


Interferon gamma release assays vs the tuberculin skin test
Susceptibility testing; Salmonella spp.
Plasmodium vivax; treatment of the hypnozoite stage
Cord formation; acid-fast bacteria
Aspergillus morphology
Intrinsic resistance of Aspergillus species
Burkholderia cepacia complex; antimicrobial intrinsically resistant
Histological diagnosis of Coccidioides infection
Nitrofurantoin; uncomplicated cystitis
Colonic mucosal biopsy; cytomegalovirus colitis
Gram stain; reagent effects
Tetracycline susceptible Enterobacteriaceae; susceptibility to minocycline and doxycycline
Taenia saginata identification and mode of infection
Francisella tularensis; growth characteristics
Lysis-centrifugation blood cultures; enhanced recovery
Serology to infer hepatitis B virus (HBV) status
Strongyloides larva; clinical symptoms and identification
Gastric aspirate; pulmonary mycobacteria in young children
Detection of Norovirus by molecular techniques
Anaerobic gram-positive bacilli; Gram staining characteristics
Inhibition of daptomycin by pulmonary surfactant
Naegleria fowleri; amoebic meningoencephalitis
Identify Proteus mirabilis; swarming on agar plate
Enterococci penicillin-binding protein 5 (PBP5); which cephalosporins do not bind
RNA (e.g. from HIV-1); reverse transcribed to DNA before polymerase chain reaction

2015
232) Laboratory detection of West Nile virus; serology vs. polymerase chain reaction
233) M. gordonae; contaminant from tap water
234) Cysticercosis; Taenia solium ova
235) Acanthamoeba species; preferred culture medium
236) Mycobacterium abscessus; growth and Gram stain characteristics
237) Examination of auramine O stain for mycobacteria
238) Chlamydia trachomatis nucleic acid testing
239) Trypanosoma cruzi in a Giemsa-stained blood smear; identification
240) Laboratory identification of Zygomycetes
241) Negri bodies; rabies infection
242) Naegleria fowleri; primary amoebic meningoencephalitis
243) Nocardia; beaded gram-positive bacilli, modified acid fast
244) Malassezia furfur; growth requirements, parenteral nutrition
245) Vibrio; thiosulfate citrate bile salts agar
246) Gram stain; reagent effects
247) Laboratory diagnosis of rotavirus
248) Granulicatella and Abiotrophia; growth characteristics

249) HIV testing in a newborn


250) Identify Proteus mirabilis; growth characteristics on agar plate
251) Dematiaceous mold; phaeohyphomycosis
252) Hepatitis B virus; surface antibody positive, vaccination
253) Strongyloides larva; clinical symptoms and identification
254) Appropriate susceptibility testing for Staphylococcus saprophyticus
255) Candida identification; germ tube
256) Biochemical and morphological characteristics of Acinetobacter baumannii
257) Symptoms of parainfluenza virus
258) Trichosporon; cryptococcal latex agglutination assay and microscopic morphology
259) Cyclospora cayetanensis morphology and staining properties
260) Confirmatory testing for extended spectrum beta lactamases
261) Methicillin-resistant S. aureus; Ceftaroline
262) Fusarium; contact lens infections
263) Streptococcus pneumoniae; biochemical features, community acquired pneumonia
264) Cryptococcal meningitis in HIV patients and antigen testing
265) Identification of mycobacteria; pigmentation and photoreactivity
266) Plasmodium ovale in a Giemsa-stained peripheral blood smear
267) Laboratory testing for Lyme disease; serology
268) Carbapenem resistance in E. coli and epidemiological link to India; NDM-1
269) False positives on QuantiFERON-TB Gold
270) Progressive multifocal leukoencephalopathy; diagnosis, JC virus
271) Capnocytophaga growth properties and clinical history

TRANSFUSION MEDICINE
2012
276) Composition of prothrombin complex concentrates
277) Organisms transmitted in red blood cell transfusions
278) Donath-Landsteiner antibodies; C3d + DAT, do not interfere with routine testing
279) Rh immune globulin, anti-D; D positive patients with immune thrombocytopenic purpura (ITP)
280) Regulatory requirement for transfusion committee
281) HLA loci (A, B, C, DR) matching; successful outcome in stem cell transplantation
282) Use of Rh immune globulin (RhIg) when giving Rh positive platelets to a Rh negative patient
283) Cryoprecipitated AHF; factor and fibrinogen contents
284) The FDA requires next day reporting death of a patient from a complication of transfusion
285) Differentiating transfusion associated circulatory overload and transfusion-related acute lung injury
286) Antibody to low incidence antigens
287) Specific gravity of the various cells in blood
288) Antibody panel red cells; are blood group
289) Jehovahs Witness patients; acceptable transfusion products
290) Infectious disease screening of blood donors
291) Mothers genotype; homozygous for HPA1b
292) Storage of hematopoietic stem cells
293) Cirrhotic patients; interpreting coagulation studies

294) ABO/Rh testing before transfusion; red blood cell component


295) Kell antigen; presence on erythroid precursor cells
296) Blood utilization audits
297) Identification of alloantibodies on panel
298) Maximum volume of blood collected; allogeneic blood donor
299) Indications for weak D Testing
300) Critical titer for anti-D; when to consider for invasive therapeutic procedures
301) Understanding the different types of Von Willebrand disease
302) Platelet transfusion; platelet count increment
303) Calculation for plasma volume
304) Hematopoietic stem cell allograft; RBC transfusion ABO type selection
305) HLA and clinical presentations: HFE, B27, DQ6
306) Efficiency of plasma constituents removal in relation to volume exchanged
307) Post transfusion purpura
308) Ceftriaxone; severe intravascular immune hemolysis in pediatric sickle cell patients
309) Fresh Frozen Plasma (FFP) thawed; label and expiration
310) Calculation of percent platelet recovery
311) Component storage after irradiation
312) Donor deferral; Creutzfeldt-Jacob disease
313) Dosing and indications for Rh immune globulin
314) Characteristics of granulocytes product
2013
276) Identify antibody specificity from red blood cell antibody panel
277) Cryoprecipitate; indications for transfusion
278) Red blood cell antibody panel; identify antibody against high frequency antigen
279) Cryoprecipitated antihemophilic factor; factor and fibrinogen contents
280) Pro- and retrospective audits can be used to analyze use of the transfusion service
281) TA-GVHD has a mortality rate of >90% due to presence of marrow aplasia
282) Frequency of transfusion reactions
283) Enzyme treatment and Duffy antibody reactivity
284) ABO Typing: forward and reverse typing
285) Donor reactions; hypovolemic and vasovagal reactions
286) Perioperative blood management with antibody to high frequency antigen
287) Warfarin reversal in a non bleeding patient with high international normalized ratio (INR)
288) Deleted
289) Clotting factors depletion after plasma exchange
290) Antineutrophil antibodies; transfusion-related acute lung injury
291) Prothrombin complex concentrate; corrects the prothrombin time (INR) in a patient on warfarin
292) Clinical diagnosis of transfusion-related acute lung injury
293) Reissuing Red Blood Cell units; requirements
294) Factor XII deficiency; bleeding disorder
295) Expiration time of blood components stored in different solutions
296) Platelet antigens associated with platelet transfusion refractoriness
297) Calculate the number of vials of RhoGAM; from Kleihauer-Betke result

298) Benefits of leukoreduction


299) Direct Coombs; IgG, C3d detection
300) Hematopoietic stem cell allograft; transfusion ABO type selection
301) Hemochromatosis; labeling donor units
302) Fresh Frozen Plasma infusion; thrombotic thrombocytopenic purpura
303) Patients with history of alloantibodies; crossmatch
304) HLA and clinical presentations: HFE, B27, DQ6
305) Deleted
306) Therapeutic phlebotomy; indications
307) Therapeutic plasma exchange most efficiently removes IgM
308) Wieners Rh-Hr phenotype; f antigen specificity
309) Estimated increase in hematocrit after transfusion
310) Donor deferral; Creutzfeldt-Jacob disease
311) U antigen; characteristics
312) Post-transfusion; store patient sample and transfused segment
313) Positive antibody screen; red blood cell panel interpretation
314) Expected increase in platelet count after transfusion
315) Directed donor criteria
2014
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Warfarin overdose, prothrombin complex concentrate


Paresthesias due to citrate toxicity; blood progenitor cell donors
Blood product choices; emergency transfusion
Hemochromatosis; therapy
Cryoprecipitated antihemophilic factor; factor and fibrinogen contents
Use of aPTT in screening for factor deficiency
Transfusion support for ABO incompatible stem cell transplant
Bacterial contamination of blood products
Patients with Factor XI deficiency undergoing surgery at sites with low fibrinolytic activity
Complications of chronic transfusion, sickle cell anemia
Laboratory investigation of neonatal alloimmune thrombocytopenic purpura (NAITP)
Rh immune globulin usage; infant types weak D positive
Emergency transfusion; acceptable blood selection
Antibodies to human neutrophil antigens; transfusion related acute lung injury
Gamma irradiation; clinical blood component applications
Prevention of graft versus host disease; gamma irradiation
Antibody panel; interpretation
Immune hemolysis due to drugs
Rh immune globulin therapy; immune thrombocytopenic purpura
Autoantibody; antibody panel presentation
Rh immune globulin; autoimmune thrombocytopenia
Diseases for which lookback is required in accord with FDA 21 CFR 610
Category I indication for therapeutic plasma exchange in accordance with ASFA Guidelines
Transfusion trigger; uncomplicated patient
Composition of cryoprecipitate

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HLA and clinical presentations: HFE, B27, DQ6


Allogeneic blood donor qualification with history of Babesiosis
Choosing blood components based on patient and donor blood type
Neonatal red cells; antigens expressed
Fresh Frozen Plasma; factor deficiencies
Direct antiglobulin test positive for IgG; elution/eluate identifies the IgG specificity
Transfusion related acute lung injury (TRALI) differential diagnosis
Fucosyltransferase; H and SE genes
Blood component storage conditions
Donor deferral; Creutzfeldt-Jacob disease
Hemolytic transfusion reaction; clinical and laboratory findings
Auto anti-I; Mycoplasma pneumonia infections
Paroxysmal cold hemoglobinuria; characteristics
Patient O positive with known antibodies; emergency transfusion, Rh
Coagulation factor half-life
Plasma exchange; principles of removal

2015
272) Iron overload from chronic red cell transfusions
273) Causes of transfusion related mortality and transfusion reactions
274) Blood transfusion support for solid organ transplants
275) History of viral hepatitis; deferral status
276) Therapeutic plasma exchange in hyperviscosity syndrome
277) Determine platelet transfusion response; body surface area, corrected count increment (CCI)
278) ABO typing discrepancies caused by rouleaux
279) Hemoglobin electrophoresis and associated clinical disorders
280) Principal cause of transfusion-related acute lung injury (TRALI)
281) Advantages and adverse reactions from autologous blood
282) HLA and clinical presentations: HFE, B27, DQ6
283) Hemolysis in ABO mismatched hematopoietic progenitor cell transplantation
284) ABO typing using tube methodology
285) Indications for use of intravenous immune globulin
286) Blood bank modifications of platelets for neonatal alloimmune thrombocytopenia (NAITP)
287) Red blood cell parasite disorders
288) Hematopoietic progenitor cell collection in pediatric patients
289) Antibody panel interpretation and associated antibody properties
290) Factor VIII is used for hemophilia A
291) Serologic findings in post-transfusion purpura
292) Investigation of a positive direct antiglobulin test with hemolysis
293) Effect of Rh type on Fresh Frozen Plasma transfusion
294) Cryoprecipitated antihemophilic factor; factor and fibrinogen contents
295) Pathophysiology and laboratory testing in thrombotic thrombocytopenic purpura (TTP)
296) Audits of transfusions; appropriateness of blood component usage
297) Frequency of apheresis platelet donation
298) AABB minimal requirements for granulocytes dose

299) Red cell exchange to treat Babesiosis


300) Hemolytic disease of the fetus and newborn
301) Deleted
302) Development of inhibitors in patients with hemophilia and its treatment options
303) Alloantibody to E antigen; using Weiner Rh nomenclature
304) Determine number of units cryoprecipitate to increase patients fibrinogen
305) Appropriate temperature for storage of blood products
306) Platelet refractoriness
307) Storage and expiration requirements for cryoprecipitate
308) Pathogenesis of transfusion-associated graft-vs-host disease
309) Donor deferral; Creutzfeldt-Jacob disease
310) Labile coagulation factors in plasma
311) Reporting of biologic product deviations in accord with 21 CFR 606

HEMATOPATHOLOGY
.
2012
315) Systemic mastocytosis involving bone marrow
316) Cat scratch disease
317) Lymphoplasmacytic lymphoma
318) Mantle cell lymphoma; immunophenotype
319) Nasal T/NK lymphoma; necrosis
320) Phenotypic and histologic features of primary splenic marginal zone lymphoma
321) Changes in the bone marrow trabecula in patients with renal failure
322) Morphologic features of hyaline vascular Castleman disease
323) Myeloproliferative disease; leukoerythroblastic anemia
324) Myc /IgH translocation in Burkitt lymphoma
325) Bone marrow involvement by follicular lymphoma
326) Dermatopathic lymphadenopathy, late stage, associated with chronic dermatitis
327) Origin of Reed-Sternberg cells
328) Immunophenotype of most normal plasma cells
329) Nodular lymphocyte, predominant Hodgkin lymphoma; identification
2013
316) Lymph node follicular lymphoma; t(14;18) translocation
317) Mantle cell lymphoma versus chronic lymphocytic leukemia
318) Angioimmunoblastic T-cell Lymphoma
319) Mantle cell lymphoma; immunophenotype
320) Hairy cell leukemia; flow cytometric immunophenotyping
321) Nasal T/NK lymphoma; necrosis
322) Megakaryocyte morphology in myelodysplastic syndromes (MDS) with isolated del(5q)
323) Chronic idiopathic myelofibrosis; characteristics
324) Monoclonal gammopathy of undetermined significance; multiple myeloma
325) Mycosis fungoides
326) Nodular sclerosis classical Hodgkin lymphoma; abnormal B-cell program, expresses PAX5

327) Mast cell disease can be associated with a non-mast cell hematopoietic malignancy
328) HIV and Parvovirus
329) Nodular lymphocyte, predominant Hodgkin lymphoma; identification
330) Castleman disease; clinical and morphologic features
2014
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Morphologic features of hairy cell leukemia in bone marrow biopsy


Kikuchi lymphadenitis; histologic features
Key feature of Langerhans cells
Splenic marginal zone lymphoma; diagnose
Strong, uniform TdT expression; B lymphoblastic leukemia/lymphoma
Mantle cell lymphoma; immunophenotype
Granulocytic dysplasia; specimen preferred
Nasal T/NK lymphoma; necrosis
Mycosis fungoides
Gelatinous transformation of bone marrow and hyaluronic acid
Castleman disease; associated with HHV8 infection in the multicentric type
Reactive follicular hyperplasia
Nodular lymphocyte, predominant Hodgkin lymphoma; identification
Lymphoproliferative disorders, cyclin D1 expression

2015
312) Nodular lymphocyte, predominant Hodgkin lymphoma; identification
313) International Prognostic Scoring Index; myelodysplastic syndromes
314) Mantle cell lymphoma; immunophenotype
315) Reactive lymphoid hyperplasia, follicular type
316) Anaplastic large cell lymphoma
317) Lymph node biopsy; classical Hodgkin lymphoma - immunophenotype
318) Myeloproliferative disorder with JAK-2 mutation
319) Kimura disease; benign chronic inflammatory disease in the head and neck region
320) Features of lymphoplasmacytic lymphoma
321) Extramedullary hematopoiesis in splenic red pulp
322) Essential thrombocythemia; normocellular marrow
323) Nasal T/NK lymphoma; necrosis
324) Features of poor fixation in a bone marrow specimen
325) Toxoplasma lymphadenitis
326) Myeloid sarcoma cells; myeloperoxidase

LABORATORY ADMINISTRATION
2012
330) Regulating agencies for biohazardous materials
331) Laboratory information system; validation
332) Define benchmarking
333) Federal regulatory; referral to diagnostic facility in which there is a financial interest

334) The AP post-analytic phase includes the issuance of a complete surgical pathology report
335) Root cause analysis helps to identify the primary cause and contributing factors to a sentinel event
336) Root cause analysis; retrospective process
337) Quality control record; retention time
338) Computer interfaces
339) Goals of laboratory automation of pre-analytic processing
340) How pixel color information is stored
341) SWOT analysis; applications
342) Definition of management
343) Digital pathology
344) Measure of precision; coefficient of variation
345) Logical observation identifiers, names and codes (LOINC); purpose
346) Proficiency testing
347) Blood products; large expense item
2013
331) Criterion based job description
332) Error classification; anatomic pathology
333) Interface engines; purposes
334) Elements required to establish medical malpractice
335) Diagnosis codes for billing
336) Instruments performing same analyte; comparison and quality control
337) Productivity; measure of outputs per input resources
338) Sentinel event definition
339) Federal law describing rules for administration of salaries and wages
340) Failure mode effects analysis; evaluation of pre-analytic system changes
341) HIPAA compliance; release of personal health information
342) HL7; common standard used for system interfaces
343) Pre-analysis steps in automation
344) Material safety data sheets; information provided
345) Occupation Safety and Health Administration; bloodborne pathogen standard
346) Logical observation identifiers, names and codes (LOINC); purpose
347) Privileged communications and medical records
348) Quality improvement models
349) College of American Pathologists Phase II deficiency
350) Accounts receivables
351) Blood products; large expense item
2014
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Occurrence Insurance; definition


Electronic medical record; approval process
Duty of the medical director regarding work space
Record retention
Meaningful use stage 2
Medical staff bylaws governed by the board

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Exempt employee status; salaried professional workers


JCAHO, CLIA ' 88; directorship requirements
Family and Medical Leave Act (FMLA)
HIPAA breach
Part A; category of services
Strategic planning; development of execution disciplines
High complexity laboratories; laboratory director regulations
Logical observation identifiers, names and codes (LOINC); purpose
"Deemed" status; inspect and accredit clinical laboratories
Patient privacy and security
Lean; work process improvement
Clinical Laboratory Improvement Amendment (CLIA 1988); waived tests and quality assurance
Interventions to improve patient safety by reducing laboratory errors
Blood products; large expense item

2015
327) Appointment process; privileges granted to hospital medical staff
328) Pareto Principle applied to quality control in the laboratory
329) Formula for return on investment when looking at new technologies
330) Six Sigma; quality management tool
331) Understand principles of document management
332) Developing a strategic plan
333) Blood products; large expense item
334) Understanding the core competencies as developed by ABMS and ACGME
335) Branding and brand differentiation
336) 5S technique
337) Logical observation identifiers, names and codes (LOINC); purpose
338) Proficiency testing; failures and criteria to resume testing
339) Understanding allowable interview questions
340) Deleted
341) Understanding provisions set forth in HIPAA
342) Statistical tools for result validation
343) Criteria for malpractice
344) Test utilization management tools

MOLECULAR PATHOLOGY
2012
348) Cytogenetic alteration in Turner syndrome
349) Molecular markers to assess bone marrow engraftment
350) Isothermal amplification for transcription mediated amplification and nucleic acid sequence based
amplification
351) FISH probe design, Ewings sarcoma
352) Current status of DNA sequencing
353) Cytogenetic alterations in Prader-Willi and Angelman syndromes

354) Sibling match HLA-A,B,C and DR loci; likelihood


355) Limitations of genome-wide association studies
356) Dominant gene expressed in hetero and homozygous states
357) Polymerase chain reaction; common problems
358) Recommendations for presymptomatic genetic testing in minors
359) Aspects of karyotyping and FISH analysis
360) Detection of triplet expansion in Fragile X syndrome
361) Autosomal recessive inheritance
362) Types of genetic variation and significance with regard to disease
363) Heavy chain CDR3 length depends on V, D, and J segments
364) Maternal cell contamination
365) Warfarin pharmacogenomics
2013
352) Common controls used for molecular assays
353) Post-transplant lymphoproliferative disorder, Epstein-Barr virus and real time polymerase chain reaction
354) Whole exome and whole genome DNA sequencing
355) Isothermal amplification for transcription mediated amplification and nucleic acid sequence based
amplification
356) Next generation sequence coverage
357) Genetic mechanism of Huntington disease
358) Dominant gene expressed in hetero and homozygous states
359) Cytogenetic features of Fragile X syndrome
360) Develop "lab developed" test; requirements
361) Genetic testing- informed consent / patient autonomy
362) X-linked recessive condition; characteristics
363) Karyotype interpretation; amniotic fluid
364) FISH image; genotype trisomy 21
365) Warfarin sensitivity genotyping and pharmacodynamic vs pharmacokinetic target
366) Type of epigenetic modification
367) Genomic imprinting
368) Heavy chain CDR3 length depends on V, D, and J segments
369) Calculation of HER2/neu amplification signal
370) Laboratory errors
2014
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350)
351)
352)
353)
354)
355)
356)

Patenting genes
Chemistry used by next generation sequencing
Composition of nucleosome
Variation in hepatitis C treatment
Isothermal amplification for transcription mediated amplification and nucleic acid sequence based
amplification
Dominant gene expressed in hetero and homozygous states
Burkitt lymphoma translocations dysregulate C-MYC
Inappropriate bands in control sample

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Fanconis anemia; chromosomal instability


DNA identity testing; short tandem repeats (STR)
Southern Blot analysis of a patient with Fragile X syndrome and CGG repeat expansion
FISH analysis using break-apart probe for MLL gene
Carrier risk in autosomal recessive diseases
Mixed chimerism; chronic myeloid leukemia
Testing for prenatal aneuploidy
Heavy chain CDR3; V, D, and J segments
DNA measurements
Number of human genes

2015
345) Dominant gene expressed in hetero and homozygous states
346) Comparative genome hybridization
347) Risk analysis of autosomal recessive inheritance
348) Prader-Willi syndrome
349) HIV viral load testing by reverse transcription polymerase chain reaction amplification
350) FISH genotype; hemizygosity for ELN
351) Metabolism of drugs by cytochrome p450
352) Chromosome analysis, karyotype of metaphase spread; deletion
353) DNA quality in formalin fixed tissue
354) Karyotype of partial molar pregnancy
355) Interpretation of paternity tests
356) Consequences of a HIPAA violation
357) Chemistry used by next generation sequencing
358) Likelihood of HLA identical genotype in siblings
359) Heavy chain CDR3 length; V, D, and J segments
360) Understanding the effect different mutations have on the function of a protein
361) Isothermal amplification for transcription mediated amplification and nucleic acid sequence based
amplification
362) Karyotype; chronic myelogenous leukemia (CML)